Understanding brain mechanisms that control autonomic function

Grant number: FT170100363 | Funding period: 2017 - 2021

Completed

Abstract

This project aims to understand the how the brain regulates sympathetic nerve activity, thereby increasing our understanding of the biology and function of nascent neurons on the adult brain stem. This challenges the current notion that new neurons are only made during development. The project will also determine how brain inflammation impacts blood-brain barrier function and affects sympathetic nerve regulation. The basic fundamental insights and conceptual advances into how autonomic function is controlled by the brain will provide a better understanding of these fundamental processes and will contribute to Australia’s priority research areas to improve health and advance product developme..

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Related publications (14)

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Associations Between Systemic and Cerebral Inflammation in an Ovine Model of Cardiopulmonary Bypass.

Khalid Elsaafien, Jasmine M Sloan, Roger G Evans, Andrew D Cochrane, Bruno Marino, Peter R McCall, Sally G Hood, Song T Yao, Willian S Korim, Simon R Bailey, Alemayehu H Jufar, Rachel M Peiris, Rinaldo Bellomo, Lachlan F Miles, Clive N May, Yugeesh R Lankadeva

2023-04-01

BACKGROUND: Intraoperative inflammation may contribute to postoperative neurocognitive disorders after cardiac surgery requiring c..

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Renal, Cardiac, and Autonomic Effects of Catheter-Based Renal Denervation in Ovine Heart Failure

Lindsea C Booth, R Anethra U de Silva, Roberto B Pontes, Song T Yao, Sally G Hood, Yugeesh R Lankadeva, Junko Kosaka, Nina Eikelis, Gavin W Lambert, Markus P Schlaich, Clive N May

2021-09-01

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Transcriptome Analysis Reveals Downregulation of Urocortin Expression in the Hypothalamo-Neurohypophysial System of Spontaneously Hypertensive Rats

Andrew Martin, Andre S Mecawi, Vagner R Antunes, Song T Yao, Jose Antunes-Rodrigues, Julian FR Paton, Alex Paterson, Michael Greenwood, Olivera Sarenac, Bojana Savic, Nina Japundzic-Zigon, David Murphy, Charles CT Hindmarch

2021-03-17

The chronically increased blood pressure characteristic of essential hypertension represents an insidious and cumulative risk for ..

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Selective optogenetic stimulation of efferent fi bers in the vagus nerve of a large mammal

Lindsea C Booth, Song T Yao, Alla Korsak, David GS Farmer, Sally G Hood, Daniel McCormick, Quinn Boesley, Angela A Connelly, Stuart J McDougall, Willian S Korim, Sarah-Jane Guild, Svetlana Mastitskaya, Phuong Le, Anja G Teschemacher, Sergey Kasparov, Gareth L Ackland, Simon C Malpas, Robin M McAllen, Andrew M Allen, Clive N May

2021-01-01

BACKGROUND: Electrical stimulation applied to individual organs, peripheral nerves, or specific brain regions has been used to tre..

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Systemic administration of pentoxifylline attenuates the development of hypertension in renovascular hypertensive rats

Anthony Setiadi, Willian S Korim, Clive N May, Song T Yao

2020-07-14

There is evidence to suggest that hypertension involves a chronic low-grade systemic inflammatory response; however, the underlyin..

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The inflammatory cytokine, interleukin-1-beta, drives central immune cell infiltration, changes in sympathetic nerve activity and blood pressure

Song Yao, Alicia Chan, Khalid Elsaafien, Willian Korim

2020-04-01

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Chemoattraction and Recruitment of Activated Immune Cells, Central Autonomic Control, and Blood Pressure Regulation

Khalid Elsaafien, Willian S Korim, Anthony Setiadi, Clive N May, Song T Yao

2019-08-02

Inflammatory mediators play a critical role in the regulation of sympathetic outflow to cardiovascular organs in hypertension. Eme..

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In renovascular hypertension, TNF- type-1 receptors in the area postrema mediate increases in cardiac and renal sympathetic nerve activity and blood pressure

Willian S Korim, Khalid Elsaafien, Jeremy R Basser, Anthony Setiadi, Clive N May, Song T Yao

2019-05-01

AIMS: Neuroinflammation is a common feature in renovascular, obesity-related, and angiotensin II mediated hypertension. There is e..

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In Renovascular Hypertension, TNF‐α Type‐1 Receptors in the Area Postrema Mediate Increases in Cardiac and Renal Sympathetic Nerve Activity and Blood Pressure

Willian S Korim, Khalid Elsaafien, Jeremy Basser, Anthony Setiadi, Clive N May, Song T Yao

2019-04-01

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The Chemoattraction of Immune Cells into the Hypothalamic Paraventricular Nucleus Elicits Sympathetically‐Mediated Blood Pressure Elevations in Hypertension

Khalid Elsaafien, Willian Seji Korim, Clive Newton May, Song Tieng Yao

2019-04-01

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Glycinergic neurotransmission in the rostral ventrolateral medulla controls the time course of baroreflex-mediated sympathoinhibition

Hong Gao, Willian S Korim, Song T Yao, Cheryl M Heesch, Andrei V Derbenev

2019-01-01

KEY POINTS: To maintain appropriate blood flow to various tissues of the body under a variety of physiological states, autonomic n..

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CCL2‐CCR2 Signalling in the Hypothalamic Paraventricular Nucleus Elicits Sympathetic‐Mediated Blood Pressure Elevations Through Monocyte and Lymphocyte Recruitment

Khalid Elsaafien, Willian Seji Korim, Clive Newton May, Song Tieng Yao

2018-04-01

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NOVEL ROLE OF GLYCINE IN CONTROL OF SYMPATHETIC OUTFLOW

Gao Hong, Willian S Korim, Song T Yao, Cheryl M Heesch, Andrei V Derbenev

2018-04-01

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The role of the blood-brain barrier in hypertension

Anthony Setiadi, Willian S Korim, Khalid Elsaafien, Song T Yao

2018-03-01

What is the topic of this review? This review highlights the importance of the blood-brain barrier in the context of diseases invo..

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