BENCH TO BESIDE TRANSLATIONAL STUDIES TO DEVELOP TREATMENTS FOR PREECLAMPSIA
Grant number: 1142636 | Funding period: 2018 - 2022
Preeclampsia is a common, devastating complication of pregnancy responsible for the loss of countless mothers and babies. There is no medical treatment. Excitingly we have identified 2 medications, safe in pregnancy: metformin and sulfasalazine that may treat this disease. We plan to introduce these medications into the clinic to see whether they may be an effective treatment for preeclampsia. If successful, these medications have the potential to improve the lives of women and babies globally.
Related publications (10)
Growth trajectory of preterm small-for-gestational-age neonates
Claire L Molony, Richard Hiscock, Jonathan Kaufman, Emerson Keenan, Roxanne Hastie, Fiona C Brownfoot
AIM: To assess the growth trajectory of preterm small-for-gestational-age (SGA) neonates compared to preterm non-small-for-gestati..
Nicotinamide and its effects on endothelial dysfunction and secretion of antiangiogenic factors by primary human placental cells and tissues
Fiona Brownfoot, Natalie Binder, Roxanne Hastie, Alesia Harper, Sally Beard, Laura Tuohey, Emerson Keenan, Stephen Tong, Natalie Hannan
Preeclampsia is a serious pregnancy complication associated with elevated antiangiogenic markers and endothelial dysfunction. Rece..
Management of late preterm preeclampsia: a comparison of maternal and fetal indications for delivery
Stephanie Galibert, Emerson Keenan, Roxanne Hastie, Fiona C Brownfoot
OBJECTIVE: To investigate delivery indications for women with late preterm preeclampsia and evaluate whether disease characteristi..
Pravastatin as the statin of choice for reducing pre-eclampsia-associated endothelial dysfunction
Natasha de Alwis, Sally Beard, Yeukai T Mangwiro, Natalie K Binder, Tu'uhevaha J Kaitu'u-Lino, Fiona C Brownfoot, Stephen Tong, Natalie J Hannan
OBJECTIVES: There is avid interest in pravastatin as a therapeutic intervention for pre-eclampsia, however little is known on stat..
Accuracy of clinical suspicion of growth restriction at term despite a normal growth ultrasound: A retrospective cohort study
Brittany Green, Lisa Hui, Roxanne Hastie, Stephen Tong, Fiona C Brownfoot
BACKGROUND: Small for gestational age (SGA) is a major determinant of poor perinatal outcome. Detecting SGA at term using ultrasou..
Entropy Profiling for Detection of Fetal Arrhythmias in Short Length Fetal Heart Rate Recordings
Emerson Keenan, Radhagayrathi K Udhayakumar, Chandan K Karmakar, Fiona C Brownfoot, Marimuthu Palaniswami
The use of fetal heart rate (FHR) recordings for assessing fetal wellbeing is an integral component of obstetric care. Recently, n..
Systematic review of areca (betel nut) use and adverse pregnancy outcomes
Manarangi De Silva, Leeanne Panisi, Fiona C Brownfoot, Anthea Lindquist, Susan P Walker, Stephen Tong, Roxanne Hastie
BACKGROUND: Betel nut is the fourth most commonly abused substance worldwide and has been associated with significant adverse heal..
Prediction of adverse maternal outcomes in preeclampsia at term
Tarini D Paul, Roxanne Hastie, Stephen Tong, Emerson Keenan, Richard Hiscock, Fiona C Brownfoot
Preeclampsia complicates 5-8% of all pregnancies and is associated with high rates of maternal and perinatal morbidity. The majori..