STAR POLYMERS AS NOVEL ANTIMICROBIAL AND IMMUNOMODULATORY AGENTS

Grant number: 1142472 | Funding period: 2018 - 2021

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Abstract

The rise in antibiotic resistance in bacteria is considered as a major public health threat that is not being met by antibiotic research. This project will modify a novel star polymer that we have shown kills antibiotic resistant bacteria but does not induce resistance. The project will make and characterise new versions of the star polymer to produce antimicrobial materials that target and kill the multi-drug resistant bacteria that are a major cause of bacterial infections and death.

Related publications (13)

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Cationic Antimicrobial Peptides Are Leading the Way to Combat Oropathogenic Infections.

Bruce Lin, Rong Li, Thomas NG Handley, John D Wade, Wenyi Li, Neil M O'Brien-Simpson

2021-11-12

Oral dental infections are one of the most common diseases affecting humans, with caries and periodontal disease having the highes..

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Chemically modified and conjugated antimicrobial peptides against superbugs

Wenyi Li, Frances Separovic, Neil M O'Brien-Simpson, John D Wade

2021-04-21

Antimicrobial resistance (AMR) is one of the greatest threats to human health that, by 2050, will lead to more deaths from bacteri..

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Recent Applications of Aggregation Induced Emission Probes for Antimicrobial Peptide Studies

Tracey Luu, Wenyi Li, Neil M O'Brien-Simpson, Yuning Hong

2021-03-25

Antimicrobial peptides (AMPs) are being intensively investigated as they are considered promising alternatives to antibiotics wher..

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Human glucose-dependent insulinotropic polypeptide (GIP) is an antimicrobial adjuvant re-sensitising multidrug-resistant Gram-negative bacteria

Da'san MM Jaradat, Nehaya Al-Karablieh, Basmah HM Zaarer, Wenyi Li, Khalil KY Saleh, Anas J Rasras, Saeid Abu-Romman, Neil M O'Brien-Simpson, John D Wade

2021-03-01

Increasing antibiotic resistance in Gram-negative bacteria has mandated the development of both novel antibiotics and alternative ..

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Multifunctional Antimicrobial Polypeptide-Selenium Nanoparticles Combat Drug-Resistant Bacteria

Tao Huang, James A Holden, Eric C Reynolds, Daniel E Heath, Neil M O'Brien-Simpson, Andrea J O'Connor

2020-12-16

Antibiotic-resistant bacteria are a severe threat to human health. The World Health Organization's Global Antimicrobial Surveillan..

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(Re)Defining the Proline-Rich Antimicrobial Peptide Family and the Identification of Putative New Members

Nicholas G Welch, Wenyi Li, Mohammed Akhter Hossain, Frances Separovic, Neil M O'Brien-Simpson, John D Wade

2020-12-01

As we rapidly approach a post-antibiotic era in which multi-drug resistant bacteria are ever-pervasive, antimicrobial peptides (AM..

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Peripheral memory T-cell profile is modified in patients undergoing periodontal management

Nidhi Medara, Jason C Lenzo, Katrina A Walsh, James A Holden, Eric C Reynolds, Ivan B Darby, Neil M O'Brien-Simpson

2020-11-22

AIMS: T-cells are known to have a role in periodontitis, however, the effect of periodontal therapy on peripheral memory T-cells i..

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Peripheral T helper cell profiles during management of periodontitis

Nidhi Medara, Jason C Lenzo, Katrina A Walsh, Neil M O'Brien-Simpson, Eric C Reynolds, Ivan B Darby

2020-11-12

AIM: Periodontitis has been associated with other systemic diseases with underlying inflammation responsible for the shared link. ..

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Antimicrobial nanoparticle coatings for medical implants: Design challenges and prospects

Xin Li, Tao Huang, Daniel E Heath, Neil M O'Brien-Simpson, Andrea J O'Connor

2020-11-01

Microbial colonization, infection, and biofilm formation are major complications in the use of implants and are the predominant ri..

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Ring opening polymerization of α-amino acids: advances in synthesis, architecture and applications of polypeptides and their hybrids.

Alicia Rasines Mazo, Stephanie Allison-Logan, Fatemeh Karimi, Nicholas Jun-An Chan, Wenlian Qiu, Wei Duan, Neil M O'Brien-Simpson, Greg G Qiao

2020-07-21

Polypeptides have attracted considerable attention in recent decades due to their inherent biodegradability and tunable cytocompat..

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Chemical Modification of Cellulose Membranes for SPOT Synthesis

Wenyi Li, John Wade, Eric Reynolds, Neil M O'Brien-Simpson

2020-01-01

Since the development of solid-phase peptide synthesis in the 1960s, many laboratories have modified the technology for the produc..

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The 9-Fluorenylmethoxycarbonyl (Fmoc) Group in Chemical Peptide Synthesis - Its Past, Present, and Future

Wenyi Li, Neil M O'Brien-Simpson, Mohammed Akhter Hossain, John D Wade

2020-01-01

The chemical formation of the peptide bond has long fascinated and challenged organic chemists. It requires not only the activatio..

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Combating bacterial resistance by combination of antibiotics with antimicrobial peptides

Dean E Sheard, Neil M O'Brien-Simpson, John D Wade, Frances Separovic

2019-02-01

The overuse of antibiotics in the healthcare and agricultural industries has led to the worldwide spread of bacterial resistance. ..