CAN WE PREDICT PSYCHOSIS AND CAN IT BE PREVENTED?
Grant number: 1137687 | Funding period: 2018 - 2023
It remains unclear what the causes of schizophrenia and other psychotic disorders are and what the most effective interventions are for preventing onset of disorder in those at risk. The current research program consists of a number of interrelated studies of how psychosis develops, the most effective sequential treatments to prevent the onset of disorder in high risk young people, and testing clinical criteria to identify young people at risk of a range of serious mental illnesses.
Related publications (27)
Investigation of structural brain correlates of neurological soft signs in individuals at ultra-high risk for psychosis
Ya Wang, Esmee E Braam, Cassandra MJ Wannan, Tamsyn E Van Rheenen, Raymond CK Chan, Barnaby Nelson, Patrick D McGorry, Alison R Yung, Ashleigh Lin, Warrick J Brewer, John Koutsogiannis, Stephen J Wood, Dennis Velakoulis, Christos Pantelis, Vanessa L Cropley
Increased severity of neurological soft signs (NSS) in schizophrenia have been associated with abnormal brain morphology in cerebe..
Toxoplasma gondii, Herpesviridae and long-term risk of transition to first-episode psychosis in an ultra high-risk sample.
E Burkhardt, M Berger, RH Yolken, A Lin, HP Yuen, SJ Wood, SM Francey, A Thompson, PD McGorry, B Nelson, AR Yung, GP Amminger
BACKGROUND: Ultra high-risk (UHR) criteria were introduced to identify people at imminent risk of developing psychosis. To improve..
Cognitive ability and metabolic physical health in first-episode psychosis
Sarah Whitson, Brian O'Donoghue, Robert Hester, Lara Baldwin, Susy Harrigan, Shona Francey, Jessica Graham, Barnaby Nelson, Aswin Ratheesh, Mario Alvarez-Jimenez, Alex Fornito, Christos Pantelis, Hok Pan Yuen, Andrew Thompson, Melissa Kerr, Michael Berk, Stephen J Wood, Patrick McGorry, Kelly Allott
Cognitive impairments are a core feature of first-episode psychosis (FEP), arising before illness onset and antipsychotic exposure..
Preventive interventions for individuals at ultra high risk for psychosis: An updated and extended meta-analysis
Cristina Mei, Mark van der Gaag, Barnaby Nelson, Filip Smit, Hok Pan Yuen, Maximus Berger, Marija Krcmar, Paul French, G Paul Amminger, Andreas Bechdolf, Pim Cuijpers, Alison R Yung, Patrick D McGorry
Intervention at the earliest illness stage, in ultra or clinical high-risk individuals, or indicated prevention, currently represe..
Toward a Complex Network of Risks for Psychosis: Combining Trauma, Cognitive Biases, Depression, and Psychotic-like Experiences on a Large Sample of Young Adults
Lukasz Gaweda, Renata Pionke, Jessica Hartmann, Barnaby Nelson, Andrzej Cechnicki, Dorota Frydecka
Although the linkage between traumatic life events and psychotic-like experiences (PLEs) is well established, the knowledge of pot..
Differentiating the effect of antipsychotic medication and illness on brain volume reductions in first-episode psychosis: A Longitudinal, Randomised, Triple-blind, Placebo-controlled MRI Study
Sidhant Chopra, Alex Fornito, Shona M Francey, Brian O'Donoghue, Vanessa Cropley, Barnaby Nelson, Jessica Graham, Lara Baldwin, Steven Tahtalian, Hok Pan Yuen, Kelly Allott, Mario Alvarez-Jimenez, Susy Harrigan, Kristina Sabaroedin, Christos Pantelis, Stephen J Wood, Patrick McGorry
Changes in brain volume are a common finding in Magnetic Resonance Imaging (MRI) studies of people with psychosis and numerous lon..
Distinguishing schizophrenia spectrum from non-spectrum disorders among young patients with first episode psychosis and at high clinical risk: The role of basic self-disturbance and neurocognition
Jessica Spark, Lukasz Gaweda, Kelly Allott, Jessica A Hartmann, Bradley N Jack, Dan Koren, Suzie Lavoie, Emily Li, Patrick D McGorry, Josef Parnas, Andrea Polari, Louis A Sass, Thomas Whitford, Barnaby Nelson
INTRODUCTION: The distinction between the schizophrenia spectrum and other types of disorders may be clinically relevant in terms ..
Intervention strategies for ultra-high risk for psychosis: Progress in delaying the onset and reducing the impact of first-episode psychosis
Patrick D McGorry, Cristina Mei, Jessica Hartmann, Alison R Yung, Barnaby Nelson
Over a quarter of a century ago, the formulation of the "at risk mental state" and operational criteria to prospectively identify ..
Does cortical brain morphology act as a mediator between childhood trauma and transition to psychosis in young individuals at ultra-high risk?
Marta Rapado-Castro, Sarah Whittle, Christos Pantelis, Andrew Thompson, Barnaby Nelson, Eleni P Ganella, Ashleigh Lin, Renate LEP Reniers, Patrick D McGorry, Alison R Yung, Stephen J Wood, Cali F Bartholomeusz
BACKGROUND: Childhood trauma, particularly sexual abuse, has been associated with transition to psychosis in individuals at "ultra..
Emotion Recognition and Adverse Childhood Experiences in Individuals at Clinical High Risk of Psychosis
Stefania Tognin, Ana Catalan, Gemma Modinos, Matthew J Kempton, Amaia Bilbao, Barnaby Nelson, Christos Pantelis, Anita Riecher-Rossler, Rodrigo Bressan, Neus Barrantes-Vidal, Marie-Odile Krebs, Merete Nordentoft, Stephan Ruhrmann, Gabriele Sachs, Bart PF Rutten, Jim van Os, Lieuwe de Haan, Mark van der Gaag, Philip McGuire, Lucia R Valmaggia
OBJECTIVE: To investigate the association between facial affect recognition (FAR) and type of adverse childhood experiences (ACEs)..
Impaired olfactory ability associated with larger left hippocampus and rectus volumes at earliest stages of schizophrenia: A sign of neuroinflammation?
Yuri Masaoka, Dennis Velakoulis, Warrick J Brewer, Vanessa L Cropley, Cali F Bartholomeusz, Alison R Yung, Barnaby Nelson, Dominic Dwyer, Cassandra MJ Wannan, Masahiko Izumizaki, Patrick D McGorry, Stephen J Wood, Christos Pantelis
Impaired olfactory identification has been reported as a first sign of schizophrenia during the earliest stages of illness, includ..
Do schizotypal or borderline personality disorders predict onset of psychotic disorder or persistent attenuated psychotic symptoms in patients at high clinical risk?
H Hadar, H Zhang, LJ Phillips, GP Amminger, GE Berger, EYH Chen, L de Haan, JA Hartmann, IB Hickie, S Lavoie, C Markulev, PD McGorry, N Mossaheb, DH Nieman, M Nordentoft, A Riecher-Rossler, MR Schafer, M Schloegelhofer, S Smesny, A Thompson
Has improved treatment contributed to the declining rate of transition to psychosis in ultra-high-risk cohorts?
MJC Formica, LJ Phillips, JA Hartmann, AR Yung, SJ Wood, A Lin, GP Amminger, PD McGorry, B Nelson
BACKGROUND: The factors contributing to declining psychotic disorder transition rates in ultra-high-risk populations remain unclea..
Basic self-disturbances are associated with Sense of Coherence in patients with psychotic disorders
Ingrid Hartveit Svendsen, Merete Glenne Oie, Paul Moller, Barnaby Nelson, Ingrid Melle, Elisabeth Haug
BACKGROUND: The Sense of Coherence (SOC) theory gives a possible explanation of how people can experience subjective good health d..
Basic symptoms in young people at ultra-high risk of psychosis: Association with clinical characteristics and outcomes
S Youn, LJ Phillips, GP Amminger, G Berger, EYH Chen, L de Haan, JA Hartmann, IB Hickie, S Lavoie, C Markulev, PD McGorry, N Mossaheb, DH Nieman, M Nordentoft, A Riecher-Rossler, MR Schafer, M Schloegelhofer, S Smesny, A Thompson, S Verma
There has been limited research into the predictive value of basic symptoms and their relationship with other psychopathology in p..
From Speech Illusions to Onset of Psychotic Disorder: Applying Network Analysis to an Experimental Measure of Aberrant Experiences
Lindy-Lou Boyette, Adela-Maria Isvoranu, Frederike Schirmbeck, Eva Velthorst, Claudia JP Simons, Neus Barrantes-Vidal, Rodrigo Bressan, Matthew J Kempton, Marie-Odile Krebs, Philip McGuire, Barnaby Nelson, Merete Nordentoft, Anita Riecher-Rössler, Stephan Ruhrmann, Bart P Rutten, Gabriele Sachs, Lucia R Valmaggia, Mark van der Gaag, Denny Borsboom, Lieuwe de Haan
<jats:title>Abstract</jats:title> <jats:p>Aberrant perceptional experiences are a potential early marker of psychos..
The prognostic significance of attenuated psychotic symptoms in help-seeking youth
H Hazan, T Spelman, GP Amminger, I Hickie, PD McGorry, LJ Phillips, R Purcell, SJ Wood, AR Yung, B Nelson
BACKGROUND: Recent findings suggest that attenuated psychotic symptoms (APS) might serve as a risk factor for general mental healt..
Aripiprazole compared with placebo for auditory verbal hallucinations in youth with borderline personality disorder: Protocol for the VERBATIM randomized controlled trial
Andrew M Chanen, Jennifer Betts, Henry Jackson, Patrick McGorry, Barnaby Nelson, Sue M Cotton, Cali Bartholomeusz, Martina Jovev, Aswin Ratheesh, Christopher Davey, Christos Pantelis, Louise McCutcheon, Shona Francey, Amit Bhaduri, Danielle Lowe, Victoria Rayner, Katherine Thompson
AIM: Up to half of patients with borderline personality disorder report auditory verbal hallucinations that are phenomenologically..
Can antipsychotic dose reduction lead to better functional recovery in first-episode psychosis? A randomized controlled-trial of antipsychotic dose reduction. The reduce trial: Study protocol
Amber Weller, John Gleeson, Mario Alvarez-Jimenez, Patrick McGorry, Barnaby Nelson, Kelly Allott, Sarah Bendall, Cali Bartholomeusz, Peter Koval, Susy Harrigan, Brian O'Donoghue, Alex Fornito, Christos Pantelis, G Paul Amminger, Aswin Ratheesh, Andrea Polari, Stephen J Wood, Kristi van der El, Carli Ellinghaus, Jesse Gates
Antipsychotic medication has been the mainstay of treatment for psychotic illnesses for over 60 years. This has been associated wi..
Improving functional outcomes in early-stage bipolar disorder: The protocol for the REsearch into COgnitive and behavioural VERsatility trial
Sue M Cotton, Michael Berk, Henry Jackson, Greg Murray, Kate Filia, Melissa Hasty, Andrew Chanen, Christopher Davey, Barnaby Nelson, Aswin Ratheesh, Craig MacNeil
AIM: Young people with bipolar disorder (BD) commonly experience reduced quality of life, persistent symptoms and impaired functio..
Basic self-disturbances independently predict recovery in psychotic disorders: A seven year follow-up study
Ingrid Hartveit Svendsen, Merete G Oie, Paul Moller, Barnaby Nelson, Elisabeth Haug, Ingrid Melle
BACKGROUND: Recovery is the ultimate goal of psychosis treatment. Basic self-disturbances (BSDs) are non-psychotic phenomena assoc..
The relationship between childhood trauma and clinical characteristics in ultra-high risk for psychosis youth
Chloe de Vos, Andrew Thompson, Paul Amminger, Sarah Bendall, Lieuwe de Haan, Jessica Hartmann, Suzie Lavoie, Connie Markulev, Patrick McGorry, Dorien Nieman, Lisa Phillips, Ulrich Reininghaus, Hok Pan Yuen, Alison Yung, Barnaby Nelson
Mounting evidence suggests that a history of childhood trauma (CT) is associated with an increased risk of developing a psychotic ..
Dynamic prediction of transition to psychosis using joint modelling
HP Yuen, A Mackinnon, J Hartmann, GP Amminger, C Markulev, S Lavoie, MR Schaefer, A Polari, N Mossaheb, M Schloegelhofer, S Smesny, IB Hickie, G Berger, EYH Chen, L de Haan, DH Nieman, M Nordentoft, A Riecher-Roessler, S Verma, A Thompson
Considerable research has been conducted seeking risk factors and constructing prediction models for transition to psychosis in in..