DEVELOPING AND EVALUATING A MULTIMODAL ANTIBIOTIC ALLERGY STRATEGY TO IMPROVE ANTIMICROBIAL STEWARDSHIP IN HIGH-RISK ANTIBIOTIC USAGE POPULATIONS
Grant number: 1139902 | Funding period: 2018 - 2022
Antibiotic allergies lead to the use of inferior antibiotics and generation of “superbugs”. Antibiotic allergy testing removes up to 90% of allergies, although remains unavailable to many and unreliable in some severe antibiotic reactions. We aim to validate antibiotic allergy bedside tools and programs, and develop laboratory tests that can diagnose and prevent severe antibiotic allergies, to improve appropriate antibiotic prescribing and patient outcomes.
Related publications (11)
Cross-reactivity between vancomycin, teicoplanin, and telavancin in patients with HLA-A∗32:01-positive vancomycin-induced DRESS sharing an HLA class II haplotype.
Nontaya Nakkam, Andrew Gibson, Effie Mouhtouris, Katherine C Konvinse, Natasha Holmes, Kyra Y Chua, Pooja Deshpande, Danmeng Li, David A Ostrov, Jason Trubiano, Elizabeth J Phillips
CAPSULE SUMMARY: All fifteen patients with HLA-A*32:01 restricted vancomycin-induced DRESS, showed negative ex vivo responses to d..
Development and Validation of a Penicillin Allergy Clinical Decision Rule
Jason A Trubiano, Sara Vogrin, Kyra YL Chua, Jack Bourke, James Yun, Abby Douglas, Cosby A Stone, Roger Yu, Lauren Groenendijk, Natasha E Holmes, Elizabeth J Phillips
Importance: Penicillin allergy is a significant public health issue for patients, antimicrobial stewardship programs, and health s..
Antimicrobial anaphylaxis: the changing face of severe antimicrobial allergy
Victoria Hall, Micah Wong, Maitri Munsif, Brittany R Stevenson, Katie Elliott, Michaela Lucas, Ashleigh J Baird, Eugene Athan, Melissa Young, Robert Pickles, Allen C Cheng, Andrew J Stewardson, Ar K Aung, Jason A Trubiano
OBJECTIVES: The epidemiology, clinical characteristics and outcomes of antimicrobial-associated anaphylaxis remain ill-defined. We..
Outcomes of an electronic medical record (EMR)-driven intensive care unit (ICU)-antimicrobial stewardship (AMS) ward round: Assessing the "Five Moments of Antimicrobial Prescribing"
Misha Devchand, Andrew J Stewardson, Karen F Urbancic, Sharmila Khumra, Andrew A Mahony, Steven Walker, Kent Garrett, M Lindsay Grayson, Jason A Trubiano
High prevalence of antibiotic allergies in cladribine-treated patients with hairy cell leukemia - lessons for immunopathogenesis and prescribing
Zaal Meher-Homji, Constantine S Tam, Jim Siderov, John Francis Seymour, Natasha E Holmes, Kyra YL Chua, Elizabeth J Phillips, Monica A Slavin, Jason A Trubiano