INTERPLAY BETWEEN METABOLIC REPROGRAMMING AND ONCOGENIC SIGNALLING IN THE CELLULAR RESPONSE TO CHEMOTHERAPY

Grant number: 1146642 | Funding period: 2018 - 2021

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Abstract

Chemotherapy resistance is a major barrier to the treatment of triple-negative breast cancer (TNBC). We seek to uncover an intimate link between cell metabolism and oncogenic signalling pathways in regulating the cellular response to chemotherapy. Our studies will identify a critical mechanism limiting the therapeutic efficacy of chemotherapy and investigate combination therapy strategies that could improve the treatment of TNBC.

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