AN EVIDENCE BASED FRAMEWORK FOR ESTABLISHING PUBLIC HEALTH MICROBIAL GENOMICS IN AUSTRALIA
Grant number: 1149991 | Funding period: 2018 - 2024
Microbial genomics is a powerful laboratory tool to characterise human pathogens at the highest level, allowing greater understanding of the source and spread of pathogens that infect humans. In this project, through close links with the Victorian Government, we will determine how this exciting new technology can best be applied to prevent the spread of high risk human pathogens, and inform public health action.
Related publications (11)
Detection of Chimeric Cellular: HIV mRNAs Generated Through Aberrant Splicing in HIV-1 Latently Infected Resting CD4 T Cells
Michelle Y-H Lee, Georges Khoury, Moshe Olshansky, Secondo Sonza, Glen P Carter, James McMahon, Timothy P Stinear, Stephen J Turner, Sharon R Lewin, Damian FJ Purcell
Latent HIV-1 provirus in infected individuals on suppressive therapy does not always remain transcriptionally silent. Both HIV-1 L..
Optimising genomic approaches for identifying vancomycin-resistant Enterococcus faecium transmission in healthcare settings
Charlie Higgs, Norelle L Sherry, Torsten Seemann, Kristy Horan, Hasini Walpola, Paul Kinsella, Katherine Bond, Deborah A Williamson, Caroline Marshall, Jason C Kwong, M Lindsay Grayson, Timothy P Stinear, Claire L Gorrie, Benjamin P Howden
Vancomycin-resistant Enterococcus faecium (VREfm) is a major nosocomial pathogen. Identifying VREfm transmission dynamics permits ..
Search and Contain: Impact of an Integrated Genomic and Epidemiological Surveillance and Response Program for Control of Carbapenemase-producing Enterobacterales
Courtney R Lane, Judith Brett, Mark Schultz, Claire L Gorrie, Kerrie Stevens, Donna RM Cameron, Siobhan St George, Annaliese van Diemen, Marion Easton, Rhonda L Stuart, Michelle Sait, Anton Y Peleg, Andrew J Stewardson, Allen C Cheng, Denis W Spelman, Mary Jo Waters, Susan A Ballard, Norelle L Sherry, Deborah A Williamson, Finn Romanes
BACKGROUND: Multiresistant organisms (MROs) pose a critical threat to public health. Population-based programs for control of MROs..
Genomic diversity of antimicrobial resistance in non-typhoidal Salmonella in Victoria, Australia.
Cheryll M Sia, Sarah L Baines, Mary Valcanis, Darren YJ Lee, Anders Gonçalves da Silva, Susan A Ballard, Marion Easton, Torsten Seemann, Benjamin P Howden, Danielle J Ingle, Deborah A Williamson
Non-typhoidal Salmonella (NTS) is the second most common cause of foodborne bacterial gastroenteritis in Australia with antimicr..
Key parameters for genomics-based real-time detection and tracking of multidrug-resistant bacteria: a systematic analysis
Claire L Gorrie, Anders Goncalves Da Silva, Danielle J Ingle, Charlie Higgs, Torsten Seemann, Timothy P Stinear, Deborah A Williamson, Jason C Kwong, M Lindsay Grayson, Norelle L Sherry, Benjamin P Howden
BACKGROUND: Pairwise single nucleotide polymorphisms (SNPs) are a cornerstone of genomic approaches to the inference of transmissi..
Genomics-informed responses in the elimination of COVID-19 in Victoria, Australia: an observational, genomic epidemiological study
Courtney R Lane, Norelle L Sherry, Ashleigh F Porter, Sebastian Duchene, Kristy Horan, Patiyan Andersson, Mathilda Wilmot, Annabelle Turner, Sally Dougall, Sandra A Johnson, Michelle Sait, Anders Gonsalves da Silva, Susan A Ballard, Tuyet Hoang, Timothy P Stinear, Leon Caly, Vitali Sintchenko, Rikki Graham, Jamie McMahon, David Smith
BACKGROUND: A cornerstone of Australia's ability to control COVID-19 has been effective border control with an extensive supervise..
An implementation science approach to evaluating pathogen whole genome sequencing in public health
Angeline S Ferdinand, Margaret Kelaher, Courtney R Lane, Anders Goncalves da Silva, Norelle L Sherry, Susan A Ballard, Patiyan Andersson, Tuyet Hoang, Justin T Denholm, Marion Easton, Benjamin P Howden, Deborah A Williamson
BACKGROUND: Pathogen whole genome sequencing (WGS) is being incorporated into public health surveillance and disease control syste..
Prolonged Outbreak of Multidrug-Resistant Shigella sonnei Harboring bla(CTX-M-27) in Victoria, Australia
Danielle J Ingle, Patiyan Andersson, Mary Valcanis, Jessica Barnden, Anders Goncalves da Silva, Kristy A Horan, Torsten Seemann, Marion Easton, Deborah A Williamson, Norelle L Sherry, Benjamin P Howden
In Australia, cases of shigellosis usually occur in returned travelers from regions of shigellosis endemicity or in men who have s..
Tracking the COVID-19 pandemic in Australia using genomics
Torsten Seemann, Courtney R Lane, Norelle L Sherry, Sebastian Duchene, Anders Goncalves da Silva, Leon Caly, Michelle Sait, Susan A Ballard, Kristy Horan, Mark B Schultz, Tuyet Hoang, Marion Easton, Sally Dougall, Timothy P Stinear, Julian Druce, Mike Catton, Brett Sutton, Annaliese van Diemen, Charles Alpren, Deborah A Williamson
Genomic sequencing has significant potential to inform public health management for SARS-CoV-2. Here we report high-throughput gen..
Bridging of Neisseria gonorrhoeae lineages across sexual networks in the HIV pre-exposure prophylaxis era
Deborah A Williamson, Eric PF Chow, Claire L Gorrie, Torsten Seemann, Danielle J Ingle, Nasra Higgins, Marion Easton, George Taiaroa, Yonatan H Grad, Jason C Kwong, Christopher K Fairley, Marcus Y Chen, Benjamin P Howden
Whole genome sequencing (WGS) has been used to investigate transmission of Neisseria gonorrhoeae, but to date, most studies have n..
Genomics for Molecular Epidemiology and Detecting Transmission of Carbapenemase-Producing Enterobacterales in Victoria, Australia, 2012 to 2016
Norelle L Sherry, Courtney R Lane, Jason C Kwong, Mark Schultz, Michelle Sait, Kerrie Stevens, Susan Ballard, Anders Goncalves da Silva, Torsten Seemann, Claire L Gorrie, Timothy P Stinear, Deborah A Williamson, Judith Brett, Annaliese van Diemen, Marion Easton, Benjamin P Howden
Carbapenemase-producing Enterobacterales (CPE) are being increasingly reported in Australia, and integrated clinical and genomic s..