Understanding interactions between gut epithelial stem cells and neurons
Grant number: DE180100261 | Funding period: 2018 - 2020
This project aims to investigate the interaction between gut neurons and the epithelial stem cell compartment, as well as the relationship between age-related loss of enteric neurons and changes in gut epithelial stem cells. This project will include novel co-culturing of organoids and enteric neurospheres, which will identify mechanisms by which nerves influence the epithelia. The outcome of the project will be a better understanding of the biology of the body’s most highly proliferative, long-lived stem cells, intestinal epithelial stem cells. This could have significant long term impact on the quality of life in an ageing population.
Related publications (3)
Role of JNK, MEK and adenylyl cyclase signalling in speed and directionality of enteric neural crest-derived cells
Marlene M Hao, Annette J Bergner, TH Nguyen Huynh, Paige Dissanayake, Laura E Burnett, C Danielle Hopkins, Kevin Zeng, Heather M Young, Lincon A Stamp
BACKGROUND: Cells derived from the neural crest colonize the developing gut and give rise to the enteric nervous system. The rate ..
Fine scale differences within the vagal neural crest for enteric nervous system formation
Johanna E Simkin, Dongcheng Zhang, Lincon A Stamp, Donald F Newgreen
The enteric nervous system is mostly derived from vagal neural crest (NC) cells adjacent to somites (s)1-7. We used in ovo focal f..
The enteric neural crest progressively loses capacity to form enteric nervous system
Dongcheng Zhang, Benjamin N Rollo, Nandor Nagy, Lincon Stamp, Donald F Newgreen
Cells of the vagal neural crest (NC) form most of the enteric nervous system (ENS) by a colonising wave in the embryonic gut, with..