IMPORTANCE OF FUNCTIONAL ANTIBODIES AGAINST INFECTIOUS DISEASES

Grant number: 1140509 | Funding period: 2018 - 2022

Completed

Abstract

Antibodies are highly functional proteins capable of recognizing infectious disease pathogens and instructing surrounding immune cells to attack them. This project aims to identify specific antibody targets on HIV and Mycobacterium Tuberculosis associated with protection/control of disease and to understand the mechanisms behind the most functional antibodies. Ultimately, these studies will guide the development of future vaccines and therapies against these deadly pathogens.

Related publications (8)

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Identifying Targets of Protective Antibodies against Severe Malaria in Papua, Indonesia, Using Locally Expressed Domains of Plasmodium falciparum Erythrocyte Membrane Protein 1

Janavi S Rambhatla, Gerry Q Tonkin-Hill, Eizo Takashima, Takafumi Tsuboi, Rintis Noviyanti, Leily Trianty, Boni F Sebayang, Daniel A Lampah, Jutta Marfurt, Ric N Price, Nicholas M Anstey, Anthony T Papenfuss, Timon Damelang, Amy W Chung, Michael F Duffy, Stephen J Rogerson

2022-02-01

Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), a diverse family of multidomain proteins expressed on the surface o..

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Targeting BMI-1 in B cells restores effective humoral immune responses and controls chronic viral infection

Andrea Di Pietro, Jack Polmear, Lucy Cooper, Timon Damelang, Tabinda Hussain, Lauren Hailes, Kristy O'Donnell, Vibha Udupa, Tian Mi, Simon Preston, Areen Shtewe, Uri Hershberg, Stephen J Turner, Nicole L La Gruta, Amy W Chung, David M Tarlinton, Christopher D Scharer, Kim L Good-Jacobson

2021-11-29

Ineffective antibody-mediated responses are a key characteristic of chronic viral infection. However, our understanding of the int..

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Developing a multivariate prediction model of antibody features associated with protection of malaria-infected pregnant women from placental malaria

Elizabeth H Aitken, Timon Damelang, Amaya Ortega-Pajares, Agersew Alemu, Wina Hasang, Saber Dini, Holger W Unger, Maria Ome-Kaius, Morten A Nielsen, Ali Salanti, Joe Smith, Stephen Kent, P Mark Hogarth, Bruce D Wines, Julie A Simpson, Amy Chung, Stephen J Rogerson

2021-06-29

BACKGROUND: Plasmodium falciparum causes placental malaria, which results in adverse outcomes for mother and child. P. falciparum-..

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Systems serology detects functionally distinct coronavirus antibody features in children and elderly

Kevin J Selva, Carolien E van de Sandt, Melissa M Lemke, Christina Y Lee, Suzanne K Shoffner, Brendon Y Chua, Samantha K Davis, Thi HO Nguyen, Louise C Rowntree, Luca Hensen, Marios Koutsakos, Chinn Yi Wong, Francesca Mordant, David C Jackson, Katie L Flanagan, Jane Crowe, Shidan Tosif, Melanie R Neeland, Philip Sutton, Paul Licciardi

2021-04-01

The hallmarks of COVID-19 are higher pathogenicity and mortality in the elderly compared to children. Examining baseline SARS-CoV-..

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Antibody mediated activation of natural killer cells in malaria exposed pregnant women

Timon Damelang, Elizabeth H Aitken, Wina Hasang, Ester Lopez, Martin Killian, Holger W Unger, Ali Salanti, Alexis Shub, Elizabeth McCarthy, Katherine Kedzierska, Martha Lappas, Stephen J Kent, Stephen J Rogerson, Amy W Chung

2021-02-18

Immune effector responses against Plasmodium falciparum include antibody-mediated activation of innate immune cells, which can ind..

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Serological and cellular inflammatory signatures in end-stage kidney disease and latent tuberculosis

Milla R McLean, Kathleen M Wragg, Ester Lopez, Sandra A Kiazyk, Terry Blake Ball, Joe Bueti, Stephen J Kent, Jennifer A Juno, Amy W Chung

2021-01-01

OBJECTIVES: Tuberculosis comorbidity with chronic diseases including diabetes, HIV and chronic kidney disease is of rising concern..

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Immune responses to SARS-CoV-2 in three children of parents with symptomatic COVID-19

Shidan Tosif, Melanie R Neeland, Philip Sutton, Paul V Licciardi, Sohinee Sarkar, Kevin J Selva, Anh Ha Do Lien, Celeste Donato, Zheng Quan Toh, Rachel Higgins, Carolien Van de Sandt, Melissa M Lemke, Christina Y Lee, Suzanne K Shoffner, Katie L Flanagan, Kelly B Arnold, Francesca L Mordant, Kim Mulholland, Julie Bines, Kate Dohle

2020-11-11

Compared to adults, children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have predominantly mild or asymptom..

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Suboptimal SARS-CoV-2-specific CD8( ) T cell response associated with the prominent HLA-A*02:01 phenotype

Jennifer R Habel, Thi HO Nguyen, Carolien E van de Sandt, Jennifer A Juno, Priyanka Chaurasia, Kathleen Wragg, Marios Koutsakos, Luca Hensen, Xiaoxiao Jia, Brendon Chua, Wuji Zhang, Hyon-Xhi Tan, Katie L Flanagan, Denise L Doolan, Joseph Torresi, Weisan Chen, Linda M Wakim, Allen C Cheng, Peter C Doherty, Jan Petersen

2020-09-29

An improved understanding of human T cell-mediated immunity in COVID-19 is important for optimizing therapeutic and vaccine strate..

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