NOVEL OCTAPEPTIN ANTIBIOTICS TARGETING EXTREMELY DRUG RESISTANT 'SUPERBUGS'

Grant number: 1128891 | Funding period: 2017 - 2022

Completed

Abstract

The World Health Organization (WHO) has identified antimicrobial resistance as one of the three greatest threats to human health. Many clinicians worldwide have already been confronted with the reality of infections caused by extremely drug resistant (XDR) bacterial 'superbugs' resistant to all available antibiotics. This project aims to develop safe and efficacious octapeptin antibiotics for the treatment of life-threatening infections caused by problematic XDR ‘superbugs'.

Related publications (2)

Synthesis and structure-activity relationships of teixobactin

John A Karas, Fan Chen, Elena K Schneider-Futschik, Zhisen Kang, Maytham Hussein, James Swarbrick, Daniel Hoyer, Andrew M Giltrap, Richard J Payne, Jian Li, Tony Velkov

2019-12-02

The discovery of antibiotics has led to the effective treatment of bacterial infections that were otherwise fatal and has had a tr..

The impact of backbone N-methylation on the structure-activity relationship of Leu(10)-teixobactin

Tony Velkov, James D Swarbrick, Maytham H Hussein, Elena K Schneider-Futschik, Daniel Hoyer, Jian Li, John A Karas

2019-08-06

Antimicrobial resistance is a serious threat to global human health; therefore, new anti-infective therapeutics are required. The ..

University of Melbourne Researchers

Tony Velkov Biochemistry and Pharmacology