Mitochondria: a target for intracellular bacterial pathogens.
Grant number: DP180101298 | Funding period: 2018 - 2020
This project aims to understand how intracellular bacterial pathogens target mitochondria. Coxiella burnetii is a unique and significant pathogen of humans and commercially important animals that uses effector proteins to control host cell functions. A cohort of these effectors target mitochondria. Since mitochondria are key players in cell health, the intended outcome of this research is to understand the role of the mitochondrially-targeted effector proteins. The project will determine the importance of mitochondrial protein trafficking for Coxiella pathogenesis and how mitochondrial function is altered during infection. This will provide understanding of how bacterial pathogens manipulate..View full description
Related publications (5)
Mapping bacterial effector arsenals: in vivo and in silico approaches to defining the protein features dictating effector secretion by bacteria
Yi Wei Lee, Jiawei Wang, Hayley J Newton, Trevor Lithgow
Many bacterial pathogens rely on dedicated secretion systems to translocate virulence proteins termed 'effectors' into host cells...
EirA Is a Novel Protein Essential for Intracellular Replication of Coxiella burnetii
Miku Kuba, Nitika Neha, Patrice Newton, Yi Wei Lee, Vicki Bennett-Wood, Abderrahman Hachani, David P De Souza, Brunda Nijagal, Saravanan Dayalan, Dedreia Tull, Malcolm J McConville, Fiona M Sansom, Hayley J Newton
The zoonotic bacterial pathogen Coxiella burnetii is the causative agent of Q fever, a febrile illness which can cause a serious c..
Biogenesis of the Spacious Coxiella-Containing Vacuole Depends on Host Transcription Factors TFEB and TFE3
Bhavna Padmanabhan, Laura F Fielden, Abderrahman Hachani, Patrice Newton, David R Thomas, Hyun-Jung Cho, Chen Ai Khoo, Diana Stojanovski, Craig R Roy, Nichollas E Scott, Hayley J Newton
Coxiella burnetii is an obligate intracellular bacterial pathogen that replicates inside the lysosome-derived Coxiella-containing ..
SopF, a phosphoinositide binding effector, promotes the stability of the nascent Salmonella-containing vacuole
Nicole Lau, Amanda L Haeberle, Brittany J O'Keeffe, Eleanor A Latomanski, Jean Celli, Hayley J Newton, Leigh A Knodler
The enteric bacterial pathogen Salmonella enterica serovar Typhimurium (S. Typhimurium), utilizes two type III secretion systems (..