THE FUTURE OF HIV CARE - LONG TERM REMISSION AND ELIMINATING CO-MORBIDITIES

Antiretroviral Initiation at >= 800 CD4 Cells/mm(3) Associated With Lower Human Immunodeficiency Virus Reservoir Size

Thomas A Rasmussen, Sunil K Ahuja, Locadiah Kuwanda, Michael J Vjecha, Fleur Hudson, Luxshimi Lal, Ajantha Rhodes, Judy Chang, Sarah Palmer, Paula Auberson-Munderi, Henry Mugerwa, Robin Wood, Sharlaa Badal-Faesen, Sandy Pillay, Rosie Mngqibisa, Alberto LaRosa, Jose Hildago, Kathy Petoumenos, Chris Chiu, Joseph Lutaakome

2022-11-14

BACKGROUND: Identifying factors that determine the frequency of latently infected CD4+ T cells on antiretroviral therapy (ART) may..

Immune checkpoint blockade in HIV

Celine Gubser, Chris Chiu, Sharon R Lewin, Thomas A Rasmussen

2022-02-02

Antiretroviral therapy (ART) has dramatically improved life expectancy for people with HIV (PWH) and helps to restore immune funct..

Balancing Statistical Power and Risk in HIV Cure Clinical Trial Design

Jillian SY Lau, Deborah Cromer, Mykola Pinkevych, Sharon R Lewin, Thomas A Rasmussen, James H McMahon, Miles P Davenport

2022-02-01

BACKGROUND: Analytical treatment interruptions (ATI) are pauses of antiretroviral therapy (ART) in the context of human immunodefi..

Combination Immune Checkpoint Blockade Enhances IL-2 and CD107a Production from HIV-Specific T Cells Ex Vivo in People Living with HIV on Antiretroviral Therapy

Chris Y Chiu, Judy J Chang, Ashanti Dantanarayana, Ajantha Solomon, Vanessa A Evans, Rachel Pascoe, Celine Gubser, Lydie Trautman, Remi Fromentin, Nicolas Chomont, James H McMahon, Paul U Cameron, Thomas A Rasmussen, Sharon R Lewin

2022-01-01

In people with HIV (PWH) on antiretroviral therapy (ART), immune dysfunction persists, including elevated expression of immune che..

Cell-Associated Human Immunodeficiency Virus (HIV) Ribonucleic Acid Has a Circadian Cycle in Males With HIV on Antiretroviral Therapy

Jared Stern, Ajantha Solomon, Ashanti Dantanarayana, Rachel Pascoe, Arnold Reynaldi, Miles P Davenport, Jeffrey Milush, Steven G Deeks, Wendy Hartogensis, Frederick M Hecht, Leslie Cockerham, Michael Roche, Sharon R Lewin

2021-11-24

BACKGROUND: Circadian transcription factors that regulate cell-autonomous circadian clocks can also increase human immunodeficienc..

Integrated immune dynamics define correlates of COVID-19 severity and antibody responses

Marios Koutsakos, Louise C Rowntree, Luca Hensen, Brendon Y Chua, Carolien E van de Sandt, Jennifer R Habel, Wuji Zhang, Xiaoxiao Jia, Lukasz Kedzierski, Thomas M Ashhurst, Givanna H Putri, Felix Marsh-Wakefield, Mark N Read, Davis N Edwards, E Bridie Clemens, Chinn Yi Wong, Francesca L Mordant, Jennifer A Juno, Fatima Amanat, Jennifer Audsley

2021-03-16

SARS-CoV-2 causes a spectrum of COVID-19 disease, the immunological basis of which remains ill defined. We analyzed 85 SARS-CoV-2-..

Multiply spliced HIV RNA is a predictive measure of virus production ex vivo and in vivo following reversal of HIV latency

Jennifer M Zerbato, Georges Khoury, Wei Zhao, Matthew J Gartner, Rachel D Pascoe, Ajantha Rhodes, Ashanti Dantanarayana, Megan Gooey, Jenny Anderson, Peter Bacchetti, Steven G Deeks, James McMahon, Michael Roche, Thomas A Rasmussen, Damian FJ Purcell, Sharon R Lewin

2021-02-26

BACKGROUND: One strategy being pursued to clear latently infected cells that persist in people living with HIV (PLWH) on antiretro..

Intrahepatic CXCL10 is strongly associated with liver fibrosis in HIV-Hepatitis B co-infection

Kasha P Singh, Jennifer M Zerbato, Wei Zhao, Sabine Braat, Claire Deleage, G Surekha Tennakoon, Hugh Mason, Ashanti Dantanarayana, Ajantha Rhodes, Jake W Rhodes, Joe Torresi, Andrew N Harman, Peter A Revill, Megan Crane, Jacob D Estes, Anchalee Avihingsanon, Sharon R Lewin, Jennifer Audsley

2020-09-01

In HIV-hepatitis B virus (HBV) co-infection, adverse liver outcomes including liver fibrosis occur at higher frequency than in HBV..

Longitudinal analysis of subtype C envelope tropism for memory CD4( )T cell subsets over the first 3 years of untreated HIV-1 infection

Matthew J Gartner, Paul R Gorry, Carolin Tumpach, Jingling Zhou, Ashanti Dantanarayana, J Judy Chang, Thomas A Angelovich, Paula Ellenberg, Annemarie E Laumaea, Molati Nonyane, Penny L Moore, Sharon R Lewin, Melissa J Churchill, Jacqueline K Flynn, Michael Roche

2020-08-06

BACKGROUND: HIV-1 infects a wide range of CD4+ T cells with different phenotypic properties and differing expression levels of ent..

A gathering storm: HIV infection and nonalcoholic fatty liver disease in low and middle-income countries

Nitin Kapoor, Jennifer Audsley, Priscilla Rupali, Joe Sasadeusz, Thomas Paul, Nihal Thomas, Sharon R Lewin

2019-06-01

: Despite the decreasing total incidence of liver-related deaths, liver disease remains one of the major non-AIDS causes of morbid..

HIV latency reversing agents act through Tat post translational modifications

Georges Khoury, Talia M Mota, Shuang Li, Carolin Tumpach, Michelle Y Lee, Jonathan Jacobson, Leigh Harty, Jenny L Anderson, Sharon R Lewin, Damian FJ Purcell

2018-05-11

BACKGROUND: Different classes of latency reversing agents (LRAs) are being evaluated to measure their effects in reactivating HIV ..

HIV cure research: print and online media reporting in Australia

Jennifer Power, Bianca Fileborn, Gary W Dowsett, Jayne Lucke, Graham Brown, Jeanne Ellard, Sharon R Lewin, Joseph D Tucker, Sean Slavin, Jeremy Sugarman, Sophie Hill

2017-10-01

OBJECTIVES: While still in its early stages, recent scientific research towards a cure for HIV has generated widespread media inte..