DEVELOPMENT AND SELECTION OF MAIT CELLS

A high-dimensional cytometry atlas of peripheral blood over the human life span

Sedigheh Jalali, Christopher M Harpur, Adam T Piers, Maria Auladell, Louis Perriman, Shuo Li, Kim An, Jeremy Anderson, Stuart P Berzins, Paul Licciardi, Thomas M Ashhurst, Igor E Konstantinov, Daniel G Pellicci

2022-11-06

Age can profoundly affect susceptibility to a broad range of human diseases. Children are more susceptible to some infectious dise..

The NKT cell TCR repertoire can accommodate structural modifications to the lipid and orientation of the terminal carbohydrate of iGb3

Garth Cameron, Janice MH Cheng, Dale I Godfrey, Mattie SM Timmer, Bridget L Stocker, Emma M Dangerfield

2022-06-22

Isoglobotrihexosylceramide (iGb3) is a known NKT cell agonist, however the specific interactions required to trigger NKT cell TCR ..

An unconventional view of COVID-19 T cell immunity

Hui-Fern Koay, Thomas S Fulford, Dale I Godfrey

2020-12-01

In this issue of JEM, Jouan et al. (https://doi.org/10.1084/jem.20200872) report the activation and skewed function of unconventio..

A single-domain bispecific antibody targeting CD1d and the NKT T-cell receptor induces a potent antitumor response

Roeland Lameris, Adam Shahine, Daniel G Pellicci, Adam P Uldrich, Stephanie Gras, Jerome Le Nours, Richard WJ Groen, Jana Vree, Scott JJ Reddiex, Sergio M Quinones-Parra, Stewart K Richardson, Amy R Howell, Sonja Zweegman, Dale I Godfrey, Tanja D de Gruijl, Jamie Rossjohn, Hans J van der Vliet

2020-11-01

Antibody-mediated modulation of major histocompatibility complex (MHC) molecules, or MHC class I-like molecules, could constitute ..

Thymic development of unconventional T cells: how NKT cells, MAIT cells and gamma delta T cells emerge

Daniel G Pellicci, Hui-Fern Koay, Stuart P Berzins

2020-06-24

T cell lineages are defined by specialized functions and differential expression of surface antigens, cytokines and transcription ..

Human Mucosal-Associated Invariant T Cells in Older Individuals Display Expanded TCR alpha beta Clonotypes with Potent Antimicrobial Responses

Liyen Loh, Nicholas A Gherardin, Sneha Sant, Ludivine Grzelak, Jeremy Chase Crawford, Nicola L Bird, Hui-Fern Koay, Carolien E van de Sandt, Marcela L Moreira, Martha Lappas, E Kaitlynn Allen, Jane Crowe, Thomas Loudovaris, Katie L Flanagan, Kylie M Quinn, Jamie Rossjohn, Paul G Thomas, Sidonia BG Eckle, James McCluskey, Dale I Godfrey

2020-03-01

Mucosal-associated invariant T (MAIT) cells are important for immune responses against microbial infections. Although known to und..

A divergent transcriptional landscape underpins the development and functional branching of MAIT cells

H-F Koay, S Su, D Amann-Zalcenstein, SR Daley, I Comerford, L Miosge, CE Whyte, IE Konstantinov, Y d'Udekem, T Baldwin, PF Hickey, SP Berzins, JYW Mak, Y Sontani, CM Roots, T Sidwell, A Kallies, Z Chen, S Nussing, K Kedzierska

2019-11-01

MR1-restricted mucosal-associated invariant T (MAIT) cells play a unique role in the immune system. These cells develop intrathymi..

The biology and functional importance of MAIT cells

Dale Godfrey, Hui-Fern Koay, James McCluskey, Nicholas A Gherardin

2019-09-01

In recent years, a population of unconventional T cells called 'mucosal-associated invariant T cells' (MAIT cells) has captured th..

Chronically stimulated human MAIT cells are unexpectedly potent IL-13 producers

Jason Kelly, Yosuke Minoda, Tobias Meredith, Garth Cameron, Marie-Sophie Philipp, Daniel G Pellicci, Alexandra J Corbett, Christian Kurts, Daniel HD Gray, Dale Godfrey, George Kannourakis, Stuart P Berzins

2019-07-19

Mucosal-associated invariant T (MAIT) cells are unconventional T cells that recognize antigens derived from riboflavin biosynthesi..

Diverse MR1-restricted T cells in mice and humans.

Hui-Fern Koay, Nicholas A Gherardin, Calvin Xu, Rebecca Seneviratna, Zhe Zhao, Zhenjun Chen, David P Fairlie, James McCluskey, Daniel G Pellicci, Adam P Uldrich, Dale I Godfrey

2019-05-21

Mucosal-associated invariant T (MAIT) cells express an invariant TRAV1/TRAJ33 TCR-α chain and are restricted to the MHC-I-like mol..

Development of mucosal-associated invariant T cells

Hui-Fern Koay, Dale I Godfrey, Daniel G Pellicci

2018-07-01

Mucosal-associated invariant T (MAIT) cells develop in the thymus and migrate into the periphery to become the largest antigen-spe..