STAR POLYMERS AS NOVEL ANTIMICROBIAL AND IMMUNOMODULATORY AGENTS

Grant number: 1142472 | Funding period: 2018 - 2021

Completed

Abstract

The rise in antibiotic resistance in bacteria is considered as a major public health threat that is not being met by antibiotic research. This project will modify a novel star polymer that we have shown kills antibiotic resistant bacteria but does not induce resistance. The project will make and characterise new versions of the star polymer to produce antimicrobial materials that target and kill the multi-drug resistant bacteria that are a major cause of bacterial infections and death.

Related publications (25)

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The effect of tailing lipidation on the bioactivity of antimicrobial peptides and their aggregation tendency Special Issue: Emerging Investigators

Bruce Lin, Andrew Hung, William Singleton, Kevion K Darmawan, Rachael Moses, Bicheng Yao, Hongkang Wu, Anders Barlow, Sani Marc-Antoine, Alastair J Sloan, Mohammed Akhter Hossain, John D Wade, Yuning Hong, Neil M O'Brien-Simpson, Wenyi Li

2023-02-24

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The overview of antimicrobial peptide‐coated implants against oral bacterial infections

Zhe Sun, Li Ma, Xiaodong Sun, Alastair J Sloan, Neil M O'Brien‐Simpson, Wenyi Li

2023-01-14

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The 'Danse Macabre'-Neutrophils the Interactive Partner Affecting Oral Cancer Outcomes

Sara Hadjigol, Bansari A Shah, Neil M O'Brien-Simpson

2022-06-16

Over the past few decades, tremendous advances in the prevention, diagnosis, and treatment of cancer have taken place. However for..

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Star-Peptide Polymers are Multi-Drug-Resistant Gram-Positive Bacteria Killers

Wenyi Li, Sara Hadjigol, Alicia Rasines Mazo, James Holden, Jason Lenzo, Steven J Shirbin, Anders Barlow, Sadegh Shabani, Tao Huang, Eric C Reynolds, Greg G Qiao, Neil M O'Brien-Simpson

2022-06-08

Antibiotic resistance in bacteria, especially Gram-positive bacteria like Staphylococcus aureus, is gaining considerable momentum ..

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Evaluation of Potential DnaK Modulating Proline-Rich Antimicrobial Peptides Identified by Computational Screening

Thomas NG Handley, Wenyi Li, Nicholas G Welch, Neil M O'Brien-Simpson, Mohammed Akhter Hossain, John D Wade

2022-04-13

The day is rapidly approaching where current antibiotic therapies will no longer be effective due to the development of multi-drug..

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Vernetzte Polypeptide durch RAFT‐vermittelte Polymerisation zum kontinuierlichen Aufbau von Polymerfilmen

Nicholas J Chan, Sarah Lentz, Paul A Gurr, Shereen Tan, Thomas Scheibel, Greg G Qiao

2022-02-21

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Enhancing proline-rich antimicrobial peptide action by homodimerization: influence of bifunctional linker

Wenyi Li, Feng Lin, Andrew Hung, Anders Barlow, Marc-Antoine Sani, Rita Paolini, William Singleton, James Holden, Mohammed Akhter Hossain, Frances Separovic, Neil M O'Brien-Simpson, John D Wade

2022-02-01

Antimicrobial peptides (AMPs) are host defense peptides, and unlike conventional antibiotics, they possess potent broad spectrum a..

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Systematic comparison of activity and mechanism of antimicrobial peptides against nosocomial pathogens

Bruce Lin, Andrew Hung, Rong Li, Anders Barlow, William Singleton, Tamara Matthyssen, Marc-Antoine D Sani, Mohammed Akhter Hossain, John Wade, Neil M O'Brien-Simpson, Wenyi Li

2022-01-24

The World Health Organisation has deemed several multi-drug resistant (MDR) nosocomial bacterial pathogens to be of significant th..

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Crosslinked Polypeptide Films via RAFT-Mediated Continuous Assembly of Polymers

Nicholas J Chan, Sarah Lentz, Paul A Gurr, Shereen Tan, Thomas Scheibel, Greg G Qiao

2022-01-12

Polypeptide coatings are a cornerstone in the field of surface modification due to their widespread biological potential. As their..

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The Potential of Modified and Multimeric Antimicrobial Peptide Materials as Superbug Killers

Tamara Matthyssen, Wenyi Li, James A Holden, Jason C Lenzo, Sara Hadjigol, Neil M O'Brien-Simpson

2022-01-10

Antimicrobial peptides (AMPs) are found in nearly all living organisms, show broad spectrum antibacterial activity, and can modula..

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The Potential of Calcium Phosphate Nanoparticles as Adjuvants and Vaccine Delivery Vehicles

Zhe Sun, Wenyi Li, Jason C Lenzo, James A Holden, Michael J McCullough, Andrea J O'Connor, Neil M O'Brien-Simpson

2021-12-22

Vaccination is one of the most efficacious and cost-effective ways to protect people from infectious diseases and potentially canc..

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Tumor Associated Macrophages: Origin, Recruitment, Phenotypic Diversity, and Targeting

Tetiana Hourani, James A Holden, Wenyi Li, Jason C Lenzo, Sara Hadjigol, Neil M O'Brien-Simpson

2021-12-20

The tumor microenvironment (TME) is known to have a strong influence on tumorigenesis, with various components being involved in t..

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Cationic Antimicrobial Peptides Are Leading the Way to Combat Oropathogenic Infections

Bruce Lin, Rong Li, Thomas NG Handley, John D Wade, Wenyi Li, Neil M O'Brien-Simpson

2021-09-30

Oral dental infections are one of the most common diseases affecting humans, with caries and periodontal disease having the highes..

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Chemically modified and conjugated antimicrobial peptides against superbugs

Wenyi Li, Frances Separovic, Neil M O'Brien-Simpson, John D Wade

2021-04-21

Antimicrobial resistance (AMR) is one of the greatest threats to human health that, by 2050, will lead to more deaths from bacteri..

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Recent Applications of Aggregation Induced Emission Probes for Antimicrobial Peptide Studies

Tracey Luu, Wenyi Li, Neil M O'Brien-Simpson, Yuning Hong

2021-03-25

Antimicrobial peptides (AMPs) are being intensively investigated as they are considered promising alternatives to antibiotics wher..

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Human glucose-dependent insulinotropic polypeptide (GIP) is an antimicrobial adjuvant re-sensitising multidrug-resistant Gram-negative bacteria

Da'san MM Jaradat, Nehaya Al-Karablieh, Basmah HM Zaarer, Wenyi Li, Khalil KY Saleh, Anas J Rasras, Saeid Abu-Romman, Neil M O'Brien-Simpson, John D Wade

2021-03-01

Increasing antibiotic resistance in Gram-negative bacteria has mandated the development of both novel antibiotics and alternative ..

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Multifunctional Antimicrobial Polypeptide-Selenium Nanoparticles Combat Drug-Resistant Bacteria

Tao Huang, James A Holden, Eric C Reynolds, Daniel E Heath, Neil M O'Brien-Simpson, Andrea J O'Connor

2020-12-16

Antibiotic-resistant bacteria are a severe threat to human health. The World Health Organization's Global Antimicrobial Surveillan..

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(Re)Defining the Proline-Rich Antimicrobial Peptide Family and the Identification of Putative New Members

Nicholas G Welch, Wenyi Li, Mohammed Akhter Hossain, Frances Separovic, Neil M O'Brien-Simpson, John D Wade

2020-12-01

As we rapidly approach a post-antibiotic era in which multi-drug resistant bacteria are ever-pervasive, antimicrobial peptides (AM..

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Peripheral memory T-cell profile is modified in patients undergoing periodontal management

Nidhi Medara, Jason C Lenzo, Katrina A Walsh, James A Holden, Eric C Reynolds, Ivan B Darby, Neil M O'Brien-Simpson

2020-11-22

AIMS: T-cells are known to have a role in periodontitis, however, the effect of periodontal therapy on peripheral memory T-cells i..

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Peripheral T helper cell profiles during management of periodontitis

Nidhi Medara, Jason C Lenzo, Katrina A Walsh, Neil M O'Brien-Simpson, Eric C Reynolds, Ivan B Darby

2020-11-12

AIM: Periodontitis has been associated with other systemic diseases with underlying inflammation responsible for the shared link. ..

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Antimicrobial nanoparticle coatings for medical implants: Design challenges and prospects

Xin Li, Tao Huang, Daniel E Heath, Neil M O'Brien-Simpson, Andrea J O'Connor

2020-11-01

Microbial colonization, infection, and biofilm formation are major complications in the use of implants and are the predominant ri..

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Ring opening polymerization of α-amino acids: advances in synthesis, architecture and applications of polypeptides and their hybrids.

Alicia Rasines Mazo, Stephanie Allison-Logan, Fatemeh Karimi, Nicholas Jun-An Chan, Wenlian Qiu, Wei Duan, Neil M O'Brien-Simpson, Greg G Qiao

2020-07-21

Polypeptides have attracted considerable attention in recent decades due to their inherent biodegradability and tunable cytocompat..

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Chemical Modification of Cellulose Membranes for SPOT Synthesis

Wenyi Li, John Wade, Eric Reynolds, Neil M O'Brien-Simpson

2020-01-01

Since the development of solid-phase peptide synthesis in the 1960s, many laboratories have modified the technology for the produc..

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The 9-Fluorenylmethoxycarbonyl (Fmoc) Group in Chemical Peptide Synthesis - Its Past, Present, and Future

Wenyi Li, Neil M O'Brien-Simpson, Mohammed Akhter Hossain, John D Wade

2020-01-01

The chemical formation of the peptide bond has long fascinated and challenged organic chemists. It requires not only the activatio..

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Combating bacterial resistance by combination of antibiotics with antimicrobial peptides

Dean E Sheard, Neil M O'Brien-Simpson, John D Wade, Frances Separovic

2019-02-25

The overuse of antibiotics in the healthcare and agricultural industries has led to the worldwide spread of bacterial resistance. ..