DEVELOPING AND EVALUATING A MULTIMODAL ANTIBIOTIC ALLERGY STRATEGY TO IMPROVE ANTIMICROBIAL STEWARDSHIP IN HIGH-RISK ANTIBIOTIC USAGE POPULATIONS

The Role of In Vivo and Ex Vivo Diagnostic Tools in Severe Delayed Immune-Mediated Adverse Antibiotic Drug Reactions

Ana Copaescu, Effie Mouhtouris, Sara Vogrin, Fiona James, Kyra YL Chua, Natasha E Holmes, Abby Douglas, Monica A Slavin, Heather Cleland, Celia Zubrinich, Ar Kar Aung, Michelle SY Goh, Elizabeth J Phillips, Jason A Trubiano

2021-05-01

BACKGROUND: The use of in vivo and ex vivo diagnostic tools for delayed immune-mediated adverse drug reactions is currently ill de..

Cross-reactivity between vancomycin, teicoplanin, and telavancin in patients with HLA-A*32:01-positive vancomycin-induced DRESS sharing an HLA class II haplotype

Nontaya Nakkam, Andrew Gibson, Effie Mouhtouris, Katherine C Konvinse, Natasha E Holmes, Kyra Y Chua, Pooja Deshpande, Danmeng Li, David A Ostrov, Jason Trubiano, Elizabeth J Phillips

2021-01-01

CAPSULE SUMMARY: All fifteen patients with HLA-A*32:01 restricted vancomycin-induced DRESS, showed negative ex vivo responses to d..

Alterations in Smell or Taste-Classic Coronavirus Disease 2019?

Jason A Trubiano, Sara Vogrin, Jason C Kwong, Natasha Homes

2020-10-15

Analysis of Skin-Resident Memory T Cells Following Drug Hypersensitivity Reactions

Jason A Trubiano, Claire L Gordon, Clara Castellucci, Susan N Christo, Simone L Park, Effie Mouhtouris, Katherine Konvinse, Morgan Rose, Michelle Goh, Alan S Boyd, Elizabeth J Phillips, Laura K Mackay

2020-07-01

Development and Validation of a Penicillin Allergy Clinical Decision Rule

Jason A Trubiano, Sara Vogrin, Kyra YL Chua, Jack Bourke, James Yun, Abby Douglas, Cosby A Stone, Roger Yu, Lauren Groenendijk, Natasha E Holmes, Elizabeth J Phillips

2020-05-01

Importance: Penicillin allergy is a significant public health issue for patients, antimicrobial stewardship programs, and health s..

Safety of cephalosporins in penicillin class severe delayed hypersensitivity reactions

Jason A Trubiano, Kyra YL Chua, Natasha E Holmes, Abby P Douglas, Effie Mouhtouris, Michelle Goh, Elizabeth J Phillips

2020-03-01

Antimicrobial anaphylaxis: the changing face of severe antimicrobial allergy

Victoria Hall, Micah Wong, Maitri Munsif, Brittany R Stevenson, Katie Elliott, Michaela Lucas, Ashleigh J Baird, Eugene Athan, Melissa Young, Robert Pickles, Allen C Cheng, Andrew J Stewardson, Ar K Aung, Jason A Trubiano

2020-01-01

OBJECTIVES: The epidemiology, clinical characteristics and outcomes of antimicrobial-associated anaphylaxis remain ill-defined. We..

Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Associated with Carbonic Anhydrase Inhibitors: Epidemiology, Genetics, and Insights into Mechanisms

Jason A Trubiano, David A Ostrov, Elizabeth J Phillips

2019-11-01

Outcomes of an electronic medical record (EMR)-driven intensive care unit (ICU)-antimicrobial stewardship (AMS) ward round: Assessing the "Five Moments of Antimicrobial Prescribing"

Misha Devchand, Andrew J Stewardson, Karen F Urbancic, Sharmila Khumra, Andrew A Mahony, Steven Walker, Kent Garrett, M Lindsay Grayson, Jason A Trubiano

2019-10-01

OBJECTIVE: The primary objective of this study was to examine the impact of an electronic medical record (EMR)-driven intensive ca..

Long-term impacts of antibiotic allergy testing on patient perceptions and antibiotic utilization.

N Tan, NE Holmes, KY Chua, AJ Stewardson, JA Trubiano

2019-09-01

Objectives: To define the long-term impacts of antibiotic allergy testing (AAT) on patient allergy perception and antibiotic utili..

High prevalence of antibiotic allergies in cladribine-treated patients with hairy cell leukemia - lessons for immunopathogenesis and prescribing

Zaal Meher-Homji, Constantine S Tam, Jim Siderov, John Francis Seymour, Natasha E Holmes, Kyra YL Chua, Elizabeth J Phillips, Monica A Slavin, Jason A Trubiano

2019-06-26

The relationship between hematological malignancy and chemotherapy on the prevalence of antibiotic allergy label (AAL) is ill-defi..

The Global Implications of the Gentamicin Histamine Contamination: Sorting Fact from Fiction

Jason A Trubiano, Claire Keith, Misha Devchand, Kent Garrett

2019-02-01

Beyond Penicillin: Rapid Desensitization for Specific Flucloxacillin Hypersensitivity

JC Kwong, K Urbancic, JA Trubiano

2018-12-01

Beta-lactam therapy for severe staphylococcal infections is associated with superior outcomes, compared to non-beta-lactam therapy..

Dapsone safety in hematology patients: Pathways to optimizing Pneumocystis jirovecii pneumonia prophylaxis in hematology malignancy and transplant recipients

Karen F Urbancic, Daisy Pisasale, Joel Wight, Jason A Trubiano

2018-12-01

Dapsone may be used for Pneumocystis jirovecii pneumonia (PJP) prophylaxis in hematology patients receiving immunosuppressive ther..

The Safety and Efficacy of an Oral Penicillin Challenge Program in Cancer Patients: A Multicenter Pilot Study

Jason A Trubiano, Olivia Smibert, Abby Douglas, Misha Devchand, Belinda Lambros, Natasha E Holmes, Kyra Y Chua, Elizabeth J Phillips, Monica A Slavin

2018-12-01

Antibiotic allergies are reported by up to 1 in 4 cancer patients, almost 50% of which are considered low risk and precede the can..