BENCH TO BESIDE TRANSLATIONAL STUDIES TO DEVELOP TREATMENTS FOR PREECLAMPSIA

Influence of the photopolymerization matrix on the indicator response of optical fiber pH sensors

KJ Lee, PK Capon, H Ebendorff-Heidepriem, E Keenan, F Brownfoot, EP Schartner

2023-02-01

Optical fiber pH sensors work by observing a change in the indicator's optical signal caused by variations in pH and these indicat..

Sulfasalazine for the treatment of preeclampsia in a nitric oxide synthase antagonist mouse model.

Natalie K Binder, Natasha de Alwis, Sally Beard, Elif Kadife, Alesia Harper, Tu'uhevaha J Kaitu'u-Lino, Fiona C Brownfoot, Natalie J Hannan

2023-02-01

INTRODUCTION: Development of a therapeutic that targets the pathophysiological elements of preeclampsia would be a major advance f..

An estriol-eluting pessary to treat pelvic organ prolapse.

Jingjunjiao Long, Ghada Zidan, Ali Seyfoddin, Stephen Tong, Fiona C Brownfoot, Prathima Chowdary

2022-11-21

Pelvic organ prolapse affects up to 50% of parous women. Commonly used treatment options have unwelcome attributes; pessaries can ..

The effect of metformin on cardiovascular markers in female mice consuming a high fat diet.

Natasha de Alwis, Natalie K Binder, Yeukai TM Mangwiro, Natasha Pritchard, Sally Beard, Tu'uhevaha J Kaitu'u-Lino, Fiona Brownfoot, Natalie J Hannan

2022-11-01

BACKGROUND: Metformin, widely used to treat diabetes, is now considered a candidate therapeutic for treatment of cardiovascular di..

Associations Between Soluble fms-Like Tyrosine Kinase-1 and Placental Growth Factor and Disease Severity Among Women With Preterm Eclampsia and Preeclampsia

Roxanne Hastie, Lina Bergman, Susan P Walker, Tu'uhevaha Kaitu'u-Lino, Natalie J Hannan, Fiona Brownfoot, Sonja Schell, Alesia Harper, Ping Cannon, Catherine A Cluver, Stephen Tong

2022-08-16

Background The angiogenic factors soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) are postulated to..

Detection of fetal arrhythmias in non-invasive fetal ECG recordings using data-driven entropy profiling

Emerson Keenan, Chandan Karmakar, Radhagayathri K Udhayakumar, Fiona C Brownfoot, Igor Lakhno, Vyacheslav Shulgin, Joachim A Behar, Marimuthu Palaniswami

2022-02-28

Objective.Fetal arrhythmias are a life-threatening disorder occurring in up to 2% of pregnancies. If identified, many fetal arrhyt..

Hydroxychloroquine reduces soluble Flt-1 secretion from human cytotrophoblast, but does not mitigate markers of endothelial dysfunction in vitro.

Elif Kadife, Natalie Hannan, Alesia Harper, Natalie Binder, Sally Beard, Fiona C Brownfoot

2022-01-01

Preeclampsia is a multi-system disease that can have severe, even fatal implications for the mother and fetus. Abnormal placentati..

Evaluation of Mesh and Sensor Resolution for Finite Element Modeling of Non-Invasive Fetal ECG Signals.

Emerson Keenan, Chandan Karmakar, Fiona C Brownfoot, Marimuthu Palaniswami

2021-11-01

Non-invasive fetal electrocardiography (NI-FECG) is an emerging tool with novel diagnostic potential for monitoring fetal wellbein..

Growth trajectory of preterm small-for-gestational-age neonates

Claire L Molony, Richard Hiscock, Jonathan Kaufman, Emerson Keenan, Roxanne Hastie, Fiona C Brownfoot

2021-09-10

AIM: To assess the growth trajectory of preterm small-for-gestational-age (SGA) neonates compared to preterm non-small-for-gestati..

Nicotinamide and its effects on endothelial dysfunction and secretion of antiangiogenic factors by primary human placental cells and tissues

Fiona Brownfoot, Natalie Binder, Roxanne Hastie, Alesia Harper, Sally Beard, Laura Tuohey, Emerson Keenan, Stephen Tong, Natalie Hannan

2021-06-01

Preeclampsia is a serious pregnancy complication associated with elevated antiangiogenic markers and endothelial dysfunction. Rece..

Uncovering the Molecular Cause of Preeclampsia-The Role of Glutathionylation of the Na plus /K plus ATPase Transporter

Fiona Claire Brownfoot

2021-02-22

Management of late preterm preeclampsia: a comparison of maternal and fetal indications for delivery

Stephanie Galibert, Emerson Keenan, Roxanne Hastie, Fiona C Brownfoot

2021-02-01

OBJECTIVE: To investigate delivery indications for women with late preterm preeclampsia and evaluate whether disease characteristi..

Personalized Anatomic Modeling for Noninvasive Fetal ECG: Methodology and Applications

Emerson Keenan, Chandan Karmakar, Fiona C Brownfoot, Marimuthu Palaniswami

2021-01-01

Fetal cardiac monitoring is one of the cornerstones of modern obstetric care. Noninvasive fetal electrocardiography (NI-FECG) is a..

Novel approaches to combat preeclampsia: from new drugs to innovative delivery

Natasha de Alwis, Natalie K Binder, Sally Beard, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong, Fiona Brownfoot, Natalie J Hannan

2020-12-01

Preeclampsia is a complex disease affecting 2-8% of pregnancies worldwide. It poses significant risk of maternal and perinatal mor..

Esomeprazole and sulfasalazine in combination additively reduce sFlt-1 secretion and diminish endothelial dysfunction: potential for a combination treatment for preeclampsia

Natalie K Binder, Fiona C Brownfoot, Sally Beard, Ping Cannon, Tuong V Nguyen, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino, Natalie J Hannan

2020-10-01

Development and repurposing of therapies that show promise in the prevention or treatment of preeclampsia would be a major advance..

Combining metformin and sulfasalazine additively reduces the secretion of antiangiogenic factors from the placenta: Implications for the treatment of preeclampsia

Fiona C Brownfoot, Roxanne Hastie, Natalie J Hannan, Ping Cannon, Tuong Nguyen, Laura Tuohey, Cathy Cluver, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

2020-06-01

INTRODUCTION: The antiangiogenic factors soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sENG) are elevated in p..

Pravastatin as the statin of choice for reducing pre-eclampsia-associated endothelial dysfunction

Natasha de Alwis, Sally Beard, Yeukai T Mangwiro, Natalie K Binder, Tu'uhevaha J Kaitu'u-Lino, Fiona C Brownfoot, Stephen Tong, Natalie J Hannan

2020-04-01

OBJECTIVES: There is avid interest in pravastatin as a therapeutic intervention for pre-eclampsia, however little is known on stat..

Accuracy of clinical suspicion of growth restriction at term despite a normal growth ultrasound: A retrospective cohort study

Brittany Green, Lisa Hui, Roxanne Hastie, Stephen Tong, Fiona C Brownfoot

2020-01-09

BACKGROUND: Small for gestational age (SGA) is a major determinant of poor perinatal outcome. Detecting SGA at term using ultrasou..

Entropy Profiling for Detection of Fetal Arrhythmias in Short Length Fetal Heart Rate Recordings

Emerson Keenan, Radhagayrathi K Udhayakumar, Chandan K Karmakar, Fiona C Brownfoot, Marimuthu Palaniswami

2020-01-01

The use of fetal heart rate (FHR) recordings for assessing fetal wellbeing is an integral component of obstetric care. Recently, n..

Sulfasalazine decreases soluble fms-like tyrosine kinase-1 secretion potentially via inhibition of upstream placental epidermal growth factor receptor signalling

Roxanne Hastie, Fiona C Brownfoot, Ping Cannon, Nguyen Vi, Laura Tuohey, Natalie J Hannan, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

2019-11-01

OBJECTIVES: Preeclampsia is a hypertensive disorder of pregnancy with no available medical treatment. We recently reported sulfasa..

Systematic review of areca (betel nut) use and adverse pregnancy outcomes

Manarangi De Silva, Leeanne Panisi, Fiona C Brownfoot, Anthea Lindquist, Susan P Walker, Stephen Tong, Roxanne Hastie

2019-10-03

BACKGROUND: Betel nut is the fourth most commonly abused substance worldwide and has been associated with significant adverse heal..

Prediction of adverse maternal outcomes in preeclampsia at term

Tarini D Paul, Roxanne Hastie, Stephen Tong, Emerson Keenan, Richard Hiscock, Fiona C Brownfoot

2019-10-01

Preeclampsia complicates 5-8% of all pregnancies and is associated with high rates of maternal and perinatal morbidity. The majori..

Predictive Value of the Signs and Symptoms Preceding Eclampsia A Systematic Review

Roxanne Hastie, Fiona C Brownfoot, Catherine A Cluver, Susan P Walker, Susanne Hesselman, Stephen Tong, Lina Bergman

2019-10-01

OBJECTIVE: To estimate the predictive value of signs and symptoms that occur before onset of eclampsia among pregnant women. DATA ..

Proton Pump Inhibitors and Preeclampsia Risk Among 157 720 Women A Swedish Population Register-Based Cohort Study

Roxanne Hastie, Lina Bergman, Catherin A Cluver, Anna Wikman, Natalie J Hannan, Susan P Walker, Anna-Karin Wikstrom, Stephen Tong, Susanne Hesselman

2019-05-01

Preeclampsia is a hypertensive disorder of pregnancy characterized by maternal endothelial dysfunction and end-organ damage. The a..

A Systematic Review of Proton Pump Inhibitors for the Prevention and Treatment of Preeclampsia and Gestational Hypertension

Manarangi De Silva, Fiona Brownfoot, Natalie J Hannan, Susan P Walker, Catherine A Cluver, Anthea Lindquist, Stephen Tong, Roxanne Hastie

2019-01-01

Disulfiram inhibits placental soluble FMS-like tyrosine kinase-1 and soluble endoglin secretion independent of the proteasome

Roxanne Hastie, Louie Ye, Natalie J Hannan, Fiona C Brownfoot, Ping Cannon, Vi Nguyen, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

2018-10-01

Preeclampsia is associated with intermittent placental hypoxia, inflammation and the release of antiangiogenic factors, namely sFL..