CENTRE FOR RESEARCH EXCELLENCE IN MALARIA ELIMINATION

Seeking an optimal dosing regimen for OZ439-DSM265 combination therapy for treating uncomplicated falciparum malaria

Saber Dini, Sophie G Zaloumis, David J Price, Nathalie Gobeau, Anne Kümmel, Mohammed Cherkaoui, Joerg J Moehrle, James S McCarthy, Julie A Simpson

<jats:title>Abstract</jats:title><jats:p>The efficacy of Artemisinin-based Combination Therapies (ACTs), the first- line treatment..

Seeking an optimal dosing regimen for OZ439/DSM265 combination therapy for treating uncomplicated falciparum malaria

Saber Dini, Sophie G Zaloumis, David J Price, Nathalie Gobeau, Anne Kummel, Mohammed Cherkaoui, Joerg J Moehrle, James S McCarthy, Julie A Simpson

2021-09-01

BACKGROUND: The efficacy of artemisinin-based combination therapies (ACTs), the first-line treatments for uncomplicated falciparum..

Investigating differences in village-level heterogeneity of malaria infection and household risk factors in Papua New Guinea

Desmond Gul, Daniela Rodriguez-Rodriguez, Elma Nate, Alma Auwan, Mary Salib, Lina Lorry, John B Keven, Michelle Katusele, Jason Rosado, Natalie Hofmann, Maria Ome-Kaius, Cristian Koepfli, Ingrid Felger, James W Kazura, Manuel W Hetzel, Ivo Mueller, Stephan Karl, Archie CA Clements, Freya J Fowkes, Moses Laman

2021-08-16

Malaria risk is highly heterogeneous. Understanding village and household-level spatial heterogeneity of malaria risk can support ..

Surveillance of molecular markers of Plasmodium falciparum artemisinin resistance (kelch13 mutations) in Papua New Guinea between 2016 and 2018

Dulcie Lautu-Gumal, Zahra Razook, Tamarah Koleala, Elma Nate, Samuel McEwen, Diana Timbi, Manuel W Hetzel, Evelyn Lavu, Nakapi Tefuarani, Leo Makita, James Kazura, Ivo Mueller, William Pomat, Moses Laman, Leanne J Robinson, Alyssa E Barry

2021-08-01

Plasmodium falciparum resistance to artemisinin-based combination therapy (ACT) is a global threat to malaria control and eliminat..

Application of 23 Novel Serological Markers for Identifying Recent Exposure to Plasmodium vivax Parasites in an Endemic Population of Western Thailand

Sadudee Chotirat, Narimane Nekkab, Chalermpon Kumpitak, Jenni Hietanen, Michael T White, Kirakorn Kiattibutr, Patiwat Sa-angchai, Jessica Brewster, Kael Schoffer, Eizo Takashima, Takafumi Tsuboi, Matthias Harbers, Chetan E Chitnis, Julie Healer, Wai-Hong Tham, Wang Nguitragool, Ivo Mueller, Jetsumon Sattabongkot, Rhea J Longley

2021-06-29

Thailand is aiming for malaria elimination by the year 2030. However, the high proportion of asymptomatic infections and the prese..

Development and Validation of an In Silico Decision Tool To Guide Optimization of Intravenous Artesunate Dosing Regimens for Severe Falciparum Malaria Patients

Sophie G Zaloumis, Jason M Whyte, Joel Tarning, Sanjeev Krishna, James M McCaw, Pengxing Cao, Michael T White, Saber Dini, Freya J Fowkes, Richard J Maude, Peter Kremsner, Arjen Dondorp, Ric N Price, Nicholas J White, Julie A Simpson

2021-06-01

Most deaths from severe falciparum malaria occur within 24 h of presentation to a hospital. Intravenous (i.v.) artesunate is the f..

Global economic costs due to vivax malaria and the potential impact of its radical cure: A modelling study

Angela Devine, Katherine E Battle, Niamh Meagher, Rosalind E Howes, Saber Dini, Peter W Gething, Julie A Simpson, Ric N Price, Yoel Lubell

2021-06-01

BACKGROUND: In 2017, an estimated 14 million cases of Plasmodium vivax malaria were reported from Asia, Central and South America,..

Community-based molecular and serological surveillance of subclinical malaria in Myanmar

Katherine O'Flaherty, Win Han Oo, Sophie G Zaloumis, Julia C Cutts, Kyaw Zayar Aung, Myat Mon Thein, Damien R Drew, Zahra Razook, Alyssa E Barry, Naanki Parischa, Nyi Nyi Zaw, Htin Kyaw Thu, Aung Thi, Wai Yan Min Htay, Aung Paing Soe, Julie A Simpson, James G Beeson, Paul A Agius, Freya JI Fowkes

2021-05-28

BACKGROUND: In the Greater Mekong Subregion (GMS), current malaria surveillance strategies rely on a network of village health vol..

Mechanisms and targets of Fc gamma-receptor mediated immunity to malaria sporozoites

Gaoqian Feng, Bruce D Wines, Liriye Kurtovic, Jo-Anne Chan, Philippe Boeuf, Vanessa Mollard, Anton Cozijnsen, Damien R Drew, Rob J Center, Daniel L Marshall, Sandra Chishimba, Geoffrey McFadden, Arlene E Dent, Kiprotich Chelimo, Michelle J Boyle, James W Kazura, P Mark Hogarth, James G Beeson

2021-03-19

A highly protective vaccine will greatly facilitate achieving and sustaining malaria elimination. Understanding mechanisms of anti..

Single-cell RNA sequencing reveals developmental heterogeneity among Plasmodium berghei sporozoites

Anthony A Ruberto, Caitlin Bourke, Nicolas Merienne, Thomas Obadia, Rogerio Amino, Ivo Mueller

2021-02-22

In the malaria-causing parasite's life cycle, Plasmodium sporozoites must travel from the midgut of a mosquito to the salivary gla..

Heterogeneity in response to serological exposure markers of recent Plasmodium vivax infections in contrasting epidemiological contexts

Jason Rosado, Michael T White, Rhea J Longley, Marcus Lacerda, Wuelton Monteiro, Jessica Brewster, Jetsumon Sattabongkot, Mitchel Guzman-Guzman, Alejandro Llanos-Cuentas, Joseph M Vinetz, Dionicia Gamboa, Ivo Mueller

2021-02-01

BACKGROUND: Antibody responses as serological markers of Plasmodium vivax infection have been shown to correlate with exposure, bu..

Th2-like T Follicular Helper Cells Promote Functional Antibody Production during Plasmodium falciparum Infection

Jo-Anne Chan, Jessica R Loughland, Fabian de Labastida Rivera, Arya SheelaNair, Dean W Andrew, Nicholas L Dooley, Bruce D Wines, Fiona H Amante, Lachlan Webb, P Mark Hogarth, James S McCarthy, James G Beeson, Christian R Engwerda, Michelle J Boyle

2020-12-22

CD4+ T follicular helper cells (Tfh) are key drivers of antibody development. During Plasmodium falciparum malaria in children, th..

A comparison of non-magnetic and magnetic beads for measuring IgG antibodies against Plasmodium vivax antigens in a multiplexed bead-based assay using Luminex technology (Bio-Plex 200 or MAGPIX)

Ramin Mazhari, Jessica Brewster, Rich Fong, Caitlin Bourke, Zoe SJ Liu, Eizo Takashima, Takafumi Tsuboi, Wai-Hong Tham, Matthias Harbers, Chetan Chitnis, Julie Healer, Maria Ome-Kaius, Jetsumon Sattabongkot, James Kazura, Leanne J Robinson, Christopher King, Ivo Mueller, Rhea J Longley

2020-12-04

Multiplexed bead-based assays that use Luminex® xMAP® technology have become popular for measuring antibodies against proteins of ..

Emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations on the island of New Guinea

Olivo Miotto, Makoto Sekihara, Shin-Ichiro Tachibana, Masato Yamauchi, Richard D Pearson, Roberto Amato, Sonia Goncalves, Somya Mehra, Rintis Noviyanti, Jutta Marfurt, Sarah Auburn, Ric N Price, Ivo Mueller, Mie Ikeda, Toshiyuki Mori, Makoto Hirai, Livingstone Tavul, Manuel W Hetzel, Moses Laman, Alyssa E Barry

2020-12-01

The rapid and aggressive spread of artemisinin-resistant Plasmodium falciparum carrying the C580Y mutation in the kelch13 gene is ..

Artemisinin Resistance and the Unique Selection Pressure of a Short-acting Antimalarial

David S Khoury, Pengxing Cao, Sophie G Zaloumis, Miles P Davenport

2020-11-01

Resistance to the artemisinin derivatives, our most effective antimalarial drugs, has not manifest as a classical resistance pheno..

The risk of adverse clinical outcomes following treatment of Plasmodium vivax malaria with and without primaquine in Papua, Indonesia

Kamala Thriemer, Jeanne-Rini Poespoprodjo, Enny Kenangalem, Nicholas M Douglas, Paulus Sugiarto, Nicholas M Anstey, Julie Anne Simpson, Ric N Price

2020-11-01

The widespread use of primaquine (PQ) radical cure for P. vivax, is constrained by concerns over its safety. We used routinely col..

Evaluation of the effectiveness of topical repellent distributed by village health volunteer networks against Plasmodium spp. infection in Myanmar: A stepped-wedge cluster randomised trial

Paul A Agius, Julia C Cutts, Win Han Oo, Aung Thi, Katherine O'Flaherty, Kyaw Zayar Aung, Htin Kyaw Thu, Poe Poe Aung, Myat Mon Thein, Nyi Nyi Zaw, Wai Yan Min Htay, Aung Paing Soe, Zahra Razook, Alyssa E Barry, Win Htike, Angela Devine, Julie A Simpson, Brendan S Crabb, James G Beeson, Naanki Pasricha

2020-08-01

BACKGROUND: The World Health Organization has yet to endorse deployment of topical repellents for malaria prevention as part of pu..

Identifying and combating the impacts of COVID-19 on malaria

Stephen J Rogerson, James G Beeson, Moses Laman, Jeanne Rini Poespoprodjo, Timothy William, Julie A Simpson, Ric N Price

2020-07-30

BACKGROUND: The COVID-19 pandemic has resulted in millions of infections, hundreds of thousands of deaths and major societal disru..

Implementing parasite genotyping into national surveillance frameworks: feedback from control programmes and researchers in the Asia-Pacific region

Rintis Noviyanti, Olivo Miotto, Alyssa Barry, Jutta Marfurt, Sasha Siegel, Thuy-Nhien Nguyen, Hong Quang Huynh, Nancy Dian Anggraeni, Ferdinand Laihad, Yaobao Liu, Maria Endang Sumiwi, Hidayat Trimarsanto, Farah Coutrier, Nadia Fadila, Najia Ghanchi, Fatema Tuj Johora, Agatha Mia Puspitasari, Livingstone Tavul, Leily Trianty, Retno Ayu Setya Utami

2020-07-27

The Asia-Pacific region faces formidable challenges in achieving malaria elimination by the proposed target in 2030. Molecular sur..

Development and validation of serological markers for detecting recent Plasmodium vivax infection

Rhea J Longley, Michael T White, Eizo Takashima, Jessica Brewster, Masayuki Morita, Matthias Harbers, Thomas Obadia, Leanne J Robinson, Fumie Matsuura, Zoe SJ Liu, Connie SN Li-Wai-Suen, Wai-Hong Tham, Julie Healer, Christele Huon, Chetan E Chitnis, Wang Nguitragool, Wuelton Monteiro, Carla Proietti, Denise L Doolan, Andre M Siqueira

2020-05-01

A major gap in the Plasmodium vivax elimination toolkit is the identification of individuals carrying clinically silent and undete..

Malaria Parasite Clearance: What Are We Really Measuring?

David S Khoury, Sophie G Zaloumis, Matthew J Grigg, Ashraful Haque, Miles P Davenport

2020-05-01

Antimalarial drugs are vital for treating malaria and controlling transmission. Measuring drug efficacy in the field requires larg..

Quantification of glucose-6-phosphate dehydrogenase activity by spectrophotometry: A systematic review and meta-analysis

Daniel A Pfeffer, Benedikt Ley, Rosalind E Howes, Patrick Adu, Mohammad Shafiul Alam, Pooja Bansil, Yap Boum, Marcelo Brito, Pimlak Charoenkwan, Archie Clements, Liwang Cui, Zeshuai Deng, Ochaka Julie Egesie, Fe Esperanza Espino, Michael E von Fricken, Muzamil Mahdi Abdel Hamid, Yongshu He, Gisela Henriques, Wasif Ali Khan, Nimol Khim

2020-05-01

BACKGROUND: The radical cure of Plasmodium vivax and P. ovale requires treatment with primaquine or tafenoquine to clear dormant l..

Complement in malaria immunity and vaccines

Liriye Kurtovic, Michelle J Boyle, D Herbert Opi, Alexander T Kennedy, Wai-Hong Tham, Linda Reiling, Jo-Anne Chan, James G Beeson

2020-01-01

Developing efficacious vaccines for human malaria caused by Plasmodium falciparum is a major global health priority, although this..

The risk of Plasmodium vivax parasitaemia after P. falciparum malaria: An individual patient data meta-analysis from the WorldWide Antimalarial Resistance Network

Mohammad S Hossain, Robert J Commons, Nicholas M Douglas, Kamala Thriemer, Bereket H Alemayehu, Chanaki Amaratunga, Anupkumar R Anvikar, Elizabeth A Ashley, Puji BS Asih, Verena I Carrara, Chanthap Lon, Umberto D'Alessandro, Timothy ME Davis, Arjen M Dondorp, Michael D Edstein, Rick M Fairhurst, Marcelo U Ferreira, Jimee Hwang, Bart Janssens, Harin Karunajeewa

2020-01-01

BACKGROUND: There is a high risk of Plasmodium vivax parasitaemia following treatment of falciparum malaria. Our study aimed to qu..

Modeling the dynamics of Plasmodium falciparum gametocytes in humans during malaria infection

Pengxing Cao, Katharine A Collins, Sophie Zaloumis, Thanaporn Wattanakul, Joel Tarning, Julie A Simpson, James McCarthy, James M McCaw

2019-10-29

Renewed efforts to eliminate malaria have highlighted the potential to interrupt human-to-mosquito transmission - a process mediat..

The efficacy of dihydroartemisinin-piperaquine and artemether-lumefantrine with and without primaquine on Plasmodium vivax recurrence: A systematic review and individual patient data meta-analysis

Robert J Commons, Julie A Simpson, Kamala Thriemer, Tesfay Abreha, Ishag Adam, Nicholas M Anstey, Ashenafi Assefa, Ghulam R Awab, J Kevin Baird, Bridget E Barber, Cindy S Chu, Prabin Dahal, Andre Daher, Timothy ME Davis, Arjen M Dondorp, Matthew J Grigg, Georgina S Humphreys, Jimee Hwang, Harin Karunajeewa, Moses Laman

2019-10-01

BACKGROUND: Artemisinin-based combination therapy (ACT) is recommended for uncomplicated Plasmodium vivax malaria in areas of emer..

The haematological consequences of Plasmodium vivax malaria after chloroquine treatment with and without primaquine: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis

Robert J Commons, Julie A Simpson, Kamala Thriemer, Cindy S Chu, Nicholas M Douglas, Tesfay Abreha, Sisay G Alemu, Arletta Anez, Nicholas M Anstey, Abraham Aseffa, Ashenafi Assefa, Ghulam R Awab, J Kevin Baird, Bridget E Barber, Isabelle Borghini-Fuhrer, Umberto D'Alessandro, Prabin Dahal, Andre Daher, Peter J de Vries, Annette Erhart

2019-08-01

BACKGROUND: Malaria causes a reduction in haemoglobin that is compounded by primaquine, particularly in patients with glucose-6-ph..

Ozonide Antimalarial Activity in the Context of Artemisinin-Resistant Malaria

Carlo Giannangelo, Freya JI Fowkes, Julie A Simpson, Susan A Charman, Darren J Creek

2019-07-01

The ozonides are one of the most advanced drug classes in the antimalarial development pipeline and were designed to improve on li..

Modelling the population dynamics of Plasmodium falciparum gametocytes in humans during malaria infection

Pengxing Cao, Katharine Collins, Sophie Zaloumis, Thanaporn Wattanakul, Joel Tarning, Julie Simpson, James McCarthy, James McCaw

2019-05-17

Every year over two hundred million people are infected with the malaria parasite. Renewed efforts to eliminate malaria has highli..

Malaria morbidity and mortality following introduction of a universal policy of artemisinin-based treatment for malaria in Papua, Indonesia: A longitudinal surveillance study

Enny Kenangalem, Jeanne Rini Poespoprodjo, Nicholas M Douglas, Faustina Helena Burdam, Ketut Gdeumana, Ferry Chalfein, null Prayoga, Franciscus Thio, Angela Devine, Jutta Marfurt, Govert Waramori, Shunmay Yeung, Rintis Noviyanti, Pasi Penttinen, Michael J Bangs, Paulus Sugiarto, Julie A Simpson, Yati Soenarto, Nicholas M Anstey, Ric N Price

2019-05-01

BACKGROUND: Malaria control activities can have a disproportionately greater impact on Plasmodium falciparum than on P. vivax in a..

Safety of primaquine in infants with Plasmodium vivax malaria in Papua, Indonesia

Agus Setyadi, Eggi Arguni, Enny Kenangalem, Afdhal Hasanuddin, Daniel A Lampah, Kamala Thriemer, Nicholas M Anstey, Paulus Sugiarto, Julie A Simpson, Ric N Price, Nicholas M Douglas, Jeanne R Poespoprodjo

2019-04-02

BACKGROUND: Primaquine (PQ) prevents relapses of vivax malaria but may induce severe haemolysis in glucose-6-phosphate dehydrogena..

Induction and decay of functional complement-fixing antibodies by the RTS,S malariavaccine in children, and a negative impact of malaria exposure

Liriye Kurtovic, Paul A Agius, Gaoqian Feng, Damien R Drew, Itziar Ubillos, Jahit Sacarlal, John J Aponte, Freya JI Fowkes, Carlota Dobano, James G Beeson

2019-02-25

BACKGROUND: Leading malaria vaccine, RTS,S, is based on the circumsporozoite protein (CSP) of sporozoites. RTS,S confers partial p..

Risk of Plasmodium vivax parasitaemia after Plasmodium falciparum infection: a systematic review and meta-analysis

Robert J Commons, Julie A Simpson, Kamala Thriemer, Mohammad S Hossain, Nicholas M Douglas, Georgina S Humphreys, Carol H Sibley, Philippe J Guerin, Ric N Price

2019-01-01

BACKGROUND: A 14-day course of primaquine is used for radical cure of Plasmodium vivax and Plasmodium ovale malaria only. We quant..

Neutrophils and Malaria

Elizabeth H Aitken, Agersew Alemu, Stephen J Rogerson

2018-12-19

Neutrophils are abundant in the circulation and are one of the immune system's first lines of defense against infection. There has..

The Rough Guide to Monocytes in Malaria Infection

Amaya Ortega-Pajares, Stephen J Rogerson

2018-12-07

While half of the world's population is at risk of malaria, the most vulnerable are still children under five, pregnant women and ..

In Silico Investigation of the Decline in Clinical Efficacy of Artemisinin Combination Therapies Due to Increasing Artemisinin and Partner Drug Resistance

Sophie G Zaloumis, Pengxing Cao, Saber Dini, Miles P Davenport, Deborah Cromer, David S Khoury, Freya JI Fowkes, James M McCaw, Julie A Simpson

2018-12-01

Antimalarial treatment currently relies on an artemisinin derivative and a longer-acting partner drug. With the emergence of resis..

Investigating the Efficacy of Triple Artemisinin-Based Combination Therapies for Treating Plasmodium falciparum Malaria Patients Using Mathematical Modeling

Saber Dini, Sophie Zaloumis, Pengxing Cao, Ric N Price, Freya J Fowkes, E Rob W van der Pluijm, James M McCaw, Julie A Simpson

2018-11-01

The first line treatment for uncomplicated falciparum malaria is artemisinin-based combination therapy (ACT), which consists of an..

Within-host modeling of blood-stage malaria

David S Khoury, Rosemary Aogo, Georges Randriafanomezantsoa-Radohery, James M McCaw, Julie A Simpson, James S McCarthy, Ashraful Haque, Deborah Cromer, Miles P Davenport

2018-09-01

Malaria infection continues to be a major health problem worldwide and drug resistance in the major human parasite species, Plasmo..