ADVANCING NANOMEDICINE THROUGH PARTICLE TECHNOLOGY
Grant number: 1135806 | Funding period: 2018 - 2022
This proposal will support the development of advanced particle systems to improve the delivery of medicines in neurological diseases, HIV, diabetes and cancer. It will provide important insights for particle-based therapeutic delivery that are expected to underpin progress on nanotechnology in the areas of biology and medicine. These developments in nanotechnology-enabled medicines towards commercialisation will ultimately improve the health and quality of life of Australians.
Related publications (80)
Stereoselective Growth of Small Molecule Patches on Nanoparticles
Jiajing Zhou, Matthew N Creyer, Amanda Chen, Wonjun Yim, Rene PM Lafleur, Tengyu He, Zhixing Lin, Ming Xu, Pedram Abbasi, Jianfeng Wu, Tod A Pascal, Frank Caruso, Jesse V Jokerst
Patchy nanoparticles featuring tunable surface domains with spatial and chemical specificity are of fundamental interest, especial..
Robust and Versatile Coatings Engineered via Simultaneous Covalent and Noncovalent Interactions
Jiajing Zhou, Matthew Penna, Zhixing Lin, Yiyuan Han, Rene PM Lafleur, Yijiao Qu, Joseph J Richardson, Irene Yarovsky, Jesse V Jokerst, Frank Caruso
Interfacial modular assembly has emerged as an adaptable strategy for engineering the surface properties of substrates in biomedic..
Quantitatively Tracking Bio-Nano Interactions of Metal-Phenolic Nanocapsules by Mass Cytometry
Shiyao Li, Yi Ju, Jiajing Zhou, Ka Fung Noi, Andrew J Mitchell, Tian Zheng, Stephen J Kent, Christopher JH Porter, Frank Caruso
Polymer nanocapsules, with a hollow structure, are increasingly finding widespread use as drug delivery carriers; however, quantit..
Fluorinated Metal-Organic Coatings with Selective Wettability
Shuaijun Pan, Joseph J Richardson, Andrew J Christofferson, Quinn A Besford, Tian Zheng, Barry J Wood, Xiaofei Duan, Maximiliano Jesus Jara Fornerod, Christopher F McConville, Irene Yarovsky, Stefan Guldin, Lei Jiang, Frank Caruso
Surface chemistry is a major factor that determines the wettability of materials, and devising broadly applicable coating strategi..
A Focus on "Bio" in Bio-Nanoscience: The Impact of Biological Factors on Nanomaterial Interactions
Christina Cortez-Jugo, Ewa Czuba-Wojnilowicz, Abigail Tan, Frank Caruso
Bio-nanoscience research encompasses studies on the interactions of nanomaterials with biological structures or what is commonly r..
NFAT signaling in human mesenchymal stromal cells affects extracellular matrix remodeling and antifungal immune responses
Federico Tidu, Marco De Zuani, Shyam Sushama Jose, Kamila Bendickova, Lukas Kubala, Frank Caruso, Francesca Cavalieri, Giancarlo Forte, Jan Fric
Mesenchymal stromal cells (MSCs) combined with calcineurin-nuclear factor of activated T cell (CN-NFAT) inhibitors are being teste..
Influence of Poly(ethylene glycol) Molecular Architecture on Particle Assembly and Ex Vivo Particle-Immune Cell Interactions in Human Blood
Jiaying Song, Yi Ju, Thakshila H Amarasena, Zhixing Lin, Srinivas Mettu, Jiajing Zhou, Md Arifur Rahim, Ching-Seng Ang, Christina Cortez-Jugo, Stephen J Kent, Frank Caruso
Poly(ethylene glycol) (PEG) is widely used in particle assembly to impart biocompatibility and stealth-like properties in vivo for..
Exploiting Supramolecular Dynamics in Metal-Phenolic Networks to Generate Metal-Oxide and Metal-Carbon Networks
Shuaijun Pan, Eirini Goudeli, Jingqu Chen, Zhixing Lin, Qi-Zhi Zhong, Wenjie Zhang, Haitao Yu, Rui Guo, Joseph J Richardson, Frank Caruso
Supramolecular complexation is a powerful strategy for engineering materials in bulk and at interfaces. Metal-phenolic networks (M..
In Vivo T Cell-Targeting Nanoparticle Drug Delivery Systems: Considerations for Rational Design
Paula M Cevaal, Abdalla Ali, Ewa Czuba-Wojnilowicz, Jori Symons, Sharon R Lewin, Christina Cortez-Jugo, Frank Caruso
T cells play an important role in immunity and repair and are implicated in diseases, including blood cancers, viral infections, a..
X-ray-Based Techniques to Study the Nano-Bio Interface
Carlos Sanchez-Cano, Ramon A Alvarez-Puebla, John M Abendroth, Tobias Beck, Robert Blick, Yuan Cao, Frank Caruso, Indranath Chakraborty, Henry N Chapman, Chunying Chen, Bruce E Cohen, Andre LC Conceição, David P Cormode, Daxiang Cui, Kenneth A Dawson, Gerald Falkenberg, Chunhai Fan, Neus Feliu, Mingyuan Gao, Elisabetta Gargioni
X-ray-based analytics are routinely applied in many fields, including physics, chemistry, materials science, and engineering. The ..
Programmable Phototaxis of Metal-Phenolic Particle Microswimmers
Gan Lin, Joseph J Richardson, Heba Ahmed, Quinn A Besford, Andrew J Christofferson, Sebastian Beyer, Zhixing Lin, Amgad R Rezk, Marco Savioli, Jiajing Zhou, Chris F McConville, Christina Cortez-Jugo, Leslie Y Yeo, Frank Caruso
Light-driven directional motion is common in nature but remains a challenge for synthetic microparticles, particularly regarding c..
Microemulsion-Assisted Templating of Metal-Stabilized Poly(ethylene glycol) Nanoparticles
Gan Lin, Christina Cortez-Jugo, Yi Ju, Quinn A Besford, Timothy M Ryan, Shuaijun Pan, Joseph J Richardson, Frank Caruso
Poly(ethylene glycol) (PEG) is well known to endow nanoparticles (NPs) with low-fouling and stealth-like properties that can reduc..
Metal–Phenolic Networks as Tunable Buffering Systems
Jingqu Chen, Shuaijun Pan, Jiajing Zhou, Robert Seidel, Sebastian Beyer, Zhixing Lin, Joseph J Richardson, Frank Caruso
The buffering effects displayed by pH‐responsive polymers have recently gained attention in diverse fields such as nanomedicine an..
Catalytically Active Copper Phosphate-Dextran Sulfate Microparticle Coatings for Bioanalyte Sensing
Pietro Pacchin Tomanin, Sukhvir Kaur Bhangu, Frank Caruso, Francesca Cavalieri
Engineering reactive and functional nanostructured surfaces is important for enhancing the sensitivity and versatility of biosenso..
Engineered Coatings via the Assembly of Amino-Quinone Networks
Qi-Zhi Zhong, Joseph J Richardson, Ai He, Tian Zheng, Rene PM Lafleur, Jianhua Li, Wen-Ze Qiu, Denzil Furtado, Shuaijun Pan, Zhi-Kang Xu, Ling-Shu Wan, Frank Caruso
Engineering coatings with precise physicochemical properties allows for control over the interface of a material and its interacti..
Person-Specific Biomolecular Coronas Modulate Nanoparticle Interactions with Immune Cells in Human Blood
Yi Ju, Hannah G Kelly, Laura F Dagley, Arnold Reynaldi, Timothy E Schlub, Sukhdeep K Spall, Craig A Bell, Jiwei Cui, Andrew J Mitchell, Zhixing Lin, Adam K Wheatley, Kristofer J Thurecht, Miles P Davenport, Andrew Webb, Frank Caruso, Stephen J Kent
When nanoparticles interact with human blood, a multitude of plasma components adsorb onto the surface of the nanoparticles, formi..
Polyphenol-Based Nanoparticles for Intracellular Protein Delivery via Competing Supramolecular Interactions
Yiyuan Han, Jiajing Zhou, Yingjie Hu, Zhixing Lin, Yutian Ma, Joseph J Richardson, Frank Caruso
Intracellular delivery of proteins is a promising strategy for regulating cellular behavior and therefore has attracted interest f..
Particle engineering enabled by polyphenol-mediated supramolecular networks.
Jiajing Zhou, Zhixing Lin, Matthew Penna, Shuaijun Pan, Yi Ju, Shiyao Li, Yiyuan Han, Jingqu Chen, Gan Lin, Joseph J Richardson, Irene Yarovsky, Frank Caruso
We report a facile strategy for engineering diverse particles based on the supramolecular assembly of natural polyphenols and a se..
Dynamic Electrophoretic Assembly of Metal–Phenolic Films: Accelerated Formation and Cytocompatible Detachment
Gyeongwon Yun, Wongu Youn, Hojae Lee, Sang Yeong Han, Mariana B Oliveira, Hyeoncheol Cho, Frank Caruso, João F Mano, Insung S Choi
Material-independent coating has emerged as an advanced tool for interface engineering in numerous applications, including drug de..
Protein Component of Oyster Glycogen Nanoparticles: An Anchor Point for Functionalization
Quinn A Besford, Alessia CG Weiss, Jonas Schubert, Timothy M Ryan, Manfred F Maitz, Pietro Pacchin Tomanin, Marco Savioli, Carsten Werner, Andreas Fery, Frank Caruso, Francesca Cavalieri
Biosourced nanoparticles have a range of desirable properties for therapeutic applications, including biodegradability and low imm..
Programmable Permeability of Metal–Phenolic Network Microcapsules
Jingqu Chen, Shuaijun Pan, Jiajing Zhou, Qi-Zhi Zhong, Yijiao Qu, Joseph J Richardson, Frank Caruso
Developing materials with programmable permeability for cargo encapsulation and release is challenging but important in a number o..
Template-Mediated Assembly of DNA into Microcapsules for Immunological Modulation
Yijiao Qu, Yi Ju, Christina Cortez-Jugo, Zhixing Lin, Shiyao Li, Jiajing Zhou, Yutian Ma, Agata Glab, Stephen J Kent, Francesca Cavalieri, Frank Caruso
There is a need for effective vaccine delivery systems and vaccine adjuvants without extraneous excipients that can compromise or ..
Distribution of Particles in Human Stem Cell-Derived 3D Neuronal Cell Models: Effect of Particle Size, Charge, and Density
Ewa Czuba-Wojnilowicz, Sara Miellet, Agata Glab, Serena Viventi, Francesca Cavalieri, Christina Cortez-Jugo, Mirella Dottori, Frank Caruso
Neurodegenerative diseases are generally characterized by a progressive loss of neuronal subpopulations, with no available cure to..
Dissecting the intracellular signalling and fate of a DNA nanosensor by super-resolution and quantitative microscopy.
Agata Glab, Alessandro Bertucci, Fabiana Martino, Marcin Wojnilowicz, Alessia Amodio, Mariano Venanzi, Francesco Ricci, Giancarlo Forte, Frank Caruso, Francesca Cavalieri
DNA nanodevices have been developed as platforms for the manipulation of gene expression, delivery of molecular payloads, and dete..
Nanoengineering multifunctional hybrid interfaces using adhesive glycogen nanoparticles.
Pietro Pacchin Tomanin, Jiajing Zhou, Alessia Amodio, Rita Cimino, Agata Glab, Francesca Cavalieri, Frank Caruso
Multifunctional and biodegradable nanostructured hybrid interfaces based on biopolymers are potentially useful in many application..
Understanding the Uptake of Nanomedicines at Different Stages of Brain Cancer Using a Modular Nanocarrier Platform and Precision Bispecific Antibodies
Zachary H Houston, Jens Bunt, Kok-Siong Chen, Simon Puttick, Christopher B Howard, Nicholas L Fletcher, Adrian V Fuchs, Jiwei Cui, Yi Ju, Gary Cowin, Xin Song, Andrew W Boyd, Stephen M Mahler, Linda J Richards, Frank Caruso, Kristofer J Thurecht
Increasing accumulation and retention of nanomedicines within tumor tissue is a significant challenge, particularly in the case of..
Self-assembling influenza nanoparticle vaccines drive extended germinal center activity and memory B cell maturation.
Hannah G Kelly, Hyon-Xhi Tan, Jennifer A Juno, Robyn Esterbauer, Yi Ju, Wenbo Jiang, Verena C Wimmer, Brigette C Duckworth, Joanna R Groom, Frank Caruso, Masaru Kanekiyo, Stephen J Kent, Adam K Wheatley
Protein-based, self-assembling nanoparticles elicit superior immunity compared with soluble protein vaccines, but the immune mecha..
Surface Modification of Spider Silk Particles to Direct Biomolecular Corona Formation.
Alessia CG Weiss, Heike M Herold, Sarah Lentz, Matthew Faria, Quinn A Besford, Ching-Seng Ang, Frank Caruso, Thomas Scheibel
In recent years, spider silk-based materials have attracted attention because of their biocompatibility, processability, and biode..
Modulating the Selectivity and Stealth Properties of Ellipsoidal Polymersomes through a Multivalent Peptide Ligand Display
Kristel C Tjandra, Chelsea R Forest, Chin Ken Wong, Sheilajen Alcantara, Hannah G Kelly, Yi Ju, Martina H Stenzel, Joshua A McCarroll, Maria Kavallaris, Frank Caruso, Stephen J Kent, Pall Thordarson
There is a need for improved nanomaterials to simultaneously target cancer cells and avoid non‐specific clearance by phagocytes. A..
Particle-mediated delivery of frataxin plasmid to a human sensory neuronal model of Friedreich's ataxia.
Ewa Czuba-Wojnilowicz, Serena Viventi, Sara E Howden, Simon Maksour, Amy E Hulme, Christina Cortez-Jugo, Mirella Dottori, Frank Caruso
Increasing frataxin protein levels through gene therapy is envisaged to improve therapeutic outcomes for patients with Friedreich'..
Engineering of Nebulized Metal-Phenolic Capsules for Controlled Pulmonary Deposition
Yi Ju, Christina Cortez-Jugo, Jingqu Chen, Ting-Yi Wang, Andrew J Mitchell, Evelyn Tsantikos, Nadja Bertleff-Zieschang, Yu-Wei Lin, Jiaying Song, Yizhe Cheng, Srinivas Mettu, Md Arifur Rahim, Shuaijun Pan, Gyeongwon Yun, Margaret L Hibbs, Leslie Y Yeo, Christoph E Hagemeyer, Frank Caruso
Particle-based pulmonary delivery has great potential for delivering inhalable therapeutics for local or systemic applications. Th..
Cobalt-Directed Assembly of Antibodies onto Metal-Phenolic Networks for Enhanced Particle Targeting.
Wenjie Zhang, Quinn A Besford, Andrew J Christofferson, Patrick Charchar, Joseph J Richardson, Aaron Elbourne, Kristian Kempe, Christoph E Hagemeyer, Matthew R Field, Chris F McConville, Irene Yarovsky, Frank Caruso
The orientation-specific immobilization of antibodies onto nanoparticles, to preserve antibody-antigen recognition, is a key chall..
Polyphenol-Mediated Assembly of Proteins for Engineering Functional Materials
Yiyuan Han, Zhixing Lin, Jiajing Zhou, Gyeongwon Yun, Rui Guo, Joseph J Richardson, Frank Caruso
Functional materials composed of proteins have attracted much interest owing to the inherent and diverse functionality of proteins..
Ordered Mesoporous Metal-Phenolic Network Particles.
Zhixing Lin, Jiajing Zhou, Christina Cortez-Jugo, Yiyuan Han, Yutian Ma, Shuaijun Pan, Eric Hanssen, Joseph J Richardson, Frank Caruso
Mesoporous metal-organic networks have attracted widespread interest owing to their potential applications in diverse fields inclu..
Self-Assembly of a Metal-Phenolic Sorbent for Broad-Spectrum Metal Sequestration
Md Arifur Rahim, Gan Lin, Pietro Pacchin Tomanin, Yi Ju, Anders Barlow, Mattias Bjornmalm, Frank Caruso
Metal contamination of water bodies from industrial effluents presents a global threat to the aquatic ecosystem. To address this c..
The Biomolecular Corona in 2D and Reverse: Patterning Metal–Phenolic Networks on Proteins, Lipids, Nucleic Acids, Polysaccharides, and Fingerprints
G Yun, JJ Richardson, M Capelli, Y Hu, QA Besford, ACG Weiss, H Lee, IS Choi, BC Gibson, P Reineck, F Caruso
The adsorption of biomolecules onto nanomaterials can alter the performance of the nanomaterials in vitro and in vivo. Recent stud..
Modular Assembly of Host-Guest Metal-Phenolic Networks Using Macrocyclic Building Blocks
Shuaijun Pan, Rui Guo, Nadja Bertleff-Zieschang, Shanshan Li, Quinn A Besford, Qi-Zhi Zhong, Gyeongwon Yun, Yunti Zhang, Francesca Cavalieri, Yi Ju, Eirini Goudeli, Joseph J Richardson, Frank Caruso
The manipulation of interfacial properties has broad implications for the development of high‐performance coatings. Metal–phenolic..
A radiolabeled drug tracing method to study neurotrophin-3 retention and distribution in the cochlea after nano-based local delivery
Patrick Lam, Niliksha Gunewardene, Yutian Ma, Frank Caruso, Nguyen Trung, Brianna Flynn, Andrew K Wise, Rachael T Richardson
Hearing loss is the most common sensory deficit worldwide with no approved therapeutics for treatment. Local neurotrophin delivery..
Expanding the Toolbox of Metal-Phenolic Networks via Enzyme-Mediated Assembly
Qi-Zhi Zhong, Joseph J Richardson, Shiyao Li, Wenjie Zhang, Yi Ju, Jianhua Li, Shuaijun Pan, Jingqu Chen, Frank Caruso
Functional coatings are of considerable interest because of their fundamental implications for interfacial assembly and promise fo..
Metal-Phenolic Coatings as a Platform to Trigger Endosomal Escape of Nanoparticles.
Jingqu Chen, Jianhua Li, Jiajing Zhou, Zhixing Lin, Francesca Cavalieri, Ewa Czuba-Wojnilowicz, Yingjie Hu, Agata Glab, Yi Ju, Joseph J Richardson, Frank Caruso
The intracellular delivery of functional nanoparticles (NPs) and the release of therapeutic payloads at a target site are central ..
Ricocheting Droplets Moving on Super-Repellent Surfaces
Shuaijun Pan, Rui Guo, Joseph J Richardson, Joseph D Berry, Quinn A Besford, Mattias Bjornmalm, Gyeongwon Yun, Ruoxi Wu, Zhixing Lin, Qi-Zhi Zhong, Jiajing Zhou, Qiang Sun, Jianhua Li, Yanbing Lu, Zhichao Dong, Margaret Katherine Banks, Weijian Xu, Jianhui Jiang, Lei Jiang, Frank Caruso
Droplet bouncing on repellent solid surfaces (e.g., the lotus leaf effect) is a common phenomenon that has aroused interest in var..
Engineering Biocoatings To Prolong Drug Release from Supraparticles
Yutian Ma, Christina Cortez-Jugo, Jianhua Li, Zhixing Lin, Rachael T Richardson, Yiyuan Han, Jiajing Zhou, Mattias Bjornmalm, Orlagh M Feeney, Qi-Zhi Zhong, Christopher JH Porter, Andrew K Wise, Frank Caruso
Supraparticles (SPs) assembled from smaller colloidal nanoparticles can serve as depots of therapeutic compounds and are of intere..
Oxidation-Mediated Kinetic Strategies for Engineering Metal-Phenolic Networks
Qi-Zhi Zhong, Shiyao Li, Jingqu Chen, Ke Xie, Shuaijun Pan, Joseph J Richardson, Frank Caruso
The tunable growth of metal–organic materials has implications for engineering particles and surfaces for diverse applications. Sp..
Revisiting cell-particle association in vitro: A quantitative method to compare particle performance.
Matthew Faria, Ka Fung Noi, Qiong Dai, Mattias Björnmalm, Stuart T Johnston, Kristian Kempe, Frank Caruso, Edmund J Crampin
Nanoengineering has the potential to revolutionize medicine by designing drug delivery systems that are both efficacious and highl..
Cellular Targeting of Bispecific Antibody-Functionalized Poly(ethylene glycol) Capsules: Do Shape and Size Matter?
Danzi Song, Jiwei Cui, Yi Ju, Matthew Faria, Huanli Sun, Christopher B Howard, Kristofer J Thurecht, Frank Caruso
In the present study, a capsule system that consists of a stealth carrier based on poly(ethylene glycol) (PEG) and functionalized ..
Template-Free Synthesis of Chemically Asymmetric Silica Nanotubes for Selective Cargo Loading and Sustained Drug Release
Chao Deng, Qian Zhang, Cong Fu, Fangzhou Zhou, Wuli Yang, Deliang Yi, Xingdong Wang, Yi Tang, Frank Caruso, Yajun Wang
SiO2 nanotubes (NTs), with uniform diameter (∼25 nm) and tailored shell thickness (1–5 nm), and featuring chemically asymmetric su..
SupraCells: Living Mammalian Cells Protected within Functional Modular Nanoparticle-Based Exoskeletons
Wei Zhu, Jimin Guo, Shahrouz Amini, Yi Ju, Jacob Ongudi Agola, Andreas Zimpel, Jin Shang, Achraf Noureddine, Frank Caruso, Stefan Wuttke, Jonas G Croissant, C Jeffrey Brinker
Creating a synthetic exoskeleton from abiotic materials to protect delicate mammalian cells and impart them with new functionaliti..
The Future of Layer-by-Layer Assembly: A Tribute to ACS Nano Associate Editor Helmuth Mohwald
Shuang Zhao, Frank Caruso, Lars Daehne, Gero Decher, Bruno G De Geest, Jinchen Fan, Neus Feliu, Yury Gogotsi, Paula T Hammond, Mark C Hersam, Ali Khademhosseini, Nicholas Kotov, Stefano Leporatti, Yan Li, Fred Lisdat, Luis M Liz-Marzan, Sergio Moya, Paul Mulvaney, Andrey L Rogach, Sathi Roy
Layer-by-layer (LbL) assembly is a widely used tool for engineering materials and coatings. In this Perspective, dedicated to the ..
Link between Low-Fouling and Stealth: A Whole Blood Biomolecular Corona and Cellular Association Analysis on Nanoengineered Particles
Alessia CG Weiss, Hannah G Kelly, Matthew Faria, Quinn A Besford, Adam K Wheatley, Ching-Seng Ang, Edmund J Crampin, Frank Caruso, Stephen J Kent
Upon exposure to human blood, nanoengineered particles interact with a multitude of plasma components, resulting in the formation ..
Selective Metal-Phenolic Assembly from Complex Multicomponent Mixtures
Gan Lin, Md Arifur Rahim, Michael G Leeming, Christina Cortez-Jugo, Quinn A Besford, Yi Ju, Qi-Zhi Zhong, Stuart T Johnston, Jiajing Zhou, Frank Caruso
Selective self-assembly in multicomponent mixtures offers a method for isolating desired components from complex systems for the r..
Modulating Targeting of Poly(ethylene glycol) Particles to Tumor Cells Using Bispecific Antibodies
Jiwei Cui, Yi Ju, Zachary H Houston, Joshua J Class, Nicholas L Fletcher, Sheilajen Alcantara, Qiong Dai, Christopher B Howard, Stephen M Mahler, Adam K Wheatley, Robert De Rose, Paul T Brannon, Brett M Paterson, Paul S Donnelly, Kristoferj Thurecht, Frank Caruso, Stephen J Kent
Low-fouling or "stealth" particles composed of poly(ethylene glycol) (PEG) display a striking ability to evade phagocytic cell upt..
Modular Metal-Organic Polyhedra Superassembly: From Molecular-Level Design to Targeted Drug Delivery
Wei Zhu, Jimin Guo, Yi Ju, Rita E Serda, Jonas G Croissant, Jin Shang, Eric Coker, Jacob Ongudi Agola, Qi-Zhi Zhong, Yuan Ping, Frank Caruso, C Jeffrey Brinker
Targeted drug delivery remains at the forefront of biomedical research but remains a challenge to date. Herein, the first superass..
Protein Adsorption and Coordination-Based End-Tethering of Functional Polymers on Metal-Phenolic Network Films
Blaise L Tardy, Joseph J Richardson, Vichida Nithipipat, Kristian Kempe, Junling Guo, Kwun Lun Cho, Md Arifur Rahim, Hirotaka Ejima, Frank Caruso
Metal-phenolic network (MPN) coatings have generated increasing interest owing to their biologically inspired nature, facile fabri..
Tuning the Mechanical Behavior of Metal-Phenolic Networks through Building Block Composition
Gyeongwon Yun, Joseph J Richardson, Matthew Biviano, Frank Caruso
Metal-phenolic networks (MPNs) are an emerging class of functional metal-organic materials with a high degree of modularity in ter..
Metal-dependent inhibition of amyloid fibril formation: synergistic effects of cobalt-tannic acid networks
Wenjie Zhang, Andrew J Christofferson, Quinn A Besford, Joseph J Richardson, Junling Guo, Yi Ju, Kristian Kempe, Irene Yarovsky, Frank Caruso
Metal-phenolic networks (MPNs) have received widespread interest owing to their modular incorporation of functional metal ions and..
In Situ Characterization of Protein Corona Formation on Silica Microparticles Using Confocal Laser Scanning Microscopy Combined with Microfluidics
Alessia CG Weiss, Kilian Krueger, Quinn A Besford, Mathias Schlenk, Kristian Kempe, Stephan Foerster, Frank Caruso
In biological fluids, proteins bind to particles, forming so-called protein coronas. Such adsorbed protein layers significantly in..
Ligand-Functionalized Poly(ethylene glycol) Particles for Tumor Targeting and Intracellular Uptake.
Jiwei Cui, Karen Alt, Yi Ju, Sylvia T Gunawan, Julia A Braunger, Ting-Yi Wang, Yunlu Dai, Qiong Dai, Joseph J Richardson, Junling Guo, Mattias Björnmalm, Christoph E Hagemeyer, Frank Caruso
Drug carriers typically require both stealth and targeting properties to minimize nonspecific interactions with healthy cells and ..
Super-resolution Imaging of Proton Sponge-Triggered Rupture of Endosomes and Cytosolic Release of Small Interfering RNA
Marcin Wojnilowicz, Agata Glab, Alessandro Bertucci, Frank Caruso, Francesca Cavalieri
The intracellular delivery of nucleic acids and proteins remains a key challenge in the development of biological therapeutics. In..
Cobalt Phosphate Nanostructures for Non-Enzymatic Glucose Sensing at Physiological pH
Pietro Pacchin Tomanin, Pavel V Cherepanov, Quinn A Besford, Andrew J Christofferson, Alessia Amodio, Chris F McConville, Irene Yarovsky, Frank Caruso, Francesca Cavalieri
Nanostructured materials have potential as platforms for analytical assays and catalytic reactions. Herein, we report the synthesi..
Overcoming the Blood-Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases
Denzil Furtado, Mattias Bjornmalm, Scott Ayton, Ashley I Bush, Kristian Kempe, Frank Caruso
Therapies directed toward the central nervous system remain difficult to translate into improved clinical outcomes. This is largel..
Spray Assembly of Metal-Phenolic Networks: Formation, Growth, and Applications
Qi-Zhi Zhong, Shuaijun Pan, Md Arifur Rahim, Gyeongwon Yun, Jianhua Li, Yi Ju, Zhixing Lin, Yiyuan Han, Yutian Ma, Joseph J Richardson, Frank Caruso
Hybrid conformal coatings, such as metal-phenolic networks (MPNs) that are constructed from the coordination-driven assembly of na..
Self-Assembled Metal-Phenolic Networks on Emulsions as Low-Fouling and pH-Responsive Particles
Quinn A Besford, Yi Ju, Ting-Yi Wang, Gyeongwon Yun, PavelV Cherepanov, Christoph E Hagemeyer, Francesca Cavalieri, Frank Caruso
Interfacial self-assembly is a powerful organizational force for fabricating functional nanomaterials, including nanocarriers, for..
Gel-Mediated Electrospray Assembly of Silica Supraparticles for Sustained Drug Delivery
Yutian Ma, Mattias Bjoernmalm, Andrew K Wise, Christina Cortez-Jugo, Eve Revalor, Yi Ju, Orlagh M Feeney, Rachael T Richardson, Eric Hanssen, Robert K Shepherd, Christopher JH Porter, Frank Caruso
Supraparticles (SPs) composed of smaller colloidal particles provide a platform for the long-term, controlled release of therapeut..
Glycogen-nucleic acid constructs for gene silencing in multicellular tumor spheroids
Marcin Wojnilowicz, Quinn A Besford, Yun-Long Wu, Xian Jun Loh, Julia A Braunger, Agata Glab, Christina Cortez-Jugo, Frank Caruso, Francesca Cavalieri
The poor penetration of nanocarrier-siRNA constructs into tumor tissue is a major hurdle for the in vivo efficacy of siRNA therape..
Minimum information reporting in bio-nano experimental literature
Matthew Faria, Mattias Bjornmalm, Kristofer J Thurecht, Stephen J Kent, Robert G Parton, Maria Kavallaris, Angus PR Johnston, J Justin Gooding, Simon R Corrie, Ben J Boyd, Pall Thordarson, Andrew K Whittaker, Molly M Stevens, Clive A Prestidge, Christopher JH Porter, Wolfgang J Parak, Thomas P Davis, Edmund J Crampin, Frank Caruso
Studying the interactions between nanoengineered materials and biological systems plays a vital role in the development of biologi..
Low-Fouling and Biodegradable Protein-Based Particles for Thrombus Imaging
Thomas Bonnard, Anand Jayapadman, Jasmine A Putri, Jiwei Cui, Yi Ju, Catherine Carmichael, Thomas A Angelovich, Stephen H Cody, Shauna French, Karline Pascaud, Hannah A Pearce, Shweta Jagdale, Frank Caruso, Christoph E Hagemeyer
Nanomedicine holds great promise for vascular disease diagnosis and specific therapy, yet rapid sequestration by the mononuclear p..