PRIMING, RECRUITMENT AND RETENTION OF INFLUENZA VIRUS SPECIFIC CD8 T CELLS IN THE UPPER AIRWAYS
Grant number: 1143735 | Funding period: 2018 - 2021
Influenza virus gains entry into the body by inhalation and initiates its replication cycle within the upper airways. This early stage of infection, when the amount of influenza virus is low, provides the ideal window of opportunity for an effective immune response to limit disease progression. In this proposal we will define the immunity that can be evoked within the upper airways and determine immune mechanisms left behind that can safeguard this region from this important respiratory pathogen
Related publications (1)
Intranasal Delivery of a Chitosan-Hydrogel Vaccine Generates Nasal Tissue Resident Memory CD8( ) T Cells That Are Protective against Influenza Virus Infection
James G Bedford, Irina Caminschi, Linda M Wakim
Rapid antigen clearance from the nasal mucosa is one of the major challenges in the development of intranasal vaccines. Here, we t..