Uncovering novel metabolic processes in eukaryotic cells
Grant number: DP180102729 | Funding period: 2018 - 2021
This project aims to investigate the origin and function of the large number of chemically undefined metabolites that occur in all cells. The project will utilise advanced analytical techniques, as well as computational and genetic approaches, to characterise the chemical structures of these metabolites and identity the enzymes involved in their synthesis and degradation. It will provide new information on the metabolic capacity of eukaryotic cells and allow the generation of more accurate models of metabolism. These outcomes have important biotechnology applications and will identify metabolic processes that underpin normal and disease states in animals and human cells.
Related publications (2)
Non-canonical metabolic pathways in the malaria parasite detected by isotope-tracing metabolomics
Simon A Cobbold, Madel Tutor, Philip Frasse, Emma McHugh, Markus Karnthaler, Darren J Creek, Audrey Odom John, Leann Tilley, Stuart A Ralph, Malcolm J McConville
The malaria parasite, Plasmodium falciparum, proliferates rapidly in human erythrocytes by actively scavenging multiple carbon sou..
The Metabolite Repair Enzyme Phosphoglycolate Phosphatase Regulates Central Carbon Metabolism and Fosmidomycin Sensitivity in Plasmodium falciparum
Laure Dumont, Mark B Richardson, Phillip van der Peet, Danushka S Marapana, Tony Triglia, Matthew WA Dixon, Alan F Cowman, Spencer J Williams, Leann Tilley, Malcolm J McConville, Simon A Cobbold
Members of the haloacid dehalogenase (HAD) family of metabolite phosphatases play an important role in regulating multiple pathway..