THE METAFIND (METAGENOMICS FOR INFECTIOUS DISEASES) PROJECT: DEVELOPING CLINICAL METAGENOMICSTO IMPROVE THE HEALTHCARE OF PATIENTS WITH INFECTIONS

Optimising genomic approaches for identifying vancomycin-resistant Enterococcus faecium transmission in healthcare settings

Charlie Higgs, Norelle L Sherry, Torsten Seemann, Kristy Horan, Hasini Walpola, Paul Kinsella, Katherine Bond, Deborah A Williamson, Caroline Marshall, Jason C Kwong, M Lindsay Grayson, Timothy P Stinear, Claire L Gorrie, Benjamin P Howden

2022-01-26

Vancomycin-resistant Enterococcus faecium (VREfm) is a major nosocomial pathogen. Identifying VREfm transmission dynamics permits ..

Search and Contain: Impact of an Integrated Genomic and Epidemiological Surveillance and Response Program for Control of Carbapenemase-producing Enterobacterales

Courtney R Lane, Judith Brett, Mark Schultz, Claire L Gorrie, Kerrie Stevens, Donna RM Cameron, Siobhan St George, Annaliese van Diemen, Marion Easton, Rhonda L Stuart, Michelle Sait, Anton Y Peleg, Andrew J Stewardson, Allen C Cheng, Denis W Spelman, Mary Jo Waters, Susan A Ballard, Norelle L Sherry, Deborah A Williamson, Finn Romanes

2021-12-06

BACKGROUND: Multiresistant organisms (MROs) pose a critical threat to public health. Population-based programs for control of MROs..

Key parameters for genomics-based real-time detection and tracking of multidrug-resistant bacteria: a systematic analysis

Claire L Gorrie, Anders Goncalves Da Silva, Danielle J Ingle, Charlie Higgs, Torsten Seemann, Timothy P Stinear, Deborah A Williamson, Jason C Kwong, M Lindsay Grayson, Norelle L Sherry, Benjamin P Howden

2021-11-02

BACKGROUND: Pairwise single nucleotide polymorphisms (SNPs) are a cornerstone of genomic approaches to the inference of transmissi..

Staff to staff transmission as a driver of healthcare worker infections with COVID-19

Claire L Gordon, Jason A Trubiano, Natasha E Holmes, Kyra YL Chua, Jeff Feldman, Greg Young, Norelle L Sherry, M Lindsay Grayson, Jason C Kwong

2021-10-21

BACKGROUND: High rates of healthcare worker (HCW) infections due to COVID-19 have been attributed to several factors, including in..

Multi-site assessment of rapid, point-of-care antigen testing for the diagnosis of SARS-CoV-2 infection in a low-prevalence setting: A validation and implementation study

Stephen Muhi, Nick Tayler, Tuyet Hoang, Susan A Ballard, Maryza Graham, Amanda Rojek, Jason C Kwong, Jason A Trubiano, Olivia Smibert, George Drewett, Fiona James, Emma Gardiner, Socheata Chea, Nicole Isles, Michelle Sait, Shivani Pasricha, George Taiaroa, Julie McAuley, Eloise Williams, Katherine B Gibney

2021-03-02

BACKGROUND: In Australia, COVID-19 diagnosis relies on RT-PCR testing which is relatively costly and time-consuming. To date, few ..

Co-circulation of Multidrug-resistant Shigella Among Men Who Have Sex With Men in Australia

Danielle J Ingle, Marion Easton, Mary Valcanis, Torsten Seemann, Jason C Kwong, Nicola Stephens, Glen P Carter, Anders Goncalves da Silva, James Adamopoulos, Sarah L Baines, Kathryn E Holt, Eric PF Chow, Christopher K Fairley, Marcus Y Chen, Martyn D Kirk, Benjamin P Howden, Deborah A Williamson

2019-11-01

BACKGROUND: In urban Australia, the burden of shigellosis is either in returning travelers from shigellosis-endemic regions or in ..

Bridging of Neisseria gonorrhoeae lineages across sexual networks in the HIV pre-exposure prophylaxis era

Deborah A Williamson, Eric PF Chow, Claire L Gorrie, Torsten Seemann, Danielle J Ingle, Nasra Higgins, Marion Easton, George Taiaroa, Yonatan H Grad, Jason C Kwong, Christopher K Fairley, Marcus Y Chen, Benjamin P Howden

2019-09-05

Whole genome sequencing (WGS) has been used to investigate transmission of Neisseria gonorrhoeae, but to date, most studies have n..

Genomics for Molecular Epidemiology and Detecting Transmission of Carbapenemase-Producing Enterobacterales in Victoria, Australia, 2012 to 2016

Norelle L Sherry, Courtney R Lane, Jason C Kwong, Mark Schultz, Michelle Sait, Kerrie Stevens, Susan Ballard, Anders Goncalves da Silva, Torsten Seemann, Claire L Gorrie, Timothy P Stinear, Deborah A Williamson, Judith Brett, Annaliese van Diemen, Marion Easton, Benjamin P Howden

2019-09-01

Carbapenemase-producing Enterobacterales (CPE) are being increasingly reported in Australia, and integrated clinical and genomic s..

Reconstruction of the Genomes of Drug-Resistant Pathogens for Outbreak Investigation through Metagenomic Sequencing

Andre Mu, Jason C Kwong, Nicole S Isles, Anders Goncalves da Silva, Mark B Schultz, Susan A Ballard, Courtney R Lane, Glen P Carter, Deborah A Williamson, Torsten Seemann, Timothy P Stinear, Benjamin P Howden

2019-01-01

Culture-independent methods that target genome fragments have shown promise in identifying certain pathogens, but the holy grail o..

Beyond Penicillin: Rapid Desensitization for Specific Flucloxacillin Hypersensitivity

JC Kwong, K Urbancic, JA Trubiano

2018-12-01

Beta-lactam therapy for severe staphylococcal infections is associated with superior outcomes, compared to non-beta-lactam therapy..

The changing landscape of vancomycin-resistant Enterococcus faecium in Australia: a population-level genomic study

Robyn S Lee, Anders Goncalves da Silva, Sarah L Baines, Janet Strachan, Susan Ballard, Glen P Carter, Jason C Kwong, Mark B Schultz, Dieter M Bulach, Torsten Seemann, Timothy P Stinear, Benjamin P Howden

2018-12-01

BACKGROUND: Vancomycin-resistant Enterococcus faecium (VREfm) represent a major source of nosocomial infection worldwide. In Austr..