DEVELOPING AND EVALUATING A MULTIMODAL ANTIBIOTIC ALLERGY STRATEGY TO IMPROVE ANTIMICROBIAL STEWARDSHIP IN HIGH-RISK ANTIBIOTIC USAGE POPULATIONS
Grant number: 1139902 | Funding period: 2018 - 2022
Antibiotic allergies lead to the use of inferior antibiotics and generation of “superbugs”. Antibiotic allergy testing removes up to 90% of allergies, although remains unavailable to many and unreliable in some severe antibiotic reactions. We aim to validate antibiotic allergy bedside tools and programs, and develop laboratory tests that can diagnose and prevent severe antibiotic allergies, to improve appropriate antibiotic prescribing and patient outcomes.
Related publications (15)
The Role of In Vivo and Ex Vivo Diagnostic Tools in Severe Delayed Immune-Mediated Adverse Antibiotic Drug Reactions
Ana Copaescu, Effie Mouhtouris, Sara Vogrin, Fiona James, Kyra YL Chua, Natasha E Holmes, Abby Douglas, Monica A Slavin, Heather Cleland, Celia Zubrinich, Ar Kar Aung, Michelle SY Goh, Elizabeth J Phillips, Jason A Trubiano
BACKGROUND: The use of in vivo and ex vivo diagnostic tools for delayed immune-mediated adverse drug reactions is currently ill de..
Cross-reactivity between vancomycin, teicoplanin, and telavancin in patients with HLA-A*32:01-positive vancomycin-induced DRESS sharing an HLA class II haplotype
Nontaya Nakkam, Andrew Gibson, Effie Mouhtouris, Katherine C Konvinse, Natasha E Holmes, Kyra Y Chua, Pooja Deshpande, Danmeng Li, David A Ostrov, Jason Trubiano, Elizabeth J Phillips
CAPSULE SUMMARY: All fifteen patients with HLA-A*32:01 restricted vancomycin-induced DRESS, showed negative ex vivo responses to d..
Development and Validation of a Penicillin Allergy Clinical Decision Rule
Jason A Trubiano, Sara Vogrin, Kyra YL Chua, Jack Bourke, James Yun, Abby Douglas, Cosby A Stone, Roger Yu, Lauren Groenendijk, Natasha E Holmes, Elizabeth J Phillips
Importance: Penicillin allergy is a significant public health issue for patients, antimicrobial stewardship programs, and health s..
Antimicrobial anaphylaxis: the changing face of severe antimicrobial allergy
Victoria Hall, Micah Wong, Maitri Munsif, Brittany R Stevenson, Katie Elliott, Michaela Lucas, Ashleigh J Baird, Eugene Athan, Melissa Young, Robert Pickles, Allen C Cheng, Andrew J Stewardson, Ar K Aung, Jason A Trubiano
OBJECTIVES: The epidemiology, clinical characteristics and outcomes of antimicrobial-associated anaphylaxis remain ill-defined. We..
Outcomes of an electronic medical record (EMR)-driven intensive care unit (ICU)-antimicrobial stewardship (AMS) ward round: Assessing the "Five Moments of Antimicrobial Prescribing"
Misha Devchand, Andrew J Stewardson, Karen F Urbancic, Sharmila Khumra, Andrew A Mahony, Steven Walker, Kent Garrett, M Lindsay Grayson, Jason A Trubiano
OBJECTIVE: The primary objective of this study was to examine the impact of an electronic medical record (EMR)-driven intensive ca..
High prevalence of antibiotic allergies in cladribine-treated patients with hairy cell leukemia - lessons for immunopathogenesis and prescribing
Zaal Meher-Homji, Constantine S Tam, Jim Siderov, John Francis Seymour, Natasha E Holmes, Kyra YL Chua, Elizabeth J Phillips, Monica A Slavin, Jason A Trubiano
The relationship between hematological malignancy and chemotherapy on the prevalence of antibiotic allergy label (AAL) is ill-defi..
Dapsone safety in hematology patients: Pathways to optimizing Pneumocystis jirovecii pneumonia prophylaxis in hematology malignancy and transplant recipients
Karen F Urbancic, Daisy Pisasale, Joel Wight, Jason A Trubiano
Dapsone may be used for Pneumocystis jirovecii pneumonia (PJP) prophylaxis in hematology patients receiving immunosuppressive ther..
The Safety and Efficacy of an Oral Penicillin Challenge Program in Cancer Patients: A Multicenter Pilot Study
Jason A Trubiano, Olivia Smibert, Abby Douglas, Misha Devchand, Belinda Lambros, Natasha E Holmes, Kyra Y Chua, Elizabeth J Phillips, Monica A Slavin
Antibiotic allergies are reported by up to 1 in 4 cancer patients, almost 50% of which are considered low risk and precede the can..