STAR POLYMERS AS NOVEL ANTIMICROBIAL AND IMMUNOMODULATORY AGENTS
Grant number: 1142472 | Funding period: 2018 - 2021
The rise in antibiotic resistance in bacteria is considered as a major public health threat that is not being met by antibiotic research. This project will modify a novel star polymer that we have shown kills antibiotic resistant bacteria but does not induce resistance. The project will make and characterise new versions of the star polymer to produce antimicrobial materials that target and kill the multi-drug resistant bacteria that are a major cause of bacterial infections and death.
Related publications (13)
Cationic Antimicrobial Peptides Are Leading the Way to Combat Oropathogenic Infections.
Bruce Lin, Rong Li, Thomas NG Handley, John D Wade, Wenyi Li, Neil M O'Brien-Simpson
Oral dental infections are one of the most common diseases affecting humans, with caries and periodontal disease having the highes..
Human glucose-dependent insulinotropic polypeptide (GIP) is an antimicrobial adjuvant re-sensitising multidrug-resistant Gram-negative bacteria
Da'san MM Jaradat, Nehaya Al-Karablieh, Basmah HM Zaarer, Wenyi Li, Khalil KY Saleh, Anas J Rasras, Saeid Abu-Romman, Neil M O'Brien-Simpson, John D Wade
Increasing antibiotic resistance in Gram-negative bacteria has mandated the development of both novel antibiotics and alternative ..
Multifunctional Antimicrobial Polypeptide-Selenium Nanoparticles Combat Drug-Resistant Bacteria
Tao Huang, James A Holden, Eric C Reynolds, Daniel E Heath, Neil M O'Brien-Simpson, Andrea J O'Connor
Antibiotic-resistant bacteria are a severe threat to human health. The World Health Organization's Global Antimicrobial Surveillan..
(Re)Defining the Proline-Rich Antimicrobial Peptide Family and the Identification of Putative New Members
Nicholas G Welch, Wenyi Li, Mohammed Akhter Hossain, Frances Separovic, Neil M O'Brien-Simpson, John D Wade
As we rapidly approach a post-antibiotic era in which multi-drug resistant bacteria are ever-pervasive, antimicrobial peptides (AM..
Peripheral memory T-cell profile is modified in patients undergoing periodontal management
Nidhi Medara, Jason C Lenzo, Katrina A Walsh, James A Holden, Eric C Reynolds, Ivan B Darby, Neil M O'Brien-Simpson
AIMS: T-cells are known to have a role in periodontitis, however, the effect of periodontal therapy on peripheral memory T-cells i..
Peripheral T helper cell profiles during management of periodontitis
Nidhi Medara, Jason C Lenzo, Katrina A Walsh, Neil M O'Brien-Simpson, Eric C Reynolds, Ivan B Darby
AIM: Periodontitis has been associated with other systemic diseases with underlying inflammation responsible for the shared link. ..
Antimicrobial nanoparticle coatings for medical implants: Design challenges and prospects
Xin Li, Tao Huang, Daniel E Heath, Neil M O'Brien-Simpson, Andrea J O'Connor
Microbial colonization, infection, and biofilm formation are major complications in the use of implants and are the predominant ri..
Ring opening polymerization of α-amino acids: advances in synthesis, architecture and applications of polypeptides and their hybrids.
Alicia Rasines Mazo, Stephanie Allison-Logan, Fatemeh Karimi, Nicholas Jun-An Chan, Wenlian Qiu, Wei Duan, Neil M O'Brien-Simpson, Greg G Qiao
Polypeptides have attracted considerable attention in recent decades due to their inherent biodegradability and tunable cytocompat..
The 9-Fluorenylmethoxycarbonyl (Fmoc) Group in Chemical Peptide Synthesis - Its Past, Present, and Future
Wenyi Li, Neil M O'Brien-Simpson, Mohammed Akhter Hossain, John D Wade
The chemical formation of the peptide bond has long fascinated and challenged organic chemists. It requires not only the activatio..
Combating bacterial resistance by combination of antibiotics with antimicrobial peptides
Dean E Sheard, Neil M O'Brien-Simpson, John D Wade, Frances Separovic
The overuse of antibiotics in the healthcare and agricultural industries has led to the worldwide spread of bacterial resistance. ..