ADVANCING NANOMEDICINE THROUGH PARTICLE TECHNOLOGY
Grant number: 1135806 | Funding period: 2018 - 2022
This proposal will support the development of advanced particle systems to improve the delivery of medicines in neurological diseases, HIV, diabetes and cancer. It will provide important insights for particle-based therapeutic delivery that are expected to underpin progress on nanotechnology in the areas of biology and medicine. These developments in nanotechnology-enabled medicines towards commercialisation will ultimately improve the health and quality of life of Australians.
Related publications (60)
Person-Specific Biomolecular Coronas Modulate Nanoparticle Interactions with Immune Cells in Human Blood.
Yi Ju, Hannah G Kelly, Laura F Dagley, Arnold Reynaldi, Timothy E Schlub, Sukhdeep K Spall, Craig A Bell, Jiwei Cui, Andrew J Mitchell, Zhixing Lin, Adam K Wheatley, Kristofer J Thurecht, Miles P Davenport, Andrew I Webb, Frank Caruso, Stephen J Kent
When nanoparticles interact with human blood, a multitude of plasma components adsorb onto the surface of the nanoparticles, formi..
Polyphenol-Based Nanoparticles for Intracellular Protein Delivery via Competing Supramolecular Interactions.
Yiyuan Han, Jiajing Zhou, Yingjie Hu, Zhixing Lin, Yutian Ma, Joseph J Richardson, Frank Caruso
Intracellular delivery of proteins is a promising strategy for regulating cellular behavior and therefore has attracted interest f..
Catalytically Active Copper Phosphate-Dextran Sulfate Microparticle Coatings for Bioanalyte Sensing
Pietro Pacchin Tomanin, Sukhvir Kaur Bhangu, Frank Caruso, Francesca Cavalieri
Engineering reactive and functional nanostructured surfaces is important for enhancing the sensitivity and versatility of biosenso..
Dynamic Electrophoretic Assembly of Metal–Phenolic Films: Accelerated Formation and Cytocompatible Detachment
Gyeongwon Yun, Wongu Youn, Hojae Lee, Sang Yeong Han, Mariana B Oliveira, Hyeoncheol Cho, Frank Caruso, João F Mano, Insung S Choi
Material-independent coating has emerged as an advanced tool for interface engineering in numerous applications, including drug de..
Protein Component of Oyster Glycogen Nanoparticles: An Anchor Point for Functionalization
Quinn A Besford, Alessia CG Weiss, Jonas Schubert, Timothy M Ryan, Manfred F Maitz, Pietro Pacchin Tomanin, Marco Savioli, Carsten Werner, Andreas Fery, Frank Caruso, Francesca Cavalieri
Biosourced nanoparticles have a range of desirable properties for therapeutic applications, including biodegradability and low imm..
Programmable Permeability of Metal–Phenolic Network Microcapsules
Jingqu Chen, Shuaijun Pan, Jiajing Zhou, Qi-Zhi Zhong, Yijiao Qu, Joseph J Richardson, Frank Caruso
Developing materials with programmable permeability for cargo encapsulation and release is challenging but important in a number o..
Template-Mediated Assembly of DNA into Microcapsules for Immunological Modulation
Yijiao Qu, Yi Ju, Christina Cortez-Jugo, Zhixing Lin, Shiyao Li, Jiajing Zhou, Yutian Ma, Agata Glab, Stephen J Kent, Francesca Cavalieri, Frank Caruso
There is a need for effective vaccine delivery systems and vaccine adjuvants without extraneous excipients that can compromise or ..
Distribution of Particles in Human Stem Cell-Derived 3D Neuronal Cell Models: Effect of Particle Size, Charge, and Density
Ewa Czuba-Wojnilowicz, Sara Miellet, Agata Glab, Serena Viventi, Francesca Cavalieri, Christina Cortez-Jugo, Mirella Dottori, Frank Caruso
Neurodegenerative diseases are generally characterized by a progressive loss of neuronal subpopulations, with no available cure to..
Dissecting the intracellular signalling and fate of a DNA nanosensor by super-resolution and quantitative microscopy.
Agata Glab, Alessandro Bertucci, Fabiana Martino, Marcin Wojnilowicz, Alessia Amodio, Mariano Venanzi, Francesco Ricci, Giancarlo Forte, Frank Caruso, Francesca Cavalieri
DNA nanodevices have been developed as platforms for the manipulation of gene expression, delivery of molecular payloads, and dete..
Understanding the Uptake of Nanomedicines at Different Stages of Brain Cancer Using a Modular Nanocarrier Platform and Precision Bispecific Antibodies
Zachary H Houston, Jens Bunt, Kok-Siong Chen, Simon Puttick, Christopher B Howard, Nicholas L Fletcher, Adrian V Fuchs, Jiwei Cui, Yi Ju, Gary Cowin, Xin Song, Andrew W Boyd, Stephen M Mahler, Linda J Richards, Frank Caruso, Kristofer J Thurecht
Increasing accumulation and retention of nanomedicines within tumor tissue is a significant challenge, particularly in the case of..
Self-assembling influenza nanoparticle vaccines drive extended germinal center activity and memory B cell maturation.
Hannah G Kelly, Hyon-Xhi Tan, Jennifer A Juno, Robyn Esterbauer, Yi Ju, Wenbo Jiang, Verena C Wimmer, Brigette C Duckworth, Joanna R Groom, Frank Caruso, Masaru Kanekiyo, Stephen J Kent, Adam K Wheatley
Protein-based, self-assembling nanoparticles elicit superior immunity compared with soluble protein vaccines, but the immune mecha..
Surface Modification of Spider Silk Particles to Direct Biomolecular Corona Formation.
Alessia CG Weiss, Heike M Herold, Sarah Lentz, Matthew Faria, Quinn A Besford, Ching-Seng Ang, Frank Caruso, Thomas Scheibel
In recent years, spider silk-based materials have attracted attention because of their biocompatibility, processability, and biode..
Modulating the Selectivity and Stealth Properties of Ellipsoidal Polymersomes through a Multivalent Peptide Ligand Display
Kristel C Tjandra, Chelsea R Forest, Chin Ken Wong, Sheilajen Alcantara, Hannah G Kelly, Yi Ju, Martina H Stenzel, Joshua A McCarroll, Maria Kavallaris, Frank Caruso, Stephen J Kent, Pall Thordarson
There is a need for improved nanomaterials to simultaneously target cancer cells and avoid non‐specific clearance by phagocytes. A..
Particle-mediated delivery of frataxin plasmid to a human sensory neuronal model of Friedreich's ataxia.
Ewa Czuba-Wojnilowicz, Serena Viventi, Sara E Howden, Simon Maksour, Amy E Hulme, Christina Cortez-Jugo, Mirella Dottori, Frank Caruso
Increasing frataxin protein levels through gene therapy is envisaged to improve therapeutic outcomes for patients with Friedreich'..
Nanoengineering multifunctional hybrid interfaces using adhesive glycogen nanoparticles.
Pietro Pacchin Tomanin, Jiajing Zhou, Alessia Amodio, Rita Cimino, Agata Glab, Francesca Cavalieri, Frank Caruso
Multifunctional and biodegradable nanostructured hybrid interfaces based on biopolymers are potentially useful in many application..
Engineering of Nebulized Metal-Phenolic Capsules for Controlled Pulmonary Deposition
Yi Ju, Christina Cortez-Jugo, Jingqu Chen, Ting-Yi Wang, Andrew J Mitchell, Evelyn Tsantikos, Nadja Bertleff-Zieschang, Yu-Wei Lin, Jiaying Song, Yizhe Cheng, Srinivas Mettu, Md Arifur Rahim, Shuaijun Pan, Gyeongwon Yun, Margaret L Hibbs, Leslie Y Yeo, Christoph E Hagemeyer, Frank Caruso
Particle-based pulmonary delivery has great potential for delivering inhalable therapeutics for local or systemic applications. Th..
Cobalt-Directed Assembly of Antibodies onto Metal-Phenolic Networks for Enhanced Particle Targeting.
Wenjie Zhang, Quinn A Besford, Andrew J Christofferson, Patrick Charchar, Joseph J Richardson, Aaron Elbourne, Kristian Kempe, Christoph E Hagemeyer, Matthew R Field, Chris F McConville, Irene Yarovsky, Frank Caruso
The orientation-specific immobilization of antibodies onto nanoparticles, to preserve antibody-antigen recognition, is a key chall..
Polyphenol-Mediated Assembly of Proteins for Engineering Functional Materials
Yiyuan Han, Zhixing Lin, Jiajing Zhou, Gyeongwon Yun, Rui Guo, Joseph J Richardson, Frank Caruso
Functional materials composed of proteins have attracted much interest owing to the inherent and diverse functionality of proteins..
Ordered Mesoporous Metal-Phenolic Network Particles.
Zhixing Lin, Jiajing Zhou, Christina Cortez-Jugo, Yiyuan Han, Yutian Ma, Shuaijun Pan, Eric Hanssen, Joseph J Richardson, Frank Caruso
Mesoporous metal-organic networks have attracted widespread interest owing to their potential applications in diverse fields inclu..
Self-Assembly of a Metal-Phenolic Sorbent for Broad-Spectrum Metal Sequestration
Md Arifur Rahim, Gan Lin, Pietro Pacchin Tomanin, Yi Ju, Anders Barlow, Mattias Bjornmalm, Frank Caruso
Metal contamination of water bodies from industrial effluents presents a global threat to the aquatic ecosystem. To address this c..
The Biomolecular Corona in 2D and Reverse: Patterning Metal–Phenolic Networks on Proteins, Lipids, Nucleic Acids, Polysaccharides, and Fingerprints
G Yun, JJ Richardson, M Capelli, Y Hu, QA Besford, ACG Weiss, H Lee, IS Choi, BC Gibson, P Reineck, F Caruso
The adsorption of biomolecules onto nanomaterials can alter the performance of the nanomaterials in vitro and in vivo. Recent stud..
A radiolabeled drug tracing method to study neurotrophin-3 retention and distribution in the cochlea after nano-based local delivery.
Patrick Lam, Niliksha Gunewardene, Yutian Ma, Frank Caruso, Trung Nguyen, Brianna Flynn, Andrew K Wise, Rachael T Richardson
Hearing loss is the most common sensory deficit worldwide with no approved therapeutics for treatment. Local neurotrophin delivery..
Expanding the Toolbox of Metal-Phenolic Networks via Enzyme-Mediated Assembly
Qi-Zhi Zhong, Joseph J Richardson, Shiyao Li, Wenjie Zhang, Yi Ju, Jianhua Li, Shuaijun Pan, Jingqu Chen, Frank Caruso
Functional coatings are of considerable interest because of their fundamental implications for interfacial assembly and promise fo..
Metal-Phenolic Coatings as a Platform to Trigger Endosomal Escape of Nanoparticles.
Jingqu Chen, Jianhua Li, Jiajing Zhou, Zhixing Lin, Francesca Cavalieri, Ewa Czuba-Wojnilowicz, Yingjie Hu, Agata Glab, Yi Ju, Joseph J Richardson, Frank Caruso
The intracellular delivery of functional nanoparticles (NPs) and the release of therapeutic payloads at a target site are central ..
Engineering Biocoatings To Prolong Drug Release from Supraparticles
Yutian Ma, Christina Cortez-Jugo, Jianhua Li, Zhixing Lin, Rachael T Richardson, Yiyuan Han, Jiajing Zhou, Mattias Bjornmalm, Orlagh M Feeney, Qi-Zhi Zhong, Christopher JH Porter, Andrew K Wise, Frank Caruso
Supraparticles (SPs) assembled from smaller colloidal nanoparticles can serve as depots of therapeutic compounds and are of intere..
Oxidation-Mediated Kinetic Strategies for Engineering Metal-Phenolic Networks
Qi-Zhi Zhong, Shiyao Li, Jingqu Chen, Ke Xie, Shuaijun Pan, Joseph J Richardson, Frank Caruso
The tunable growth of metal–organic materials has implications for engineering particles and surfaces for diverse applications. Sp..
Revisiting cell-particle association in vitro: A quantitative method to compare particle performance.
Matthew Faria, Ka Fung Noi, Qiong Dai, Mattias Björnmalm, Stuart T Johnston, Kristian Kempe, Frank Caruso, Edmund J Crampin
Nanoengineering has the potential to revolutionize medicine by designing drug delivery systems that are both efficacious and highl..
Cellular Targeting of Bispecific Antibody-Functionalized Poly(ethylene glycol) Capsules: Do Shape and Size Matter?
Danzi Song, Jiwei Cui, Yi Ju, Matthew Faria, Huanli Sun, Christopher B Howard, Kristofer J Thurecht, Frank Caruso
In the present study, a capsule system that consists of a stealth carrier based on poly(ethylene glycol) (PEG) and functionalized ..
Template-Free Synthesis of Chemically Asymmetric Silica Nanotubes for Selective Cargo Loading and Sustained Drug Release
Chao Deng, Qian Zhang, Cong Fu, Fangzhou Zhou, Wuli Yang, Deliang Yi, Xingdong Wang, Yi Tang, Frank Caruso, Yajun Wang
SiO2 nanotubes (NTs), with uniform diameter (∼25 nm) and tailored shell thickness (1–5 nm), and featuring chemically asymmetric su..
The Future of Layer-by-Layer Assembly: A Tribute to ACS Nano Associate Editor Helmuth Mohwald
Shuang Zhao, Frank Caruso, Lars Daehne, Gero Decher, Bruno G De Geest, Jinchen Fan, Neus Feliu, Yury Gogotsi, Paula T Hammond, Mark C Hersam, Ali Khademhosseini, Nicholas Kotov, Stefano Leporatti, Yan Li, Fred Lisdat, Luis M Liz-Marzan, Sergio Moya, Paul Mulvaney, Andrey L Rogach, Sathi Roy
Link between Low-Fouling and Stealth: A Whole Blood Biomolecular Corona and Cellular Association Analysis on Nanoengineered Particles
Alessia CG Weiss, Hannah G Kelly, Matthew Faria, Quinn A Besford, Adam K Wheatley, Ching-Seng Ang, Edmund J Crampin, Frank Caruso, Stephen J Kent
Upon exposure to human blood, nanoengineered particles interact with a multitude of plasma components, resulting in the formation ..
Modulating Targeting of Poly(ethylene glycol) Particles to Tumor Cells Using Bispecific Antibodies
Jiwei Cui, Yi Ju, Zachary H Houston, Joshua J Class, Nicholas L Fletcher, Sheilajen Alcantara, Qiong Dai, Christopher B Howard, Stephen M Mahler, Adam K Wheatley, Robert De Rose, Paul T Brannon, Brett M Paterson, Paul S Donnelly, Kristoferj Thurecht, Frank Caruso, Stephen J Kent
Modular Metal-Organic Polyhedra Superassembly: From Molecular-Level Design to Targeted Drug Delivery
Wei Zhu, Jimin Guo, Yi Ju, Rita E Serda, Jonas G Croissant, Jin Shang, Eric Coker, Jacob Ongudi Agola, Qi-Zhi Zhong, Yuan Ping, Frank Caruso, C Jeffrey Brinker
Targeted drug delivery remains at the forefront of biomedical research but remains a challenge to date. Herein, the first superass..
Metal-dependent inhibition of amyloid fibril formation: synergistic effects of cobalt-tannic acid networks
Wenjie Zhang, Andrew J Christofferson, Quinn A Besford, Joseph J Richardson, Junling Guo, Yi Ju, Kristian Kempe, Irene Yarovsky, Frank Caruso
Metal–phenolic networks (MPNs) have received widespread interest owing to their modular incorporation of functional metal ions and..
Ligand-Functionalized Poly(ethylene glycol) Particles for Tumor Targeting and Intracellular Uptake.
Jiwei Cui, Karen Alt, Yi Ju, Sylvia T Gunawan, Julia A Braunger, Ting-Yi Wang, Yunlu Dai, Qiong Dai, Joseph J Richardson, Junling Guo, Mattias Björnmalm, Christoph E Hagemeyer, Frank Caruso
Drug carriers typically require both stealth and targeting properties to minimize nonspecific interactions with healthy cells and ..
Minimum information reporting in bio-nano experimental literature
Matthew Faria, Mattias Bjornmalm, Kristofer J Thurecht, Stephen J Kent, Robert G Parton, Maria Kavallaris, Angus PR Johnston, J Justin Gooding, Simon R Corrie, Ben J Boyd, Pall Thordarson, Andrew K Whittaker, Molly M Stevens, Clive A Prestidge, Christopher JH Porter, Wolfgang J Parak, Thomas P Davis, Edmund J Crampin, Frank Caruso
Low-Fouling and Biodegradable Protein-Based Particles for Thrombus Imaging
Thomas Bonnard, Anand Jayapadman, Jasmine A Putri, Jiwei Cui, Yi Ju, Catherine Carmichael, Thomas A Angelovich, Stephen H Cody, Shauna French, Karline Pascaud, Hannah A Pearce, Shweta Jagdale, Frank Caruso, Christoph E Hagemeyer