DEVELOPING AND EVALUATING A MULTIMODAL ANTIBIOTIC ALLERGY STRATEGY TO IMPROVE ANTIMICROBIAL STEWARDSHIP IN HIGH-RISK ANTIBIOTIC USAGE POPULATIONS

Grant number: 1139902 | Funding period: 2018 - 2022

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Abstract

Antibiotic allergies lead to the use of inferior antibiotics and generation of “superbugs”. Antibiotic allergy testing removes up to 90% of allergies, although remains unavailable to many and unreliable in some severe antibiotic reactions. We aim to validate antibiotic allergy bedside tools and programs, and develop laboratory tests that can diagnose and prevent severe antibiotic allergies, to improve appropriate antibiotic prescribing and patient outcomes.

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CAPSULE SUMMARY: All fifteen patients with HLA-A*32:01 restricted vancomycin-induced DRESS, showed negative ex vivo responses to d..

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Importance: Penicillin allergy is a significant public health issue for patients, antimicrobial stewardship programs, and health s..

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Victoria Hall, Micah Wong, Maitri Munsif, Brittany R Stevenson, Katie Elliott, Michaela Lucas, Ashleigh J Baird, Eugene Athan, Melissa Young, Robert Pickles, Allen C Cheng, Andrew J Stewardson, Ar K Aung, Jason A Trubiano

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OBJECTIVES: The epidemiology, clinical characteristics and outcomes of antimicrobial-associated anaphylaxis remain ill-defined. We..

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