Iron, ferroptosis and the biology of ageing
Grant number: DP180101248 | Funding period: 2018 - 2021
This project aims to determine how and when regulation of iron is lost. Failing iron metabolism during life may dictate the rate of ageing by driving a newly discovered cell death program. Combining biology, chemistry and physics, this collaborative project aims to transform the understanding of the fundamental mechanisms of biological ageing. Anticipated outcomes include new assays for measuring iron in biology and identification of potential pathways that regulate death signaling and lifespan. Outcomes will benefit life sciences and biotechnology industries.
Related publications (4)
Therapeutic potential of iron modulating drugs in a mouse model of multiple system atrophy
Jay J Shukla, Nadia Stefanova, Ashley Bush, Gawain McColl, David Finkelstein, Erin J McAllum
Multiple System Atrophy (MSA) is a rare neurodegenerative synucleinopathy which leads to severe disability followed by death withi..
Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans
Nicole L Jenkins, Simon A James, Agus Salim, Fransisca Sumardy, Terence P Speed, Marcus Conrad, Des R Richardson, Ashley Bush, Gawain McColl
All eukaryotes require iron. Replication, detoxification, and a cancer-protective form of regulated cell death termed ferroptosis,..
Regional iron distribution and soluble ferroprotein profiles in the healthy human brain
Erin J McAllum, Dominic J Hare, Irene Volitakis, Catriona A McLean, Ashley I Bush, David I Finkelstein, Blaine R Roberts
Iron is essential for brain development and health where its redox properties are used for a number of neurological processes. How..
Simultaneous nanostructure and chemical imaging of intact whole nematodes
Michael WM Jones, Nicholas W Phillips, Brian Abbey, Dominic J Hare, Grant A van Riessen, David J Vine, Martin D de Jonge, Gawain McColl
Biological X-ray fluorescence microscopy (XFM) is an important tool for determining quantitative distributions of bioinorganics an..