NEUROBIOLOGY OF CHILDHOOD SPEECH DISORDERS: IMPROVING DETECTION, DIAGNOSIS AND CLINICAL CARE
Grant number: 1127144 | Funding period: 2017 - 2019
One in 20 children have a speech disorder at school entry, with lifelong deficits in psychosocial, academic and employment outcomes. Little is known about the aetiology of speech disorders, preventing targeted care. We combine expertise in speech pathology, gene discovery and brain imaging, to advance knowledge on gene and brain contributions to speech disorder. We will have direct impacts on clinical care including detection, diagnosis and counselling, optimising outcomes for affected children.
Related publications (21)
Atypical development of Broca's area in a large family with inherited stuttering
Daisy GY Thompson-Lake, Thomas S Scerri, Susan Block, Samantha J Turner, Sheena Reilly, Elaina Kefalianos, Alexandra F Bonthrone, Ingo Helbig, Melanie Bahlo, Ingrid E Scheffer, Michael S Hildebrand, Frederique J Liegeois, Angela T Morgan
Developmental stuttering is a condition of speech dysfluency, characterized by pauses, blocks, prolongations and sound or syllable..
Severe speech impairment is a distinguishing feature of FOXP1-related disorder
Ruth O Braden, David J Amor, Simon E Fisher, Cristina Mei, Candace T Myers, Heather Mefford, Deepak Gill, Siddharth Srivastava, Lindsay C Swanson, Himanshu Goel, Ingrid E Scheffer, Angela T Morgan
AIM: To delineate the speech and language phenotype of a cohort of individuals with FOXP1-related disorder. METHOD: We administere..
A Modeling-Guided Case Study of Disordered Speech in Minimally Verbal Children With Autism Spectrum Disorder
Karen Chenausky, Amanda Brignell, Angela T Morgan, Andrea C Norton, Helen B Tager-Flusberg, Gottfried Schlaug, Frank H Guenther
Purpose Understanding what limits speech development in minimally verbal (MV) children with autism spectrum disorder (ASD) is impo..
Speech, Language, and Oromotor Skills in Patients With Polymicrogyria
Ruth O Braden, Jessica O Boyce, Chloe A Stutterd, Kate Pope, Himanshu Goel, Richard J Leventer, Ingrid E Scheffer, Angela T Morgan
OBJECTIVE: To determine whether specific speech, language, and oromotor profiles are associated with different patterns of polymic..
Interventions for children and adolescents who stutter: A systematic review, meta-analysis, and evidence map
Amanda Brignell, Michelle Krahe, Martin Downes, Elaina Kefalianos, Sheena Reilly, Angela Morgan
PURPOSE: This systematic review critically appraises and maps the evidence for stuttering interventions in childhood and adolescen..
Factor analysis of signs of childhood apraxia of speech
Karen Chenausky, Amanda Brignell, Angela Morgan, Danielle Gagne, Andrea Norton, Helen Tager-Flusberg, Gottfried Schlaug, Aaron Shield, Jordan R Green
PURPOSE: To investigate the latent factors underlying signs of childhood apraxia of speech (CAS) in a group of 57 children with CA..
A systematic review of interventions for adults who stutter
Amanda Brignell, Michelle Krahe, Martin Downes, Elaina Kefalianos, Sheena Reilly, Angela T Morgan
Purpose To examine the effectiveness of (i) face to face interventions (ii) models of service delivery and (iii) psychological tre..
Severe childhood speech disorder: Gene discovery highlights transcriptional dysregulation
Michael S Hildebrand, Victoria E Jackson, Thomas S Scerri, Olivia Van Reyk, Matthew Coleman, Ruth O Braden, Samantha Turner, Kristin A Rigbye, Amber Boys, Sarah Barton, Richard Webster, Michael Fahey, Kerryn Saunders, Bronwyn Parry-Fielder, Georgia Paxton, Michael Hayman, David Coman, Himanshu Goel, Anne Baxter, Alan Ma
OBJECTIVE: Determining the genetic basis of speech disorders provides insight into the neurobiology of human communication. Despit..
Prevalence and features of comorbid stuttering and speech sound disorder at age 4 years
Rachael Unicomb, Elaina Kefalianos, Sheena Reilly, Fallon Cook, Angela Morgan
BACKGROUND: Stuttering and speech sound disorder may co-occur during early childhood, although the exact rate of comorbidity in a ..
Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response
Jennifer L Johnson, Loredana Stoica, Yuwei Liu, Ping Jun Zhu, Abhisek Bhattacharya, Shelly A Buffington, Redwan Huq, N Tony Eissa, Ola Larsson, Bo T Porse, Deepti Domingo, Urwah Nawaz, Renee Carroll, Lachlan Jolly, Tom S Scerri, Hyung-Goo Kim, Amanda Brignell, Matthew J Coleman, Ruth Braden, Usha Kini
In humans, disruption of nonsense-mediated decay (NMD) has been associated with neurodevelopmental disorders (NDDs) such as autism..
Recessive variants in ZNF142 cause a complex neurodevelopmental disorder with intellectual disability, speech impairment, seizures, and dystonia
Kamal Khan, Michael Zech, Angela T Morgan, David J Amor, Matej Skorvanek, Tahir N Khan, Michael S Hildebrand, Victoria E Jackson, Thomas S Scerri, Matthew Coleman, Kristin A Rigbye, Ingrid E Scheffer, Melanie Bahlo, Matias Wagner, Daniel D Lam, Riccardo Berutti, Petra Havrankova, Anna Fecikova, Tim M Strom, Vladimir Han
PURPOSE: The purpose of this study was to expand the genetic architecture of neurodevelopmental disorders, and to characterize the..
Expansion of phenotype of DDX3X syndrome: six new cases
Bryony Beal, Ian Hayes, Julie McGaughran, David J Amor, Christina Miteff, Victoria Jackson, Olivia van Reyk, Gopinath Subramanian, Michael S Hildebrand, Angela T Morgan, Himanshu Goel
Pathogenic variants in DDX3X have recently been identified to be a relatively common cause of intellectual disability in females. ..
Looking to the Future: Speech, Language, and Academic Outcomes in an Adolescent with Childhood Apraxia of Speech
Samantha J Turner, Adam P Vogel, Bronwyn Parry-Fielder, Rhonda Campbell, Ingrid E Scheffer, Angela T Morgan
OBJECTIVE: The clinical course of childhood apraxia of speech (CAS) is poorly understood. Of the few longitudinal studies in the f..
Speech and language in bilateral perisylvian polymicrogyria: a systematic review
Ruth O Braden, Richard J Leventer, Anna Jansen, Ingrid E Scheffer, Angela T Morgan
AIM: We aimed to systematically review the speech production, language, and oral function phenotype of bilateral perisylvian polym..
A set of regulatory genes co-expressed in embryonic human brain is implicated in disrupted speech development
Else Eising, Amaia Carrion-Castillo, Arianna Vino, Edythe A Strand, Kathy J Jakielski, Thomas S Scerri, Michael S Hildebrand, Richard Webster, Alan Ma, Bernard Mazoyer, Clyde Francks, Melanie Bahlo, Ingrid E Scheffer, Angela T Morgan, Lawrence D Shriberg, Simon E Fisher
Genetic investigations of people with impaired development of spoken language provide windows into key aspects of human biology. O..
Dorsal language stream anomalies in an inherited speech disorder
Frederique J Liegeois, Samantha J Turner, Angela Mayes, Alexandra F Bonthrone, Amber Boys, Libby Smith, Bronwyn Parry-Fielder, Simone Mandelstam, Megan Spencer-Smith, Melanie Bahlo, Tom S Scerri, Michael S Hildebrand, Ingrid E Scheffer, Alan Connelly, Angela T Morgan
Speech disorders are highly prevalent in the preschool years, but frequently resolve. The neurobiological basis of the most persis..
Receptive and expressive language characteristics of school-aged children with non-syndromic cleft lip and/or palate
Jessica O Boyce, Nicky Kilpatrick, Sheena Reilly, Annette Da Costa, Angela T Morgan
BACKGROUND: Research investigating language skills in school-aged children with non-syndromic cleft lip and/or palate is sparse. P..
Atypical Callosal Morphology in Children with Speech Sound Disorder
Eileen Luders, Florian Kurth, Lauren Pigdon, Gina Conti-Ramsden, Sheena Reilly, Angela T Morgan
Speech sound disorder (SSD) is common, yet its neurobiology is poorly understood. Recent studies indicate atypical structural and ..
Improving child speech disorder assessment by incorporating out-of-domain adult speech
Daniel Smith, Alex Sneddon, Lauren Ward, Andreas Duenser, Jill Freyne, David Silvera-Tawil, Angela Morgans
This paper describes the continued development of a system to provide early assessment of speech development issues in children an..