CAN WE PREDICT PSYCHOSIS AND CAN IT BE PREVENTED?
Grant number: 1137687 | Funding period: 2018 - 2023
It remains unclear what the causes of schizophrenia and other psychotic disorders are and what the most effective interventions are for preventing onset of disorder in those at risk. The current research program consists of a number of interrelated studies of how psychosis develops, the most effective sequential treatments to prevent the onset of disorder in high risk young people, and testing clinical criteria to identify young people at risk of a range of serious mental illnesses.
Related publications (50)
Impact of adverse childhood experiences on educational achievements in young people at clinical high risk of developing psychosis
Stefania Tognin, Ana Catalan, Matthew J Kempton, Barnaby Nelson, Patrick McGorry, Anita Riecher-Rossler, Rodrigo Bressan, Neus Barrantes-Vidal, Marie-Odile Krebs, Merete Nordentoft, Stephan Ruhrmann, Gabriele Sachs, Bart PF Rutten, Jim van Os, Lieuwe de Haan, Mark van der Gaag, Philip R McGuire, Lucia Valmaggia
BACKGROUND: Adverse childhood experiences (ACE) can affect educational attainments, but little is known about their impact on educ..
Phenomenology as a resource for translational research in mental health: methodological trends, challenges and new directions.
R Ritunnano, D Papola, MR Broome, B Nelson
This editorial reflects on current methodological trends in translational research in mental health. It aims to build a bridge bet..
A systematic review and meta-analysis of global and social functioning among people at risk of bipolar disorder.
M Watson, K Filia, A Stevens, S Cotton, B Nelson, A Ratheesh
BACKGROUND: Functional status could predict development of bipolar disorder (BD) or have clinical significance. The relationship b..
A seven-year longitudinal study of the association between neurocognitive function and basic self-disorders in schizophrenia
E Haug, MG Øie, IH Svendsen, P Møller, B Nelson, I Melle
Introduction: Basic self-disorders (SDs) and neurocognitive impairments are fundamental trait-like aspects of schizophrenia spectr..
Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis
Helen Baldwin, Joaquim Radua, Mathilde Antoniades, Shalaila S Haas, Sophia Frangou, Ingrid Agartz, Paul Allen, Ole A Andreassen, Kimberley Atkinson, Peter Bachman, Inmaculada Baeza, Cali F Bartholomeusz, Michael WL Chee, Tiziano Colibazzi, Rebecca E Cooper, Cheryl M Corcoran, Vanessa L Cropley, Bjorn H Ebdrup, Adriana Fortea, Louise Birkedal Glenthoj
Individuals at Clinical High Risk for Psychosis (CHR-P) demonstrate heterogeneity in clinical profiles and outcome features. Howev..
Has improved treatment contributed to the declining rate of transition to psychosis in ultra-high-risk cohorts?
MJC Formica, LJ Phillips, JA Hartmann, AR Yung, SJ Wood, A Lin, GP Amminger, PD McGorry, B Nelson
BACKGROUND: The factors contributing to declining psychotic disorder transition rates in ultra-high-risk populations remain unclea..
Pineal morphology of the clinical high-risk state for psychosis and different psychotic disorders
Tsutomu Takahashi, Stephen J Wood, Alison R Yung, Barnaby Nelson, Ashleigh Lin, Hok Pan Yuen, Lisa J Phillips, Michio Suzuki, Patrick D McGorry, Dennis Velakoulis, Christos Pantelis
BACKGROUND: Pineal volume reductions have been reported in schizophrenia and clinical high-risk states for the development of psyc..
Machine learning based prediction and the influence of complement - Coagulation pathway proteins on clinical outcome: Results from the NEURAPRO trial
Subash Raj Susai, David Mongan, Colm Healy, Mary Cannon, Gerard Cagney, Kieran Wynne, Jonah F Byrne, Connie Markulev, Miriam R Schafer, Maximus Berger, Nilufar Mossaheb, Monika Schlogelhofer, Stefan Smesny, Ian B Hickie, Gregor E Berger, Eric YH Chen, Lieuwe de Haan, Dorien H Nieman, Merete Nordentoft, Anita Riecher-Rossler
BACKGROUND: Functional outcomes are important measures in the overall clinical course of psychosis and individuals at clinical hig..
Characterizing Use of a Multicomponent Digital Intervention to Predict Treatment Outcomes in First-Episode Psychosis: Cluster Analysis.
Shaunagh O'Sullivan, Lianne Schmaal, Simon D'Alfonso, Yara Jo Toenders, Lee Valentine, Carla McEnery, Sarah Bendall, Barnaby Nelson, John F Gleeson, Mario Alvarez-Jimenez
BACKGROUND: Multicomponent digital interventions offer the potential for tailored and flexible interventions that aim to address h..
Young migrants to Australia identified as being at ultra-high risk for psychosis: Pathways to care and clinical characteristics
Brian O'Donoghue, Andrea Polari, Patrick McGorry, Barnaby Nelson
INTRODUCTION: Despite the established finding that migrants are at higher risk of developing a first-episode psychosis, they are u..
Differential trajectories of tobacco smoking in people at ultra-high risk for psychosis: Associations with clinical outcomes.
Frederike Schirmbeck, Els van der Ven, Lindy-Lou Boyette, Philip McGuire, Lucia R Valmaggia, Matthew J Kempton, Mark van der Gaag, Anita Riecher-Rössler, Neus Barrantes-Vidal, Barnaby Nelson, Marie-Odile Krebs, Stephan Ruhrmann, Gabriele Sachs, Bart PF Rutten, Merete Nordentoft, null EU-GEI High Risk Study Group, Lieuwe de Haan, Jentien M Vermeulen
OBJECTIVE: People at ultra-high risk (UHR) for psychosis have a high prevalence of tobacco smoking, and rates are even higher amon..
Identifying Electroencephalography Biomarkers in Individuals at Clinical High Risk for Psychosis in an International Multi-Site Study.
Sarah Kerins, Judith Nottage, Gonzalo Salazar de Pablo, Matthew J Kempton, Stefania Tognin, Dorien H Niemann, Lieuwe de Haan, Thérèse van Amelsvoort, Jun Soo Kwon, Barnaby Nelson, Romina Mizrahi, Philip McGuire, Paolo Fusar-Poli, null PSYSCAN Consortium
BACKGROUND: The clinical high-risk for psychosis (CHR-P) paradigm was introduced to detect individuals at risk of developing psych..
The Relationship Between Grey Matter Volume and Clinical and Functional Outcomes in People at Clinical High Risk for Psychosis.
Stefania Tognin, Anja Richter, Matthew J Kempton, Gemma Modinos, Mathilde Antoniades, Matilda Azis, Paul Allen, Matthijs G Bossong, Jesus Perez, Christos Pantelis, Barnaby Nelson, Paul Amminger, Anita Riecher-Rössler, Neus Barrantes-Vidal, Marie-Odile Krebs, Birte Glenthøj, Stephan Ruhrmann, Gabriele Sachs, Bart PF Rutten, Lieuwe de Haan
OBJECTIVE: To examine the association between baseline alterations in grey matter volume (GMV) and clinical and functional outcome..
Momentary Manifestations of Negative Symptoms as Predictors of Clinical Outcomes in People at High Risk for Psychosis: Experience Sampling Study
Isabell Paetzold, Karlijn SFM Hermans, Anita Schick, Barnaby Nelson, Eva Velthorst, Frederike Schirmbeck, Jim van Os, Craig Morgan, Mark van der Gaag, Lieuwe de Haan, Lucia Valmaggia, Philip McGuire, Matthew Kempton, Inez Myin-Germeys, Ulrich Reininghaus
BACKGROUND: Negative symptoms occur in individuals at ultrahigh risk (UHR) for psychosis. Although there is evidence that observer..
The association of plasma inflammatory markers with omega-3 fatty acids and their mediating role in psychotic symptoms and functioning: An analysis of the NEURAPRO clinical trial
Subash Raj Susai, David Mongan, Colm Healy, Mary Cannon, Barnaby Nelson, Connie Markulev, Miriam R Schafer, Maximus Berger, Nilufar Mossaheb, Monika Schloegelhofer, Stefan Smesny, Ian B Hickie, Gregor E Berger, Eric YH Chen, Lieuwe de Haan, Dorien H Nieman, Merete Nordentoft, Anita Riecher-Roessler, Swapna Verma, Andrew Thompson
There is increasing evidence that dysregulation of polyunsaturated fatty acids (FAs) mediated membrane function plays a role in th..
Investigation of structural brain correlates of neurological soft signs in individuals at ultra-high risk for psychosis
Ya Wang, Esmee E Braam, Cassandra MJ Wannan, Tamsyn E Van Rheenen, Raymond CK Chan, Barnaby Nelson, Patrick D McGorry, Alison R Yung, Ashleigh Lin, Warrick J Brewer, John Koutsogiannis, Stephen J Wood, Dennis Velakoulis, Christos Pantelis, Vanessa L Cropley
Increased severity of neurological soft signs (NSS) in schizophrenia have been associated with abnormal brain morphology in cerebe..
Toxoplasma gondii, Herpesviridae and long-term risk of transition to first-episode psychosis in an ultra high-risk sample
E Burkhardt, M Berger, RH Yolken, A Lin, HP Yuen, SJ Wood, SM Francey, A Thompson, PD McGorry, B Nelson, AR Yung, GP Amminger
BACKGROUND: Ultra high-risk (UHR) criteria were introduced to identify people at imminent risk of developing psychosis. To improve..
Functional Connectivity in Antipsychotic-Treated and Antipsychotic-Naive Patients With First-Episode Psychosis and Low Risk of Self-harm or Aggression A Secondary Analysis of a Randomized Clinical Trial
Sidhant Chopra, Shona M Francey, Brian O'Donoghue, Kristina Sabaroedin, Aurina Arnatkeviciute, Vanessa Cropley, Barnaby Nelson, Jessica Graham, Lara Baldwin, Steven Tahtalian, Hok Pan Yuen, Kelly Allott, Mario Alvarez-Jimenez, Susy Harrigan, Christos Pantelis, Stephen J Wood, Patrick McGorry, Alex Fornito
IMPORTANCE: Altered functional connectivity (FC) is a common finding in resting-state functional magnetic resonance imaging (rs-fM..
Preventive interventions for individuals at ultra high risk for psychosis: An updated and extended meta-analysis
Cristina Mei, Mark van der Gaag, Barnaby Nelson, Filip Smit, Hok Pan Yuen, Maximus Berger, Marija Krcmar, Paul French, G Paul Amminger, Andreas Bechdolf, Pim Cuijpers, Alison R Yung, Patrick D McGorry
Intervention at the earliest illness stage, in ultra or clinical high-risk individuals, or indicated prevention, currently represe..
Association of Structural Magnetic Resonance Imaging Measures With Psychosis Onset in Individuals at Clinical High Risk for Developing Psychosis An ENIGMA Working Group Mega-analysis
Maria Jalbrzikowski, Rebecca A Hayes, Stephen J Wood, Dorte Nordholm, Juan H Zhou, Paolo Fusar-Poli, Peter J Uhlhaas, Tsutomu Takahashi, Gisela Sugranyes, Yoo Bin Kwak, Daniel H Mathalon, Naoyuki Katagiri, Christine I Hooker, Lukasz Smigielski, Tiziano Colibazzi, Esther Via, Jinsong Tang, Shinsuke Koike, Paul E Rasser, Chantal Michel
IMPORTANCE: The ENIGMA clinical high risk (CHR) for psychosis initiative, the largest pooled neuroimaging sample of individuals at..
Toward a Complex Network of Risks for Psychosis: Combining Trauma, Cognitive Biases, Depression, and Psychotic-like Experiences on a Large Sample of Young Adults
Lukasz Gaweda, Renata Pionke, Jessica Hartmann, Barnaby Nelson, Andrzej Cechnicki, Dorota Frydecka
Although the linkage between traumatic life events and psychotic-like experiences (PLEs) is well established, the knowledge of pot..
Differentiating the effect of antipsychotic medication and illness on brain volume reductions in first-episode psychosis: A Longitudinal, Randomised, Triple-blind, Placebo-controlled MRI Study
Sidhant Chopra, Alex Fornito, Shona M Francey, Brian O'Donoghue, Vanessa Cropley, Barnaby Nelson, Jessica Graham, Lara Baldwin, Steven Tahtalian, Hok Pan Yuen, Kelly Allott, Mario Alvarez-Jimenez, Susy Harrigan, Kristina Sabaroedin, Christos Pantelis, Stephen J Wood, Patrick McGorry
Changes in brain volume are a common finding in Magnetic Resonance Imaging (MRI) studies of people with psychosis and numerous lon..
Cognitive ability and metabolic physical health in first-episode psychosis
Sarah Whitson, Brian O'Donoghue, Robert Hester, Lara Baldwin, Susy Harrigan, Shona Francey, Jessica Graham, Barnaby Nelson, Aswin Ratheesh, Mario Alvarez-Jimenez, Alex Fornito, Christos Pantelis, Hok Pan Yuen, Andrew Thompson, Melissa Kerr, Michael Berk, Stephen J Wood, Patrick McGorry, Kelly Allott
Cognitive impairments are a core feature of first-episode psychosis (FEP), arising before illness onset and antipsychotic exposure..
Intervention strategies for ultra-high risk for psychosis: Progress in delaying the onset and reducing the impact of first-episode psychosis
Patrick D McGorry, Cristina Mei, Jessica Hartmann, Alison R Yung, Barnaby Nelson
Over a quarter of a century ago, the formulation of the "at risk mental state" and operational criteria to prospectively identify ..
Distinguishing schizophrenia spectrum from non-spectrum disorders among young patients with first episode psychosis and at high clinical risk: The role of basic self-disturbance and neurocognition
Jessica Spark, Lukasz Gaweda, Kelly Allott, Jessica A Hartmann, Bradley N Jack, Dan Koren, Suzie Lavoie, Emily Li, Patrick D McGorry, Josef Parnas, Andrea Polari, Louis A Sass, Thomas Whitford, Barnaby Nelson
INTRODUCTION: The distinction between the schizophrenia spectrum and other types of disorders may be clinically relevant in terms ..
Cognitive functioning throughout adulthood and illness stages in individuals with psychotic disorders and their unaffected siblings
Eva Velthorst, Josephine Mollon, Robin M Murray, Lieuwe de Haan, Inez Myin Germeys, David C Glahn, Celso Arango, Els van der Ven, Marta Di Forti, Miguel Bernardo, Sinan Guloksuz, Philippe Delespaul, Gisela Mezquida, Silvia Amoretti, Julio Bobes, Pilar A Saiz, Maria Paz Garcia-Portilla, Jose Luis Santos, Estela Jimenez-Lopez, Julio Sanjuan
Important questions remain about the profile of cognitive impairment in psychotic disorders across adulthood and illness stages. T..
The reality of at risk mental state services: a response to recent criticisms
Alison R Yung, Stephen J Wood, Ashok Malla, Barnaby Nelson, Patrick McGorry, Jai Shah
BACKGROUND: In the 1990s criteria were developed to detect individuals at high and imminent risk of developing a psychotic disorde..
Clinical, cognitive and neuroanatomical associations of serum NMDAR autoantibodies in people at clinical high risk for psychosis
Thomas A Pollak, Matthew J Kempton, Conrad Iyegbe, Angela Vincent, Sarosh R Irani, Ester Coutinho, David A Menassa, Leslie Jacobson, Lieuwe de Haan, Stephan Ruhrmann, Gabriele Sachs, Anita Riecher-Roessler, Marie-Odile Krebs, Paul Amminger, Birte Glenthoj, Neus Barrantes-Vidal, Jim van Os, Bart PF Rutten, Rodrigo A Bressan, Mark van der Gaag
Serum neuronal autoantibodies, such as those to the NMDA receptor (NMDAR), are detectable in a subgroup of patients with psychotic..
Does cortical brain morphology act as a mediator between childhood trauma and transition to psychosis in young individuals at ultra-high risk?
Marta Rapado-Castro, Sarah Whittle, Christos Pantelis, Andrew Thompson, Barnaby Nelson, Eleni P Ganella, Ashleigh Lin, Renate LEP Reniers, Patrick D McGorry, Alison R Yung, Stephen J Wood, Cali F Bartholomeusz
BACKGROUND: Childhood trauma, particularly sexual abuse, has been associated with transition to psychosis in individuals at "ultra..
Emotion Recognition and Adverse Childhood Experiences in Individuals at Clinical High Risk of Psychosis
Stefania Tognin, Ana Catalan, Gemma Modinos, Matthew J Kempton, Amaia Bilbao, Barnaby Nelson, Christos Pantelis, Anita Riecher-Rossler, Rodrigo Bressan, Neus Barrantes-Vidal, Marie-Odile Krebs, Merete Nordentoft, Stephan Ruhrmann, Gabriele Sachs, Bart PF Rutten, Jim van Os, Lieuwe de Haan, Mark van der Gaag, Philip McGuire, Lucia R Valmaggia
OBJECTIVE: To investigate the association between facial affect recognition (FAR) and type of adverse childhood experiences (ACEs)..
Impaired olfactory ability associated with larger left hippocampus and rectus volumes at earliest stages of schizophrenia: A sign of neuroinflammation?
Yuri Masaoka, Dennis Velakoulis, Warrick J Brewer, Vanessa L Cropley, Cali F Bartholomeusz, Alison R Yung, Barnaby Nelson, Dominic Dwyer, Cassandra MJ Wannan, Masahiko Izumizaki, Patrick D McGorry, Stephen J Wood, Christos Pantelis
Impaired olfactory identification has been reported as a first sign of schizophrenia during the earliest stages of illness, includ..
Do schizotypal or borderline personality disorders predict onset of psychotic disorder or persistent attenuated psychotic symptoms in patients at high clinical risk?
H Hadar, H Zhang, LJ Phillips, GP Amminger, GE Berger, EYH Chen, L de Haan, JA Hartmann, IB Hickie, S Lavoie, C Markulev, PD McGorry, N Mossaheb, DH Nieman, M Nordentoft, A Riecher-Rossler, MR Schafer, M Schloegelhofer, S Smesny, A Thompson
Basic self-disturbances are associated with Sense of Coherence in patients with psychotic disorders
Ingrid Hartveit Svendsen, Merete Glenne Oie, Paul Moller, Barnaby Nelson, Ingrid Melle, Elisabeth Haug
BACKGROUND: The Sense of Coherence (SOC) theory gives a possible explanation of how people can experience subjective good health d..
Basic symptoms in young people at ultra-high risk of psychosis: Association with clinical characteristics and outcomes
S Youn, LJ Phillips, GP Amminger, G Berger, EYH Chen, L de Haan, JA Hartmann, IB Hickie, S Lavoie, C Markulev, PD McGorry, N Mossaheb, DH Nieman, M Nordentoft, A Riecher-Rossler, MR Schafer, M Schloegelhofer, S Smesny, A Thompson, S Verma
There has been limited research into the predictive value of basic symptoms and their relationship with other psychopathology in p..
From Speech Illusions to Onset of Psychotic Disorder: Applying Network Analysis to an Experimental Measure of Aberrant Experiences
Lindy-Lou Boyette, Adela-Maria Isvoranu, Frederike Schirmbeck, Eva Velthorst, Claudia JP Simons, Neus Barrantes-Vidal, Rodrigo Bressan, Matthew J Kempton, Marie-Odile Krebs, Philip McGuire, Barnaby Nelson, Merete Nordentoft, Anita Riecher-Rössler, Stephan Ruhrmann, Bart P Rutten, Gabriele Sachs, Lucia R Valmaggia, Mark van der Gaag, Denny Borsboom, Lieuwe de Haan
<jats:title>Abstract</jats:title> <jats:p>Aberrant perceptional experiences are a potential early marker of psychos..
The prognostic significance of attenuated psychotic symptoms in help-seeking youth
H Hazan, T Spelman, GP Amminger, I Hickie, PD McGorry, LJ Phillips, R Purcell, SJ Wood, AR Yung, B Nelson
BACKGROUND: Recent findings suggest that attenuated psychotic symptoms (APS) might serve as a risk factor for general mental healt..
Aripiprazole compared with placebo for auditory verbal hallucinations in youth with borderline personality disorder: Protocol for the VERBATIM randomized controlled trial
Andrew M Chanen, Jennifer Betts, Henry Jackson, Patrick McGorry, Barnaby Nelson, Sue M Cotton, Cali Bartholomeusz, Martina Jovev, Aswin Ratheesh, Christopher Davey, Christos Pantelis, Louise McCutcheon, Shona Francey, Amit Bhaduri, Danielle Lowe, Victoria Rayner, Katherine Thompson
AIM: Up to half of patients with borderline personality disorder report auditory verbal hallucinations that are phenomenologically..
Can antipsychotic dose reduction lead to better functional recovery in first-episode psychosis? A randomized controlled-trial of antipsychotic dose reduction. The reduce trial: Study protocol
Amber Weller, John Gleeson, Mario Alvarez-Jimenez, Patrick McGorry, Barnaby Nelson, Kelly Allott, Sarah Bendall, Cali Bartholomeusz, Peter Koval, Susy Harrigan, Brian O'Donoghue, Alex Fornito, Christos Pantelis, G Paul Amminger, Aswin Ratheesh, Andrea Polari, Stephen J Wood, Kristi van der El, Carli Ellinghaus, Jesse Gates
UNLABELLED: Antipsychotic medication has been the mainstay of treatment for psychotic illnesses for over 60 years. This has been a..
Improving functional outcomes in early-stage bipolar disorder: The protocol for the REsearch into COgnitive and behavioural VERsatility trial
Sue M Cotton, Michael Berk, Henry Jackson, Greg Murray, Kate Filia, Melissa Hasty, Andrew Chanen, Christopher Davey, Barnaby Nelson, Aswin Ratheesh, Craig MacNeil
AIM: Young people with bipolar disorder (BD) commonly experience reduced quality of life, persistent symptoms and impaired functio..
Basic self-disturbances independently predict recovery in psychotic disorders: A seven year follow-up study
Ingrid Hartveit Svendsen, Merete G Oie, Paul Moller, Barnaby Nelson, Elisabeth Haug, Ingrid Melle
BACKGROUND: Recovery is the ultimate goal of psychosis treatment. Basic self-disturbances (BSDs) are non-psychotic phenomena assoc..
Individualized Prediction of Transition to Psychosis in 1,676 Individuals at Clinical High Risk: Development and Validation of a Multivariable Prediction Model Based on Individual Patient Data Meta-Analysis
Aaltsje Malda, Nynke Boonstra, Hans Barf, Steven de Jong, Andre Aleman, Jean Addington, Marita Pruessner, Dorien Nieman, Lieuwe de Haan, Anthony Morrison, Anita Riecher-Roessler, Erich Studerus, Stephan Ruhrmann, Frauke Schultze-Lutter, Suk Kyoon An, Shinsuke Koike, Kiyoto Kasai, Barnaby Nelson, Patrick McGorry, Stephen Wood
Background: The Clinical High Risk state for Psychosis (CHR-P) has become the cornerstone of modern preventive psychiatry. The nex..
The relationship between childhood trauma and clinical characteristics in ultra-high risk for psychosis youth
Chloe de Vos, Andrew Thompson, Paul Amminger, Sarah Bendall, Lieuwe de Haan, Jessica Hartmann, Suzie Lavoie, Connie Markulev, Patrick McGorry, Dorien Nieman, Lisa Phillips, Ulrich Reininghaus, Hok Pan Yuen, Alison Yung, Barnaby Nelson
Mounting evidence suggests that a history of childhood trauma (CT) is associated with an increased risk of developing a psychotic ..
Dynamic prediction of transition to psychosis using joint modelling
HP Yuen, A Mackinnon, J Hartmann, GP Amminger, C Markulev, S Lavoie, MR Schaefer, A Polari, N Mossaheb, M Schloegelhofer, S Smesny, IB Hickie, G Berger, EYH Chen, L de Haan, DH Nieman, M Nordentoft, A Riecher-Roessler, S Verma, A Thompson
Considerable research has been conducted seeking risk factors and constructing prediction models for transition to psychosis in in..
Recent Meta-Analyses in the Clinical High Risk for Psychosis Population: Clinical Interpretation of Findings and Suggestions for Future Research
Barnaby Nelson, Gunter Paul Amminger, Patrick Denistoon McGorry
One of the major advances over the past 20 years in psychiatry is the capacity not only to identify people at incipient risk for p..