The Hunt For New-Generation Lipopeptide Antibiotics Targeting Gram-Negative ‘Superbugs’

Grant number: 1086825 | Funding period: 2017 - 2018



The dry antibiotic discovery and development pipeline, together with the increasing incidence of bacterial resistance in the clinic has been dubbed ‘the perfect storm’. This project involves the design, synthesis and preclinical evaluation of a new generation of polymyxin-like lipopeptides that have low nephrotoxicity and specifically target polymyxin-resistant Gram-negative ‘superbugs’.