GENETIC CONTROL OF ISLET INFLAMMATION IN DIABETES
Grant number: 1130222 | Funding period: 2017 - 2020
Diabetes is a major health epidemic; and both type 1 and type 2 diabetes can lead to the development of diabetic complications - the major cause of morbidity and mortality from diabetes. Loss of islet function is a key factor in diabetes and my testable hypothesis is that islet inflammation contributes to this process. We will investigate how genes effect islet inflammation. New understanding could lead to biomarkers for determining who is susceptible & new treatment opportunities.
Related publications (1)
Inhibition of Y1 receptor signaling improves islet transplant outcome
Kim Loh, Yan-Chuan Shi, Stacey Walters, Mohammed Bensellam, Kailun Lee, Katsuya Dezaki, Masanori Nakata, Chi Kin Ip, Jeng Yie Chan, Esteban N Gurzov, Helen E Thomas, Michaela Waibel, James Cantley, Thomas W Kay, Toshihiko Yada, D Ross Laybutt, Shane T Grey, Herbert Herzog
Failure to secrete sufficient quantities of insulin is a pathological feature of type-1 and type-2 diabetes, and also reduces the ..