INTERPLAY BETWEEN METABOLIC REPROGRAMMING AND ONCOGENIC SIGNALLING IN THE CELLULAR RESPONSE TO CHEMOTHERAPY
Grant number: 1146642 | Funding period: 2018 - 2021
Chemotherapy resistance is a major barrier to the treatment of triple-negative breast cancer (TNBC). We seek to uncover an intimate link between cell metabolism and oncogenic signalling pathways in regulating the cellular response to chemotherapy. Our studies will identify a critical mechanism limiting the therapeutic efficacy of chemotherapy and investigate combination therapy strategies that could improve the treatment of TNBC.
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Internal tandem duplication of the FMS-like tyrosine kinase 3 gene (FLT3-ITD) occurs in 30% of all acute myeloid leukemias (AML). ..