USING TWIN AND FAMILY STUDIES TO MAKE GENOMICS RELEVANT TO POPULATION HEALTH

Grant number: 1137349 | Funding period: 2018 - 2022

Completed

Abstract

This Fellowship will make major impacts on health by building on decades of research creating large studies of families, and in particular twins. One aim is to produce a simple web-based tool for women to accurately know their risk of breast cancer based on family history, mammography and genetic markers. This could transform breast and genetic screening across the world. Another is to develop new ways of analysing twin data which resolve which risk factors are causal and relevant to prevention.

Related publications (8)

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What if the age at which a woman started regular mammographic screening depended on her risk, not age?

John L Hopper, Tuong L Nguyen, Shuai Li

2022-10-19

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Genetic Aspects of Mammographic Density Measures Associated with Breast Cancer Risk

Shuai Li, Tuong L Nguyen, Nguyen-Dumont Tu, James G Dowty, Gillian S Dite, Zhoufeng Ye, Ho N Trinh, Christopher F Evans, Maxine Tan, Joohon Sung, Mark A Jenkins, Graham G Giles, John L Hopper, Melissa C Southey

2022-06-01

Cumulus, Altocumulus, and Cirrocumulus are measures of mammographic density defined at increasing pixel brightness thresholds, whi..

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Familial Aspects of Mammographic Density Measures Associated with Breast Cancer Risk

Tuong L Nguyen, Shuai Li, James G Dowty, Gillian S Dite, Zhoufeng Ye, Tu Nguyen-Dumont, Ho N Trinh, Christopher F Evans, Maxine Tan, Joohon Sung, Mark A Jenkins, Graham G Giles, Melissa C Southey, John L Hopper

2022-03-01

Cumulus, Cumulus-percent, Altocumulus, Cirrocumulus, and Cumulus-white are mammogram risk scores (MRSs) for breast cancer based on..

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Birthweight, gestational age and familial confounding in sex differences in infant mortality: a matched co-twin control study of Brazilian male-female twin pairs identified by population data linkage

Lucas Calais-Ferreira, Marcos E Barreto, Everton Mendonca, Gillian S Dite, Martha Hickey, Paulo H Ferreira, Katrina J Scurrah, John L Hopper

2021-11-29

BACKGROUND: In infancy, males are at higher risk of dying than females. Birthweight and gestational age are potential confounders ..

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Variation in the risk of colorectal cancer in families with Lynch syndrome: a retrospective cohort study

Mark A Jenkins

2021-06-28

BACKGROUND: Existing clinical practice guidelines for carriers of pathogenic variants of DNA mismatch repair genes (Lynch syndrome..

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Enhancing Value and Uptake for Whole-Population Cohorts of Children and Parents: Methods to Integrate Registries into the Generation Victoria Cohort

Valerie Sung, Katrina Williams, Ella Perlow, Yanhong J Hu, Susannah Ahern, Joanne M Said, Bill Karanatsios, John L Hopper, John J McNeil, Leo Donnan, Sharon Goldfeld, Melissa Wake

2021-04-01

Health registries are critical to understanding, benchmarking and improving quality of care for specific diseases and conditions, ..

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An independent external validation of melanoma risk prediction models using the Australian Melanoma Family Study

K Vuong, BK Armstrong, D Espinoza, JL Hopper, JF Aitken, GG Giles, H Schmid, GJ Mann, AE Cust, K McGeechan

2021-02-01

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Predictors and consequences of health anxiety symptoms: a novel twin modeling study

C Lopez-Sola, M Bui, JL Hopper, LF Fontenelle, CG Davey, C Pantelis, P Alonso, OA van den Heuvel, BJ Harrison

2018-03-01

OBJECTIVE: The question of how to best conceptualize health anxiety (HA) from a diagnostic and etiological perspective remains deb..