THE ROLE OF ESTROGEN SIGNALLING IN THE DEVELOPMENT AND PROGRESS OF NEOVASCULARISATION IN MACULAR DEGENERATION

Grant number: 1141587 | Funding period: 2018 - 2023

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Abstract

Age-related macular degeneration is a common eye disease. In the advanced stages of the disease, abnormal and leaky blood vessels form, causing permanent and severe vision loss. A novel treatment is the application of the sex hormone, estrogen, which could halt abnormal blood vessel growth in the eye. This project aims to confirm the protective effects of estrogen on eye health and whether mutations in estrogen-related genes alter the risk of vision loss due to abnormal blood vessel growth.

University of Melbourne Researchers