EFFECTS OF TESTOSTERONE AND OESTROGEN ON BODY COMPOSITION

Grant number: 1143333 | Funding period: 2018 - 2021

Active

Abstract

Masculinising and feminising hormones such as testosterone and oestrogen respectively are important hormones controlling the amount of muscle, fat and bone in the body. By studying people with conditions such as prostate cancer where these hormone levels are disrupted, we aim to understand how testosterone and oestrogen affects various body systems, which may lead to new treatments for important public health problems of frailty, obesity and heart disease, and osteoporosis.

Related publications (23)

Scholarly works icon

Feminizing Hormone Therapy Prescription Patterns and Cardiovascular Risk Factors in Aging Transgender Individuals in Australia

Matthew I Balcerek, Brendan J Nolan, Adam Brownhill, Peggy Wong, Peter Locke, Jeffrey D Zajac, Ada S Cheung

<jats:sec><jats:title>Context</jats:title><jats:p>The safety and efficacy of feminizing hormone therapy in aging transgender (tran..

Scholarly works icon

Prevalence of polycythaemia with different formulations of testosterone therapy in transmasculine individuals

Brendan J Nolan, Shalem Y Leemaqz, Olivia Ooi, Pauline Cundill, Nicholas Silberstein, Peter Locke, Mathis Grossmann, Jeffrey D Zajac, Ada S Cheung

2021-06-01

BACKGROUND: Masculinising hormone therapy with testosterone is used to align an individual's physical characteristics with his or ..

Scholarly works icon

Efficacy of Micronized Progesterone for Sleep: A Systematic Review and Meta-analysis of Randomized Controlled Trial Data

Brendan J Nolan, Bonnie Liang, Ada S Cheung

2021-04-01

CONTEXT: Preclinical data has shown progesterone metabolites improve sleep parameters through positive allosteric modulation of th..

Scholarly works icon

Approach to Interpreting Common Laboratory Pathology Tests in Transgender Individuals

Ada S Cheung, Hui Yin Lim, Teddy Cook, Sav Zwickl, Ariel Ginger, Cherie Chiang, Jeffrey D Zajac

2021-03-01

CONTEXT: As the number of transgender (trans) people (including those who are binary and/or nonbinary identified) seeking gender-a..

Scholarly works icon

The impact of the first three months of the COVID-19 pandemic on the Australian trans community

Sav Zwickl, Lachlan M Angus, Alex Wong Fang Qi, Ariel Ginger, Kalen Eshin, Teddy Cook, Shalem Y Leemaqz, Eden Dowers, Jeffrey D Zajac, Ada S Cheung

2021-02-19

Background: Trans and gender diverse individuals (people who identify with a gender different to what was presumed for them at bir..

Scholarly works icon

The Informed Consent Model of Care for Accessing Gender-Affirming Hormone Therapy Is Associated With High Patient Satisfaction

Cassandra Spanos, Julian A Grace, Shalem Y Leemaqz, Adam Brownhill, Pauline Cundill, Peter Locke, Peggy Wong, Jeffrey D Zajac, Ada S Cheung

2021-01-01

BACKGROUND: There are 2 common approaches to assess an individual before commencing of gender-affirming hormone therapy (GAHT); a ..

Scholarly works icon

Zoledronic acid does not affect insulin resistance in men receiving androgen deprivation therapy: a prespecified secondary analysis of a randomised controlled trial.

Ada S Cheung, Rudolf Hoermann, Jasmine Zhu, Daryl Lim Joon, Jeffrey D Zajac, Mathis Grossmann

2021-01-01

Background: Animal studies suggest that undercarboxylated osteocalcin may improve insulin sensitivity via its effect on testicular..

Scholarly works icon

A systematic review of antiandrogens and feminization in transgender women

Lachlan M Angus, Brendan J Nolan, Jeffrey D Zajac, Ada S Cheung

2020-10-05

Antiandrogens are frequently used with estradiol in transgender women seeking feminization. Antiandrogens act by various mechanism..

Scholarly works icon

Differing Effects of Zoledronic Acid on Bone Microarchitecture and Bone Mineral Density in Men Receiving Androgen Deprivation Therapy: A Randomized Controlled Trial

Ada S Cheung, Rudolf Hoermann, Ali Ghasem-Zadeh, Alistair J Tinson, Vivian Ly, Stefan Milevski, Daryl Lim Joon, Jeffrey D Zajac, Ego Seeman, Mathis Grossmann

2020-07-06

Androgen deprivation therapy (ADT) given to men with prostate cancer causes rapid and severe sex steroid deficiency, leading to in..

Scholarly works icon

Global Coagulation Assays in Transgender Women on Oral and Transdermal Estradiol Therapy

Hui Yin Lim, Shalem Y Leemaqz, Niloufar Torkamani, Mathis Grossmann, Jeffrey D Zajac, Harshal Nandurkar, Prahlad Ho, Ada S Cheung

2020-07-01

Context The thrombotic effects of estradiol therapy in transgender women are unclear. Global coagulation assays (GCA) may be bette..

Scholarly works icon

Testosterone therapy considerations in oestrogen, progesterone and androgen receptor-positive breast cancer in a transgender man

Melanie Light, Thomas McFarlane, Andrew Ives, Bhaumik Shah, Elgene Lim, Mathis Grossmann, Jeffrey D Zajac, Ada S Cheung

2020-06-26

A 44-year-old premenopausal individual assigned female at birth but with a male gender identity, presented requesting masculinizin..

Scholarly works icon

Sustained remission of Lynch syndrome-associated metastatic adrenocortical carcinoma following checkpoint inhibitor therapy-associated multiorgan autoimmunity

Aditi Nevgi, Oliver Klein, Ada S Cheung

2020-06-09

Adrenocortical carcinoma (ACC) is a rare and aggressive tumour with limited treatment options for metastatic disease1 . Immunother..

Scholarly works icon

Non-Binary and Binary Gender Identity in Australian Trans and Gender Diverse Individuals

Ada S Cheung, Shalem Y Leemaqz, John WP Wong, Denise Chew, Olivia Ooi, Pauline Cundill, Nicholas Silberstein, Peter Locke, Sav Zwickl, Ren Grayson, Jeffrey D Zajac, Ken C Pang

2020-04-13

Many trans and gender diverse (TGD) people have gender identities that are not exclusively male or female but instead fall in-betw..

Scholarly works icon

Prevalence of Autism Spectrum Disorder and Attention-Deficit Hyperactivity Disorder Amongst Individuals with Gender Dysphoria: A Systematic Review

Emily Thrower, Ingrid Bretherton, Ken C Pang, Jeffrey D Zajac, Ada S Cheung

2020-03-01

Autism spectrum disorders (ASD) and attention-deficit hyperactivity disorder (ADHD) can compromise health and may be more prevalen..

Scholarly works icon

Australian endocrinologists need more training in transgender health: A national survey

Ingrid Bretherton, Mathis Grossmann, Shalem Y Leemaqz, Jeffrey D Zajac, Ada S Cheung

2020-01-01

OBJECTIVE: An increasing number of trans and gender diverse (TGD) individuals are seeking gender-affirming hormone therapy for gen..

Scholarly works icon

Health Needs of Trans and Gender Diverse Adults in Australia: A Qualitative Analysis of a National Community Survey

Sav Zwickl, Alex Wong, Ingrid Bretherton, Max Rainier, Daria Chetcuti, Jeffrey D Zajac, Ada S Cheung

2019-12-02

There is an increasing demand for trans and gender diverse (TGD) health services worldwide. Given the unique and diverse healthcar..

Scholarly works icon

Position statement on the hormonal management of adult transgender and gender diverse individuals

Ada S Cheung, Katie Wynne, Jaco Erasmus, Sally Murray, Jeffrey D Zajac

2019-08-01

INTRODUCTION: Rising demand for gender-affirming hormone therapy mandates a need for more formalised care of transgender and gende..

Scholarly works icon

Biomechanical leg muscle function during stair ambulation in men receiving androgen deprivation therapy.

Ada S Cheung, Hans A Gray, Anthony G Schache, Rudolf Hoermann, Jarrod Bicknell, Daryl Lim Joon, Jeffrey D Zajac, Marcus G Pandy, Mathis Grossmann

2019-07-16

BACKGROUND: The role of testosterone in maintaining functional performance in older men remains uncertain. METHODS: We conducted a..

Scholarly works icon

Cyproterone acetate or spironolactone in lowering testosterone concentrations for transgender individuals receiving oestradiol therapy

Lachlan Angus, Shalem Leemaqz, Olivia Ooi, Pauline Cundill, Nicholas Silberstein, Peter Locke, Jeffrey D Zajac, Ada S Cheung

2019-07-01

Background: Oestradiol with or without an anti-androgen (cyproterone acetate or spironolactone) is commonly prescribed in transfem..

Scholarly works icon

Selective Loss of Levator Ani and Leg Muscle Volumes in Men Undergoing Androgen Deprivation Therapy

Ada S Cheung, Christopher Cunningham, Dong-Kyoon Daniel Ko, Vivian Ly, Hans Gray, Rudolf Hoermann, Boyd JG Strauss, Ebrahim Bani Hassan, Gustavo Duque, Peter Ebeling, Marcus G Pandy, Jeffrey D Zajac, Mathis Grossmann

2019-06-01

CONTEXT: Androgen deprivation therapy (ADT) for prostate cancer (PCa) leads to a selective loss of leg muscle function during walk..

Scholarly works icon

Cross-sex hormone therapy in Australia: the prescription patterns of clinicians experienced in adult transgender healthcare

Ingrid Bretherton, Emily Thrower, Mathis Grossmann, Jeffrey D Zajac, Ada S Cheung

2019-02-01

BACKGROUND: Despite increasing demand for transgender healthcare, guidelines for cross-sex hormone therapy are based on low-level ..

Scholarly works icon

Gender-affirming hormone therapy and the risk of sex hormone-dependent tumours in transgender individuals-A systematic review

Thomas McFarlane, Jeffrey D Zajac, Ada S Cheung

2018-12-01

BACKGROUND: Cancers are a leading cause of death worldwide, and transgender individuals are no exception. The effects of gender-af..

Scholarly works icon

Sociodemographic and Clinical Characteristics of Transgender Adults in Australia.

Ada S Cheung, Olivia Ooi, Shalem Leemaqz, Pauline Cundill, Nicholas Silberstein, Ingrid Bretherton, Emily Thrower, Peter Locke, Mathis Grossmann, Jeffrey D Zajac

2018-01-01

Background: Over the last 10 years, increases in demand for transgender health care has occurred worldwide. There are few data on ..

University of Melbourne Researchers