EFFECTS OF TESTOSTERONE AND OESTROGEN ON BODY COMPOSITION
Grant number: 1143333 | Funding period: 2018 - 2021
Masculinising and feminising hormones such as testosterone and oestrogen respectively are important hormones controlling the amount of muscle, fat and bone in the body. By studying people with conditions such as prostate cancer where these hormone levels are disrupted, we aim to understand how testosterone and oestrogen affects various body systems, which may lead to new treatments for important public health problems of frailty, obesity and heart disease, and osteoporosis.
Related publications (23)
Feminizing Hormone Therapy Prescription Patterns and Cardiovascular Risk Factors in Aging Transgender Individuals in Australia
Matthew I Balcerek, Brendan J Nolan, Adam Brownhill, Peggy Wong, Peter Locke, Jeffrey D Zajac, Ada S Cheung
<jats:sec><jats:title>Context</jats:title><jats:p>The safety and efficacy of feminizing hormone therapy in aging transgender (tran..
Prevalence of polycythaemia with different formulations of testosterone therapy in transmasculine individuals
Brendan J Nolan, Shalem Y Leemaqz, Olivia Ooi, Pauline Cundill, Nicholas Silberstein, Peter Locke, Mathis Grossmann, Jeffrey D Zajac, Ada S Cheung
BACKGROUND: Masculinising hormone therapy with testosterone is used to align an individual's physical characteristics with his or ..
Efficacy of Micronized Progesterone for Sleep: A Systematic Review and Meta-analysis of Randomized Controlled Trial Data
Brendan J Nolan, Bonnie Liang, Ada S Cheung
CONTEXT: Preclinical data has shown progesterone metabolites improve sleep parameters through positive allosteric modulation of th..
Approach to Interpreting Common Laboratory Pathology Tests in Transgender Individuals
Ada S Cheung, Hui Yin Lim, Teddy Cook, Sav Zwickl, Ariel Ginger, Cherie Chiang, Jeffrey D Zajac
CONTEXT: As the number of transgender (trans) people (including those who are binary and/or nonbinary identified) seeking gender-a..
The impact of the first three months of the COVID-19 pandemic on the Australian trans community
Sav Zwickl, Lachlan M Angus, Alex Wong Fang Qi, Ariel Ginger, Kalen Eshin, Teddy Cook, Shalem Y Leemaqz, Eden Dowers, Jeffrey D Zajac, Ada S Cheung
Background: Trans and gender diverse individuals (people who identify with a gender different to what was presumed for them at bir..
The Informed Consent Model of Care for Accessing Gender-Affirming Hormone Therapy Is Associated With High Patient Satisfaction
Cassandra Spanos, Julian A Grace, Shalem Y Leemaqz, Adam Brownhill, Pauline Cundill, Peter Locke, Peggy Wong, Jeffrey D Zajac, Ada S Cheung
BACKGROUND: There are 2 common approaches to assess an individual before commencing of gender-affirming hormone therapy (GAHT); a ..
Zoledronic acid does not affect insulin resistance in men receiving androgen deprivation therapy: a prespecified secondary analysis of a randomised controlled trial.
Ada S Cheung, Rudolf Hoermann, Jasmine Zhu, Daryl Lim Joon, Jeffrey D Zajac, Mathis Grossmann
Background: Animal studies suggest that undercarboxylated osteocalcin may improve insulin sensitivity via its effect on testicular..
Differing Effects of Zoledronic Acid on Bone Microarchitecture and Bone Mineral Density in Men Receiving Androgen Deprivation Therapy: A Randomized Controlled Trial
Ada S Cheung, Rudolf Hoermann, Ali Ghasem-Zadeh, Alistair J Tinson, Vivian Ly, Stefan Milevski, Daryl Lim Joon, Jeffrey D Zajac, Ego Seeman, Mathis Grossmann
Androgen deprivation therapy (ADT) given to men with prostate cancer causes rapid and severe sex steroid deficiency, leading to in..
Global Coagulation Assays in Transgender Women on Oral and Transdermal Estradiol Therapy
Hui Yin Lim, Shalem Y Leemaqz, Niloufar Torkamani, Mathis Grossmann, Jeffrey D Zajac, Harshal Nandurkar, Prahlad Ho, Ada S Cheung
Context The thrombotic effects of estradiol therapy in transgender women are unclear. Global coagulation assays (GCA) may be bette..
Testosterone therapy considerations in oestrogen, progesterone and androgen receptor-positive breast cancer in a transgender man
Melanie Light, Thomas McFarlane, Andrew Ives, Bhaumik Shah, Elgene Lim, Mathis Grossmann, Jeffrey D Zajac, Ada S Cheung
A 44-year-old premenopausal individual assigned female at birth but with a male gender identity, presented requesting masculinizin..
Sustained remission of Lynch syndrome-associated metastatic adrenocortical carcinoma following checkpoint inhibitor therapy-associated multiorgan autoimmunity
Aditi Nevgi, Oliver Klein, Ada S Cheung
Adrenocortical carcinoma (ACC) is a rare and aggressive tumour with limited treatment options for metastatic disease1 . Immunother..
Non-Binary and Binary Gender Identity in Australian Trans and Gender Diverse Individuals
Ada S Cheung, Shalem Y Leemaqz, John WP Wong, Denise Chew, Olivia Ooi, Pauline Cundill, Nicholas Silberstein, Peter Locke, Sav Zwickl, Ren Grayson, Jeffrey D Zajac, Ken C Pang
Many trans and gender diverse (TGD) people have gender identities that are not exclusively male or female but instead fall in-betw..
Prevalence of Autism Spectrum Disorder and Attention-Deficit Hyperactivity Disorder Amongst Individuals with Gender Dysphoria: A Systematic Review
Emily Thrower, Ingrid Bretherton, Ken C Pang, Jeffrey D Zajac, Ada S Cheung
Autism spectrum disorders (ASD) and attention-deficit hyperactivity disorder (ADHD) can compromise health and may be more prevalen..
Australian endocrinologists need more training in transgender health: A national survey
Ingrid Bretherton, Mathis Grossmann, Shalem Y Leemaqz, Jeffrey D Zajac, Ada S Cheung
OBJECTIVE: An increasing number of trans and gender diverse (TGD) individuals are seeking gender-affirming hormone therapy for gen..
Health Needs of Trans and Gender Diverse Adults in Australia: A Qualitative Analysis of a National Community Survey
Sav Zwickl, Alex Wong, Ingrid Bretherton, Max Rainier, Daria Chetcuti, Jeffrey D Zajac, Ada S Cheung
There is an increasing demand for trans and gender diverse (TGD) health services worldwide. Given the unique and diverse healthcar..
Position statement on the hormonal management of adult transgender and gender diverse individuals
Ada S Cheung, Katie Wynne, Jaco Erasmus, Sally Murray, Jeffrey D Zajac
INTRODUCTION: Rising demand for gender-affirming hormone therapy mandates a need for more formalised care of transgender and gende..
Biomechanical leg muscle function during stair ambulation in men receiving androgen deprivation therapy.
Ada S Cheung, Hans A Gray, Anthony G Schache, Rudolf Hoermann, Jarrod Bicknell, Daryl Lim Joon, Jeffrey D Zajac, Marcus G Pandy, Mathis Grossmann
BACKGROUND: The role of testosterone in maintaining functional performance in older men remains uncertain. METHODS: We conducted a..
Cyproterone acetate or spironolactone in lowering testosterone concentrations for transgender individuals receiving oestradiol therapy
Lachlan Angus, Shalem Leemaqz, Olivia Ooi, Pauline Cundill, Nicholas Silberstein, Peter Locke, Jeffrey D Zajac, Ada S Cheung
Background: Oestradiol with or without an anti-androgen (cyproterone acetate or spironolactone) is commonly prescribed in transfem..
Selective Loss of Levator Ani and Leg Muscle Volumes in Men Undergoing Androgen Deprivation Therapy
Ada S Cheung, Christopher Cunningham, Dong-Kyoon Daniel Ko, Vivian Ly, Hans Gray, Rudolf Hoermann, Boyd JG Strauss, Ebrahim Bani Hassan, Gustavo Duque, Peter Ebeling, Marcus G Pandy, Jeffrey D Zajac, Mathis Grossmann
CONTEXT: Androgen deprivation therapy (ADT) for prostate cancer (PCa) leads to a selective loss of leg muscle function during walk..
Cross-sex hormone therapy in Australia: the prescription patterns of clinicians experienced in adult transgender healthcare
Ingrid Bretherton, Emily Thrower, Mathis Grossmann, Jeffrey D Zajac, Ada S Cheung
BACKGROUND: Despite increasing demand for transgender healthcare, guidelines for cross-sex hormone therapy are based on low-level ..
Gender-affirming hormone therapy and the risk of sex hormone-dependent tumours in transgender individuals-A systematic review
Thomas McFarlane, Jeffrey D Zajac, Ada S Cheung
BACKGROUND: Cancers are a leading cause of death worldwide, and transgender individuals are no exception. The effects of gender-af..
Sociodemographic and Clinical Characteristics of Transgender Adults in Australia.
Ada S Cheung, Olivia Ooi, Shalem Leemaqz, Pauline Cundill, Nicholas Silberstein, Ingrid Bretherton, Emily Thrower, Peter Locke, Mathis Grossmann, Jeffrey D Zajac
Background: Over the last 10 years, increases in demand for transgender health care has occurred worldwide. There are few data on ..