ADVANCING NANOMEDICINE THROUGH PARTICLE TECHNOLOGY

Person-Specific Biomolecular Coronas Modulate Nanoparticle Interactions with Immune Cells in Human Blood.

Yi Ju, Hannah G Kelly, Laura F Dagley, Arnold Reynaldi, Timothy E Schlub, Sukhdeep K Spall, Craig A Bell, Jiwei Cui, Andrew J Mitchell, Zhixing Lin, Adam K Wheatley, Kristofer J Thurecht, Miles P Davenport, Andrew I Webb, Frank Caruso, Stephen J Kent

2020-10-28

When nanoparticles interact with human blood, a multitude of plasma components adsorb onto the surface of the nanoparticles, formi..

Polyphenol-Based Nanoparticles for Intracellular Protein Delivery via Competing Supramolecular Interactions.

Yiyuan Han, Jiajing Zhou, Yingjie Hu, Zhixing Lin, Yutian Ma, Joseph J Richardson, Frank Caruso

2020-10-27

Intracellular delivery of proteins is a promising strategy for regulating cellular behavior and therefore has attracted interest f..

Catalytically Active Copper Phosphate-Dextran Sulfate Microparticle Coatings for Bioanalyte Sensing

Pietro Pacchin Tomanin, Sukhvir Kaur Bhangu, Frank Caruso, Francesca Cavalieri

2020-09-28

Engineering reactive and functional nanostructured surfaces is important for enhancing the sensitivity and versatility of biosenso..

Dynamic Electrophoretic Assembly of Metal–Phenolic Films: Accelerated Formation and Cytocompatible Detachment

Gyeongwon Yun, Wongu Youn, Hojae Lee, Sang Yeong Han, Mariana B Oliveira, Hyeoncheol Cho, Frank Caruso, João F Mano, Insung S Choi

2020-09-22

Material-independent coating has emerged as an advanced tool for interface engineering in numerous applications, including drug de..

Protein Component of Oyster Glycogen Nanoparticles: An Anchor Point for Functionalization

Quinn A Besford, Alessia CG Weiss, Jonas Schubert, Timothy M Ryan, Manfred F Maitz, Pietro Pacchin Tomanin, Marco Savioli, Carsten Werner, Andreas Fery, Frank Caruso, Francesca Cavalieri

2020-09-02

Biosourced nanoparticles have a range of desirable properties for therapeutic applications, including biodegradability and low imm..

Programmable Permeability of Metal–Phenolic Network Microcapsules

Jingqu Chen, Shuaijun Pan, Jiajing Zhou, Qi-Zhi Zhong, Yijiao Qu, Joseph J Richardson, Frank Caruso

2020-08-25

Developing materials with programmable permeability for cargo encapsulation and release is challenging but important in a number o..

Template-Mediated Assembly of DNA into Microcapsules for Immunological Modulation

Yijiao Qu, Yi Ju, Christina Cortez-Jugo, Zhixing Lin, Shiyao Li, Jiajing Zhou, Yutian Ma, Agata Glab, Stephen J Kent, Francesca Cavalieri, Frank Caruso

2020-08-06

There is a need for effective vaccine delivery systems and vaccine adjuvants without extraneous excipients that can compromise or ..

Distribution of Particles in Human Stem Cell-Derived 3D Neuronal Cell Models: Effect of Particle Size, Charge, and Density

Ewa Czuba-Wojnilowicz, Sara Miellet, Agata Glab, Serena Viventi, Francesca Cavalieri, Christina Cortez-Jugo, Mirella Dottori, Frank Caruso

2020-08-01

Neurodegenerative diseases are generally characterized by a progressive loss of neuronal subpopulations, with no available cure to..

Dissecting the intracellular signalling and fate of a DNA nanosensor by super-resolution and quantitative microscopy.

Agata Glab, Alessandro Bertucci, Fabiana Martino, Marcin Wojnilowicz, Alessia Amodio, Mariano Venanzi, Francesco Ricci, Giancarlo Forte, Frank Caruso, Francesca Cavalieri

2020-07-13

DNA nanodevices have been developed as platforms for the manipulation of gene expression, delivery of molecular payloads, and dete..

Understanding the Uptake of Nanomedicines at Different Stages of Brain Cancer Using a Modular Nanocarrier Platform and Precision Bispecific Antibodies

Zachary H Houston, Jens Bunt, Kok-Siong Chen, Simon Puttick, Christopher B Howard, Nicholas L Fletcher, Adrian V Fuchs, Jiwei Cui, Yi Ju, Gary Cowin, Xin Song, Andrew W Boyd, Stephen M Mahler, Linda J Richards, Frank Caruso, Kristofer J Thurecht

2020-05-27

Increasing accumulation and retention of nanomedicines within tumor tissue is a significant challenge, particularly in the case of..

Self-assembling influenza nanoparticle vaccines drive extended germinal center activity and memory B cell maturation.

Hannah G Kelly, Hyon-Xhi Tan, Jennifer A Juno, Robyn Esterbauer, Yi Ju, Wenbo Jiang, Verena C Wimmer, Brigette C Duckworth, Joanna R Groom, Frank Caruso, Masaru Kanekiyo, Stephen J Kent, Adam K Wheatley

2020-05-21

Protein-based, self-assembling nanoparticles elicit superior immunity compared with soluble protein vaccines, but the immune mecha..

Surface Modification of Spider Silk Particles to Direct Biomolecular Corona Formation.

Alessia CG Weiss, Heike M Herold, Sarah Lentz, Matthew Faria, Quinn A Besford, Ching-Seng Ang, Frank Caruso, Thomas Scheibel

2020-05-20

In recent years, spider silk-based materials have attracted attention because of their biocompatibility, processability, and biode..

Modulating the Selectivity and Stealth Properties of Ellipsoidal Polymersomes through a Multivalent Peptide Ligand Display

Kristel C Tjandra, Chelsea R Forest, Chin Ken Wong, Sheilajen Alcantara, Hannah G Kelly, Yi Ju, Martina H Stenzel, Joshua A McCarroll, Maria Kavallaris, Frank Caruso, Stephen J Kent, Pall Thordarson

2020-05-19

There is a need for improved nanomaterials to simultaneously target cancer cells and avoid non‐specific clearance by phagocytes. A..

Glycogen as a Building Block for Advanced Biological Materials

Quinn A Besford, Francesca Cavalieri, Frank Caruso

2020-05-07

Biological nanoparticles found in living systems possess distinct molecular architectures and diverse functions. Glycogen is a uni..

Particle-mediated delivery of frataxin plasmid to a human sensory neuronal model of Friedreich's ataxia.

Ewa Czuba-Wojnilowicz, Serena Viventi, Sara E Howden, Simon Maksour, Amy E Hulme, Christina Cortez-Jugo, Mirella Dottori, Frank Caruso

2020-05-07

Increasing frataxin protein levels through gene therapy is envisaged to improve therapeutic outcomes for patients with Friedreich'..

Nanoengineering multifunctional hybrid interfaces using adhesive glycogen nanoparticles.

Pietro Pacchin Tomanin, Jiajing Zhou, Alessia Amodio, Rita Cimino, Agata Glab, Francesca Cavalieri, Frank Caruso

2020-03-27

Multifunctional and biodegradable nanostructured hybrid interfaces based on biopolymers are potentially useful in many application..

Engineering of Nebulized Metal-Phenolic Capsules for Controlled Pulmonary Deposition

Yi Ju, Christina Cortez-Jugo, Jingqu Chen, Ting-Yi Wang, Andrew J Mitchell, Evelyn Tsantikos, Nadja Bertleff-Zieschang, Yu-Wei Lin, Jiaying Song, Yizhe Cheng, Srinivas Mettu, Md Arifur Rahim, Shuaijun Pan, Gyeongwon Yun, Margaret L Hibbs, Leslie Y Yeo, Christoph E Hagemeyer, Frank Caruso

2020-03-18

Particle-based pulmonary delivery has great potential for delivering inhalable therapeutics for local or systemic applications. Th..

Nanomedicine toward 2040.

Joseph J Richardson, Frank Caruso

2020-03-11

Nanomedicine as a research field has existed for about two decades, and it is therefore timely to discuss what the next 20 years i..

Cobalt-Directed Assembly of Antibodies onto Metal-Phenolic Networks for Enhanced Particle Targeting.

Wenjie Zhang, Quinn A Besford, Andrew J Christofferson, Patrick Charchar, Joseph J Richardson, Aaron Elbourne, Kristian Kempe, Christoph E Hagemeyer, Matthew R Field, Chris F McConville, Irene Yarovsky, Frank Caruso

2020-03-10

The orientation-specific immobilization of antibodies onto nanoparticles, to preserve antibody-antigen recognition, is a key chall..

Polyphenol-Mediated Assembly of Proteins for Engineering Functional Materials

Yiyuan Han, Zhixing Lin, Jiajing Zhou, Gyeongwon Yun, Rui Guo, Joseph J Richardson, Frank Caruso

2020-03-01

Functional materials composed of proteins have attracted much interest owing to the inherent and diverse functionality of proteins..

Ordered Mesoporous Metal-Phenolic Network Particles.

Zhixing Lin, Jiajing Zhou, Christina Cortez-Jugo, Yiyuan Han, Yutian Ma, Shuaijun Pan, Eric Hanssen, Joseph J Richardson, Frank Caruso

2020-01-08

Mesoporous metal-organic networks have attracted widespread interest owing to their potential applications in diverse fields inclu..

Self-Assembly of a Metal-Phenolic Sorbent for Broad-Spectrum Metal Sequestration

Md Arifur Rahim, Gan Lin, Pietro Pacchin Tomanin, Yi Ju, Anders Barlow, Mattias Bjornmalm, Frank Caruso

2020-01-08

Metal contamination of water bodies from industrial effluents presents a global threat to the aquatic ecosystem. To address this c..

The Biomolecular Corona in 2D and Reverse: Patterning Metal–Phenolic Networks on Proteins, Lipids, Nucleic Acids, Polysaccharides, and Fingerprints

G Yun, JJ Richardson, M Capelli, Y Hu, QA Besford, ACG Weiss, H Lee, IS Choi, BC Gibson, P Reineck, F Caruso

2020-01-03

The adsorption of biomolecules onto nanomaterials can alter the performance of the nanomaterials in vitro and in vivo. Recent stud..

A radiolabeled drug tracing method to study neurotrophin-3 retention and distribution in the cochlea after nano-based local delivery.

Patrick Lam, Niliksha Gunewardene, Yutian Ma, Frank Caruso, Trung Nguyen, Brianna Flynn, Andrew K Wise, Rachael T Richardson

2020-01-01

Hearing loss is the most common sensory deficit worldwide with no approved therapeutics for treatment. Local neurotrophin delivery..

Expanding the Toolbox of Metal-Phenolic Networks via Enzyme-Mediated Assembly

Qi-Zhi Zhong, Joseph J Richardson, Shiyao Li, Wenjie Zhang, Yi Ju, Jianhua Li, Shuaijun Pan, Jingqu Chen, Frank Caruso

2020-01-01

Functional coatings are of considerable interest because of their fundamental implications for interfacial assembly and promise fo..

Metal-Phenolic Coatings as a Platform to Trigger Endosomal Escape of Nanoparticles.

Jingqu Chen, Jianhua Li, Jiajing Zhou, Zhixing Lin, Francesca Cavalieri, Ewa Czuba-Wojnilowicz, Yingjie Hu, Agata Glab, Yi Ju, Joseph J Richardson, Frank Caruso

2019-10-22

The intracellular delivery of functional nanoparticles (NPs) and the release of therapeutic payloads at a target site are central ..

Engineering Biocoatings To Prolong Drug Release from Supraparticles

Yutian Ma, Christina Cortez-Jugo, Jianhua Li, Zhixing Lin, Rachael T Richardson, Yiyuan Han, Jiajing Zhou, Mattias Bjornmalm, Orlagh M Feeney, Qi-Zhi Zhong, Christopher JH Porter, Andrew K Wise, Frank Caruso

2019-09-09

Supraparticles (SPs) assembled from smaller colloidal nanoparticles can serve as depots of therapeutic compounds and are of intere..

Oxidation-Mediated Kinetic Strategies for Engineering Metal-Phenolic Networks

Qi-Zhi Zhong, Shiyao Li, Jingqu Chen, Ke Xie, Shuaijun Pan, Joseph J Richardson, Frank Caruso

2019-09-02

The tunable growth of metal–organic materials has implications for engineering particles and surfaces for diverse applications. Sp..

Revisiting cell-particle association in vitro: A quantitative method to compare particle performance.

Matthew Faria, Ka Fung Noi, Qiong Dai, Mattias Björnmalm, Stuart T Johnston, Kristian Kempe, Frank Caruso, Edmund J Crampin

2019-08-10

Nanoengineering has the potential to revolutionize medicine by designing drug delivery systems that are both efficacious and highl..

Cellular Targeting of Bispecific Antibody-Functionalized Poly(ethylene glycol) Capsules: Do Shape and Size Matter?

Danzi Song, Jiwei Cui, Yi Ju, Matthew Faria, Huanli Sun, Christopher B Howard, Kristofer J Thurecht, Frank Caruso

2019-08-01

In the present study, a capsule system that consists of a stealth carrier based on poly(ethylene glycol) (PEG) and functionalized ..

Stealth and Targeting of Ligand-Functionalized Poly(ethylene glycol) Particles

Yi Ju, Jiwei Cui, Karen Alt, Stephen Kent, Christoph Hagemeyer, Frank Caruso

2019-06-26

Oral presentation at 10th International Nanomedicine Conference

Nebulization of Phenolic Capsules for Pulmonary Delivery

Christina Cortez-Jugo, Yi Ju, Leslie Yeo, Christoph Hagemeyer, Frank Caruso

2019-06-24

Oral presentation at 10th International Conference on Materials for Advanced Technologies

Template-Free Synthesis of Chemically Asymmetric Silica Nanotubes for Selective Cargo Loading and Sustained Drug Release

Chao Deng, Qian Zhang, Cong Fu, Fangzhou Zhou, Wuli Yang, Deliang Yi, Xingdong Wang, Yi Tang, Frank Caruso, Yajun Wang

2019-06-11

SiO2 nanotubes (NTs), with uniform diameter (∼25 nm) and tailored shell thickness (1–5 nm), and featuring chemically asymmetric su..

Unraveling Biointeractions with Nanoengineered Hydrogel Particles

Frank Caruso

2019-06-03

Oral presentation at Summit on Functional Nanocolloids

SupraCells: Living Mammalian Cells Protected within Functional Modular Nanoparticle-Based Exoskeletons

Wei Zhu, Jimin Guo, Shahrouz Amini, Yi Ju, Jacob Ongudi Agola, Andreas Zimpel, Jin Shang, Achraf Noureddine, Frank Caruso, Stefan Wuttke, Jonas G Croissant, C Jeffrey Brinker

2019-06-01

The Future of Layer-by-Layer Assembly: A Tribute to ACS Nano Associate Editor Helmuth Mohwald

Shuang Zhao, Frank Caruso, Lars Daehne, Gero Decher, Bruno G De Geest, Jinchen Fan, Neus Feliu, Yury Gogotsi, Paula T Hammond, Mark C Hersam, Ali Khademhosseini, Nicholas Kotov, Stefano Leporatti, Yan Li, Fred Lisdat, Luis M Liz-Marzan, Sergio Moya, Paul Mulvaney, Andrey L Rogach, Sathi Roy

2019-06-01

Link between Low-Fouling and Stealth: A Whole Blood Biomolecular Corona and Cellular Association Analysis on Nanoengineered Particles

Alessia CG Weiss, Hannah G Kelly, Matthew Faria, Quinn A Besford, Adam K Wheatley, Ching-Seng Ang, Edmund J Crampin, Frank Caruso, Stephen J Kent

2019-05-28

Upon exposure to human blood, nanoengineered particles interact with a multitude of plasma components, resulting in the formation ..

Selective Metal-Phenolic Assembly from Complex Multicomponent Mixtures

Gan Lin, Md Arifur Rahim, Michael G Leeming, Christina Cortez-Jugo, Quinn A Besford, Yi Ju, Qi-Zhi Zhong, Stuart T Johnston, Jiajing Zhou, Frank Caruso

2019-05-15

Modulating Targeting of Poly(ethylene glycol) Particles to Tumor Cells Using Bispecific Antibodies

Jiwei Cui, Yi Ju, Zachary H Houston, Joshua J Class, Nicholas L Fletcher, Sheilajen Alcantara, Qiong Dai, Christopher B Howard, Stephen M Mahler, Adam K Wheatley, Robert De Rose, Paul T Brannon, Brett M Paterson, Paul S Donnelly, Kristoferj Thurecht, Frank Caruso, Stephen J Kent

2019-05-01

Nanoengineering of poly(ethylene glycol) particles for stealth and targeting

Frank Caruso

2019-03-31

Nanoengineering of poly(ethylene glycol) particles for stealth and targeting

Frank Caruso

2019-03-31

Bio-Nano Interactions of Metal-Phenolic Networks

Frank Caruso

2019-03-23

Oral presentation at 3rd International Symposium on Translational Nanomedicine

Modular Metal-Organic Polyhedra Superassembly: From Molecular-Level Design to Targeted Drug Delivery

Wei Zhu, Jimin Guo, Yi Ju, Rita E Serda, Jonas G Croissant, Jin Shang, Eric Coker, Jacob Ongudi Agola, Qi-Zhi Zhong, Yuan Ping, Frank Caruso, C Jeffrey Brinker

2019-03-22

Targeted drug delivery remains at the forefront of biomedical research but remains a challenge to date. Herein, the first superass..

Protein Adsorption and Coordination-Based End-Tethering of Functional Polymers on Metal-Phenolic Network Films

Blaise L Tardy, Joseph J Richardson, Vichida Nithipipat, Kristian Kempe, Junling Guo, Kwun Lun Cho, Md Arifur Rahim, Hirotaka Ejima, Frank Caruso

2019-03-01

Tuning the Mechanical Behavior of Metal-Phenolic Networks through Building Block Composition

Gyeongwon Yun, Joseph J Richardson, Matthew Biviano, Frank Caruso

2019-02-13

Phenolic Building Blocks for the Assembly of Functional Materials

Md Arifur Rahim, Samantha L Kristufek, Shuaijun Pan, Joseph J Richardson, Frank Caruso

2019-02-11

Metal-dependent inhibition of amyloid fibril formation: synergistic effects of cobalt-tannic acid networks

Wenjie Zhang, Andrew J Christofferson, Quinn A Besford, Joseph J Richardson, Junling Guo, Yi Ju, Kristian Kempe, Irene Yarovsky, Frank Caruso

2019-01-28

Metal–phenolic networks (MPNs) have received widespread interest owing to their modular incorporation of functional metal ions and..

In Situ Characterization of Protein Corona Formation on Silica Microparticles Using Confocal Laser Scanning Microscopy Combined with Microfluidics

Alessia CG Weiss, Kilian Krueger, Quinn A Besford, Mathias Schlenk, Kristian Kempe, Stephan Foerster, Frank Caruso

2019-01-16

Ligand-Functionalized Poly(ethylene glycol) Particles for Tumor Targeting and Intracellular Uptake.

Jiwei Cui, Karen Alt, Yi Ju, Sylvia T Gunawan, Julia A Braunger, Ting-Yi Wang, Yunlu Dai, Qiong Dai, Joseph J Richardson, Junling Guo, Mattias Björnmalm, Christoph E Hagemeyer, Frank Caruso

2019-01-01

Drug carriers typically require both stealth and targeting properties to minimize nonspecific interactions with healthy cells and ..

Super-resolution Imaging of Proton Sponge-Triggered Rupture of Endosomes and Cytosolic Release of Small Interfering RNA

Marcin Wojnilowicz, Agata Glab, Alessandro Bertucci, Frank Caruso, Francesca Cavalieri

2019-01-01

Cobalt Phosphate Nanostructures for Non-Enzymatic Glucose Sensing at Physiological pH

Pietro Pacchin Tomanin, Pavel V Cherepanov, Quinn A Besford, Andrew J Christofferson, Alessia Amodio, Chris F McConville, Irene Yarovsky, Frank Caruso, Francesca Cavalieri

2018-12-12

Overcoming the Blood-Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases

Denzil Furtado, Mattias Bjornmalm, Scott Ayton, Ashley I Bush, Kristian Kempe, Frank Caruso

2018-11-15

Spray Assembly of Metal-Phenolic Networks: Formation, Growth, and Applications

Qi-Zhi Zhong, Shuaijun Pan, Md Arifur Rahim, Gyeongwon Yun, Jianhua Li, Yi Ju, Zhixing Lin, Yiyuan Han, Yutian Ma, Joseph J Richardson, Frank Caruso

2018-10-03

Self-Assembled Metal-Phenolic Networks on Emulsions as Low-Fouling and pH-Responsive Particles

Quinn A Besford, Yi Ju, Ting-Yi Wang, Gyeongwon Yun, PavelV Cherepanov, Christoph E Hagemeyer, Francesca Cavalieri, Frank Caruso

2018-09-27

Gel-Mediated Electrospray Assembly of Silica Supraparticles for Sustained Drug Delivery

Yutian Ma, Mattias Bjoernmalm, Andrew K Wise, Christina Cortez-Jugo, Eve Revalor, Yi Ju, Orlagh M Feeney, Rachael T Richardson, Eric Hanssen, Robert K Shepherd, Christopher JH Porter, Frank Caruso

2018-09-19

Nanoengineering of Poly(ethylene glycol) Particles for Stealth and Targeting

Jiwei Cui, Mattias Bjornmalm, Yi Ju, Frank Caruso

2018-09-18

Glycogen-nucleic acid constructs for gene silencing in multicellular tumor spheroids

Marcin Wojnilowicz, Quinn A Besford, Yun-Long Wu, Xian Jun Loh, Julia A Braunger, Agata Glab, Christina Cortez-Jugo, Frank Caruso, Francesca Cavalieri

2018-09-01

Minimum information reporting in bio-nano experimental literature

Matthew Faria, Mattias Bjornmalm, Kristofer J Thurecht, Stephen J Kent, Robert G Parton, Maria Kavallaris, Angus PR Johnston, J Justin Gooding, Simon R Corrie, Ben J Boyd, Pall Thordarson, Andrew K Whittaker, Molly M Stevens, Clive A Prestidge, Christopher JH Porter, Wolfgang J Parak, Thomas P Davis, Edmund J Crampin, Frank Caruso

2018-09-01

Low-Fouling and Biodegradable Protein-Based Particles for Thrombus Imaging

Thomas Bonnard, Anand Jayapadman, Jasmine A Putri, Jiwei Cui, Yi Ju, Catherine Carmichael, Thomas A Angelovich, Stephen H Cody, Shauna French, Karline Pascaud, Hannah A Pearce, Shweta Jagdale, Frank Caruso, Christoph E Hagemeyer

2018-07-01

Self-Assembly of Nano- to Macroscopic Metal–Phenolic Materials

G Yun, Quinn Besford, S Johnston, JJ Richardson, Shuaijun Pan, M Biviano, F Caruso

2018-01-01

The self-assembly of molecular building blocks into well-defined macroscopic materials is desirable for developing emergent functi..