ADVANCING NANOMEDICINE THROUGH PARTICLE TECHNOLOGY

Supramolecular Polyphenol‐DNA Microparticles for In Vivo Adjuvant and Antigen Co‐Delivery and Immune Stimulation

Yijiao Qu, Robert De Rose, Chan‐Jin Kim, Jiajing Zhou, Zhixing Lin, Yi Ju, Sukhvir Kaur Bhangu, Christina Cortez‐Jugo, Francesca Cavalieri, Frank Caruso

2023-03-13

An Engineered Nanosugar Enables Rapid and Sustained Glucose-Responsive Insulin Delivery in Diabetic Mice.

Rong Xu, Sukhvir Kaur Bhangu, Karly C Sourris, Domitilla Vanni, Marc-Antoine Sani, John A Karas, Karen Alt, Be'eri Niego, Anukreity Ale, Quinn A Besford, Brendan Dyett, Joshua Patrick, Irena Carmichael, Jonathan E Shaw, Frank Caruso, Mark E Cooper, Christoph E Hagemeyer, Francesca Cavalieri

2023-03-12

Glucose-responsive insulin-delivery platforms that are sensitive to dynamic glucose concentration fluctuations and provide both ra..

Direct synthesis of amorphous coordination polymers and metal-organic frameworks

Zhixing Lin, Joseph J Richardson, Jiajing Zhou, Frank Caruso

2023-03-06

Coordination polymers (CPs) and their subset, metal–organic frameworks (MOFs), can have porous structures and hybrid physicochemic..

Layer-by-Layer Particles Deliver Epigenetic Silencing siRNA to HIV-1 Latent Reservoir Cell Types

Ewa Czuba-Wojnilowicz, Vera Klemm, Christina Cortez-Jugo, Stuart Turville, Anupriya Aggarwal, Frank Caruso, Anthony D Kelleher, Chantelle L Ahlenstiel

2023-02-27

For over two decades, nanomaterials have been employed to facilitate intracellular delivery of small interfering RNA (siRNA), both..

Supramolecular Polyphenol-DNA Microparticles for In Vivo Adjuvant and Antigen Co-Delivery and Immune Stimulation

Yijiao Qu, Robert De Rose, Chan-Jin Kim, Jiajing Zhou, Zhixing Lin, Yi Ju, Sukhvir Kaur Bhangu, Christina Cortez-Jugo, Francesca Cavalieri, Frank Caruso

2023-02-10

DNA-based materials have attracted interest due to the tunable structure and encoded biological functionality of nucleic acids. A ..

Highly Stable and Active Flexible Electrocatalysts Derived from Lotus Fibers

Zhen Liu, Xuxu Wang, Rui Guo, Joseph J Richardson, Tianzheng Wang, Weijian Xu, Frank Caruso, Shuaijun Pan

2023-01-29

The stability and activity of electrocatalysts are fundamental in energy-related applications (e.g., hydrogen generation and energ..

Synthesis of Thermoresponsive, Catechol-Rich Poly(ethylene glycol) Brush Polymers for Attenuating Cellular Oxidative Stress

Francesca Ercole, Chan-Jin Kim, Nam V Dao, Warren KL Tse, Michael R Whittaker, Frank Caruso, John F Quinn

2022-12-05

Herein, we report a platform to integrate customizable quantities of catechol units into polymers by reacting caffeic acid carboni..

The mechanical regulation of RNA binding protein hnRNPC in the failing heart

Fabiana Martino, Nandan Mysore Varadarajan, Ana Rubina Perestrelo, Vaclav Hejret, Helena Durikova, Dragana Vukic, Vladimir Horvath, Francesca Cavalieri, Frank Caruso, Waleed S Albihlal, Andre P Gerber, Mary A O'Connell, Stepanka Vanacova, Stefania Pagliari, Giancarlo Forte

2022-11-23

Cardiac pathologies are characterized by intense remodeling of the extracellular matrix (ECM) that eventually leads to heart failu..

mRNA Treatment Rescues Niemann-Pick Disease Type C1 in Patient Fibroblasts

Denzil Furtado, Christina Cortez-Jugo, Ya Hui Hung, Ashley I Bush, Frank Caruso

2022-09-20

Messenger RNA (mRNA) holds great potential as a disease-modifying treatment for a wide array of monogenic disorders. Niemann-Pick ..

Polyphenol-Functionalized Cubosomes as Thrombolytic Drug Carriers

Haitao Yu, Jason S Palazzolo, Yi Ju, Be'eri Niego, Shuaijun Pan, Christoph E Hagemeyer, Frank Caruso

2022-09-13

The safe administration of thrombolytic agents is a challenge for the treatment of acute thrombosis. Lipid-based nanoparticle drug..

Experimental Quantification of Interactions Between Drug Delivery Systems and Cells In Vitro: A Guide for Preclinical Nanomedicine Evaluation

Paula M Cevaal, Michael Roche, Sharon R Lewin, Frank Caruso, Matthew Faria

2022-09-01

A major component of designing drug delivery systems concerns how to amplify or attenuate interactions with specific cell types. F..

Influence of protein corona on the interaction of glycogen-siRNA constructs with ex vivo human blood immune cells

Marcin Wojnilowicz, Petra Laznickova, Yi Ju, Ching-Seng Ang, Federico Tidu, Kamila Bendickova, Giancarlo Forte, Magdalena Plebanski, Frank Caruso, Francesca Cavalieri, Jan Fric

2022-08-23

Glycogen-nucleic acid constructs i.e., glycoplexes are emerging promising platforms for the alteration of gene expression and tran..

Site‐Selective Coordination Assembly of Dynamic Metal‐Phenolic Networks

Wanjun Xu, Shuaijun Pan, Benjamin B Noble, Jingqu Chen, Zhixing Lin, Yiyuan Han, Jiajing Zhou, Joseph J Richardson, Irene Yarovsky, Frank Caruso

2022-08-22

Engineering Programmable DNA Particles and Capsules Using Catechol-Functionalized DNA Block Copolymers

Chan-Jin Kim, Francesca Ercole, Eirini Goudeli, Sukhvir Kaur Bhangu, Jingqu Chen, Matthew Faria, John F Quinn, Frank Caruso

2022-08-02

DNA block copolymer (DBC) assemblies have attracted attention because of their tunable properties (e.g., programmability, high bio..

Site-Selective Coordination Assembly of Dynamic Metal-Phenolic Networks

Wanjun Xu, Shuaijun Pan, Benjamin B Noble, Jingqu Chen, Zhixing Lin, Yiyuan Han, Jiajing Zhou, Joseph J Richardson, Irene Yarovsky, Frank Caruso

2022-07-13

Coordination states of metal-organic materials are known to dictate their physicochemical properties and applications in various f..

Role of Molecular Interactions in Supramolecular Polypeptide-Polyphenol Networks for Engineering Functional Materials

Yiyuan Han, Rene PM Lafleur, Jiajing Zhou, Wanjun Xu, Zhixing Lin, Joseph J Richardson, Frank Caruso

2022-07-01

Supramolecular assembly affords the development of a wide range of polypeptide-based biomaterials for drug delivery and nanomedici..

Protein precoating modulates biomolecular coronas and nanocapsule-immune cell interactions in human blood

Shiyao Li, Yi Ju, Jiajing Zhou, Matthew Faria, Ching-Seng Ang, Andrew J Mitchell, Qi-Zhi Zhong, Tian Zheng, Stephen J Kent, Frank Caruso

2022-06-09

The biomolecular corona that forms on particles upon contact with blood plays a key role in the fate and utility of nanomedicines...

Nanostructured particles assembled from natural building blocks for advanced therapies

Yi Ju, Haotian Liao, Joseph J Richardson, Junling Guo, Frank Caruso

2022-04-26

Advanced treatments based on immune system manipulation, gene transcription and regulation, specific organ and cell targeting, and..

Template-Assisted Antibody Assembly: A Versatile Approach for Engineering Functional Antibody Nanoparticles

Y Hu, J Li, Y Ju, ZH Houston, NL Fletcher, R De Rose, S Fernandes, CE Hagemeyer, K Alt, KJ Thurecht, C Cortez-Jugo, F Caruso

2022-04-26

The clinical success of monoclonal antibody therapy has inspired research in understanding the fundamental molecular basis of anti..

Assembly of Metal-Phenolic Networks on Water-Soluble Substrates in Nonaqueous Media

Omid Mazaheri, Masood S Alivand, Ali Zavabeti, Steve Spoljaric, Shuaijun Pan, Deli Chen, Frank Caruso, Helen C Suter, Kathryn A Mumford

2022-03-10

Interfacial modular assemblies of eco-friendly metal–phenolic networks (MPNs) are of interest for surface and materials engineerin..

Transforming the Chemical Structure and Bio-Nano Activity of Doxorubicin by Ultrasound for Selective Killing of Cancer Cells

Sukhvir Kaur Bhangu, Soraia Fernandes, Giovanni Luca Beretta, Stella Tinelli, Marco Cassani, Agata Radziwon, Marcin Wojnilowicz, Sophia Sarpaki, Irinaios Pilatis, Nadia Zaffaroni, Giancarlo Forte, Frank Caruso, Muthupandian Ashokkumar, Francesca Cavalieri

2022-02-18

Reconfiguring the structure and selectivity of existing chemotherapeutics represents an opportunity for developing novel tumor-sel..

Immobilization and Intracellular Delivery of Structurally Nanoengineered Antimicrobial Peptide Polymers Using Polyphenol-Based Capsules

Jiaying Song, Christina Cortez-Jugo, Steven J Shirbin, Zhixing Lin, Shuaijun Pan, Greg G Qiao, Frank Caruso

2022-02-02

Structurally nanoengineered antimicrobial peptide polymers (SNAPPs) are an emerging class of antimicrobials against multidrug-resi..

Nanoscale probing and imaging of HIV-1 RNA in cells with a chimeric LNA-DNA sensor

Alessia Amodio, Marco Cassani, Liviana Mummolo, Christina Cortez-Jugo, Sukhvir Kaur Bhangu, Jori Symons, Chantelle L Ahlenstiel, Giancarlo Forte, Francesco Ricci, Anthony D Kelleher, Sharon R Lewin, Francesca Cavalieri, Frank Caruso

2022-01-31

Real-time detection and nanoscale imaging of human immunodeficiency virus type 1 ribonucleic acid (HIV-1 RNA) in latently infected..

Assembly of Bioactive Nanoparticles via Metal-Phenolic Complexation

Jingqu Chen, Shuaijun Pan, Jiajing Zhou, Zhixing Lin, Yijiao Qu, Agata Glab, Yiyuan Han, Joseph J Richardson, Frank Caruso

2022-01-30

The integration of bioactive materials (e.g., proteins and genes) into nanoparticles holds promise in fields ranging from catalysi..

Origins of Structural Elasticity in Metal-Phenolic Networks Probed by Super-Resolution Microscopy and Multiscale Simulations.

Sukhvir Kaur Bhangu, Patrick Charchar, Benjamin B Noble, Chan-Jin Kim, Shuaijun Pan, Irene Yarovsky, Francesca Cavalieri, Frank Caruso

2022-01-25

Metal-phenolic networks (MPNs) are amorphous materials that can be used to engineer functional films and particles. A fundamental ..

Triggering the nanophase separation of albumin through multivalent binding to glycogen for drug delivery in 2D and 3D multicellular constructs

Agata Radziwon, Sukhvir K Bhangu, Soraia Fernandes, Christina Cortez-Jugo, Robert De Rose, Brendan Dyett, Marcin Wojnilowicz, Petra Laznickova, Jan Fric, Giancarlo Forte, Frank Caruso, Francesca Cavalieri

2022-01-24

Engineered nanoparticles for the encapsulation of bioactive agents hold promise to improve disease diagnosis, prevention and thera..

Pharmacokinetics and biodistribution of supraparticle-delivered neurotrophin 3 in the guinea pig cochlea

Niliksha Gunewardene, Patrick Lam, Yutian Ma, Frank Caruso, Sherryl Wagstaff, Rachael T Richardson, Andrew K Wise

2022-01-13

Hearing loss is the most prevalent sensory disorder affecting nearly half a billion people worldwide. Aside from devices to assist..

Bioresponsive Polyphenol-Based Nanoparticles as Thrombolytic Drug Carriers

Haitao Yu, Jason S Palazzolo, Jiajing Zhou, Yingjie Hu, Beeri Niego, Shuaijun Pan, Yi Ju, Ting-Yi Wang, Zhixing Lin, Christoph E Hagemeyer, Frank Caruso

2022-01-12

Thrombolytic (clot-busting) therapies with plasminogen activators (PAs) are first-line treatments against acute thrombosis and isc..

Macromolecular Engineering of Thermoresponsive Metal-Phenolic Networks

Chan-Jin Kim, Francesca Ercole, Jingqu Chen, Shuaijun Pan, Yi Ju, John F Quinn, Frank Caruso

2022-01-01

Dynamic nanostructured materials that can react to physical and chemical stimuli have attracted interest in the biomedical and mat..

Luminescent Metal-Phenolic Networks for Multicolor Particle Labeling

Zhixing Lin, Jiajing Zhou, Yijiao Qu, Shuaijun Pan, Yiyuan Han, Rene PM Lafleur, Jingqu Chen, Christina Cortez-Jugo, Joseph J Richardson, Frank Caruso

2021-11-15

The development of fluorescence labeling techniques has attracted widespread interest in various fields, including biomedical scie..

Luminescent Metal‐Phenolic Networks for Multicolor Particle Labeling

Zhixing Lin, Jiajing Zhou, Yijiao Qu, Shuaijun Pan, Yiyuan Han, René PM Lafleur, Jingqu Chen, Christina Cortez‐Jugo, Joseph J Richardson, Frank Caruso

2021-11-15

Synthesis of Customizable Macromolecular Conjugates as Building Blocks for Engineering Metal–Phenolic Network Capsules with Tailorable Properties

Chan-Jin Kim, Francesca Ercole, Yi Ju, Shuaijun Pan, Jingqu Chen, Yijiao Qu, John F Quinn, Frank Caruso

2021-10-29

Metal–phenolic networks (MPNs), formed through coordination bonding between phenolic molecules and metal ions, are a promising cla..

Bio-nano Science: Better Metrics Would Accelerate Progress

Matthew Faria, Stuart T Johnston, Andrew J Mitchell, Edmund Crampin, Frank Caruso

2021-09-23

An early step of evaluating a nanomaterial’s potential for biological applications is investigating its interactions with cells an..

Robust and Versatile Coatings Engineered via Simultaneous Covalent and Noncovalent Interactions

Jiajing Zhou, Matthew Penna, Zhixing Lin, Yiyuan Han, René PM Lafleur, Yijiao Qu, Joseph J Richardson, Irene Yarovsky, Jesse V Jokerst, Frank Caruso

2021-09-06

Robust and Versatile Coatings Engineered via Simultaneous Covalent and Noncovalent Interactions

Jiajing Zhou, Matthew Penna, Zhixing Lin, Yiyuan Han, Rene PM Lafleur, Yijiao Qu, Joseph J Richardson, Irene Yarovsky, Jesse V Jokerst, Frank Caruso

2021-08-06

Interfacial modular assembly has emerged as an adaptable strategy for engineering the surface properties of substrates in biomedic..

Quantitatively Tracking Bio-Nano Interactions of Metal-Phenolic Nanocapsules by Mass Cytometry

Shiyao Li, Yi Ju, Jiajing Zhou, Ka Fung Noi, Andrew J Mitchell, Tian Zheng, Stephen J Kent, Christopher JH Porter, Frank Caruso

2021-07-21

Polymer nanocapsules, with a hollow structure, are increasingly finding widespread use as drug delivery carriers; however, quantit..

Stereoselective Growth of Small Molecule Patches on Nanoparticles

Jiajing Zhou, Matthew N Creyer, Amanda Chen, Wonjun Yim, Rene PM Lafleur, Tengyu He, Zhixing Lin, Ming Xu, Pedram Abbasi, Jianfeng Wu, Tod A Pascal, Frank Caruso, Jesse V Jokerst

2021-07-16

Patchy nanoparticles featuring tunable surface domains with spatial and chemical specificity are of fundamental interest, especial..

A Focus on "Bio" in Bio-Nanoscience: The Impact of Biological Factors on Nanomaterial Interactions

Christina Cortez-Jugo, Ewa Czuba-Wojnilowicz, Abigail Tan, Frank Caruso

2021-06-25

Bio-nanoscience research encompasses studies on the interactions of nanomaterials with biological structures or what is commonly r..

Fluorinated Metal-Organic Coatings with Selective Wettability

Shuaijun Pan, Joseph J Richardson, Andrew J Christofferson, Quinn A Besford, Tian Zheng, Barry J Wood, Xiaofei Duan, Maximiliano Jesus Jara Fornerod, Christopher F McConville, Irene Yarovsky, Stefan Guldin, Lei Jiang, Frank Caruso

2021-06-25

Surface chemistry is a major factor that determines the wettability of materials, and devising broadly applicable coating strategi..

NFAT signaling in human mesenchymal stromal cells affects extracellular matrix remodeling and antifungal immune responses

Federico Tidu, Marco De Zuani, Shyam Sushama Jose, Kamila Bendickova, Lukas Kubala, Frank Caruso, Francesca Cavalieri, Giancarlo Forte, Jan Fric

2021-06-25

Mesenchymal stromal cells (MSCs) combined with calcineurin-nuclear factor of activated T cell (CN-NFAT) inhibitors are being teste..

Influence of Poly(ethylene glycol) Molecular Architecture on Particle Assembly and Ex Vivo Particle-Immune Cell Interactions in Human Blood

Jiaying Song, Yi Ju, Thakshila H Amarasena, Zhixing Lin, Srinivas Mettu, Jiajing Zhou, Md Arifur Rahim, Ching-Seng Ang, Christina Cortez-Jugo, Stephen J Kent, Frank Caruso

2021-05-19

Poly(ethylene glycol) (PEG) is widely used in particle assembly to impart biocompatibility and stealth-like properties in vivo for..

Exploiting Supramolecular Dynamics in Metal-Phenolic Networks to Generate Metal-Oxide and Metal-Carbon Networks

Shuaijun Pan, Eirini Goudeli, Jingqu Chen, Zhixing Lin, Qi-Zhi Zhong, Wenjie Zhang, Haitao Yu, Rui Guo, Joseph J Richardson, Frank Caruso

2021-05-17

Supramolecular complexation is a powerful strategy for engineering materials in bulk and at interfaces. Metal-phenolic networks (M..

Metal–Phenolic Networks as Tunable Buffering Systems

Jingqu Chen, Shuaijun Pan, Jiajing Zhou, Robert Seidel, Sebastian Beyer, Zhixing Lin, Joseph J Richardson, Frank Caruso

2021-03-22

The buffering effects displayed by pH‐responsive polymers have recently gained attention in diverse fields such as nanomedicine an..

X-ray-Based Techniques to Study the Nano-Bio Interface

Carlos Sanchez-Cano, Ramon A Alvarez-Puebla, John M Abendroth, Tobias Beck, Robert Blick, Yuan Cao, Frank Caruso, Indranath Chakraborty, Henry N Chapman, Chunying Chen, Bruce E Cohen, Andre LC Conceicao, David P Cormode, Daxiang Cui, Kenneth A Dawson, Gerald Falkenberg, Chunhai Fan, Neus Feliu, Mingyuan Gao, Elisabetta Gargioni

2021-03-02

X-ray-based analytics are routinely applied in many fields, including physics, chemistry, materials science, and engineering. The ..

Programmable Phototaxis of Metal-Phenolic Particle Microswimmers

Gan Lin, Joseph J Richardson, Heba Ahmed, Quinn A Besford, Andrew J Christofferson, Sebastian Beyer, Zhixing Lin, Amgad R Rezk, Marco Savioli, Jiajing Zhou, Chris F McConville, Christina Cortez-Jugo, Leslie Y Yeo, Frank Caruso

2021-02-26

Light-driven directional motion is common in nature but remains a challenge for synthetic microparticles, particularly regarding c..

Protocols for Reproducible, Increased-Scale Synthesis of Engineered Particles—Bridging the “Upscaling Gap”

Steve Spoljaric, Yi Ju, Frank Caruso

2021-02-23

Large-scale, reproducible synthesis of particles is key to achieving broader material accessibility and applicability. However, di..

In Vivo T Cell-Targeting Nanoparticle Drug Delivery Systems: Considerations for Rational Design

Paula M Cevaal, Abdalla Ali, Ewa Czuba-Wojnilowicz, Jori Symons, Sharon R Lewin, Christina Cortez-Jugo, Frank Caruso

2021-02-18

T cells play an important role in immunity and repair and are implicated in diseases, including blood cancers, viral infections, a..

Engineered Coatings via the Assembly of Amino‐Quinone Networks

Qi‐Zhi Zhong, Joseph J Richardson, Ai He, Tian Zheng, René PM Lafleur, Jianhua Li, Wen‐Ze Qiu, Denzil Furtado, Shuaijun Pan, Zhi‐Kang Xu, Ling‐Shu Wan, Frank Caruso

2021-02-01

Microemulsion-Assisted Templating of Metal-Stabilized Poly(ethylene glycol) Nanoparticles

Gan Lin, Christina Cortez-Jugo, Yi Ju, Quinn A Besford, Timothy M Ryan, Shuaijun Pan, Joseph J Richardson, Frank Caruso

2021-02-01

Poly(ethylene glycol) (PEG) is well known to endow nanoparticles (NPs) with low-fouling and stealth-like properties that can reduc..

Catalytically Active Copper Phosphate-Dextran Sulfate Microparticle Coatings for Bioanalyte Sensing

Pietro Pacchin Tomanin, Sukhvir Kaur Bhangu, Frank Caruso, Francesca Cavalieri

2020-12-28

Engineering reactive and functional nanostructured surfaces is important for enhancing the sensitivity and versatility of biosenso..

Engineered Coatings via the Assembly of Amino-Quinone Networks

Qi-Zhi Zhong, Joseph J Richardson, Ai He, Tian Zheng, Rene PM Lafleur, Jianhua Li, Wen-Ze Qiu, Denzil Furtado, Shuaijun Pan, Zhi-Kang Xu, Ling-Shu Wan, Frank Caruso

2020-11-30

Engineering coatings with precise physicochemical properties allows for control over the interface of a material and its interacti..

Person-Specific Biomolecular Coronas Modulate Nanoparticle Interactions with Immune Cells in Human Blood

Yi Ju, Hannah G Kelly, Laura F Dagley, Arnold Reynaldi, Timothy E Schlub, Sukhdeep K Spall, Craig A Bell, Jiwei Cui, Andrew J Mitchell, Zhixing Lin, Adam K Wheatley, Kristofer J Thurecht, Miles P Davenport, Andrew Webb, Frank Caruso, Stephen J Kent

2020-11-24

When nanoparticles interact with human blood, a multitude of plasma components adsorb onto the surface of the nanoparticles, formi..

Polyphenol-Based Nanoparticles for Intracellular Protein Delivery via Competing Supramolecular Interactions

Yiyuan Han, Jiajing Zhou, Yingjie Hu, Zhixing Lin, Yutian Ma, Joseph J Richardson, Frank Caruso

2020-10-27

Intracellular delivery of proteins is a promising strategy for regulating cellular behavior and therefore has attracted interest f..

Particle engineering enabled by polyphenol-mediated supramolecular networks.

Jiajing Zhou, Zhixing Lin, Matthew Penna, Shuaijun Pan, Yi Ju, Shiyao Li, Yiyuan Han, Jingqu Chen, Gan Lin, Joseph J Richardson, Irene Yarovsky, Frank Caruso

2020-09-23

We report a facile strategy for engineering diverse particles based on the supramolecular assembly of natural polyphenols and a se..

Dynamic Electrophoretic Assembly of Metal–Phenolic Films: Accelerated Formation and Cytocompatible Detachment

Gyeongwon Yun, Wongu Youn, Hojae Lee, Sang Yeong Han, Mariana B Oliveira, Hyeoncheol Cho, Frank Caruso, João F Mano, Insung S Choi

2020-09-22

Material-independent coating has emerged as an advanced tool for interface engineering in numerous applications, including drug de..

Protein Component of Oyster Glycogen Nanoparticles: An Anchor Point for Functionalization

Quinn A Besford, Alessia CG Weiss, Jonas Schubert, Timothy M Ryan, Manfred F Maitz, Pietro Pacchin Tomanin, Marco Savioli, Carsten Werner, Andreas Fery, Frank Caruso, Francesca Cavalieri

2020-09-02

Biosourced nanoparticles have a range of desirable properties for therapeutic applications, including biodegradability and low imm..

Polyphenol-Mediated Assembly of Proteins for Engineering Functional Materials

2020-09-01

© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Functional materials composed of proteins have attracted much interest owing t..

Programmable Permeability of Metal–Phenolic Network Microcapsules

Jingqu Chen, Shuaijun Pan, Jiajing Zhou, Qi-Zhi Zhong, Yijiao Qu, Joseph J Richardson, Frank Caruso

2020-08-25

Developing materials with programmable permeability for cargo encapsulation and release is challenging but important in a number o..

Template-Mediated Assembly of DNA into Microcapsules for Immunological Modulation

Yijiao Qu, Yi Ju, Christina Cortez-Jugo, Zhixing Lin, Shiyao Li, Jiajing Zhou, Yutian Ma, Agata Glab, Stephen J Kent, Francesca Cavalieri, Frank Caruso

2020-08-06

There is a need for effective vaccine delivery systems and vaccine adjuvants without extraneous excipients that can compromise or ..

Distribution of Particles in Human Stem Cell-Derived 3D Neuronal Cell Models: Effect of Particle Size, Charge, and Density

Ewa Czuba-Wojnilowicz, Sara Miellet, Agata Glab, Serena Viventi, Francesca Cavalieri, Christina Cortez-Jugo, Mirella Dottori, Frank Caruso

2020-08-01

Neurodegenerative diseases are generally characterized by a progressive loss of neuronal subpopulations, with no available cure to..

Polyphenol-Mediated Assembly for Particle Engineering.

Jiajing Zhou, Zhixing Lin, Yi Ju, Md Arifur Rahim, Joseph J Richardson, Frank Caruso

2020-07-21

Polyphenols are naturally occurring compounds that are ubiquitous in plants and display a spectrum of physical, chemical, and biol..

Dissecting the intracellular signalling and fate of a DNA nanosensor by super-resolution and quantitative microscopy.

Agata Glab, Alessandro Bertucci, Fabiana Martino, Marcin Wojnilowicz, Alessia Amodio, Mariano Venanzi, Francesco Ricci, Giancarlo Forte, Frank Caruso, Francesca Cavalieri

2020-07-13

DNA nanodevices have been developed as platforms for the manipulation of gene expression, delivery of molecular payloads, and dete..

Nanoengineering multifunctional hybrid interfaces using adhesive glycogen nanoparticles.

Pietro Pacchin Tomanin, Jiajing Zhou, Alessia Amodio, Rita Cimino, Agata Glab, Francesca Cavalieri, Frank Caruso

2020-06-14

Multifunctional and biodegradable nanostructured hybrid interfaces based on biopolymers are potentially useful in many application..

Understanding the Uptake of Nanomedicines at Different Stages of Brain Cancer Using a Modular Nanocarrier Platform and Precision Bispecific Antibodies

Zachary H Houston, Jens Bunt, Kok-Siong Chen, Simon Puttick, Christopher B Howard, Nicholas L Fletcher, Adrian V Fuchs, Jiwei Cui, Yi Ju, Gary Cowin, Xin Song, Andrew W Boyd, Stephen M Mahler, Linda J Richards, Frank Caruso, Kristofer J Thurecht

2020-05-27

Increasing accumulation and retention of nanomedicines within tumor tissue is a significant challenge, particularly in the case of..

Self-assembling influenza nanoparticle vaccines drive extended germinal center activity and memory B cell maturation.

Hannah G Kelly, Hyon-Xhi Tan, Jennifer A Juno, Robyn Esterbauer, Yi Ju, Wenbo Jiang, Verena C Wimmer, Brigette C Duckworth, Joanna R Groom, Frank Caruso, Masaru Kanekiyo, Stephen J Kent, Adam K Wheatley

2020-05-21

Protein-based, self-assembling nanoparticles elicit superior immunity compared with soluble protein vaccines, but the immune mecha..

Surface Modification of Spider Silk Particles to Direct Biomolecular Corona Formation.

Alessia CG Weiss, Heike M Herold, Sarah Lentz, Matthew Faria, Quinn A Besford, Ching-Seng Ang, Frank Caruso, Thomas Scheibel

2020-05-20

In recent years, spider silk-based materials have attracted attention because of their biocompatibility, processability, and biode..

Modulating the Selectivity and Stealth Properties of Ellipsoidal Polymersomes through a Multivalent Peptide Ligand Display

Kristel C Tjandra, Chelsea R Forest, Chin Ken Wong, Sheilajen Alcantara, Hannah G Kelly, Yi Ju, Martina H Stenzel, Joshua A McCarroll, Maria Kavallaris, Frank Caruso, Stephen J Kent, Pall Thordarson

2020-05-19

There is a need for improved nanomaterials to simultaneously target cancer cells and avoid non‐specific clearance by phagocytes. A..

Glycogen as a Building Block for Advanced Biological Materials

Quinn A Besford, Francesca Cavalieri, Frank Caruso

2020-05-07

Biological nanoparticles found in living systems possess distinct molecular architectures and diverse functions. Glycogen is a uni..

Particle-mediated delivery of frataxin plasmid to a human sensory neuronal model of Friedreich's ataxia.

Ewa Czuba-Wojnilowicz, Serena Viventi, Sara E Howden, Simon Maksour, Amy E Hulme, Christina Cortez-Jugo, Mirella Dottori, Frank Caruso

2020-05-07

Increasing frataxin protein levels through gene therapy is envisaged to improve therapeutic outcomes for patients with Friedreich'..

Engineering of Nebulized Metal-Phenolic Capsules for Controlled Pulmonary Deposition

Yi Ju, Christina Cortez-Jugo, Jingqu Chen, Ting-Yi Wang, Andrew J Mitchell, Evelyn Tsantikos, Nadja Bertleff-Zieschang, Yu-Wei Lin, Jiaying Song, Yizhe Cheng, Srinivas Mettu, Md Arifur Rahim, Shuaijun Pan, Gyeongwon Yun, Margaret L Hibbs, Leslie Y Yeo, Christoph E Hagemeyer, Frank Caruso

2020-03-18

Particle-based pulmonary delivery has great potential for delivering inhalable therapeutics for local or systemic applications. Th..

Nanomedicine toward 2040.

Joseph J Richardson, Frank Caruso

2020-03-11

Nanomedicine as a research field has existed for about two decades, and it is therefore timely to discuss what the next 20 years i..

Cobalt-Directed Assembly of Antibodies onto Metal-Phenolic Networks for Enhanced Particle Targeting.

Wenjie Zhang, Quinn A Besford, Andrew J Christofferson, Patrick Charchar, Joseph J Richardson, Aaron Elbourne, Kristian Kempe, Christoph E Hagemeyer, Matthew R Field, Chris F McConville, Irene Yarovsky, Frank Caruso

2020-03-10

The orientation-specific immobilization of antibodies onto nanoparticles, to preserve antibody-antigen recognition, is a key chall..

Polyphenol-Mediated Assembly of Proteins for Engineering Functional Materials

Yiyuan Han, Zhixing Lin, Jiajing Zhou, Gyeongwon Yun, Rui Guo, Joseph J Richardson, Frank Caruso

2020-03-01

Functional materials composed of proteins have attracted much interest owing to the inherent and diverse functionality of proteins..

Ordered Mesoporous Metal-Phenolic Network Particles.

Zhixing Lin, Jiajing Zhou, Christina Cortez-Jugo, Yiyuan Han, Yutian Ma, Shuaijun Pan, Eric Hanssen, Joseph J Richardson, Frank Caruso

2020-01-08

Mesoporous metal-organic networks have attracted widespread interest owing to their potential applications in diverse fields inclu..

Self-Assembly of a Metal-Phenolic Sorbent for Broad-Spectrum Metal Sequestration

Md Arifur Rahim, Gan Lin, Pietro Pacchin Tomanin, Yi Ju, Anders Barlow, Mattias Bjornmalm, Frank Caruso

2020-01-08

Metal contamination of water bodies from industrial effluents presents a global threat to the aquatic ecosystem. To address this c..

The Biomolecular Corona in 2D and Reverse: Patterning Metal–Phenolic Networks on Proteins, Lipids, Nucleic Acids, Polysaccharides, and Fingerprints

G Yun, JJ Richardson, M Capelli, Y Hu, QA Besford, ACG Weiss, H Lee, IS Choi, BC Gibson, P Reineck, F Caruso

2020-01-03

The adsorption of biomolecules onto nanomaterials can alter the performance of the nanomaterials in vitro and in vivo. Recent stud..

Modular Assembly of Host-Guest Metal-Phenolic Networks Using Macrocyclic Building Blocks

Shuaijun Pan, Rui Guo, Nadja Bertleff-Zieschang, Shanshan Li, Quinn A Besford, Qi-Zhi Zhong, Gyeongwon Yun, Yunti Zhang, Francesca Cavalieri, Yi Ju, Eirini Goudeli, Joseph J Richardson, Frank Caruso

2020-01-02

The manipulation of interfacial properties has broad implications for the development of high‐performance coatings. Metal–phenolic..

A radiolabeled drug tracing method to study neurotrophin-3 retention and distribution in the cochlea after nano-based local delivery

Patrick Lam, Niliksha Gunewardene, Yutian Ma, Frank Caruso, Nguyen Trung, Brianna Flynn, Andrew K Wise, Rachael T Richardson

2020-01-01

Hearing loss is the most common sensory deficit worldwide with no approved therapeutics for treatment. Local neurotrophin delivery..

Expanding the Toolbox of Metal-Phenolic Networks via Enzyme-Mediated Assembly

Qi-Zhi Zhong, Joseph J Richardson, Shiyao Li, Wenjie Zhang, Yi Ju, Jianhua Li, Shuaijun Pan, Jingqu Chen, Frank Caruso

2020-01-01

Functional coatings are of considerable interest because of their fundamental implications for interfacial assembly and promise fo..

Metal-Phenolic Coatings as a Platform to Trigger Endosomal Escape of Nanoparticles.

Jingqu Chen, Jianhua Li, Jiajing Zhou, Zhixing Lin, Francesca Cavalieri, Ewa Czuba-Wojnilowicz, Yingjie Hu, Agata Glab, Yi Ju, Joseph J Richardson, Frank Caruso

2019-10-22

The intracellular delivery of functional nanoparticles (NPs) and the release of therapeutic payloads at a target site are central ..

Ricocheting Droplets Moving on Super-Repellent Surfaces

Shuaijun Pan, Rui Guo, Joseph J Richardson, Joseph D Berry, Quinn A Besford, Mattias Bjornmalm, Gyeongwon Yun, Ruoxi Wu, Zhixing Lin, Qi-Zhi Zhong, Jiajing Zhou, Qiang Sun, Jianhua Li, Yanbing Lu, Zhichao Dong, Margaret Katherine Banks, Weijian Xu, Jianhui Jiang, Lei Jiang, Frank Caruso

2019-09-12

Droplet bouncing on repellent solid surfaces (e.g., the lotus leaf effect) is a common phenomenon that has aroused interest in var..

Engineering Biocoatings To Prolong Drug Release from Supraparticles

Yutian Ma, Christina Cortez-Jugo, Jianhua Li, Zhixing Lin, Rachael T Richardson, Yiyuan Han, Jiajing Zhou, Mattias Bjornmalm, Orlagh M Feeney, Qi-Zhi Zhong, Christopher JH Porter, Andrew K Wise, Frank Caruso

2019-09-09

Supraparticles (SPs) assembled from smaller colloidal nanoparticles can serve as depots of therapeutic compounds and are of intere..

Oxidation-Mediated Kinetic Strategies for Engineering Metal-Phenolic Networks

Qi-Zhi Zhong, Shiyao Li, Jingqu Chen, Ke Xie, Shuaijun Pan, Joseph J Richardson, Frank Caruso

2019-09-02

The tunable growth of metal–organic materials has implications for engineering particles and surfaces for diverse applications. Sp..

Oxidation‐Mediated Kinetic Strategies for Engineering Metal–Phenolic Networks

Qi‐Zhi Zhong, Shiyao Li, Jingqu Chen, Ke Xie, Shuaijun Pan, Joseph J Richardson, Frank Caruso

2019-09-02

Ligand-Functionalized Poly(ethylene glycol) Particles for Tumor Targeting and Intracellular Uptake.

Jiwei Cui, Karen Alt, Yi Ju, Sylvia T Gunawan, Julia A Braunger, Ting-Yi Wang, Yunlu Dai, Qiong Dai, Joseph J Richardson, Junling Guo, Mattias Björnmalm, Christoph E Hagemeyer, Frank Caruso

2019-09-01

Drug carriers typically require both stealth and targeting properties to minimize nonspecific interactions with healthy cells and ..

Revisiting cell-particle association in vitro: A quantitative method to compare particle performance.

Matthew Faria, Ka Fung Noi, Qiong Dai, Mattias Björnmalm, Stuart T Johnston, Kristian Kempe, Frank Caruso, Edmund J Crampin

2019-08-10

Nanoengineering has the potential to revolutionize medicine by designing drug delivery systems that are both efficacious and highl..

Cellular Targeting of Bispecific Antibody-Functionalized Poly(ethylene glycol) Capsules: Do Shape and Size Matter?

Danzi Song, Jiwei Cui, Yi Ju, Matthew Faria, Huanli Sun, Christopher B Howard, Kristofer J Thurecht, Frank Caruso

2019-08-01

In the present study, a capsule system that consists of a stealth carrier based on poly(ethylene glycol) (PEG) and functionalized ..

Stealth and Targeting of Ligand-Functionalized Poly(ethylene glycol) Particles

Yi Ju, Jiwei Cui, Karen Alt, Stephen Kent, Christoph Hagemeyer, Frank Caruso

2019-06-26

Oral presentation at 10th International Nanomedicine Conference

Nebulization of Phenolic Capsules for Pulmonary Delivery

Christina Cortez-Jugo, Yi Ju, Leslie Yeo, Christoph Hagemeyer, Frank Caruso

2019-06-24

Oral presentation at 10th International Conference on Materials for Advanced Technologies

Template-Free Synthesis of Chemically Asymmetric Silica Nanotubes for Selective Cargo Loading and Sustained Drug Release

Chao Deng, Qian Zhang, Cong Fu, Fangzhou Zhou, Wuli Yang, Deliang Yi, Xingdong Wang, Yi Tang, Frank Caruso, Yajun Wang

2019-06-11

SiO2 nanotubes (NTs), with uniform diameter (∼25 nm) and tailored shell thickness (1–5 nm), and featuring chemically asymmetric su..

Unraveling Biointeractions with Nanoengineered Hydrogel Particles

Frank Caruso

2019-06-03

Oral presentation at Summit on Functional Nanocolloids

SupraCells: Living Mammalian Cells Protected within Functional Modular Nanoparticle-Based Exoskeletons

Wei Zhu, Jimin Guo, Shahrouz Amini, Yi Ju, Jacob Ongudi Agola, Andreas Zimpel, Jin Shang, Achraf Noureddine, Frank Caruso, Stefan Wuttke, Jonas G Croissant, C Jeffrey Brinker

2019-06-01

Creating a synthetic exoskeleton from abiotic materials to protect delicate mammalian cells and impart them with new functionaliti..

The Future of Layer-by-Layer Assembly: A Tribute to ACS Nano Associate Editor Helmuth Mohwald

Shuang Zhao, Frank Caruso, Lars Daehne, Gero Decher, Bruno G De Geest, Jinchen Fan, Neus Feliu, Yury Gogotsi, Paula T Hammond, Mark C Hersam, Ali Khademhosseini, Nicholas Kotov, Stefano Leporatti, Yan Li, Fred Lisdat, Luis M Liz-Marzan, Sergio Moya, Paul Mulvaney, Andrey L Rogach, Sathi Roy

2019-06-01

Layer-by-layer (LbL) assembly is a widely used tool for engineering materials and coatings. In this Perspective, dedicated to the ..

Link between Low-Fouling and Stealth: A Whole Blood Biomolecular Corona and Cellular Association Analysis on Nanoengineered Particles

Alessia CG Weiss, Hannah G Kelly, Matthew Faria, Quinn A Besford, Adam K Wheatley, Ching-Seng Ang, Edmund J Crampin, Frank Caruso, Stephen J Kent

2019-05-28

Upon exposure to human blood, nanoengineered particles interact with a multitude of plasma components, resulting in the formation ..

Selective Metal-Phenolic Assembly from Complex Multicomponent Mixtures

Gan Lin, Md Arifur Rahim, Michael G Leeming, Christina Cortez-Jugo, Quinn A Besford, Yi Ju, Qi-Zhi Zhong, Stuart T Johnston, Jiajing Zhou, Frank Caruso

2019-05-15

Selective self-assembly in multicomponent mixtures offers a method for isolating desired components from complex systems for the r..

Modulating Targeting of Poly(ethylene glycol) Particles to Tumor Cells Using Bispecific Antibodies

Jiwei Cui, Yi Ju, Zachary H Houston, Joshua J Class, Nicholas L Fletcher, Sheilajen Alcantara, Qiong Dai, Christopher B Howard, Stephen M Mahler, Adam K Wheatley, Robert De Rose, Paul T Brannon, Brett M Paterson, Paul S Donnelly, Kristoferj Thurecht, Frank Caruso, Stephen J Kent

2019-05-01

Low-fouling or "stealth" particles composed of poly(ethylene glycol) (PEG) display a striking ability to evade phagocytic cell upt..

Bio-Nano Interactions of Metal-Phenolic Networks

Frank Caruso

2019-03-23

Oral presentation at 3rd International Symposium on Translational Nanomedicine

Modular Metal-Organic Polyhedra Superassembly: From Molecular-Level Design to Targeted Drug Delivery

Wei Zhu, Jimin Guo, Yi Ju, Rita E Serda, Jonas G Croissant, Jin Shang, Eric Coker, Jacob Ongudi Agola, Qi-Zhi Zhong, Yuan Ping, Frank Caruso, C Jeffrey Brinker

2019-03-22

Targeted drug delivery remains at the forefront of biomedical research but remains a challenge to date. Herein, the first superass..

Protein Adsorption and Coordination-Based End-Tethering of Functional Polymers on Metal-Phenolic Network Films

Blaise L Tardy, Joseph J Richardson, Vichida Nithipipat, Kristian Kempe, Junling Guo, Kwun Lun Cho, Md Arifur Rahim, Hirotaka Ejima, Frank Caruso

2019-03-01

Metal-phenolic network (MPN) coatings have generated increasing interest owing to their biologically inspired nature, facile fabri..

Tuning the Mechanical Behavior of Metal-Phenolic Networks through Building Block Composition

Gyeongwon Yun, Joseph J Richardson, Matthew Biviano, Frank Caruso

2019-02-13

Metal-phenolic networks (MPNs) are an emerging class of functional metal-organic materials with a high degree of modularity in ter..

Phenolic Building Blocks for the Assembly of Functional Materials

Md Arifur Rahim, Samantha L Kristufek, Shuaijun Pan, Joseph J Richardson, Frank Caruso

2019-02-11

Phenolic materials have long been known for their use in inks, wood coatings, and leather tanning. However, there has recently bee..

Phenolische Bausteine für die Assemblierung von Funktionsmaterialien

Md Arifur Rahim, Samantha L Kristufek, Shuaijun Pan, Joseph J Richardson, Frank Caruso

2019-02-11

Metal-dependent inhibition of amyloid fibril formation: synergistic effects of cobalt-tannic acid networks

Wenjie Zhang, Andrew J Christofferson, Quinn A Besford, Joseph J Richardson, Junling Guo, Yi Ju, Kristian Kempe, Irene Yarovsky, Frank Caruso

2019-01-28

Metal-phenolic networks (MPNs) have received widespread interest owing to their modular incorporation of functional metal ions and..

In Situ Characterization of Protein Corona Formation on Silica Microparticles Using Confocal Laser Scanning Microscopy Combined with Microfluidics

Alessia CG Weiss, Kilian Krueger, Quinn A Besford, Mathias Schlenk, Kristian Kempe, Stephan Foerster, Frank Caruso

2019-01-16

In biological fluids, proteins bind to particles, forming so-called protein coronas. Such adsorbed protein layers significantly in..

Super-resolution Imaging of Proton Sponge-Triggered Rupture of Endosomes and Cytosolic Release of Small Interfering RNA

Marcin Wojnilowicz, Agata Glab, Alessandro Bertucci, Frank Caruso, Francesca Cavalieri

2019-01-01

The intracellular delivery of nucleic acids and proteins remains a key challenge in the development of biological therapeutics. In..

Cobalt Phosphate Nanostructures for Non-Enzymatic Glucose Sensing at Physiological pH

Pietro Pacchin Tomanin, Pavel V Cherepanov, Quinn A Besford, Andrew J Christofferson, Alessia Amodio, Chris F McConville, Irene Yarovsky, Frank Caruso, Francesca Cavalieri

2018-12-12

Nanostructured materials have potential as platforms for analytical assays and catalytic reactions. Herein, we report the synthesi..

Overcoming the Blood-Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases

Denzil Furtado, Mattias Bjornmalm, Scott Ayton, Ashley I Bush, Kristian Kempe, Frank Caruso

2018-11-15

Therapies directed toward the central nervous system remain difficult to translate into improved clinical outcomes. This is largel..

Spray Assembly of Metal-Phenolic Networks: Formation, Growth, and Applications

Qi-Zhi Zhong, Shuaijun Pan, Md Arifur Rahim, Gyeongwon Yun, Jianhua Li, Yi Ju, Zhixing Lin, Yiyuan Han, Yutian Ma, Joseph J Richardson, Frank Caruso

2018-10-03

Hybrid conformal coatings, such as metal-phenolic networks (MPNs) that are constructed from the coordination-driven assembly of na..

Self-Assembled Metal-Phenolic Networks on Emulsions as Low-Fouling and pH-Responsive Particles

Quinn A Besford, Yi Ju, Ting-Yi Wang, Gyeongwon Yun, PavelV Cherepanov, Christoph E Hagemeyer, Francesca Cavalieri, Frank Caruso

2018-09-27

Interfacial self-assembly is a powerful organizational force for fabricating functional nanomaterials, including nanocarriers, for..

Gel-Mediated Electrospray Assembly of Silica Supraparticles for Sustained Drug Delivery

Yutian Ma, Mattias Bjoernmalm, Andrew K Wise, Christina Cortez-Jugo, Eve Revalor, Yi Ju, Orlagh M Feeney, Rachael T Richardson, Eric Hanssen, Robert K Shepherd, Christopher JH Porter, Frank Caruso

2018-09-19

Supraparticles (SPs) composed of smaller colloidal particles provide a platform for the long-term, controlled release of therapeut..

Nanoengineering of Poly(ethylene glycol) Particles for Stealth and Targeting

Jiwei Cui, Mattias Bjornmalm, Yi Ju, Frank Caruso

2018-09-18

The assembly of particles composed solely or mainly of poly(ethylene glycol) (PEG) is an emerging area that is gaining increasing ..

Glycogen-nucleic acid constructs for gene silencing in multicellular tumor spheroids

Marcin Wojnilowicz, Quinn A Besford, Yun-Long Wu, Xian Jun Loh, Julia A Braunger, Agata Glab, Christina Cortez-Jugo, Frank Caruso, Francesca Cavalieri

2018-09-01

The poor penetration of nanocarrier-siRNA constructs into tumor tissue is a major hurdle for the in vivo efficacy of siRNA therape..

Minimum information reporting in bio-nano experimental literature

Matthew Faria, Mattias Bjornmalm, Kristofer J Thurecht, Stephen J Kent, Robert G Parton, Maria Kavallaris, Angus PR Johnston, J Justin Gooding, Simon R Corrie, Ben J Boyd, Pall Thordarson, Andrew K Whittaker, Molly M Stevens, Clive A Prestidge, Christopher JH Porter, Wolfgang J Parak, Thomas P Davis, Edmund J Crampin, Frank Caruso

2018-09-01

Studying the interactions between nanoengineered materials and biological systems plays a vital role in the development of biologi..

Self-Assembly of Nano- to Macroscopic Metal–Phenolic Materials

G Yun, Quinn Besford, S Johnston, JJ Richardson, Shuaijun Pan, M Biviano, F Caruso

2018-08-28

The self-assembly of molecular building blocks into well-defined macroscopic materials is desirable for developing emergent functi..

Low-Fouling and Biodegradable Protein-Based Particles for Thrombus Imaging

Thomas Bonnard, Anand Jayapadman, Jasmine A Putri, Jiwei Cui, Yi Ju, Catherine Carmichael, Thomas A Angelovich, Stephen H Cody, Shauna French, Karline Pascaud, Hannah A Pearce, Shweta Jagdale, Frank Caruso, Christoph E Hagemeyer

2018-07-01

Nanomedicine holds great promise for vascular disease diagnosis and specific therapy, yet rapid sequestration by the mononuclear p..