UNDERSTANDING NEUROINFLAMMATION IN ALZHEIMER'S DISEASE
Grant number: 1142989 | Funding period: 2018 - 2021
This project opens a new line of enquiry into the cellular signalling mechanisms involved in the progression of AD and establishes whether targeting the involvement of type-1 IFN signalling influences the evolution of AD. New and novel approaches are clearly required to treat AD. Importantly, we believe that neuroinflammation is common to all causes of dementia and targeting the neuroinflammatory pathways has much wider implications than targeting the primary causative pathway.
Related publications (2)
An altered glial phenotype in the NL3(R451C) mouse model of autism
Samantha M Matta, Zachery Moore, Frederick Rohan Walker, Elisa L Hill-Yardin, Peter J Crack
Autism Spectrum Disorder (ASD; autism) is a neurodevelopmental disorder characterised by deficits in social communication, and res..
Abrogation of type-I interferon signalling alters the microglial response to A beta(1-42)
Zachery Moore, Frank Mobilio, Frederick R Walker, Juliet M Taylor, Peter J Crack
Neuroinflammation and accompanying microglial dysfunction are now appreciated to be involved in Alzheimer's disease (AD) pathogene..