REGULATION OF METABOLIC DYSFUNCTION AND EXHAUSTION OF VIRUS-SPECIFIC T CELLS DURING CHRONIC INFECTION
Grant number: 1085151 | Funding period: 2017 - 2018
T cells control infections and cancer cells. During chronic infection or tumor development, however, loss of function of T cells prevents efficient clearing of pathogens or cancer cells, a phenomenon termed T cell ‘exhaustion’. We have found that the regulator protein IRF4 controls cellular nutrient usage, growth and function of T cells and that very amounts of IRF4 occur in T cells during chronic infection. We propose to examine the precise role of IRF4 in chronically stimulated T cells.
Related publications (4)
Transforming growth factor-b-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic infection
Sarah S Gabriel, Carlson Tsui, David Chisanga, Flora Weber, Manuela Llano-Leon, Patrick M Gubser, Laurent Bartholin, Fernando Souza-Fonseca-Guimaraes, Nicholas D Huntington, Wei Shi, Daniel T Utzschneider, Axel Kallies
Antigen-specific CD8+ T cells in chronic viral infections and tumors functionally deteriorate, a process known as exhaustion. Exha..
Early precursor T cells establish and propagate T cell exhaustion in chronic infection
Daniel T Utzschneider, Sarah S Gabriel, David Chisanga, Renee Gloury, Patrick M Gubser, Ajithkumar Vasanthakumar, Wei Shi, Axel Kallies
CD8+ T cells responding to chronic infections or tumors acquire an 'exhausted' state associated with elevated expression of inhibi..
Transcription Factor IRF4 Promotes CD8( ) T Cell Exhaustion and Limits the Development of Memory-like T Cells during Chronic Infection
Kevin Man, Sarah S Gabriel, Yang Liao, Renee Gloury, Simon Preston, Darren C Henstridge, Marc Pellegrini, Dietmar Zehn, Friederike Berberich-Siebelt, Mark A Febbraio, Wei Shi, Axel Kallies
During chronic stimulation, CD8+ T cells acquire an exhausted phenotype characterized by expression of inhibitory receptors, down-..
CXCR5( ) follicular cytotoxic T cells control viral infection in B cell follicles
Yew Ann Leong, Yaping Chen, Hong Sheng Ong, Di Wu, Kevin Man, Claire Deleage, Martina Minnich, Benjamin J Meckiff, Yunbo Wei, Zhaohua Hou, Dimitra Zotos, Kevin A Fenix, Anurag Atnerkar, Simon Preston, Jeffrey G Chipman, Greg J Beilman, Cody C Allison, Lei Sun, Peng Wang, Jiawei Xu
During unresolved infections, some viruses escape immunological control and establish a persistant reservoir in certain cell types..