CENTRE FOR RESEARCH EXCELLENCE IN MALARIA ELIMINATION

Pathogenicity and virulence of malaria: Sticky problems and tricky solutions

Isobel S Walker, Stephen J Rogerson

2023-12-31

Infections with Plasmodium falciparum and Plasmodium vivax cause over 600,000 deaths each year, concentrated in Africa and in youn..

Quantification of parasite clearance in Plasmodium knowlesi infections.

Jeyamalar T Thurai Rathnam, Matthew J Grigg, Saber Dini, Timothy William, Sitti Saimah Sakam, Daniel J Cooper, Giri S Rajahram, Bridget E Barber, Nicholas M Anstey, Ali Haghiri, Megha Rajasekhar, Julie A Simpson

2023-02-14

BACKGROUND: The incidence of zoonotic Plasmodium knowlesi infections in humans is rising in Southeast Asia, leading to clinical st..

Identification of novel Plasmodium vivax proteins associated with protection against clinical malaria.

Ramin Mazhari, Eizo Takashima, Rhea J Longley, Shazia Ruybal-Pesantez, Michael T White, Bernard N Kanoi, Hikaru Nagaoka, Benson Kiniboro, Peter Siba, Takafumi Tsuboi, Ivo Mueller

2023-01-25

As progress towards malaria elimination continues, the challenge posed by the parasite species Plasmodium vivax has become more ev..

A molecular barcode and web-based data analysis tool to identify imported Plasmodium vivax malaria.

Hidayat Trimarsanto, Roberto Amato, Richard D Pearson, Edwin Sutanto, Rintis Noviyanti, Leily Trianty, Jutta Marfurt, Zuleima Pava, Diego F Echeverry, Tatiana M Lopera-Mesa, Lidia M Montenegro, Alberto Tobón-Castaño, Matthew J Grigg, Bridget Barber, Timothy William, Nicholas M Anstey, Sisay Getachew, Beyene Petros, Abraham Aseffa, Ashenafi Assefa

2022-12-23

Traditionally, patient travel history has been used to distinguish imported from autochthonous malaria cases, but the dormant live..

Acquisition of antibodies to Plasmodium falciparum and Plasmodium vivax antigens in pregnant women living in a low malaria transmission area of Brazil

Meseret W Kassa, Wina Hasang, Andre Barateiro, Timon Damelang, Jessica Brewster, Jamille GG Dombrowski, Rhea JJ Longley, Amy W Chung, Gerhard Wunderlich, Ivo Mueller, Elizabeth H Aitken, Claudio RF Marinho, Stephen JJ Rogerson

2022-12-01

BACKGROUND: Pregnant women have increased susceptibility to Plasmodium falciparum malaria and acquire protective antibodies over s..

Longitudinal IgG antibody responses to Plasmodium vivax blood-stage antigens during and after acute vivax malaria in individuals living in the Brazilian Amazon

Tenzin Tashi, Aditi Upadhye, Prasun Kundu, Chunxiang Wu, Sebastien Menant, Roberta Reis Soares, Marcelo U Ferreira, Rhea J Longley, Ivo Mueller, Quyen Q Hoang, Wai-Hong Tham, Julian C Rayner, Kezia Kg Scopel, Josue C Lima-Junior, Tuan M Tran

2022-11-01

BACKGROUND: To make progress towards malaria elimination, a highly effective vaccine targeting Plasmodium vivax is urgently needed..

Stochastic Modeling of Within-Host Dynamics of Plasmodium Falciparum

Xiao Sun, James M McCaw, Pengxing Cao

2022-11-01

Malaria remains a major public health burden in South-East Asia and Africa. Mathematical models of within-host infection dynamics ..

Single-cell RNA sequencing of Plasmodium vivax sporozoites reveals stage- and species-specific transcriptomic signatures

Anthony A Ruberto, Caitlin Bourke, Amelie Vantaux, Steven P Maher, Aaron Jex, Benoit Witkowski, Georges Snounou, Ivo Mueller

2022-08-01

BACKGROUND: Plasmodium vivax sporozoites reside in the salivary glands of a mosquito before infecting a human host and causing mal..

Plasmodium vivax malaria serological exposure markers: Assessing the degree and implications of cross-reactivity with P. knowlesi

Rhea J Longley, Matthew J Grigg, Kael Schoffer, Thomas Obadia, Stephanie Hyslop, Kim A Piera, Narimane Nekkab, Ramin Mazhari, Eizo Takashima, Takafumi Tsuboi, Matthias Harbers, Kevin Tetteh, Chris Drakeley, Chetan E Chitnis, Julie Healer, Wai-Hong Tham, Jetsumon Sattabongkot, Michael T White, Daniel J Cooper, Giri S Rajahram

2022-06-21

Serological markers are a promising tool for surveillance and targeted interventions for Plasmodium vivax malaria. P. vivax is clo..

Comparison of Antibody Responses and Parasite Clearance in Artemisinin Therapeutic Efficacy Studies in the Democratic Republic of Congo and Asia

Julia C Cutts, Katherine O'Flaherty, Sophie G Zaloumis, Elizabeth A Ashley, Jo Anne Chan, Marie A Onyamboko, Caterina Fanello, Arjen M Dondorp, Nicholas P Day, Aung Pyae Phyo, Mehul Dhorda, Mallika Imwong, Rick M Fairhurst, Pharath Lim, Chanaki Amaratunga, Sasithon Pukrittayakamee, Tran Tinh Hien, Ye Htut, Mayfong Mayxay, M Abdul Faiz

2022-06-15

BACKGROUND: Understanding the effect of immunity on Plasmodium falciparum clearance is essential for interpreting therapeutic effi..

Associations of maternal iron deficiency with malaria infection in a cohort of pregnant Papua New Guinean women

Holger W Unger, Andie Bleicher, Maria Ome-Kaius, Elizabeth H Aitken, Stephen J Rogerson

2022-05-26

BACKGROUND: Iron deficiency (ID) is common in malaria-endemic settings. Intermittent preventative treatment of malaria in pregnanc..

Malaria transmission structure in the Peruvian Amazon through antibody signatures to Plasmodium vivax.

Jason Rosado, Gabriel Carrasco-Escobar, Oscar Nolasco, Katherine Garro, Hugo Rodriguez-Ferruci, Mitchel Guzman-Guzman, Alejandro Llanos-Cuentas, Joseph M Vinetz, Narimane Nekkab, Michael T White, Ivo Mueller, Dionicia Gamboa

2022-05-01

BACKGROUND: The landscape of malaria transmission in the Peruvian Amazon is temporally and spatially heterogeneous, presenting dif..

Can malaria parasites be spontaneously cleared?

Merryn S Roe, Katherine O'Flaherty, Freya J Fowkes

2022-04-13

A large body of evidence demonstrates that Plasmodium falciparum infections are chronic in malaria endemic areas; however, the not..

Anti-Gametocyte Antigen Humoral Immunity and Gametocytemia During Treatment of Uncomplicated Falciparum Malaria: A Multi-National Study

Katherine O'Flaherty, Jo-Anne Chan, Julia C Cutts, Sophie G Zaloumis, Elizabeth A Ashley, Aung Pyae Phyo, Damien R Drew, Arjen M Dondorp, Nicholas P Day, Mehul Dhorda, Rick M Fairhurst, Pharath Lim, Chanaki Amaratunga, Sasithon Pukrittayakamee, Tinh Hien Tran, Ye Htut, Mayfong Mayxay, M Abul Faiz, Olugbenga A Mokuolu, Marie A Onyamboko

2022-04-07

INTRODUCTION: Understanding the human immune response to Plasmodium falciparum gametocytes and its association with gametocytemia ..

Naturally acquired antibody kinetics against Plasmodium vivax antigens in people from a low malaria transmission region in western Thailand

Zoe Shih-Jung Liu, Jetsumon Sattabongkot, Michael White, Sadudee Chotirat, Chalermpon Kumpitak, Eizo Takashima, Matthias Harbers, Wai-Hong Tham, Julie Healer, Chetan E Chitnis, Takafumi Tsuboi, Ivo Mueller, Rhea J Longley

2022-03-09

BACKGROUND: Plasmodium vivax (P. vivax) is the dominant Plasmodium spp. causing the disease malaria in low-transmission regions ou..

Quantification of the dynamics of antibody response to malaria to inform sero-surveillance in pregnant women

ADV Tharkeshi T Dharmaratne, Saber Dini, Katherine O'Flaherty, David J Price, James Beeson, Rose McGready, Francois Nosten, Freya J Fowkes, Julie A Simpson, Sophie G Zaloumis

2022-03-05

BACKGROUND: Malaria remains a major public health threat and tools sensitive to detect infections in low malaria transmission area..

Comparison of total immunoglobulin G antibody responses to different protein fragments of Plasmodium vivax Reticulocyte binding protein 2b

Caitlin Bourke, Eizo Takashima, Li-Jin Chan, Melanie H Dietrich, Ramin Mazhari, Michael White, Jetsumon Sattabongkot, Wai-Hong Tham, Takafumi Tsuboi, Ivo Mueller, Rhea Longley

2022-03-04

BACKGROUND: Plasmodium vivax is emerging as the dominant and prevalent species causing malaria in near-elimination settings outsid..

Supervised versus unsupervised primaquine radical cure for the treatment of falciparum and vivax malaria in Papua, Indonesia: a cluster-randomised, controlled, open-label superiority trial

Jeanne Rini Poespoprodjo, Faustina Helena Burdam, Freis Candrawati, Benedikt Ley, Niamh Meagher, Enny Kenangalem, Ratni Indrawanti, Leily Trianty, Kamala Thriemer, David J Price, Julie A Simpson, Ric N Price

2022-02-23

BACKGROUND: There is a high risk of Plasmodium vivax recurrence in patients treated for Plasmodium falciparum malaria in co-endemi..

Scoping Review of Antimalarial Drug Candidates in Phase I and II Drug Development

Azrin N Abd-Rahman, Sophie Zaloumis, James S McCarthy, Julie A Simpson, Robert J Commons

2022-02-01

The emergence and spread of parasite resistance to currently available antimalarials has highlighted the importance of developing ..

The role of naturally acquired antimalarial antibodies in subclinical Plasmodium spp. infection

Katherine O'Flaherty, Merryn Roe, Freya J Fowkes

2022-01-20

Undetected subclinical Plasmodium spp. infections are a significant barrier to eliminating malaria. In malaria-endemic areas, natu..

Assessment of IgG3 as a serological exposure marker for Plasmodium vivax in areas with moderate-high malaria transmission intensity.

Yanie Tayipto, Jason Rosado, Dionicia Gamboa, Michael T White, Benson Kiniboro, Julie Healer, D Herbert Opi, James G Beeson, Eizo Takashima, Takafumi Tsuboi, Matthias Harbers, Leanne Robinson, Ivo Mueller, Rhea J Longley

2022-01-09

A more sensitive surveillance tool is needed to identify Plasmodium vivax infections for treatment and to accelerate malaria elimi..

Perspectives of health and community stakeholders on community-delivered models of malaria elimination in Lao People's Democratic Republic: A qualitative study.

May Chan Oo, Khampheng Phongluxa, Win Han Oo, Sengchanh Kounnavong, Syda Xayyavong, Chanthaly Louangphaxay, Win Htike, Julia C Cutts, Kaung Myat Thu, Galau Naw Hkawng, Freya JI Fowkes

2022-01-01

In the Lao People's Democratic Republic (Lao PDR), village health volunteers play an important role in providing health services i..

Anopheles salivary antigens as serological biomarkers of vector exposure and malaria transmission: A systematic review with multilevel modelling

Ellen A Kearney, Paul A Agius, Victor Chaumeau, Julia C Cutts, Julie A Simpson, Freya J Fowkes

2021-12-23

BACKGROUND: Entomological surveillance for malaria is inherently resource-intensive and produces crude population-level measures o..

Sustainability of a mobile phone application-based data reporting system in Myanmar's malaria elimination program: a qualitative study

Win Han Oo, Kaung Myat Thu, Julia C Cutts, Win Htike, Kyawt Mon Win, May Chan Oo, Naw Hkawng Galau, Paul A Agius, Pyae Phyo Htoon, Ellen Kearney, Aung Thi, Ye Win Aung, Min Min Thein, Kathryn Rosecrans, Kyi Tun Lwin, Aung Kyi Min, Freya J Fowkes

2021-10-18

BACKGROUND: Strengthening surveillance systems to collect near-real-time case-based data plays a fundamental role in achieving mal..

The relationship between markers of antenatal iron stores and birth outcomes differs by malaria prevention regimen-a prospective cohort study

Holger W Unger, Valentina Laurita Longo, Andie Bleicher, Maria Ome-Kaius, Stephan Karl, Julie A Simpson, Amalia Karahalios, Elizabeth H Aitken, Stephen J Rogerson

2021-10-05

BACKGROUND: Iron deficiency (ID) has been associated with adverse pregnancy outcomes, maternal anaemia, and altered susceptibility..

Investigating differences in village-level heterogeneity of malaria infection and household risk factors in Papua New Guinea

Desmond Gul, Daniela Rodriguez-Rodriguez, Elma Nate, Alma Auwan, Mary Salib, Lina Lorry, John B Keven, Michelle Katusele, Jason Rosado, Natalie Hofmann, Maria Ome-Kaius, Cristian Koepfli, Ingrid Felger, James W Kazura, Manuel W Hetzel, Ivo Mueller, Stephan Karl, Archie CA Clements, Freya J Fowkes, Moses Laman

2021-08-16

Malaria risk is highly heterogeneous. Understanding village and household-level spatial heterogeneity of malaria risk can support ..

Surveillance of molecular markers of Plasmodium falciparum artemisinin resistance (kelch13 mutations) in Papua New Guinea between 2016 and 2018

Dulcie Lautu-Gumal, Zahra Razook, Tamarah Koleala, Elma Nate, Samuel McEwen, Diana Timbi, Manuel W Hetzel, Evelyn Lavu, Nakapi Tefuarani, Leo Makita, James Kazura, Ivo Mueller, William Pomat, Moses Laman, Leanne J Robinson, Alyssa E Barry

2021-07-13

Plasmodium falciparum resistance to artemisinin-based combination therapy (ACT) is a global threat to malaria control and eliminat..

Application of 23 Novel Serological Markers for Identifying Recent Exposure to Plasmodium vivax Parasites in an Endemic Population of Western Thailand

Sadudee Chotirat, Narimane Nekkab, Chalermpon Kumpitak, Jenni Hietanen, Michael T White, Kirakorn Kiattibutr, Patiwat Sa-angchai, Jessica Brewster, Kael Schoffer, Eizo Takashima, Takafumi Tsuboi, Matthias Harbers, Chetan E Chitnis, Julie Healer, Wai-Hong Tham, Wang Nguitragool, Ivo Mueller, Jetsumon Sattabongkot, Rhea J Longley

2021-06-29

Thailand is aiming for malaria elimination by the year 2030. However, the high proportion of asymptomatic infections and the prese..

Seeking an optimal dosing regimen for OZ439/DSM265 combination therapy for treating uncomplicated falciparum malaria

Saber Dini, Sophie G Zaloumis, David J Price, Nathalie Gobeau, Anne Kummel, Mohammed Cherkaoui, Joerg J Moehrle, James S McCarthy, Julie A Simpson

2021-06-28

BACKGROUND: The efficacy of artemisinin-based combination therapies (ACTs), the first-line treatments for uncomplicated falciparum..

Beyond Binding: The Outcomes of Antibody-Dependent Complement Activation in Human Malaria

Dilini Rathnayake, Elizabeth H Aitken, Stephen J Rogerson

2021-06-08

Antibody immunity against malaria is effective but non-sterile. In addition to antibody-mediated inhibition, neutralisation or ops..

Development and Validation of an In Silico Decision Tool To Guide Optimization of Intravenous Artesunate Dosing Regimens for Severe Falciparum Malaria Patients

Sophie G Zaloumis, Jason M Whyte, Joel Tarning, Sanjeev Krishna, James M McCaw, Pengxing Cao, Michael T White, Saber Dini, Freya J Fowkes, Richard J Maude, Peter Kremsner, Arjen Dondorp, Ric N Price, Nicholas J White, Julie A Simpson

2021-06-01

Most deaths from severe falciparum malaria occur within 24 h of presentation to a hospital. Intravenous (i.v.) artesunate is the f..

Global economic costs due to vivax malaria and the potential impact of its radical cure: A modelling study

Angela Devine, Katherine E Battle, Niamh Meagher, Rosalind E Howes, Saber Dini, Peter W Gething, Julie A Simpson, Ric N Price, Yoel Lubell

2021-06-01

BACKGROUND: In 2017, an estimated 14 million cases of Plasmodium vivax malaria were reported from Asia, Central and South America,..

IgG Antibody Responses Are Preferential Compared With IgM for Use as Serological Markers for Detecting Recent Exposure to Plasmodium vivax Infection

Rhea J Longley, Michael T White, Jessica Brewster, Zoe SJ Liu, Caitlin Bourke, Eizo Takashima, Matthias Harbers, Wai-Hong Tham, Julie Healer, Chetan E Chitnis, Wuelton Monteiro, Marcus Lacerda, Jetsumon Sattabongkot, Takafumi Tsuboi, Ivo Mueller

2021-06-01

To achieve malaria elimination, new tools are required to explicitly target Plasmodium vivax. Recently, a novel panel of P. vivax ..

Community-based molecular and serological surveillance of subclinical malaria in Myanmar

Katherine O'Flaherty, Win Han Oo, Sophie G Zaloumis, Julia C Cutts, Kyaw Zayar Aung, Myat Mon Thein, Damien R Drew, Zahra Razook, Alyssa E Barry, Naanki Parischa, Nyi Nyi Zaw, Htin Kyaw Thu, Aung Thi, Wai Yan Min Htay, Aung Paing Soe, Julie A Simpson, James G Beeson, Paul A Agius, Freya JI Fowkes

2021-05-28

BACKGROUND: In the Greater Mekong Subregion (GMS), current malaria surveillance strategies rely on a network of village health vol..

A mobile phone application for malaria case-based reporting to advance malaria surveillance in Myanmar: a mixed methods evaluation

Win Han Oo, Win Htike, Julia C Cutts, Kyawt Mon Win, Kaung Myat Thu, May Chan Oo, Galau Naw Hkawng, Paul A Agius, Pyae Phyo Htoon, Nick Scott, Ellen Kearney, Clarissa Moreira, Alisa Pedrana, Mark Stoove, Thi Aung, Ye Win Aung, Min Thein Min, Kathryn Rosecrans, Kyi Tun Lwin, Aung Kyi Min

2021-03-26

BACKGROUND: To achieve malaria elimination in the Greater Mekong Subregion, including Myanmar, it is necessary to ensure all malar..

Mechanisms and targets of Fc gamma-receptor mediated immunity to malaria sporozoites

Gaoqian Feng, Bruce D Wines, Liriye Kurtovic, Jo-Anne Chan, Philippe Boeuf, Vanessa Mollard, Anton Cozijnsen, Damien R Drew, Rob J Center, Daniel L Marshall, Sandra Chishimba, Geoffrey McFadden, Arlene E Dent, Kiprotich Chelimo, Michelle J Boyle, James W Kazura, P Mark Hogarth, James G Beeson

2021-03-19

A highly protective vaccine will greatly facilitate achieving and sustaining malaria elimination. Understanding mechanisms of anti..

Single-cell RNA sequencing reveals developmental heterogeneity among Plasmodium berghei sporozoites

Anthony A Ruberto, Caitlin Bourke, Nicolas Merienne, Thomas Obadia, Rogerio Amino, Ivo Mueller

2021-02-22

In the malaria-causing parasite's life cycle, Plasmodium sporozoites must travel from the midgut of a mosquito to the salivary gla..

Heterogeneity in response to serological exposure markers of recent Plasmodium vivax infections in contrasting epidemiological contexts

Jason Rosado, Michael T White, Rhea J Longley, Marcus Lacerda, Wuelton Monteiro, Jessica Brewster, Jetsumon Sattabongkot, Mitchel Guzman-Guzman, Alejandro Llanos-Cuentas, Joseph M Vinetz, Dionicia Gamboa, Ivo Mueller

2021-02-01

BACKGROUND: Antibody responses as serological markers of Plasmodium vivax infection have been shown to correlate with exposure, bu..

Evaluation of the effectiveness and cost effectiveness of a Community-delivered Integrated Malaria Elimination (CIME) model in Myanmar: protocol for an open stepped-wedge cluster-randomised controlled trial

Win Han Oo, Aung Thi, Win Htike, Paul A Agius, Julia C Cutts, Kyawt Mon Win, Nay Yi Yi Linn, Wint Phyo Than, Galau Naw Hkawng, Kaung Myat Thu, May Chan Oo, Katherine O'Flaherty, Ellen Kearney, Nick Scott, Pwint Phyu Phyu, Aung Thu Htet, Ohnmar Myint, Lwin Lwin Yee, Zay Phyo Thant, Aung Mon

2021-01-01

INTRODUCTION: In the Greater Mekong Subregion, community health workers, known as malaria volunteers, have played a key role in re..

Th2-like T Follicular Helper Cells Promote Functional Antibody Production during Plasmodium falciparum Infection

Jo-Anne Chan, Jessica R Loughland, Fabian de Labastida Rivera, Arya SheelaNair, Dean W Andrew, Nicholas L Dooley, Bruce D Wines, Fiona H Amante, Lachlan Webb, P Mark Hogarth, James S McCarthy, James G Beeson, Christian R Engwerda, Michelle J Boyle

2020-12-22

CD4+ T follicular helper cells (Tfh) are key drivers of antibody development. During Plasmodium falciparum malaria in children, th..

A comparison of non-magnetic and magnetic beads for measuring IgG antibodies against Plasmodium vivax antigens in a multiplexed bead-based assay using Luminex technology (Bio-Plex 200 or MAGPIX)

Ramin Mazhari, Jessica Brewster, Rich Fong, Caitlin Bourke, Zoe SJ Liu, Eizo Takashima, Takafumi Tsuboi, Wai-Hong Tham, Matthias Harbers, Chetan Chitnis, Julie Healer, Maria Ome-Kaius, Jetsumon Sattabongkot, James Kazura, Leanne J Robinson, Christopher King, Ivo Mueller, Rhea J Longley

2020-12-04

Multiplexed bead-based assays that use Luminex® xMAP® technology have become popular for measuring antibodies against proteins of ..

Emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations on the island of New Guinea

Olivo Miotto, Makoto Sekihara, Shin-Ichiro Tachibana, Masato Yamauchi, Richard D Pearson, Roberto Amato, Sonia Goncalves, Somya Mehra, Rintis Noviyanti, Jutta Marfurt, Sarah Auburn, Ric N Price, Ivo Mueller, Mie Ikeda, Toshiyuki Mori, Makoto Hirai, Livingstone Tavul, Manuel W Hetzel, Moses Laman, Alyssa E Barry

2020-12-01

The rapid and aggressive spread of artemisinin-resistant Plasmodium falciparum carrying the C580Y mutation in the kelch13 gene is ..

Artemisinin Resistance and the Unique Selection Pressure of a Short-acting Antimalarial

David S Khoury, Pengxing Cao, Sophie G Zaloumis, Miles P Davenport

2020-11-01

Resistance to the artemisinin derivatives, our most effective antimalarial drugs, has not manifest as a classical resistance pheno..

The risk of adverse clinical outcomes following treatment of Plasmodium vivax malaria with and without primaquine in Papua, Indonesia

Kamala Thriemer, Jeanne-Rini Poespoprodjo, Enny Kenangalem, Nicholas M Douglas, Paulus Sugiarto, Nicholas M Anstey, Julie Anne Simpson, Ric N Price

2020-11-01

The widespread use of primaquine (PQ) radical cure for P. vivax, is constrained by concerns over its safety. We used routinely col..

Estimating the Proportion of Plasmodium vivax Recurrences Caused by Relapse: A Systematic Review and Meta-Analysis

Robert J Commons, Julie A Simpson, James Watson, Nicholas J White, Ric N Price

2020-09-01

Plasmodium vivax and Plasmodium ovale form dormant liver hypnozoites that can reactivate weeks to months following initial infecti..

Evaluation of the effectiveness of topical repellent distributed by village health volunteer networks against Plasmodium spp. infection in Myanmar: A stepped-wedge cluster randomised trial

Paul A Agius, Julia C Cutts, Win Han Oo, Aung Thi, Katherine O'Flaherty, Kyaw Zayar Aung, Htin Kyaw Thu, Poe Poe Aung, Myat Mon Thein, Nyi Nyi Zaw, Wai Yan Min Htay, Aung Paing Soe, Zahra Razook, Alyssa E Barry, Win Htike, Angela Devine, Julie A Simpson, Brendan S Crabb, James G Beeson, Naanki Pasricha

2020-08-01

BACKGROUND: The World Health Organization has yet to endorse deployment of topical repellents for malaria prevention as part of pu..

Identifying and combating the impacts of COVID-19 on malaria

Stephen J Rogerson, James G Beeson, Moses Laman, Jeanne Rini Poespoprodjo, Timothy William, Julie A Simpson, Ric N Price

2020-07-30

BACKGROUND: The COVID-19 pandemic has resulted in millions of infections, hundreds of thousands of deaths and major societal disru..

Implementing parasite genotyping into national surveillance frameworks: feedback from control programmes and researchers in the Asia-Pacific region

Rintis Noviyanti, Olivo Miotto, Alyssa Barry, Jutta Marfurt, Sasha Siegel, Thuy-Nhien Nguyen, Hong Quang Huynh, Nancy Dian Anggraeni, Ferdinand Laihad, Yaobao Liu, Maria Endang Sumiwi, Hidayat Trimarsanto, Farah Coutrier, Nadia Fadila, Najia Ghanchi, Fatema Tuj Johora, Agatha Mia Puspitasari, Livingstone Tavul, Leily Trianty, Retno Ayu Setya Utami

2020-07-27

The Asia-Pacific region faces formidable challenges in achieving malaria elimination by the proposed target in 2030. Molecular sur..

Population Pharmacokinetics and Pharmacodynamics of Chloroquine in aPlasmodium vivaxVolunteer Infection Study

Azrin N Abd-Rahman, Louise Marquart, Nathalie Gobeau, Anne Kummel, Julie A Simpson, Stephan Chalon, Jorg J Mohrle, James S McCarthy

2020-07-02

Chloroquine has been used for the treatment of malaria for > 70 years; however, chloroquine pharmacokinetic (PK) and pharmacodynam..

Development and validation of serological markers for detecting recent Plasmodium vivax infection

Rhea J Longley, Michael T White, Eizo Takashima, Jessica Brewster, Masayuki Morita, Matthias Harbers, Thomas Obadia, Leanne J Robinson, Fumie Matsuura, Zoe SJ Liu, Connie SN Li-Wai-Suen, Wai-Hong Tham, Julie Healer, Christele Huon, Chetan E Chitnis, Wang Nguitragool, Wuelton Monteiro, Carla Proietti, Denise L Doolan, Andre M Siqueira

2020-05-01

A major gap in the Plasmodium vivax elimination toolkit is the identification of individuals carrying clinically silent and undete..

Malaria Parasite Clearance: What Are We Really Measuring?

David S Khoury, Sophie G Zaloumis, Matthew J Grigg, Ashraful Haque, Miles P Davenport

2020-05-01

Antimalarial drugs are vital for treating malaria and controlling transmission. Measuring drug efficacy in the field requires larg..

Quantification of glucose-6-phosphate dehydrogenase activity by spectrophotometry: A systematic review and meta-analysis

Daniel A Pfeffer, Benedikt Ley, Rosalind E Howes, Patrick Adu, Mohammad Shafiul Alam, Pooja Bansil, Yap Boum, Marcelo Brito, Pimlak Charoenkwan, Archie Clements, Liwang Cui, Zeshuai Deng, Ochaka Julie Egesie, Fe Esperanza Espino, Michael E von Fricken, Muzamil Mahdi Abdel Hamid, Yongshu He, Gisela Henriques, Wasif Ali Khan, Nimol Khim

2020-05-01

BACKGROUND: The radical cure of Plasmodium vivax and P. ovale requires treatment with primaquine or tafenoquine to clear dormant l..

The risk of morbidity and mortality following recurrent malaria in Papua, Indonesia: a retrospective cohort study

Saber Dini, Nicholas M Douglas, Jeanne Rini Poespoprodjo, Enny Kenangalem, Paulus Sugiarto, Ian D Plumb, Ric N Price, Julie A Simpson

2020-02-20

BACKGROUND: An acute episode of malaria can be followed by multiple recurrent episodes either due to re-infection, recrudescence o..

Pregnancy-specific malarial immunity and risk of malaria in pregnancy and adverse birth outcomes: a systematic review

Julia C Cutts, Paul A Agius, Lin Zaw, Rosanna Powell, Kerryn Moore, Bridget Draper, Julie A Simpson, Freya JI Fowkes

2020-01-16

BACKGROUND: In endemic areas, pregnant women are highly susceptible to Plasmodium falciparum malaria characterized by the accumula..

Complement in malaria immunity and vaccines

Liriye Kurtovic, Michelle J Boyle, D Herbert Opi, Alexander T Kennedy, Wai-Hong Tham, Linda Reiling, Jo-Anne Chan, James G Beeson

2020-01-01

Developing efficacious vaccines for human malaria caused by Plasmodium falciparum is a major global health priority, although this..

The risk of Plasmodium vivax parasitaemia after P. falciparum malaria: An individual patient data meta-analysis from the WorldWide Antimalarial Resistance Network

Mohammad S Hossain, Robert J Commons, Nicholas M Douglas, Kamala Thriemer, Bereket H Alemayehu, Chanaki Amaratunga, Anupkumar R Anvikar, Elizabeth A Ashley, Puji BS Asih, Verena I Carrara, Chanthap Lon, Umberto D'Alessandro, Timothy ME Davis, Arjen M Dondorp, Michael D Edstein, Rick M Fairhurst, Marcelo U Ferreira, Jimee Hwang, Bart Janssens, Harin Karunajeewa

2020-01-01

BACKGROUND: There is a high risk of Plasmodium vivax parasitaemia following treatment of falciparum malaria. Our study aimed to qu..

Dealing with indeterminate outcomes in antimalarial drug efficacy trials: a comparison between complete case analysis, multiple imputation and inverse probability weighting

Prabin Dahal, Kasia Stepniewska, Philippe J Guerin, Umberto D'Alessandro, Ric N Price, Julie A Simpson

2019-11-27

BACKGROUND: Antimalarial clinical efficacy studies for uncomplicated Plasmodium falciparum malaria frequently encounter situations..

Early and late mortality after malaria in young children in Papua, Indonesia

Dewi Patriani, Eggi Arguni, Enny Kenangalem, Saber Dini, Paulus Sugiarto, Afdhal Hasanuddin, Daniel Adrian Lampah, Nicholas M Douglas, Nicholas M Anstey, Julie Anne Simpson, Ric N Price, Jeanne Rini Poespoprodjo

2019-10-30

BACKGROUND: In southern Papua, Indonesia, malaria is highly prevalent in young children and is a significant cause of morbidity an..

Modeling the dynamics of Plasmodium falciparum gametocytes in humans during malaria infection

Pengxing Cao, Katharine A Collins, Sophie Zaloumis, Thanaporn Wattanakul, Joel Tarning, Julie A Simpson, James McCarthy, James M McCaw

2019-10-29

Renewed efforts to eliminate malaria have highlighted the potential to interrupt human-to-mosquito transmission - a process mediat..

The efficacy of dihydroartemisinin-piperaquine and artemether-lumefantrine with and without primaquine on Plasmodium vivax recurrence: A systematic review and individual patient data meta-analysis

Robert J Commons, Julie A Simpson, Kamala Thriemer, Tesfay Abreha, Ishag Adam, Nicholas M Anstey, Ashenafi Assefa, Ghulam R Awab, J Kevin Baird, Bridget E Barber, Cindy S Chu, Prabin Dahal, Andre Daher, Timothy ME Davis, Arjen M Dondorp, Matthew J Grigg, Georgina S Humphreys, Jimee Hwang, Harin Karunajeewa, Moses Laman

2019-10-01

BACKGROUND: Artemisinin-based combination therapy (ACT) is recommended for uncomplicated Plasmodium vivax malaria in areas of emer..

The haematological consequences of Plasmodium vivax malaria after chloroquine treatment with and without primaquine: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis

Robert J Commons, Julie A Simpson, Kamala Thriemer, Cindy S Chu, Nicholas M Douglas, Tesfay Abreha, Sisay G Alemu, Arletta Anez, Nicholas M Anstey, Abraham Aseffa, Ashenafi Assefa, Ghulam R Awab, J Kevin Baird, Bridget E Barber, Isabelle Borghini-Fuhrer, Umberto D'Alessandro, Prabin Dahal, Andre Daher, Peter J de Vries, Annette Erhart

2019-08-01

BACKGROUND: Malaria causes a reduction in haemoglobin that is compounded by primaquine, particularly in patients with glucose-6-ph..

Ozonide Antimalarial Activity in the Context of Artemisinin-Resistant Malaria

Carlo Giannangelo, Freya JI Fowkes, Julie A Simpson, Susan A Charman, Darren J Creek

2019-07-01

The ozonides are one of the most advanced drug classes in the antimalarial development pipeline and were designed to improve on li..

Evaluating antimalarial efficacy in single-armed and comparative drug trials using competing risk survival analysis: a simulation study

Prabin Dahal, Philippe J Guerin, Ric N Price, Julie A Simpson, Kasia Stepniewska

2019-05-17

BACKGROUND: Antimalarial efficacy studies in patients with uncomplicated Plasmodium falciparum are confounded by a new infection (..

Malaria morbidity and mortality following introduction of a universal policy of artemisinin-based treatment for malaria in Papua, Indonesia: A longitudinal surveillance study

Enny Kenangalem, Jeanne Rini Poespoprodjo, Nicholas M Douglas, Faustina Helena Burdam, Ketut Gdeumana, Ferry Chalfein, null Prayoga, Franciscus Thio, Angela Devine, Jutta Marfurt, Govert Waramori, Shunmay Yeung, Rintis Noviyanti, Pasi Penttinen, Michael J Bangs, Paulus Sugiarto, Julie A Simpson, Yati Soenarto, Nicholas M Anstey, Ric N Price

2019-05-01

BACKGROUND: Malaria control activities can have a disproportionately greater impact on Plasmodium falciparum than on P. vivax in a..

Safety of primaquine in infants with Plasmodium vivax malaria in Papua, Indonesia

Agus Setyadi, Eggi Arguni, Enny Kenangalem, Afdhal Hasanuddin, Daniel A Lampah, Kamala Thriemer, Nicholas M Anstey, Paulus Sugiarto, Julie A Simpson, Ric N Price, Nicholas M Douglas, Jeanne R Poespoprodjo

2019-04-02

BACKGROUND: Primaquine (PQ) prevents relapses of vivax malaria but may induce severe haemolysis in glucose-6-phosphate dehydrogena..

Induction and decay of functional complement-fixing antibodies by the RTS,S malariavaccine in children, and a negative impact of malaria exposure

Liriye Kurtovic, Paul A Agius, Gaoqian Feng, Damien R Drew, Itziar Ubillos, Jahit Sacarlal, John J Aponte, Freya JI Fowkes, Carlota Dobano, James G Beeson

2019-02-25

BACKGROUND: Leading malaria vaccine, RTS,S, is based on the circumsporozoite protein (CSP) of sporozoites. RTS,S confers partial p..

Risk of Plasmodium vivax parasitaemia after Plasmodium falciparum infection: a systematic review and meta-analysis

Robert J Commons, Julie A Simpson, Kamala Thriemer, Mohammad S Hossain, Nicholas M Douglas, Georgina S Humphreys, Carol H Sibley, Philippe J Guerin, Ric N Price

2019-01-01

BACKGROUND: A 14-day course of primaquine is used for radical cure of Plasmodium vivax and Plasmodium ovale malaria only. We quant..

Neutrophils and Malaria

Elizabeth H Aitken, Agersew Alemu, Stephen J Rogerson

2018-12-19

Neutrophils are abundant in the circulation and are one of the immune system's first lines of defense against infection. There has..

The Rough Guide to Monocytes in Malaria Infection

Amaya Ortega-Pajares, Stephen J Rogerson

2018-12-07

While half of the world's population is at risk of malaria, the most vulnerable are still children under five, pregnant women and ..

In Silico Investigation of the Decline in Clinical Efficacy of Artemisinin Combination Therapies Due to Increasing Artemisinin and Partner Drug Resistance

Sophie G Zaloumis, Pengxing Cao, Saber Dini, Miles P Davenport, Deborah Cromer, David S Khoury, Freya JI Fowkes, James M McCaw, Julie A Simpson

2018-12-01

Antimalarial treatment currently relies on an artemisinin derivative and a longer-acting partner drug. With the emergence of resis..

Investigating the Efficacy of Triple Artemisinin-Based Combination Therapies for Treating Plasmodium falciparum Malaria Patients Using Mathematical Modeling

Saber Dini, Sophie Zaloumis, Pengxing Cao, Ric N Price, Freya J Fowkes, E Rob W van der Pluijm, James M McCaw, Julie A Simpson

2018-11-01

The first line treatment for uncomplicated falciparum malaria is artemisinin-based combination therapy (ACT), which consists of an..

Within-host modeling of blood-stage malaria

David S Khoury, Rosemary Aogo, Georges Randriafanomezantsoa-Radohery, James M McCaw, Julie A Simpson, James S McCarthy, Ashraful Haque, Deborah Cromer, Miles P Davenport

2018-09-01

Malaria infection continues to be a major health problem worldwide and drug resistance in the major human parasite species, Plasmo..