MOLECULAR BASIS OF ARTEMISININ ACTION AND RESISTANCE IN PLASMODIUM FALCIPARUM
Grant number: 1139884 | Funding period: 2018 - 2021
The malaria parasite, P. falciparum causes ~450,000 deaths each year. Resistance to the front-line antimalarial drug, artemisinin, is increasing, threatening at least another 100,000 lives per year, and potentially causing an additional ~A$500M in lost productivity. This project will identify the components of the parasite's cellular defence system that underpin resistance and will point to strategies for overcoming resistance to this important drug class.
Related publications (2)
Antibiotic inhibition of the Plasmodium apicoplast decreases haemoglobin degradation and antagonises dihydroartemisinin action
Emily M Crisafulli, Amanda De Paoli, Madel V Tutor, Ghizal Siddiqui, Darren J Creek, Leann Tilley, Stuart A Ralph
<jats:title>Abstract</jats:title><jats:p>The World Health Organisation (WHO) recommends artemisinin (ART) combinations for treatme..
Multimodal analysis of Plasmodium knowlesi-infected erythrocytes reveals large invaginations, swelling of the host cell, and rheological defects
Boyin Liu, Adam J Blanch, Arman Namvar, Olivia Carmo, Snigdha Tiash, Dean Andrew, Eric Hanssen, Vijay Rajagopal, Matthew WA Dixon, Leann Tilley
The simian parasite Plasmodium knowlesi causes severe and fatal malaria infections in humans, but the process of host cell remodel..