Understanding brain mechanisms that control autonomic function
Grant number: FT170100363 | Funding period: 2017 - 2021
This project aims to understand the how the brain regulates sympathetic nerve activity, thereby increasing our understanding of the biology and function of nascent neurons on the adult brain stem. This challenges the current notion that new neurons are only made during development. The project will also determine how brain inflammation impacts blood-brain barrier function and affects sympathetic nerve regulation. The basic fundamental insights and conceptual advances into how autonomic function is controlled by the brain will provide a better understanding of these fundamental processes and will contribute to Australia’s priority research areas to improve health and advance product developme..View full description
Related publications (14)
Associations Between Systemic and Cerebral Inflammation in an Ovine Model of Cardiopulmonary Bypass.
Khalid Elsaafien, Jasmine M Sloan, Roger G Evans, Andrew D Cochrane, Bruno Marino, Peter R McCall, Sally G Hood, Song T Yao, Willian S Korim, Simon R Bailey, Alemayehu H Jufar, Rachel M Peiris, Rinaldo Bellomo, Lachlan F Miles, Clive N May, Yugeesh R Lankadeva
BACKGROUND: Intraoperative inflammation may contribute to postoperative neurocognitive disorders after cardiac surgery requiring c..
Renal, Cardiac, and Autonomic Effects of Catheter-Based Renal Denervation in Ovine Heart Failure
Lindsea C Booth, R Anethra U de Silva, Roberto B Pontes, Song T Yao, Sally G Hood, Yugeesh R Lankadeva, Junko Kosaka, Nina Eikelis, Gavin W Lambert, Markus P Schlaich, Clive N May
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Transcriptome Analysis Reveals Downregulation of Urocortin Expression in the Hypothalamo-Neurohypophysial System of Spontaneously Hypertensive Rats
Andrew Martin, Andre S Mecawi, Vagner R Antunes, Song T Yao, Jose Antunes-Rodrigues, Julian FR Paton, Alex Paterson, Michael Greenwood, Olivera Sarenac, Bojana Savic, Nina Japundzic-Zigon, David Murphy, Charles CT Hindmarch
The chronically increased blood pressure characteristic of essential hypertension represents an insidious and cumulative risk for ..
Selective optogenetic stimulation of efferent fi bers in the vagus nerve of a large mammal
Lindsea C Booth, Song T Yao, Alla Korsak, David GS Farmer, Sally G Hood, Daniel McCormick, Quinn Boesley, Angela A Connelly, Stuart J McDougall, Willian S Korim, Sarah-Jane Guild, Svetlana Mastitskaya, Phuong Le, Anja G Teschemacher, Sergey Kasparov, Gareth L Ackland, Simon C Malpas, Robin M McAllen, Andrew M Allen, Clive N May
BACKGROUND: Electrical stimulation applied to individual organs, peripheral nerves, or specific brain regions has been used to tre..
Systemic administration of pentoxifylline attenuates the development of hypertension in renovascular hypertensive rats
Anthony Setiadi, Willian S Korim, Clive N May, Song T Yao
There is evidence to suggest that hypertension involves a chronic low-grade systemic inflammatory response; however, the underlyin..
Chemoattraction and Recruitment of Activated Immune Cells, Central Autonomic Control, and Blood Pressure Regulation
Khalid Elsaafien, Willian S Korim, Anthony Setiadi, Clive N May, Song T Yao
Inflammatory mediators play a critical role in the regulation of sympathetic outflow to cardiovascular organs in hypertension. Eme..
In renovascular hypertension, TNF- type-1 receptors in the area postrema mediate increases in cardiac and renal sympathetic nerve activity and blood pressure
Willian S Korim, Khalid Elsaafien, Jeremy R Basser, Anthony Setiadi, Clive N May, Song T Yao
AIMS: Neuroinflammation is a common feature in renovascular, obesity-related, and angiotensin II mediated hypertension. There is e..
Glycinergic neurotransmission in the rostral ventrolateral medulla controls the time course of baroreflex-mediated sympathoinhibition
Hong Gao, Willian S Korim, Song T Yao, Cheryl M Heesch, Andrei V Derbenev
KEY POINTS: To maintain appropriate blood flow to various tissues of the body under a variety of physiological states, autonomic n..