UNDERSTANDING AND EFFECTIVELY TREATING COGNITIVE AND FUNCTIONING IMPAIRMENTS IN YOUTH WITH PSYCHOSIS AND OTHER MENTAL DISORDERS
Grant number: 1141207 | Funding period: 2018 - 2022
Impaired thinking skills, such as memory, concentration and problem solving, emerge early in psychotic and other mental disorders, which has a negative impact on functioning in work and other daily activities. Current treatments are not very effective at addressing this. The research proposed in this fellowship will improve knowledge about these impairments and develop and test a range of interventions that treat thinking skill difficulties and improve daily functioning in youth mental illness.
Related publications (36)
Increased cortical surface area but not altered cortical thickness or gyrification in bipolar disorder following stabilisation from a first episode of mania
Tamsyn E Van Rheenen, Sue M Cotton, Orwa Dandash, Rebecca E Cooper, Elysha Ringin, Rothanthi Daglas-Georgiou, Kelly Allott, Yann Chye, Chao Suo, Craig Macneil, Melissa Hasty, Karen Hallam, Patrick McGorry, Alex Fornito, Murat Yucel, Christos Pantelis, Michael Berk
BACKGROUND: Despite reports of altered brain morphology in established bipolar disorder (BD), there is limited understanding of wh..
Heterogeneity of quality of life in the later stages of first-episode psychosis recovery
EL Clarke, K Allott, JF Anderson, CX Gao, KM Filia, E Killackey, SM Cotton
PURPOSE: First-episode psychosis (FEP) is characterised by wide heterogeneity in terms of symptom presentation and illness course...
Effects of omega-3 polyunsaturated fatty acid supplementation on cognitive functioning in youth at ultra-high risk for psychosis: secondary analysis of the NEURAPRO randomised controlled trial
Nicholas Cheng, Alison McLaverty, Barnaby Nelson, Connie Markulev, Miriam R Schafer, Maximus Berger, Nilufar Mossaheb, Monika Schlogelhofer, Stefan Smesny, Ian B Hicikie, Gregor E Berger, Eric YH Chen, Lieuwe de Haan, Dorien H Nieman, Merete Nordentoft, Anita Riecher-Rossler, Swapna Verma, Rebekah Street, Andrew Thompson, Hok Pan Yuen
BACKGROUND: Cognitive impairments are well-established features of psychotic disorders and are present when individuals are at ult..
Intelligence trajectories in individuals at ultra-high risk for psychosis: An 8-year longitudinal analysis
Nicholas Cheng, Ashleigh Lin, Stephen Bowden, Caroline Gao, Alison R Yung, Barnaby Nelson, Andrew Thompson, Hok Pan Yuen, Warrick J Brewer, Daniela Cagliarini, Annie Bruxner, Magenta Simmons, Christina Broussard, Christos Pantelis, Patrick D McGorry, Kelly Allott, Stephen J Wood
Cognitive impairment is a well-documented predictor of transition to a full-threshold psychotic disorder amongst individuals at ul..
A systematic review comparing caregiver burden and psychological functioning in caregivers of individuals with schizophrenia spectrum disorders and bipolar disorders
George J Karambelas, Kate Filia, Linda K Byrne, Kelly A Allott, Anuradhi Jayasinghe, Sue M Cotton
BACKGROUND: Informal primary caregivers provide crucial supports to loved ones experiencing serious mental illnesses with profound..
Cognitive strengths in first-episode psychosis: perspectives from young people with lived experience
Shayden Bryce, Ashleigh de Winter, Lisa Phillips, Nicholas Cheng, Mario Alvarez-Jimenez, Kelly Allott
Background: Identifying cognitive strengths may be one avenue for enhancing functional recovery in people with first-episode psych..
Decisional capacity in young people with first episode psychosis, major depressive disorder and no mental disorder
Kelly Allott, Sarah Whitson, Shona M Francey, Christina Bryant, Magenta B Simmons, Chiara MJ Killey
We aimed to (1) examine decisional capacity for treatment in young people (aged 15 to 25 years) with first-episode psychosis (FEP)..
The specific phenotype of depression in recent onset schizophrenia spectrum disorders: A symptom profile and network comparison to recent onset major depressive disorder without psychotic features
Sarah E Herniman, Stephen J Wood, Susan M Cotton, Kelly A Allott, Christopher Davey, Michael Berk, Lisa J Phillips
The specific phenotype of depression in recent-onset schizophrenia spectrum disorders (SSD) and its relation to non-psychotic depr..
Twelve-Month Cognitive Trajectories in Individuals at Ultra-High Risk for Psychosis: A Latent Class Analysis
K Allott, SJ Schmidt, HP Yuen, SJ Wood, B Nelson, C Markulev, S Lavoie, WJ Brewer, MR Schäfer, N Mossaheb, M Schlögelhofer, S Smesny, IB Hickie, GE Berger, EYH Chen, L De Haan, DH Nieman, M Nordentoft, A Riecher-Rössler, S Verma
Understanding longitudinal cognitive performance in individuals at ultra-high risk for psychosis (UHR) is important for informing ..
Cognitive strengths in first episode psychosis: a thematic analysis of clinicians' perspectives
Peter Steele, Nicholas Cheng, Lisa J Phillips, Shayden Bryce, Mario Alvarez-Jimenez, Kelly Allott
BACKGROUND: Cognitive deficits are associated with poor functional outcomes in individuals recovering from a first episode of psyc..
Treatments for objective and subjective cognitive functioning in young people with depression: Systematic review of current evidence
Rothanthi Daglas-Georgiou, Shayden Bryce, Gabriel Smith, Manreena Kaur, Nicholas Cheng, Magdalene De Rozario, Stephen J Wood, Kelly Allott
AIM: Cognitive deficits are recognized features of depressive disorders in youth aged 12-25. These deficits are distressing, predi..
Interrelationships between depressive symptoms and positive and negative symptoms of recent onset schizophrenia spectrum disorders: A network analytical approach
Sarah E Herniman, Lisa J Phillips, Stephen J Wood, Sue M Cotton, Edith J Liemburg, Kelly A Allott
OBJECTIVE: There is a need to better understand the interrelationships between positive and negative symptoms of recent-onset schi..
The Neuropsychological Symptoms Self-Report: psychometric properties in an adolescent and young adult mental health cohort
Kelly Allott, Caroline X Gao, Caroline Fisher, Sarah E Hetrick, Kate M Filia, Jana M Menssink, Helen E Herrman, Debra J Rickwood, Alexandra G Parker, Patrick D McGorry, Sue M Cotton
BACKGROUND: Subjective cognitive symptoms are common in young people receiving mental health treatment and are associated with poo..
Cognitive ability and metabolic physical health in first-episode psychosis
Sarah Whitson, Brian O'Donoghue, Robert Hester, Lara Baldwin, Susy Harrigan, Shona Francey, Jessica Graham, Barnaby Nelson, Aswin Ratheesh, Mario Alvarez-Jimenez, Alex Fornito, Christos Pantelis, Hok Pan Yuen, Andrew Thompson, Melissa Kerr, Michael Berk, Stephen J Wood, Patrick McGorry, Kelly Allott
Cognitive impairments are a core feature of first-episode psychosis (FEP), arising before illness onset and antipsychotic exposure..
The psychometric validity of the Montgomery-Asberg Depression Rating Scale (MADRS) in recent onset schizophrenia spectrum disorders
Sarah E Herniman, Sue M Cotton, Kelly A Allott, Lisa J Phillips, Stephen J Wood
Earlier recognition and accurate assessment of depressive symptoms is important to improving outcomes in individuals with recent-o..
Distinguishing schizophrenia spectrum from non-spectrum disorders among young patients with first episode psychosis and at high clinical risk: The role of basic self-disturbance and neurocognition
Jessica Spark, Lukasz Gaweda, Kelly Allott, Jessica A Hartmann, Bradley N Jack, Dan Koren, Suzie Lavoie, Emily Li, Patrick D McGorry, Josef Parnas, Andrea Polari, Louis A Sass, Thomas Whitford, Barnaby Nelson
INTRODUCTION: The distinction between the schizophrenia spectrum and other types of disorders may be clinically relevant in terms ..
Subjective cognitive functioning in relation to changes in levels of depression and anxiety in youth over 3 months of treatment
Kelly Allott, Caroline Gao, Sarah E Hetrick, Kate M Filia, Jana M Menssink, Caroline Fisher, Ian B Hickie, Helen E Herrman, Debra J Rickwood, Alexandra G Parker, Patrick D Mcgorry, Sue M Cotton
BACKGROUND: Subjective cognitive difficulties are common in mental illness and have a negative impact on role functioning. Little ..
Cognitive strengths-based assessment and intervention in first-episode psychosis: A complementary approach to addressing functional recovery?
Kelly Allott, Peter Steele, Frances Boyer, Ashleigh de Winter, Shayden Bryce, Mario Alvarez-Jimenez, Lisa Phillips
People who have experienced psychosis describe functional and personal recovery as a key goal of treatment. To date, the early, pe..
Compensatory Interventions for Cognitive Impairments in Psychosis: A Systematic Review and Meta-Analysis
Kelly Allott, Kristi Van-der-EL, Shayden Bryce, Emma M Parrish, Susan R McGurk, Sarah Hetrick, Christopher R Bowie, Sean Kidd, Matthew Hamilton, Eoin Killackey, Dawn Velligan
OBJECTIVE: Cognitive compensatory interventions aim to alleviate psychosocial disability by targeting functioning directly using a..
INdividual Vocational and Educational Support Trial (INVEST) for young people with borderline personality disorder: study protocol for a randomised controlled trial
Andrew M Chanen, Katie Nicol, Jennifer K Betts, Gary R Bond, Cathrine Mihalopoulos, Henry J Jackson, Katherine N Thompson, Martina Jovev, Hok Pan Yuen, Gina Chinnery, Judith Ring, Kelly Allott, Louise McCutcheon, Ashleigh P Salmon, Eoin Killackey
Background: The clinical onset of borderline personality disorder (BPD) usually occurs in young people (aged 12–25 years) and comm..
Cognitive functioning in ultra -high risk for psychosis individuals with and without depression: Secondary analysis of findings from the NEURAPRO randomized clinical trial
Sumudu Rasangi Mallawaarachchi, G Paul Amminger, John Farhall, Luke K Bolt, Barnaby Nelson, Hok Pan Yuen, Patrick D McGorry, Connie Markulev, Miriam R Schaefer, Nilufar Mossaheb, Monika Schloegelhofer, Stefan Smesny, Ian B Hickie, Gregor Emanuel Berger, Eric YH Chen, Lieuwe de Haan, Dorien H Nieman, Merete Nordentoft, Anita Riecher-Roessler, Swapna Verma
Neurocognitive impairments are well established in both ultra-high risk (UHR) for psychosis and major depressive disorder (MDD). D..
Youth access clinics in Gippsland: Barriers and enablers to service accessibility in rural settings
Erin Dolan, Kelly Allott, Amanda Proposch, Matthew Hamilton, Eoin Killackey
AIM: Approximately 15 years ago, four youth access clinics (YACs) were established in the Gippsland region to improve mental and g..
Acceptability, safety and perceived impact of providing a fact sheet to young people about cognitive symptoms in depression
Shayden Bryce, Melanie Cooke, Hok Pan Yuen, Kelly Allott
AIM: Cognitive deficits are common in young people, aged 15-25, with depression. Nevertheless, these symptoms are not routinely ad..
Harmonised collection of data in youth mental health: Towards large datasets
Suzie Lavoie, Kelly Allott, Paul Amminger, Cali Bartholomeusz, Maximus Berger, Michael Breakspear, Anjali K Henders, Rico Lee, Ashleigh Lin, Patrick McGorry, Simon Rice, Lianne Schmaal, Stephen J Wood
OBJECTIVE: The current international trend is to create large datasets with existing data and/or deposit newly collected data into..
Depressive psychopathology in first-episode schizophrenia spectrum disorders: a systematic review, meta-analysis and meta-regression
Sarah E Herniman, Kelly Allott, Lisa J Phillips, Stephen J Wood, Jacqueline Uren, Sumudu R Mallawaarachchi, Sue M Cotton
BACKGROUND: Despite knowing for many decades that depressive psychopathology is common in first-episode schizophrenia spectrum dis..
The efficacy and safety of nutrient supplements in the treatment of mental disorders: a meta-review of meta-analyses of randomized controlled trials
Joseph Firth, Scott B Teasdale, Kelly Allott, Dan Siskind, Wolfgang Marx, Jack Cotter, Nicola Veronese, Felipe Schuch, Lee Smith, Marco Solmi, Andre F Carvalho, Davy Vancampfort, Michael Berk, Brendon Stubbs, Jerome Sarris
The role of nutrition in mental health is becoming increasingly acknowledged. Along with dietary intake, nutrition can also be obt..
Thematic analysis of youth mental health providers' perceptions of neuropsychological assessment services
Garance Delagneau, Stephen C Bowden, Shayden Bryce, Kristi van-der-EL, Matthew Hamilton, Sophie Adams, Liz Burgat, Eoin Killackey, Debra Rickwood, Kelly Allott
AIM: A growing number of quantitative studies have investigated the utility of neuropsychological assessment in mental health sett..
Longitudinal Cognitive Performance in Individuals at Ultrahigh Risk for Psychosis: A 10-year Follow-up
Kelly Allott, Stephen J Wood, Hok Pan Yuen, Alison R Yung, Barnaby Nelson, Warrick J Brewer, Daniela Spiliotacopoulos, Annie Bruxner, Magenta Simmons, Christina Broussard, Sumudu Mallawaarachchi, Christos Pantelis, Patrick D McGorry, Ashleigh Lin
It remains unclear whether the onset of psychosis is associated with deterioration in cognitive performance. The aim of this study..
Subjective experiences of neurocognitive functioning in young people with major depression
Catherine Morey-Nase, Lisa J Phillips, Shayden Bryce, Sarah Hetrick, Andrea L Wright, Emma Caruana, Kelly Allott
BACKGROUND: Research suggests that young people with major depressive disorder (MDD) experience neurocognitive deficits and that t..
The Vitamins in Psychosis Study: A Randomized, Double-Blind, Placebo-Controlled Trial of the Effects of Vitamins B-12, B-6, and Folic Acid on Symptoms and Neurocognition in First-Episode Psychosis
Kelly Allott, Patrick D McGorry, Hok Pan Yuen, Joseph Firth, Tina-Marie Proffitt, Gregor Berger, Paul Maruff, Michaels K O'Regan, Alicia Papas, Timothy CB Stephens, Colin P O'Donnell
BACKGROUND: Elevated homocysteine is observed in schizophrenia and associated with illness severity. The aim of this study was to ..