MAINTENANCE OF REGULATORY T CELLS DURING INFLAMMATION AND TUMOR DEVELOPMENT BY IL-33

Grant number: 1106378 | Funding period: 2017 - 2018

Completed

Abstract

Regulatory T cells (Tregs) are required for preventing inflammation in tissues such as lung, fat and skin. We found recently, that the signalling molecule IL-33 is required for tissue Tregs and up-regulated during inflammation and tumor development. We therefore aim to determine the role of IL-33 in maintenance and function of Tregs and to identify molecular targets of IL-33 that may allow therapeutic targeting of Tregs in patients with inflammatory conditions or cancer.

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