THE ROLE OF CD1-RESTRICTED T CELLS IN HEALTH AND DISEASE
Grant number: 1144308 | Funding period: 2018 - 2018
The human immune system requires T cells for survival. Specialised populations of T cells exist that patrol the body and target unwanted lipid molecules expressed by bacteria or by cells that have become abnormal or cancerous. I will identify these T cells in human blood and skin and determine their role in protection against disease. I will explore the types of lipids molecules recognised by these T cells and use this information to help prevent human diseases.
Related publications (5)
A class of gamma delta T cell receptors recognize the underside of the antigen-presenting molecule MR1
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T cell receptors (TCRs) recognize antigens presented by major histocompatibility complex (MHC) and MHC class I-like molecules. We ..
Diverse MR1-restricted T cells in mice and humans.
Hui-Fern Koay, Nicholas A Gherardin, Calvin Xu, Rebecca Seneviratna, Zhe Zhao, Zhenjun Chen, David P Fairlie, James McCluskey, Daniel G Pellicci, Adam P Uldrich, Dale I Godfrey
Mucosal-associated invariant T (MAIT) cells express an invariant TRAV1/TRAJ33 TCR-α chain and are restricted to the MHC-I-like mol..
CD1b presents self and Borrelia burgdorferi diacylglycerols to human T cells
Peter Reinink, Michael NT Souter, Tan-Yun Cheng, Tamara van Gorkom, Stefanie Lenz, Joanna Kubler-Kielb, Klemen Strle, Kristin Kremer, Steven FT Thijsen, Allen C Steere, Dale I Godfrey, Daniel G Pellicci, D Branch Moody, Ildiko Van Rhijn
Lyme disease is a common multisystem disease caused by infection with a tick-transmitted spirochete, Borrelia burgdorferi and rela..
Altered Populations of Unconventional T Cell Lineages in Patients with Langerhans Cell Histiocytosis
Jenee Mitchell, Egle Kvedaraite, Tatiana von Bahr Greenwood, Jan-Inge Henter, Daniel G Pellicci, Stuart P Berzins, George Kannourakis
Langerhans cell histiocytosis (LCH) lesions are defined by the presence of CD1a+/CD207+ myeloid cells, but many other immune cells..