Chemosensation in Ascaris infection
Grant number: DP180102049 | Funding period: 2018 - 2022
This project aims to show the role of chemo-sensation as an equally important target for worm control, and explore pathways to prevent infection. Parasitic worms cost global food/textile industry more than $100 billion dollars per year, and cause disease in more than 1 billion people and domesticated animals world-wide. This project will use a combination of imaging, systems biology, chemical biology and microfluidic methods to provide significant benefits, such as exploring Ascaris chemo-sensation during larval migration, identify the key host queues and parasite genes regulating this process, and probe helminth chemosensation as a novel target for anti-parasitic treatments.
Related publications (8)
Generation of programmable dynamic flow patterns in microfluidics using audio signals
Peter Thurgood, Gianmarco Concilia, Nhiem Tran, Ngan Nguyen, Adam J Hawke, Elena Pirogova, Aaron R Jex, Karlheinz Peter, Sara Baratchi, Khashayar Khoshmanesh
Customised audio signals, such as musical notes, can be readily generated by audio software on smartphones and played over audio s..
Microfluidic models of the human circulatory system: versatile platforms for exploring mechanobiology and disease modeling.
Ngan Nguyen, Peter Thurgood, Nadia Chandra Sekar, Sheng Chen, Elena Pirogova, Karlheinz Peter, Sara Baratchi, Khashayar Khoshmanesh
The human circulatory system is a marvelous fluidic system, which is very sensitive to biophysical and biochemical cues. The curre..
Tunable Harmonic Flow Patterns in Microfluidic Systems through Simple Tube Oscillation
Peter Thurgood, Sergio Aguilera Suarez, Elena Pirogova, Aaron R Jex, Karlheinz Peter, Sara Baratchi, Khashayar Khoshmanesh
Generation of tunable harmonic flows at low cost in microfluidic systems is a persistent and significant obstacle to this field, s..
Studying the Response of Aortic Endothelial Cells under Pulsatile Flow Using a Compact Microfluidic System
Mokhaled Mohammed, Peter Thurgood, Christopher Gilliam, Nguyen Ngan, Elena Pirogova, Karlheinz Peter, Khashayar Khoshmanesh, Sara Baratchi
We describe a piezoelectric pumping system for studying the mechanobiology of human aortic endothelial cells (HAECs) under pulsati..
Self-sufficient, low-cost microfluidic pumps utilising reinforced balloons
Peter Thurgood, Sergio Aguilera Suarez, Sheng Chen, Christopher Gilliam, Elena Pirogova, Aaron R Jex, Sara Baratchi, Khashayar Khoshmanesh
Here, we introduce a simple method for increasing the inflation pressure of self-sufficient pressure pumps made of latex balloons...
Asynchronous generation of oil droplets using a microfluidic flow focusing system
Peter Thurgood, Sara Baratchi, Aram Arash, Elena Pirogova, Aaron R Jex, Khashayar Khoshmanesh
Here, we show that long-term exposure of PDMS based microfluidic droplet generation systems to water can reverse their characteris..
A self-sufficient pressure pump using latex balloons for microfluidic applications
Peter Thurgood, Jiu Yang Zhu, Nguyen Ngan, Saeid Nahavandi, Aaron R Jex, Elena Pirogova, Sara Baratchi, Khashayar Khoshmanesh
Here, we demonstrate a self-sufficient, inexpensive and disposable pressure pump using commercially available latex balloons. The ..