Chemosensation in Ascaris infection

Grant number: DP180102049 | Funding period: 2018 - 2022

Completed

Abstract

This project aims to show the role of chemo-sensation as an equally important target for worm control, and explore pathways to prevent infection. Parasitic worms cost global food/textile industry more than $100 billion dollars per year, and cause disease in more than 1 billion people and domesticated animals world-wide. This project will use a combination of imaging, systems biology, chemical biology and microfluidic methods to provide significant benefits, such as exploring Ascaris chemo-sensation during larval migration, identify the key host queues and parasite genes regulating this process, and probe helminth chemosensation as a novel target for anti-parasitic treatments.

Related publications (8)

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Generation of programmable dynamic flow patterns in microfluidics using audio signals

Peter Thurgood, Gianmarco Concilia, Nhiem Tran, Ngan Nguyen, Adam J Hawke, Elena Pirogova, Aaron R Jex, Karlheinz Peter, Sara Baratchi, Khashayar Khoshmanesh

2021-11-01

Customised audio signals, such as musical notes, can be readily generated by audio software on smartphones and played over audio s..

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Microfluidic models of the human circulatory system: versatile platforms for exploring mechanobiology and disease modeling.

Ngan Nguyen, Peter Thurgood, Nadia Chandra Sekar, Sheng Chen, Elena Pirogova, Karlheinz Peter, Sara Baratchi, Khashayar Khoshmanesh

2021-10-01

The human circulatory system is a marvelous fluidic system, which is very sensitive to biophysical and biochemical cues. The curre..

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Tunable Harmonic Flow Patterns in Microfluidic Systems through Simple Tube Oscillation

Peter Thurgood, Sergio Aguilera Suarez, Elena Pirogova, Aaron R Jex, Karlheinz Peter, Sara Baratchi, Khashayar Khoshmanesh

2020-10-01

Generation of tunable harmonic flows at low cost in microfluidic systems is a persistent and significant obstacle to this field, s..

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Studying the Response of Aortic Endothelial Cells under Pulsatile Flow Using a Compact Microfluidic System

Mokhaled Mohammed, Peter Thurgood, Christopher Gilliam, Nguyen Ngan, Elena Pirogova, Karlheinz Peter, Khashayar Khoshmanesh, Sara Baratchi

2019-09-17

We describe a piezoelectric pumping system for studying the mechanobiology of human aortic endothelial cells (HAECs) under pulsati..

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Self-sufficient, low-cost microfluidic pumps utilising reinforced balloons

Peter Thurgood, Sergio Aguilera Suarez, Sheng Chen, Christopher Gilliam, Elena Pirogova, Aaron R Jex, Sara Baratchi, Khashayar Khoshmanesh

2019-09-07

Here, we introduce a simple method for increasing the inflation pressure of self-sufficient pressure pumps made of latex balloons...

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Asynchronous generation of oil droplets using a microfluidic flow focusing system

Peter Thurgood, Sara Baratchi, Aram Arash, Elena Pirogova, Aaron R Jex, Khashayar Khoshmanesh

2019-07-22

Here, we show that long-term exposure of PDMS based microfluidic droplet generation systems to water can reverse their characteris..

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Transcriptomic Resources for Parasitic Nematodes of Veterinary Importance

Aaron R Jex, Robin B Gasser, Erich M Schwarz

2019-01-01

Parasitic nematodes are important pathogens of animals, causing diseases that impact on agricultural production worldwide. Researc..

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A self-sufficient pressure pump using latex balloons for microfluidic applications

Peter Thurgood, Jiu Yang Zhu, Nguyen Ngan, Saeid Nahavandi, Aaron R Jex, Elena Pirogova, Sara Baratchi, Khashayar Khoshmanesh

2018-09-21

Here, we demonstrate a self-sufficient, inexpensive and disposable pressure pump using commercially available latex balloons. The ..

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