Chemosensation in Ascaris infection
Grant number: DP180102049 | Funding period: 2018 - 2021
This project aims to show the role of chemo-sensation as an equally important target for worm control, and explore pathways to prevent infection. Parasitic worms cost global food/textile industry more than $100 billion dollars per year, and cause disease in more than 1 billion people and domesticated animals world-wide. This project will use a combination of imaging, systems biology, chemical biology and microfluidic methods to provide significant benefits, such as exploring Ascaris chemo-sensation during larval migration, identify the key host queues and parasite genes regulating this process, and probe helminth chemosensation as a novel target for anti-parasitic treatments.
Related publications (6)
Tunable Harmonic Flow Patterns in Microfluidic Systems through Simple Tube Oscillation
Peter Thurgood, Sergio Aguilera Suarez, Elena Pirogova, Aaron R Jex, Karlheinz Peter, Sara Baratchi, Khashayar Khoshmanesh
Generation of tunable harmonic flows at low cost in microfluidic systems is a persistent and significant obstacle to this field, s..
Studying the Response of Aortic Endothelial Cells under Pulsatile Flow Using a Compact Microfluidic System
Mokhaled Mohammed, Peter Thurgood, Christopher Gilliam, Nguyen Ngan, Elena Pirogova, Karlheinz Peter, Khashayar Khoshmanesh, Sara Baratchi
We describe a piezoelectric pumping system for studying the mechanobiology of human aortic endothelial cells (HAECs) under pulsati..
Self-sufficient, low-cost microfluidic pumps utilising reinforced balloons
Peter Thurgood, Sergio Aguilera Suarez, Sheng Chen, Christopher Gilliam, Elena Pirogova, Aaron R Jex, Sara Baratchi, Khashayar Khoshmanesh
Here, we introduce a simple method for increasing the inflation pressure of self-sufficient pressure pumps made of latex balloons...
Asynchronous generation of oil droplets using a microfluidic flow focusing system
Peter Thurgood, Sara Baratchi, Aram Arash, Elena Pirogova, Aaron R Jex, Khashayar Khoshmanesh
Here, we show that long-term exposure of PDMS based microfluidic droplet generation systems to water can reverse their characteris..
A self-sufficient pressure pump using latex balloons for microfluidic applications
Peter Thurgood, Jiu Yang Zhu, Nguyen Ngan, Saeid Nahavandi, Aaron R Jex, Elena Pirogova, Sara Baratchi, Khashayar Khoshmanesh
Here, we demonstrate a self-sufficient, inexpensive and disposable pressure pump using commercially available latex balloons. The ..