No pain no word gain: toward a newÂ neurobiological account of word learning
Grant number: DE180100893 | Funding period: 2018 - 2022
This project aims to generate a novel neurobiological account of word learning, going beyond a simple mapping between words and objects and recognising the sensory and socio-communicative embedding of language. Capitalising on interdisciplinary approaches to research, this project will use state-of-the-art neuroimaging to reveal the neural architecture and mechanisms supporting contextualised sensory word learning. The results are expected to bring about a paradigm shift in the fields of neurobiology of language and learning, having a profound impact on the practice of language teaching and improvement of language functioning.
Related publications (28)
Chronic Stroke Sensorimotor Impairment Is Related to Smaller Hippocampal Volumes: An ENIGMA Analysis
Artemis Zavaliangos-Petropulu, Bethany Lo, Miranda R Donnelly, Nicolas Schweighofer, Keith Lohse, Neda Jahanshad, Giuseppe Barisano, Nerisa Banaj, Michael R Borich, Lara A Boyd, Cathrin M Buetefisch, Winston D Byblow, Jessica M Cassidy, Charalambos C Charalambous, Adriana B Conforto, Julie A DiCarlo, Adrienne N Dula, Natalia Egorova-Brumley, Mark R Etherton, Wuwei Feng
Background Persistent sensorimotor impairments after stroke can negatively impact quality of life. The hippocampus is vulnerable t..
Neural correlates of co-occurring pain and depression: an activation-likelihood estimation (ALE) meta-analysis and systematic review
Carmen Jiamin Zheng, Sarah Van Drunen, Natalia Egorova-Brumley
The relationship between pain and depression is thought to be bidirectional and the underlying neurobiology 'shared' between the t..
Cortical thinning 3 years after ischaemic stroke is associated with cognitive impairment and APOE ε4.
Mohamed Salah Khlif, Natalia Egorova-Brumley, Laura J Bird, Emilio Werden, Amy Brodtmann
Cortical thinning has been described in many neurodegenerative diseases and used for both diagnosis and disease monitoring. The im..
Atrophy of Ipsilesional Hippocampal Subfields Vary Over First Year After Ischemic Stroke
Mohamed Salah Khlif, Emilio Werden, Laura J Bird, Natalia Egorova-Brumley, Amy Brodtmann
BACKGROUND: The structural integrity of hippocampal subfields has been investigated in many neurological disorders and was shown t..
Neurodegeneration Over 3 Years Following Ischaemic Stroke: Findings From the Cognition and Neocortical Volume After Stroke Study
Amy Brodtmann, Emilio Werden, Mohamed Salah Khlif, Laura J Bird, Natalia Egorova, Michele Veldsman, Heath Pardoe, Graeme Jackson, Jennifer Bradshaw, David Darby, Toby Cumming, Leonid Churilov, Geoffrey Donnan
Background: Stroke survivors are at high risk of dementia, associated with increasing age and vascular burden and with pre-existin..
Smaller spared subcortical nuclei are associated with worse post-stroke sensorimotor outcomes in 28 cohorts worldwide
Sook-Lei Liew, Artemis Zavaliangos-Petropulu, Nicolas Schweighofer, Neda Jahanshad, Catherine E Lang, Keith R Lohse, Nerisa Banaj, Giuseppe Barisano, Lee A Baugh, Anup K Bhattacharya, Bavrina Bigjahan, Michael R Borich, Lara A Boyd, Amy Brodtmann, Cathrin M Buetefisch, Winston D Byblow, Jessica M Cassidy, Charalambos C Charalambous, Valentina Ciullo, Adriana B Conforto
Up to two-thirds of stroke survivors experience persistent sensorimotor impairments. Recovery relies on the integrity of spared br..
Post-stroke fatigue is associated with resting state posterior hypoactivity and prefrontal hyperactivity
Georgia Cotter, Mohamed Salah Khlif, Laura Bird, Mark E Howard, Amy Brodtmann, Natalia Egorova-Brumley
BACKGROUND: Fatigue is associated with poor functional outcomes and increased mortality following stroke. Survivors identify fatig..
Fixel-based Analysis of Diffusion MRI: Methods, Applications, Challenges and Opportunities
Thijs Dhollander, Adam Clemente, Mervyn Singh, Frederique Boonstra, Oren Civier, Juan Dominguez Duque, Natalia Egorova, Peter Enticott, Ian Fuelscher, Sanuji Gajamange, Sila Genc, Elie Gottlieb, Christian Hyde, Phoebe Imms, Claire Kelly, Melissa Kirkovski, Scott Kolbe, Xiaoyun Liang, Atul Malhotra, Remika Mito
Diffusion MRI has provided the neuroimaging community with a powerful tool to acquire in-vivo data sensitive to microstructural fe..
Sleep architectural dysfunction and undiagnosed obstructive sleep apnea after chronic ischemic stroke
Elie Gottlieb, Mohamed S Khlif, Laura Bird, Emilio Werden, Thomas Churchward, Matthew P Pase, Natalia Egorova, Mark E Howard, Amy Brodtmann
OBJECTIVE/BACKGROUND: Sleep-wake dysfunction is bidirectionally associated with the incidence and evolution of acute stroke. It re..
Post-stroke fatigue is linked to resting state posterior hypoactivity and prefrontal hyperactivity
Georgia Cotter, Mohamed Salah Khlif, Laura Bird, Mark Howard, Amy Brodtmann, Natalia Egorova
<h4>Background and Purpose</h4> Fatigue is associated with poor functional outcomes and increased mortality following stroke. Surv..
Sleep-wake parameters can be detected in patients with chronic stroke using a multisensor accelerometer: a validation study
Elie Gottlieb, Leonid Churilov, Emilio Werden, Thomas Churchward, Matthew P Pase, Natalia Egorova, Mark E Howard, Amy Brodtmann
STUDY OBJECTIVES: Sleep-wake dysfunction is bidirectionally associated with the pathogenesis and evolution of stroke. Longitudinal..
Hippocampal subfield volumes are associated with verbal memory after first-ever ischemic stroke
Mohamed Salah Khlif, Laura J Bird, Carolina Restrepo, Wasim Khan, Emilio Werden, Natalia Egorova-Brumley, Amy Brodtmann
INTRODUCTION: Hippocampal subfield volumes are more closely associated with cognitive impairment than whole hippocampal volume in ..
Dynamic Regional Brain Atrophy Rates in the First Year After Ischemic Stroke
Amy Brodtmann, Mohamed Salah Khlif, Natalia Egorova, Michele Veldsman, Laura J Bird, Emilio Werden
BACKGROUND AND PURPOSE: Brain atrophy can be regarded as an end-organ effect of cumulative cardiovascular risk factors. Accelerate..
Regional neurodegeneration correlates with sleep-wake dysfunction after stroke
Elie Gottlieb, Natalia Egorova, Mohamed S Khlif, Wasim Khan, Emilio Werden, Matthew P Pase, Mark Howard, Amy Brodtmann
Sleep-wake disruption is a key modifiable risk factor and sequela of stroke. The pathogenesis of poststroke sleep dysfunction is u..
Three-tissue compositional analysis reveals in-vivo microstructural heterogeneity of white matter hyperintensities following stroke
Wasim Khan, Natalia Egorova, Mohamed Salah Khlif, Remika Mito, Thijs Dhollander, Amy Brodtmann
White matter hyperintensities (WMHs) are frequently observed on brain scans of older individuals and are associated with cognitive..
Pervasive White Matter Fiber Degeneration in Ischemic Stroke
Natalia Egorova, Thijs Dhollander, Mohamed Salah Khlif, Wasim Khan, Emilio Werden, Amy Brodtmann
Background and Purpose- We examined if ischemic stroke is associated with white matter degeneration predominantly confined to the ..
Between placebo and nocebo: Response to control treatment is mediated by amygdala activity and connectivity
Natalia Egorova, Fabrizio Benedetti, Randy L Gollub, Jian Kong
BACKGROUND: In experimental placebo and nocebo studies, neutral control treatments are often administered for comparison with acti..
A Human Depression Circuit Derived From Focal Brain Lesions
Jaya L Padmanabhan, Danielle Cooke, Juho Joutsa, Shan H Siddiqi, Michael Ferguson, R Ryan Darby, Louis Soussand, Andreas Horn, Na Young Kim, Joel L Voss, Andrew M Naidech, Amy Brodtmann, Natalia Egorova, Sophia Gozzi, Thanh G Phan, Maurizio Corbetta, Jordan Grafman, Michael D Fox
BACKGROUND: Focal brain lesions can lend insight into the causal neuroanatomical substrate of depression in the human brain. Howev..
A comparison of automated segmentation and manual tracing in estimating hippocampal volume in ischemic stroke and healthy control participants
Mohamed Salah Khlif, Natalia Egorova, Emilio Werden, Alberto Redolfi, Marina Boccardi, Charles S DeCarli, Evan Fletcher, Baljeet Singh, Qi Li, Laura Bird, Amy Brodtmann
Manual quantification of the hippocampal atrophy state and rate is time consuming and prone to poor reproducibility, even when per..
A neural mechanism of direct and observational conditioning for placebo and nocebo responses
Yiheng Tu, Joel Park, Seppo P Ahlfors, Sheraz Khan, Natalia Egorova, Courtney Lang, Jin Cao, Jian Kong
Classical theories suggest placebo analgesia and nocebo hyperalgesia are based on expectation and conditioned experience. Whereas ..
APOE epsilon 4 Carriers Show Delayed Recovery of Verbal Memory and Smaller Entorhinal Volume in the First Year After Ischemic Stroke
Emilio Werden, Mohamed Salah Khlif, Laura J Bird, Toby Cumming, Jennifer Bradshaw, Wasim Khan, Matthew Pase, Carolina Restrepo, Michele Veldsman, Natalia Egorova, Sheila K Patel, Elie Gottlieb, Amy Brodtmann
BACKGROUND: The apolipoprotein E (APOE) gene ɛ4 allele is a risk factor for Alzheimer's disease and cardiovascular disease. Howeve..
Assessment of longitudinal hippocampal atrophy in the first year after ischemic stroke using automatic segmentation techniques
Mohamed Salah Khlif, Emilio Werden, Natalia Egorova, Marina Boccardi, Alberto Redolfi, Laura Bird, Amy Brodtmann
We assessed first-year hippocampal atrophy in stroke patients and healthy controls using manual and automated segmentations: AdaBo..