CENTRE FOR RESEARCH EXCELLENCE IN MALARIA ELIMINATION
Grant number: 1134989 | Funding period: 2017 - 2022
The CRE will work to accelerate progress towards malaria elimination in our region, through Surveillance, to develop better ways to monitor malaria transmission and discover who is infected, and to track movement of malaria parasites and spread of drug resistance. Diagnosis, to develop and test new, more sensitive ways of detecting malaria. Treatment, to fast track development of new antimalarials, and improve access to ensure all infected people get highly effective drugs.
Related publications (38)
Seeking an optimal dosing regimen for OZ439-DSM265 combination therapy for treating uncomplicated falciparum malaria
Saber Dini, Sophie G Zaloumis, David J Price, Nathalie Gobeau, Anne Kümmel, Mohammed Cherkaoui, Joerg J Moehrle, James S McCarthy, Julie A Simpson
<jats:title>Abstract</jats:title><jats:p>The efficacy of Artemisinin-based Combination Therapies (ACTs), the first- line treatment..
Seeking an optimal dosing regimen for OZ439/DSM265 combination therapy for treating uncomplicated falciparum malaria
Saber Dini, Sophie G Zaloumis, David J Price, Nathalie Gobeau, Anne Kummel, Mohammed Cherkaoui, Joerg J Moehrle, James S McCarthy, Julie A Simpson
BACKGROUND: The efficacy of artemisinin-based combination therapies (ACTs), the first-line treatments for uncomplicated falciparum..
Investigating differences in village-level heterogeneity of malaria infection and household risk factors in Papua New Guinea
Desmond Gul, Daniela Rodriguez-Rodriguez, Elma Nate, Alma Auwan, Mary Salib, Lina Lorry, John B Keven, Michelle Katusele, Jason Rosado, Natalie Hofmann, Maria Ome-Kaius, Cristian Koepfli, Ingrid Felger, James W Kazura, Manuel W Hetzel, Ivo Mueller, Stephan Karl, Archie CA Clements, Freya J Fowkes, Moses Laman
Malaria risk is highly heterogeneous. Understanding village and household-level spatial heterogeneity of malaria risk can support ..
Surveillance of molecular markers of Plasmodium falciparum artemisinin resistance (kelch13 mutations) in Papua New Guinea between 2016 and 2018
Dulcie Lautu-Gumal, Zahra Razook, Tamarah Koleala, Elma Nate, Samuel McEwen, Diana Timbi, Manuel W Hetzel, Evelyn Lavu, Nakapi Tefuarani, Leo Makita, James Kazura, Ivo Mueller, William Pomat, Moses Laman, Leanne J Robinson, Alyssa E Barry
Plasmodium falciparum resistance to artemisinin-based combination therapy (ACT) is a global threat to malaria control and eliminat..
Application of 23 Novel Serological Markers for Identifying Recent Exposure to Plasmodium vivax Parasites in an Endemic Population of Western Thailand
Sadudee Chotirat, Narimane Nekkab, Chalermpon Kumpitak, Jenni Hietanen, Michael T White, Kirakorn Kiattibutr, Patiwat Sa-angchai, Jessica Brewster, Kael Schoffer, Eizo Takashima, Takafumi Tsuboi, Matthias Harbers, Chetan E Chitnis, Julie Healer, Wai-Hong Tham, Wang Nguitragool, Ivo Mueller, Jetsumon Sattabongkot, Rhea J Longley
Thailand is aiming for malaria elimination by the year 2030. However, the high proportion of asymptomatic infections and the prese..
Development and Validation of an In Silico Decision Tool To Guide Optimization of Intravenous Artesunate Dosing Regimens for Severe Falciparum Malaria Patients
Sophie G Zaloumis, Jason M Whyte, Joel Tarning, Sanjeev Krishna, James M McCaw, Pengxing Cao, Michael T White, Saber Dini, Freya J Fowkes, Richard J Maude, Peter Kremsner, Arjen Dondorp, Ric N Price, Nicholas J White, Julie A Simpson
Most deaths from severe falciparum malaria occur within 24 h of presentation to a hospital. Intravenous (i.v.) artesunate is the f..
Global economic costs due to vivax malaria and the potential impact of its radical cure: A modelling study
Angela Devine, Katherine E Battle, Niamh Meagher, Rosalind E Howes, Saber Dini, Peter W Gething, Julie A Simpson, Ric N Price, Yoel Lubell
BACKGROUND: In 2017, an estimated 14 million cases of Plasmodium vivax malaria were reported from Asia, Central and South America,..
Community-based molecular and serological surveillance of subclinical malaria in Myanmar
Katherine O'Flaherty, Win Han Oo, Sophie G Zaloumis, Julia C Cutts, Kyaw Zayar Aung, Myat Mon Thein, Damien R Drew, Zahra Razook, Alyssa E Barry, Naanki Parischa, Nyi Nyi Zaw, Htin Kyaw Thu, Aung Thi, Wai Yan Min Htay, Aung Paing Soe, Julie A Simpson, James G Beeson, Paul A Agius, Freya JI Fowkes
BACKGROUND: In the Greater Mekong Subregion (GMS), current malaria surveillance strategies rely on a network of village health vol..
Mechanisms and targets of Fc gamma-receptor mediated immunity to malaria sporozoites
Gaoqian Feng, Bruce D Wines, Liriye Kurtovic, Jo-Anne Chan, Philippe Boeuf, Vanessa Mollard, Anton Cozijnsen, Damien R Drew, Rob J Center, Daniel L Marshall, Sandra Chishimba, Geoffrey McFadden, Arlene E Dent, Kiprotich Chelimo, Michelle J Boyle, James W Kazura, P Mark Hogarth, James G Beeson
A highly protective vaccine will greatly facilitate achieving and sustaining malaria elimination. Understanding mechanisms of anti..
Single-cell RNA sequencing reveals developmental heterogeneity among Plasmodium berghei sporozoites
Anthony A Ruberto, Caitlin Bourke, Nicolas Merienne, Thomas Obadia, Rogerio Amino, Ivo Mueller
In the malaria-causing parasite's life cycle, Plasmodium sporozoites must travel from the midgut of a mosquito to the salivary gla..
Heterogeneity in response to serological exposure markers of recent Plasmodium vivax infections in contrasting epidemiological contexts
Jason Rosado, Michael T White, Rhea J Longley, Marcus Lacerda, Wuelton Monteiro, Jessica Brewster, Jetsumon Sattabongkot, Mitchel Guzman-Guzman, Alejandro Llanos-Cuentas, Joseph M Vinetz, Dionicia Gamboa, Ivo Mueller
BACKGROUND: Antibody responses as serological markers of Plasmodium vivax infection have been shown to correlate with exposure, bu..
Th2-like T Follicular Helper Cells Promote Functional Antibody Production during Plasmodium falciparum Infection
Jo-Anne Chan, Jessica R Loughland, Fabian de Labastida Rivera, Arya SheelaNair, Dean W Andrew, Nicholas L Dooley, Bruce D Wines, Fiona H Amante, Lachlan Webb, P Mark Hogarth, James S McCarthy, James G Beeson, Christian R Engwerda, Michelle J Boyle
CD4+ T follicular helper cells (Tfh) are key drivers of antibody development. During Plasmodium falciparum malaria in children, th..
A comparison of non-magnetic and magnetic beads for measuring IgG antibodies against Plasmodium vivax antigens in a multiplexed bead-based assay using Luminex technology (Bio-Plex 200 or MAGPIX)
Ramin Mazhari, Jessica Brewster, Rich Fong, Caitlin Bourke, Zoe SJ Liu, Eizo Takashima, Takafumi Tsuboi, Wai-Hong Tham, Matthias Harbers, Chetan Chitnis, Julie Healer, Maria Ome-Kaius, Jetsumon Sattabongkot, James Kazura, Leanne J Robinson, Christopher King, Ivo Mueller, Rhea J Longley
Multiplexed bead-based assays that use Luminex® xMAP® technology have become popular for measuring antibodies against proteins of ..
Emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations on the island of New Guinea
Olivo Miotto, Makoto Sekihara, Shin-Ichiro Tachibana, Masato Yamauchi, Richard D Pearson, Roberto Amato, Sonia Goncalves, Somya Mehra, Rintis Noviyanti, Jutta Marfurt, Sarah Auburn, Ric N Price, Ivo Mueller, Mie Ikeda, Toshiyuki Mori, Makoto Hirai, Livingstone Tavul, Manuel W Hetzel, Moses Laman, Alyssa E Barry
The rapid and aggressive spread of artemisinin-resistant Plasmodium falciparum carrying the C580Y mutation in the kelch13 gene is ..
The risk of adverse clinical outcomes following treatment of Plasmodium vivax malaria with and without primaquine in Papua, Indonesia
Kamala Thriemer, Jeanne-Rini Poespoprodjo, Enny Kenangalem, Nicholas M Douglas, Paulus Sugiarto, Nicholas M Anstey, Julie Anne Simpson, Ric N Price
The widespread use of primaquine (PQ) radical cure for P. vivax, is constrained by concerns over its safety. We used routinely col..
Evaluation of the effectiveness of topical repellent distributed by village health volunteer networks against Plasmodium spp. infection in Myanmar: A stepped-wedge cluster randomised trial
Paul A Agius, Julia C Cutts, Win Han Oo, Aung Thi, Katherine O'Flaherty, Kyaw Zayar Aung, Htin Kyaw Thu, Poe Poe Aung, Myat Mon Thein, Nyi Nyi Zaw, Wai Yan Min Htay, Aung Paing Soe, Zahra Razook, Alyssa E Barry, Win Htike, Angela Devine, Julie A Simpson, Brendan S Crabb, James G Beeson, Naanki Pasricha
BACKGROUND: The World Health Organization has yet to endorse deployment of topical repellents for malaria prevention as part of pu..
Identifying and combating the impacts of COVID-19 on malaria
Stephen J Rogerson, James G Beeson, Moses Laman, Jeanne Rini Poespoprodjo, Timothy William, Julie A Simpson, Ric N Price
BACKGROUND: The COVID-19 pandemic has resulted in millions of infections, hundreds of thousands of deaths and major societal disru..
Implementing parasite genotyping into national surveillance frameworks: feedback from control programmes and researchers in the Asia-Pacific region
Rintis Noviyanti, Olivo Miotto, Alyssa Barry, Jutta Marfurt, Sasha Siegel, Thuy-Nhien Nguyen, Hong Quang Huynh, Nancy Dian Anggraeni, Ferdinand Laihad, Yaobao Liu, Maria Endang Sumiwi, Hidayat Trimarsanto, Farah Coutrier, Nadia Fadila, Najia Ghanchi, Fatema Tuj Johora, Agatha Mia Puspitasari, Livingstone Tavul, Leily Trianty, Retno Ayu Setya Utami
The Asia-Pacific region faces formidable challenges in achieving malaria elimination by the proposed target in 2030. Molecular sur..
Development and validation of serological markers for detecting recent Plasmodium vivax infection
Rhea J Longley, Michael T White, Eizo Takashima, Jessica Brewster, Masayuki Morita, Matthias Harbers, Thomas Obadia, Leanne J Robinson, Fumie Matsuura, Zoe SJ Liu, Connie SN Li-Wai-Suen, Wai-Hong Tham, Julie Healer, Christele Huon, Chetan E Chitnis, Wang Nguitragool, Wuelton Monteiro, Carla Proietti, Denise L Doolan, Andre M Siqueira
A major gap in the Plasmodium vivax elimination toolkit is the identification of individuals carrying clinically silent and undete..
Quantification of glucose-6-phosphate dehydrogenase activity by spectrophotometry: A systematic review and meta-analysis
Daniel A Pfeffer, Benedikt Ley, Rosalind E Howes, Patrick Adu, Mohammad Shafiul Alam, Pooja Bansil, Yap Boum, Marcelo Brito, Pimlak Charoenkwan, Archie Clements, Liwang Cui, Zeshuai Deng, Ochaka Julie Egesie, Fe Esperanza Espino, Michael E von Fricken, Muzamil Mahdi Abdel Hamid, Yongshu He, Gisela Henriques, Wasif Ali Khan, Nimol Khim
BACKGROUND: The radical cure of Plasmodium vivax and P. ovale requires treatment with primaquine or tafenoquine to clear dormant l..
Complement in malaria immunity and vaccines
Liriye Kurtovic, Michelle J Boyle, D Herbert Opi, Alexander T Kennedy, Wai-Hong Tham, Linda Reiling, Jo-Anne Chan, James G Beeson
Developing efficacious vaccines for human malaria caused by Plasmodium falciparum is a major global health priority, although this..
The risk of Plasmodium vivax parasitaemia after P. falciparum malaria: An individual patient data meta-analysis from the WorldWide Antimalarial Resistance Network
Mohammad S Hossain, Robert J Commons, Nicholas M Douglas, Kamala Thriemer, Bereket H Alemayehu, Chanaki Amaratunga, Anupkumar R Anvikar, Elizabeth A Ashley, Puji BS Asih, Verena I Carrara, Chanthap Lon, Umberto D'Alessandro, Timothy ME Davis, Arjen M Dondorp, Michael D Edstein, Rick M Fairhurst, Marcelo U Ferreira, Jimee Hwang, Bart Janssens, Harin Karunajeewa
BACKGROUND: There is a high risk of Plasmodium vivax parasitaemia following treatment of falciparum malaria. Our study aimed to qu..
Modeling the dynamics of Plasmodium falciparum gametocytes in humans during malaria infection
Pengxing Cao, Katharine A Collins, Sophie Zaloumis, Thanaporn Wattanakul, Joel Tarning, Julie A Simpson, James McCarthy, James M McCaw
Renewed efforts to eliminate malaria have highlighted the potential to interrupt human-to-mosquito transmission - a process mediat..
The efficacy of dihydroartemisinin-piperaquine and artemether-lumefantrine with and without primaquine on Plasmodium vivax recurrence: A systematic review and individual patient data meta-analysis
Robert J Commons, Julie A Simpson, Kamala Thriemer, Tesfay Abreha, Ishag Adam, Nicholas M Anstey, Ashenafi Assefa, Ghulam R Awab, J Kevin Baird, Bridget E Barber, Cindy S Chu, Prabin Dahal, Andre Daher, Timothy ME Davis, Arjen M Dondorp, Matthew J Grigg, Georgina S Humphreys, Jimee Hwang, Harin Karunajeewa, Moses Laman
BACKGROUND: Artemisinin-based combination therapy (ACT) is recommended for uncomplicated Plasmodium vivax malaria in areas of emer..
The haematological consequences of Plasmodium vivax malaria after chloroquine treatment with and without primaquine: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis
Robert J Commons, Julie A Simpson, Kamala Thriemer, Cindy S Chu, Nicholas M Douglas, Tesfay Abreha, Sisay G Alemu, Arletta Anez, Nicholas M Anstey, Abraham Aseffa, Ashenafi Assefa, Ghulam R Awab, J Kevin Baird, Bridget E Barber, Isabelle Borghini-Fuhrer, Umberto D'Alessandro, Prabin Dahal, Andre Daher, Peter J de Vries, Annette Erhart
BACKGROUND: Malaria causes a reduction in haemoglobin that is compounded by primaquine, particularly in patients with glucose-6-ph..
Ozonide Antimalarial Activity in the Context of Artemisinin-Resistant Malaria
Carlo Giannangelo, Freya JI Fowkes, Julie A Simpson, Susan A Charman, Darren J Creek
The ozonides are one of the most advanced drug classes in the antimalarial development pipeline and were designed to improve on li..
Modelling the population dynamics of Plasmodium falciparum gametocytes in humans during malaria infection
Pengxing Cao, Katharine Collins, Sophie Zaloumis, Thanaporn Wattanakul, Joel Tarning, Julie Simpson, James McCarthy, James McCaw
Every year over two hundred million people are infected with the malaria parasite. Renewed efforts to eliminate malaria has highli..
Malaria morbidity and mortality following introduction of a universal policy of artemisinin-based treatment for malaria in Papua, Indonesia: A longitudinal surveillance study
Enny Kenangalem, Jeanne Rini Poespoprodjo, Nicholas M Douglas, Faustina Helena Burdam, Ketut Gdeumana, Ferry Chalfein, null Prayoga, Franciscus Thio, Angela Devine, Jutta Marfurt, Govert Waramori, Shunmay Yeung, Rintis Noviyanti, Pasi Penttinen, Michael J Bangs, Paulus Sugiarto, Julie A Simpson, Yati Soenarto, Nicholas M Anstey, Ric N Price
BACKGROUND: Malaria control activities can have a disproportionately greater impact on Plasmodium falciparum than on P. vivax in a..
Safety of primaquine in infants with Plasmodium vivax malaria in Papua, Indonesia
Agus Setyadi, Eggi Arguni, Enny Kenangalem, Afdhal Hasanuddin, Daniel A Lampah, Kamala Thriemer, Nicholas M Anstey, Paulus Sugiarto, Julie A Simpson, Ric N Price, Nicholas M Douglas, Jeanne R Poespoprodjo
BACKGROUND: Primaquine (PQ) prevents relapses of vivax malaria but may induce severe haemolysis in glucose-6-phosphate dehydrogena..
Induction and decay of functional complement-fixing antibodies by the RTS,S malariavaccine in children, and a negative impact of malaria exposure
Liriye Kurtovic, Paul A Agius, Gaoqian Feng, Damien R Drew, Itziar Ubillos, Jahit Sacarlal, John J Aponte, Freya JI Fowkes, Carlota Dobano, James G Beeson
BACKGROUND: Leading malaria vaccine, RTS,S, is based on the circumsporozoite protein (CSP) of sporozoites. RTS,S confers partial p..
Risk of Plasmodium vivax parasitaemia after Plasmodium falciparum infection: a systematic review and meta-analysis
Robert J Commons, Julie A Simpson, Kamala Thriemer, Mohammad S Hossain, Nicholas M Douglas, Georgina S Humphreys, Carol H Sibley, Philippe J Guerin, Ric N Price
BACKGROUND: A 14-day course of primaquine is used for radical cure of Plasmodium vivax and Plasmodium ovale malaria only. We quant..
In Silico Investigation of the Decline in Clinical Efficacy of Artemisinin Combination Therapies Due to Increasing Artemisinin and Partner Drug Resistance
Sophie G Zaloumis, Pengxing Cao, Saber Dini, Miles P Davenport, Deborah Cromer, David S Khoury, Freya JI Fowkes, James M McCaw, Julie A Simpson
Antimalarial treatment currently relies on an artemisinin derivative and a longer-acting partner drug. With the emergence of resis..
Investigating the Efficacy of Triple Artemisinin-Based Combination Therapies for Treating Plasmodium falciparum Malaria Patients Using Mathematical Modeling
Saber Dini, Sophie Zaloumis, Pengxing Cao, Ric N Price, Freya J Fowkes, E Rob W van der Pluijm, James M McCaw, Julie A Simpson
The first line treatment for uncomplicated falciparum malaria is artemisinin-based combination therapy (ACT), which consists of an..
Within-host modeling of blood-stage malaria
David S Khoury, Rosemary Aogo, Georges Randriafanomezantsoa-Radohery, James M McCaw, Julie A Simpson, James S McCarthy, Ashraful Haque, Deborah Cromer, Miles P Davenport
Malaria infection continues to be a major health problem worldwide and drug resistance in the major human parasite species, Plasmo..