No pain no word gain: toward a new neurobiological account of word learning

White matter microstructure and verbal fluency

Natalia Egorova-Brumley, Chen Liang, Mohamed Salah Khlif, Amy Brodtmann

2022-10-17

Poor performance on verbal fluency tasks is associated with an increased risk of post-stroke cognitive impairment. Grey matter reg..

Chronic Stroke Sensorimotor Impairment Is Related to Smaller Hippocampal Volumes: An ENIGMA Analysis

Artemis Zavaliangos-Petropulu, Bethany Lo, Miranda R Donnelly, Nicolas Schweighofer, Keith Lohse, Neda Jahanshad, Giuseppe Barisano, Nerisa Banaj, Michael R Borich, Lara A Boyd, Cathrin M Buetefisch, Winston D Byblow, Jessica M Cassidy, Charalambos C Charalambous, Adriana B Conforto, Julie A DiCarlo, Adrienne N Dula, Natalia Egorova-Brumley, Mark R Etherton, Wuwei Feng

2022-05-17

Background Persistent sensorimotor impairments after stroke can negatively impact quality of life. The hippocampus is vulnerable t..

Neural correlates of co-occurring pain and depression: an activation-likelihood estimation (ALE) meta-analysis and systematic review

Carmen Jiamin Zheng, Sarah Van Drunen, Natalia Egorova-Brumley

2022-05-11

The relationship between pain and depression is thought to be bidirectional and the underlying neurobiology 'shared' between the t..

Grey and white matter atrophy I year after stroke aphasia

Natalia Egorova-Brumley, Mohamed Salah Khlif, Emilio Werden, Laura J Bird, Amy Brodtmann

2022-03-01

Dynamic whole-brain changes occur following stroke, and not just in association with recovery. We tested the hypothesis that the p..

Cortical thinning 3 years after ischaemic stroke is associated with cognitive impairment and APOE ε4.

Mohamed Salah Khlif, Natalia Egorova-Brumley, Laura J Bird, Emilio Werden, Amy Brodtmann

2022-01-01

Cortical thinning has been described in many neurodegenerative diseases and used for both diagnosis and disease monitoring. The im..

Atrophy of Ipsilesional Hippocampal Subfields Vary Over First Year After Ischemic Stroke

Mohamed Salah Khlif, Emilio Werden, Laura J Bird, Natalia Egorova-Brumley, Amy Brodtmann

2021-11-27

BACKGROUND: The structural integrity of hippocampal subfields has been investigated in many neurological disorders and was shown t..

Neurodegeneration Over 3 Years Following Ischaemic Stroke: Findings From the Cognition and Neocortical Volume After Stroke Study

Amy Brodtmann, Emilio Werden, Mohamed Salah Khlif, Laura J Bird, Natalia Egorova, Michele Veldsman, Heath Pardoe, Graeme Jackson, Jennifer Bradshaw, David Darby, Toby Cumming, Leonid Churilov, Geoffrey Donnan

2021-10-22

Background: Stroke survivors are at high risk of dementia, associated with increasing age and vascular burden and with pre-existin..

Smaller spared subcortical nuclei are associated with worse post-stroke sensorimotor outcomes in 28 cohorts worldwide

Sook-Lei Liew, Artemis Zavaliangos-Petropulu, Nicolas Schweighofer, Neda Jahanshad, Catherine E Lang, Keith R Lohse, Nerisa Banaj, Giuseppe Barisano, Lee A Baugh, Anup K Bhattacharya, Bavrina Bigjahan, Michael R Borich, Lara A Boyd, Amy Brodtmann, Cathrin M Buetefisch, Winston D Byblow, Jessica M Cassidy, Charalambos C Charalambous, Valentina Ciullo, Adriana B Conforto

2021-10-01

Up to two-thirds of stroke survivors experience persistent sensorimotor impairments. Recovery relies on the integrity of spared br..

Post-stroke fatigue is associated with resting state posterior hypoactivity and prefrontal hyperactivity

Georgia Cotter, Mohamed Salah Khlif, Laura Bird, Mark E Howard, Amy Brodtmann, Natalia Egorova-Brumley

2021-09-27

BACKGROUND: Fatigue is associated with poor functional outcomes and increased mortality following stroke. Survivors identify fatig..

Fixel-based Analysis of Diffusion MRI: Methods, Applications, Challenges and Opportunities

Thijs Dhollander, Adam Clemente, Mervyn Singh, Frederique Boonstra, Oren Civier, Juan Dominguez Duque, Natalia Egorova, Peter Enticott, Ian Fuelscher, Sanuji Gajamange, Sila Genc, Elie Gottlieb, Christian Hyde, Phoebe Imms, Claire Kelly, Melissa Kirkovski, Scott Kolbe, Xiaoyun Liang, Atul Malhotra, Remika Mito

2021-08-04

Diffusion MRI has provided the neuroimaging community with a powerful tool to acquire in-vivo data sensitive to microstructural fe..

Sleep architectural dysfunction and undiagnosed obstructive sleep apnea after chronic ischemic stroke

Elie Gottlieb, Mohamed S Khlif, Laura Bird, Emilio Werden, Thomas Churchward, Matthew P Pase, Natalia Egorova, Mark E Howard, Amy Brodtmann

2021-05-12

OBJECTIVE/BACKGROUND: Sleep-wake dysfunction is bidirectionally associated with the incidence and evolution of acute stroke. It re..

Post-stroke fatigue is linked to resting state posterior hypoactivity and prefrontal hyperactivity

Georgia Cotter, Mohamed Salah Khlif, Laura Bird, Mark Howard, Amy Brodtmann, Natalia Egorova

2021-03-17

<h4>Background and Purpose</h4> Fatigue is associated with poor functional outcomes and increased mortality following stroke. Surv..

Sleep-wake parameters can be detected in patients with chronic stroke using a multisensor accelerometer: a validation study

Elie Gottlieb, Leonid Churilov, Emilio Werden, Thomas Churchward, Matthew P Pase, Natalia Egorova, Mark E Howard, Amy Brodtmann

2021-02-01

STUDY OBJECTIVES: Sleep-wake dysfunction is bidirectionally associated with the pathogenesis and evolution of stroke. Longitudinal..

Hippocampal subfield volumes are associated with verbal memory after first-ever ischemic stroke

Mohamed Salah Khlif, Laura J Bird, Carolina Restrepo, Wasim Khan, Emilio Werden, Natalia Egorova-Brumley, Amy Brodtmann

2021-01-01

INTRODUCTION: Hippocampal subfield volumes are more closely associated with cognitive impairment than whole hippocampal volume in ..

Dynamic Regional Brain Atrophy Rates in the First Year After Ischemic Stroke

Amy Brodtmann, Mohamed Salah Khlif, Natalia Egorova, Michele Veldsman, Laura J Bird, Emilio Werden

2020-09-01

BACKGROUND AND PURPOSE: Brain atrophy can be regarded as an end-organ effect of cumulative cardiovascular risk factors. Accelerate..

Regional neurodegeneration correlates with sleep-wake dysfunction after stroke

Elie Gottlieb, Natalia Egorova, Mohamed S Khlif, Wasim Khan, Emilio Werden, Matthew P Pase, Mark Howard, Amy Brodtmann

2020-09-01

Sleep-wake disruption is a key modifiable risk factor and sequela of stroke. The pathogenesis of poststroke sleep dysfunction is u..

Three-tissue compositional analysis reveals in-vivo microstructural heterogeneity of white matter hyperintensities following stroke

Wasim Khan, Natalia Egorova, Mohamed Salah Khlif, Remika Mito, Thijs Dhollander, Amy Brodtmann

2020-09-01

White matter hyperintensities (WMHs) are frequently observed on brain scans of older individuals and are associated with cognitive..

Pervasive White Matter Fiber Degeneration in Ischemic Stroke

Natalia Egorova, Thijs Dhollander, Mohamed Salah Khlif, Wasim Khan, Emilio Werden, Amy Brodtmann

2020-05-01

Background and Purpose- We examined if ischemic stroke is associated with white matter degeneration predominantly confined to the ..

FIBRE-SPECIFIC WHITE MATTER NEURODEGENERATION IS ASSOCIATED WITH LONG SLEEP DURATION AFTER STROKE

EW Gottlieb, N Egorova, MS Khlif, W Khan, E Werden, MP Pase, M Howard, A Brodtmann

2020-04-01

Between placebo and nocebo: Response to control treatment is mediated by amygdala activity and connectivity

Natalia Egorova, Fabrizio Benedetti, Randy L Gollub, Jian Kong

2019-12-12

BACKGROUND: In experimental placebo and nocebo studies, neutral control treatments are often administered for comparison with acti..

Predicted Brain Age After Stroke

Natalia Egorova, Franziskus Liem, Vladimir Hachinski, Amy Brodtmann

2019-12-10

Aging is a known non-modifiable risk factor for stroke. Usually, this refers to chronological rather than biological age. Biologic..

Choroid plexus volume after stroke

Natalia Egorova, Elie Gottlieb, Mohamed Salah Khlif, Neil J Spratt, Amy Brodtmann

2019-12-01

BACKGROUND: Cerebrospinal fluid circulation is crucial for the functioning of the brain. Aging and brain pathologies such as Alzhe..

A Human Depression Circuit Derived From Focal Brain Lesions

Jaya L Padmanabhan, Danielle Cooke, Juho Joutsa, Shan H Siddiqi, Michael Ferguson, R Ryan Darby, Louis Soussand, Andreas Horn, Na Young Kim, Joel L Voss, Andrew M Naidech, Amy Brodtmann, Natalia Egorova, Sophia Gozzi, Thanh G Phan, Maurizio Corbetta, Jordan Grafman, Michael D Fox

2019-11-15

BACKGROUND: Focal brain lesions can lend insight into the causal neuroanatomical substrate of depression in the human brain. Howev..

A comparison of automated segmentation and manual tracing in estimating hippocampal volume in ischemic stroke and healthy control participants

Mohamed Salah Khlif, Natalia Egorova, Emilio Werden, Alberto Redolfi, Marina Boccardi, Charles S DeCarli, Evan Fletcher, Baljeet Singh, Qi Li, Laura Bird, Amy Brodtmann

2019-01-01

Manual quantification of the hippocampal atrophy state and rate is time consuming and prone to poor reproducibility, even when per..

A neural mechanism of direct and observational conditioning for placebo and nocebo responses

Yiheng Tu, Joel Park, Seppo P Ahlfors, Sheraz Khan, Natalia Egorova, Courtney Lang, Jin Cao, Jian Kong

2019-01-01

Classical theories suggest placebo analgesia and nocebo hyperalgesia are based on expectation and conditioned experience. Whereas ..

APOE epsilon 4 Carriers Show Delayed Recovery of Verbal Memory and Smaller Entorhinal Volume in the First Year After Ischemic Stroke

Emilio Werden, Mohamed Salah Khlif, Laura J Bird, Toby Cumming, Jennifer Bradshaw, Wasim Khan, Matthew Pase, Carolina Restrepo, Michele Veldsman, Natalia Egorova, Sheila K Patel, Elie Gottlieb, Amy Brodtmann

2019-01-01

BACKGROUND: The apolipoprotein E (APOE) gene ɛ4 allele is a risk factor for Alzheimer's disease and cardiovascular disease. Howeve..

Assessment of longitudinal hippocampal atrophy in the first year after ischemic stroke using automatic segmentation techniques

Mohamed Salah Khlif, Emilio Werden, Natalia Egorova, Marina Boccardi, Alberto Redolfi, Laura Bird, Amy Brodtmann

2019-01-01

We assessed first-year hippocampal atrophy in stroke patients and healthy controls using manual and automated segmentations: AdaBo..

In the face of pain: The choice of visual cues in pain conditioning matters

N Egorova, J Park, J Kong

2017-08-01

BACKGROUND: Visual cue conditioning is a valuable experimental paradigm to investigate placebo and nocebo effects in pain. However..