Engineering the Trafficking of Nanoparticles within Cells.
Grant number: DP180100844 | Funding period: 2018 - 2020
This project aims to engineer responsive nanoparticles capable of trafficking efficiently within cells. The site of release of therapeutic cargo has importance for improving the efficacy of many treatments, for example vaccine delivery. Therefore fundamental understanding of how nanoparticle structure can be engineered to control cellular behaviour is necessary. The project will engineer new polymeric nanomaterials and investigate the impact of their structure on biological properties. The benefits of this project will include new fundamental insights into improving nanoparticle design for vaccine delivery, as well as the expansion of Australia’s knowledge base in the area of biodegradable p..View full description
Related publications (11)
Understanding the Biological Interactions of pH-Swellable Nanoparticles
Sarah S Kermaniyan, Moore Chen, Changhe Zhang, Samuel A Smith, Angus PR Johnston, Chris Such, Georgina K Such
pH-responsive nanoparticles have generated significant interest for use as drug delivery systems due to their potential for induci..
Quantifying the Endosomal Escape of pH-Responsive Nanoparticles Using the Split Luciferase Endosomal Escape Quantification Assay
Maximilian A Beach, Serena LY Teo, Moore Z Chen, Samuel A Smith, Colin W Pouton, Angus PR Johnston, Georgina K Such
All nanoparticles have the potential to revolutionize the delivery of therapeutic cargo such as peptides, proteins, and RNA. Howev..
Polyoxometalates as chemically and structurally versatile components in self-assembled materials
Yanting Gao, Manjiri Choudhari, Georgina K Such, Chris Ritchie
Polyoxometalates (POMs) are anionic molecular metal oxides with expansive diversity in terms of their composition, structure, nucl..
Rationale Design of pH-Responsive Core-Shell Nanoparticles: Polyoxometalate-Mediated Structural Reorganization
Y Gao, J Xu, C Zhang, H Venugopal, SS Kermaniyan, G Such, C Ritchie
Herein, we report the rational design of pH-responsive core-shell nanoparticles that incorporate a polyoxometalate (POM) cargo. Co..
Controlling endosomal escape using nanoparticle composition: current progress and future perspectives
Kristofer I Cupic, Joshua J Rennick, Angus PR Johnston, Georgina K Such
Polymer nanoparticles offer significant benefits for improving delivery of biological therapeutics such as DNA and proteins, as th..