Engineering the Trafficking of Nanoparticles within Cells.

Grant number: DP180100844 | Funding period: 2018 - 2020

Completed

Abstract

This project aims to engineer responsive nanoparticles capable of trafficking efficiently within cells. The site of release of therapeutic cargo has importance for improving the efficacy of many treatments, for example vaccine delivery. Therefore fundamental understanding of how nanoparticle structure can be engineered to control cellular behaviour is necessary. The project will engineer new polymeric nanomaterials and investigate the impact of their structure on biological properties. The benefits of this project will include new fundamental insights into improving nanoparticle design for vaccine delivery, as well as the expansion of Australia’s knowledge base in the area of biodegradable p..

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Related publications (11)

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pH-responsive nanoparticles have generated significant interest for use as drug delivery systems due to their potential for induci..

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Quantifying the Endosomal Escape of pH-Responsive Nanoparticles Using the Split Luciferase Endosomal Escape Quantification Assay

Maximilian A Beach, Serena LY Teo, Moore Z Chen, Samuel A Smith, Colin W Pouton, Angus PR Johnston, Georgina K Such

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All nanoparticles have the potential to revolutionize the delivery of therapeutic cargo such as peptides, proteins, and RNA. Howev..

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Polyoxometalates as chemically and structurally versatile components in self-assembled materials

Yanting Gao, Manjiri Choudhari, Georgina K Such, Chris Ritchie

2021-12-22

Polyoxometalates (POMs) are anionic molecular metal oxides with expansive diversity in terms of their composition, structure, nucl..

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Acid-Responsive Poly(glyoxylate) Self-Immolative Star Polymers

Changhe Zhang, Sarah Kermaniyan, Samuel A Smith, Elizabeth R Gillies, Georgina K Such

2021-08-19

Self-immolative polymers have significant potential for applications such as drug or gene delivery. However, to realize this poten..

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Understanding the Polymer Rearrangement of pH-Responsive Nanoparticles

Nayeleh Deirram, Sarah S Kermaniyan, Angus PR Johnston, Georgina K Such

2021-02-23

The use of self-assembled nanoparticles for drug delivery has received significant attention in recent years. However, the dynamic..

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Rationale Design of pH-Responsive Core-Shell Nanoparticles: Polyoxometalate-Mediated Structural Reorganization

Y Gao, J Xu, C Zhang, H Venugopal, SS Kermaniyan, G Such, C Ritchie

2020-11-25

Herein, we report the rational design of pH-responsive core-shell nanoparticles that incorporate a polyoxometalate (POM) cargo. Co..

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Multicompartment Polymeric Nanocarriers for Biomedical Applications

Umeka Nayanathara, Sarah S Kermaniyan, Georgina K Such

2020-09-19

Multicompartment polymeric nanocarriers which mimic the compartmentalized architecture of living cells have received considerable ..

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pH-Responsive Polymer Nanoparticles for Drug Delivery

Nayeleh Deirram, Changhe Zhang, Sarah S Kermaniyan, Angus PR Johnston, Georgina K Such

2019-05-01

Stimuli-responsive nanoparticles have the potential to improve the delivery of therapeutics to a specific cell or region within th..

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The Endosomal Escape of Nanoparticles: Toward More Efficient Cellular Delivery

Samuel A Smith, Laura I Selby, Angus PR Johnston, Georgina K Such

2019-02-01

Many emerging therapies rely on the delivery of biological cargo into the cytosol. Nanoparticle delivery systems hold great potent..

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Controlling endosomal escape using nanoparticle composition: current progress and future perspectives

Kristofer I Cupic, Joshua J Rennick, Angus PR Johnston, Georgina K Such

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Polymer nanoparticles offer significant benefits for improving delivery of biological therapeutics such as DNA and proteins, as th..

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Understanding Cell Interactions Using Modular Nanoparticle Libraries

Georgina K Such, Angus PR Johnston

2019-01-01

Nanoparticle delivery systems have significant potential to facilitate the delivery of novel therapeutics, such as proteins, DNA o..

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