How Neurons Regulate the Myelinating Process
Grant number: DP180102397 | Funding period: 2018 - 2021
This project aims to identify novel mechanisms that govern brain myelination and functions. Myelination in the brain is a lifelong process that is vital for normal nervous system functions. This project will generate a new level of understanding as to why nerve cell signals are important for myelination and brain functions, and how this is tightly regulated by cell signal transmission. The data generated will identify new mechanisms involved in the development and maintenance of a healthy brain.
Related publications (3)
The dynamics of oligodendrocyte generation: how distinct is the mouse from the human?
David G Gonsalvez, Georgina A Craig, Darragh M Walsh, Barry D Hughes, Rhiannon J Wood, Sang Won Yoo, Simon S Murray, Junhua Xiao
<jats:p>Murine oligodendrocyte generation dynamics are considered distinct from those in the human, with implications for cross-sp..
Partial deletion of p75(NTR)in large-diameter DRG neurons exerts no influence upon the survival of peripheral sensory neuronsin vivo
Zuoheng Qin, David G Gonsalvez, Rhiannon J Wood, Fatemeh Daemi, Sangwon Yoo, Jason J Ivanusic, Elizabeth J Coulson, Simon S Murray, Junhua Xiao
The p75 neurotrophin receptor (p75NTR ) is required for maintaining peripheral sensory neuron survival and function; however, the ..
Brain-Derived Neurotrophic Factor in Central Nervous System Myelination: A New Mechanism to Promote Myelin Plasticity and Repair
Jessica L Fletcher, Simon S Murray, Junhua Xiao
Brain-derived neurotrophic factor (BDNF) plays vitally important roles in neural development and plasticity in both health and dis..