DEVELOPMENT AND SELECTION OF MAIT CELLS
Grant number: 1140126 | Funding period: 2018 - 2021
MAIT cells are a recently discovered type of lymphocyte that plays a unique and important role in the immune system. However, these cells vary widely in number between healthy individuals, for reasons that are unclear. This project is designed to understand the factors that control the development of MAIT cells as a step toward regulating their numbers and activity.
Related publications (8)
A single-domain bispecific antibody targeting CD1d and the NKT T-cell receptor induces a potent antitumor response
Roeland Lameris, Adam Shahine, Daniel G Pellicci, Adam P Uldrich, Stephanie Gras, Jerome Le Nours, Richard WJ Groen, Jana Vree, Scott JJ Reddiex, Sergio M Quinones-Parra, Stewart K Richardson, Amy R Howell, Sonja Zweegman, Dale I Godfrey, Tanja D de Gruijl, Jamie Rossjohn, Hans J van der Vliet
A divergent transcriptional landscape underpins the development and functional branching of MAIT cells
H-F Koay, S Su, D Amann-Zalcenstein, SR Daley, I Comerford, L Miosge, CE Whyte, IE Konstantinov, Y d'Udekem, T Baldwin, PF Hickey, SP Berzins, JYW Mak, Y Sontani, CM Roots, T Sidwell, A Kallies, Z Chen, S Nussing, K Kedzierska
MR1-restricted mucosal-associated invariant T (MAIT) cells play a unique role in the immune system. These cells develop intrathymi..
Diverse MR1-restricted T cells in mice and humans.
Hui-Fern Koay, Nicholas A Gherardin, Calvin Xu, Rebecca Seneviratna, Zhe Zhao, Zhenjun Chen, David P Fairlie, James McCluskey, Daniel G Pellicci, Adam P Uldrich, Dale I Godfrey
Mucosal-associated invariant T (MAIT) cells express an invariant TRAV1/TRAJ33 TCR-α chain and are restricted to the MHC-I-like mol..