Mitochondria: a target for intracellular bacterial pathogens.

Grant number: DP180101298 | Funding period: 2018 - 2020

Completed

Abstract

This project aims to understand how intracellular bacterial pathogens target mitochondria. Coxiella burnetii is a unique and significant pathogen of humans and commercially important animals that uses effector proteins to control host cell functions. A cohort of these effectors target mitochondria. Since mitochondria are key players in cell health, the intended outcome of this research is to understand the role of the mitochondrially-targeted effector proteins. The project will determine the importance of mitochondrial protein trafficking for Coxiella pathogenesis and how mitochondrial function is altered during infection. This will provide understanding of how bacterial pathogens manipulate..

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Related publications (7)

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Mapping bacterial effector arsenals: in vivo and in silico approaches to defining the protein features dictating effector secretion by bacteria

Yi Wei Lee, Jiawei Wang, Hayley J Newton, Trevor Lithgow

2020-10-01

Many bacterial pathogens rely on dedicated secretion systems to translocate virulence proteins termed 'effectors' into host cells...

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EirA Is a Novel Protein Essential for Intracellular Replication of Coxiella burnetii

Miku Kuba, Nitika Neha, Patrice Newton, Yi Wei Lee, Vicki Bennett-Wood, Abderrahman Hachani, David P De Souza, Brunda Nijagal, Saravanan Dayalan, Dedreia Tull, Malcolm J McConville, Fiona M Sansom, Hayley J Newton

2020-05-01

The zoonotic bacterial pathogen Coxiella burnetii is the causative agent of Q fever, a febrile illness which can cause a serious c..

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Biogenesis of the Spacious Coxiella-Containing Vacuole Depends on Host Transcription Factors TFEB and TFE3

Bhavna Padmanabhan, Laura F Fielden, Abderrahman Hachani, Patrice Newton, David R Thomas, Hyun-Jung Cho, Chen Ai Khoo, Diana Stojanovski, Craig R Roy, Nichollas E Scott, Hayley J Newton

2020-03-01

Coxiella burnetii is an obligate intracellular bacterial pathogen that replicates inside the lysosome-derived Coxiella-containing ..

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Coxiella burnetii utilizes both glutamate and glucose during infection with glucose uptake mediated by multiple transporters

Miku Kuba, Nitika Neha, David P De Souza, Saravanan Dayalan, Joshua PM Newson, Dedreia Tull, Malcolm J McConville, Fiona M Sansom, Hayley J Newton

2019-10-15

Coxiella burnetii is a Gram-negative bacterium which causes Q fever, a complex and life-threatening infection with both acute and ..

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SopF, a phosphoinositide binding effector, promotes the stability of the nascent Salmonella-containing vacuole

Nicole Lau, Amanda L Haeberle, Brittany J O'Keeffe, Eleanor A Latomanski, Jean Celli, Hayley J Newton, Leigh A Knodler

2019-07-01

The enteric bacterial pathogen Salmonella enterica serovar Typhimurium (S. Typhimurium), utilizes two type III secretion systems (..

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Taming the Triskelion: Bacterial Manipulation of Clathrin

Eleanor A Latomanski, Hayley J Newton

2019-06-01

The entry of pathogens into nonphagocytic host cells has received much attention in the past three decades, revealing a vast array..

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Biology and Pathogenesis of Legionella

Hayley J Newton, Elizabeth L Hartland, Matthias P Machner

2018-09-19