THE ROLE OF NUCLEAR ARCHITECTURE IN THE DNA DAMAGE RESPONSE
Grant number: 1104461 | Funding period: 2017 - 2019
The goal of the proposed research is to understand how dynamic changes to the chromatin genome packaging network, interact with the DNA damage response and gene expression machinery, to repair damaged DNA and the impact this has on cancer biology. To do so we are combining cutting edge molecular biology techniques with innovative novel microscopy methods developed by our research team, that far exceed the spatiotemporal resolution currently used to study chromatin biology.
Related publications (5)
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Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection
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Ponatinib Inhibits Multiple Signaling Pathways Involved in STAT3 Signaling and Attenuates Colorectal Tumor Growth
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