NOVEL MECHANISMS OF EARLY AGE RELATED MACULAR DEGENERATION

Grant number: 1138253 | Funding period: 2018 - 2021

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Abstract

Age Related Macular degeneration (AMD) is a leading cause of blindness in Australia. In this project we will examine a novel mechanism by which the cells at the back of the eye, called retinal pigment eptihelial cells contribute to vision loss early in the disease. In addition we will examine the potential for two currently used drugs as well as a novel laser treatment in slowing the progression of disease.

Related publications (13)

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Transcriptomic Profiling of Human Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Over Time

Grace E Lidgerwood, Anne Senabouth, Casey JA Smith-Anttila, Vikkitharan Gnanasambandapillai, Dominik C Kaczorowski, Daniela Amann-Zalcenstein, Erica L Fletcher, Shalin H Naik, Alex W Hewitt, Joseph E Powell, Alice Pébay

<jats:title>Abstract</jats:title><jats:p>Human pluripotent stem cell (hPSC)-derived progenies are immature versions of cells, pres..

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Retinal ganglion cell dysfunction in mice following acute intraocular pressure is exacerbated by P2X7 receptor knockout

Anna YM Wang, Vickie HY Wong, Pei Ying Lee, Bang V Bui, Stefanie Dudczig, Kirstan A Vessey, Erica L Fletcher

2021-02-18

There is increasing evidence for the vulnerability of specific retinal ganglion cell (RGC) types in those with glaucoma and in ani..

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Transcriptomic Profiling of Human Pluripotent Stem Cell-derived Retinal Pigment Epithelium over Time.

Grace E Lidgerwood, Anne Senabouth, Casey JA Smith-Anttila, Vikkitharan Gnanasambandapillai, Dominik C Kaczorowski, Daniela Amann-Zalcenstein, Erica L Fletcher, Shalin H Naik, Alex W Hewitt, Joseph E Powell, Alice Pébay

2020-12-08

Human pluripotent stem cell (hPSC)-derived progenies are immature versions of cells, presenting a potential limitation to the accu..

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Photoreceptor Degeneration in Pro23His Transgenic Rats (Line 3) Involves Autophagic and Necroptotic Mechanisms

Kiana Kakavand, Andrew I Jobling, Ursula Greferath, Kirstan A Vessey, Robb U de Iongh, Erica L Fletcher

2020-11-03

Photoreceptor death contributes to 50% of irreversible vision loss in the western world. Pro23His (P23H) transgenic albino rat str..

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Potential mechanisms of retinal ganglion cell type-specific vulnerability in glaucoma

Anna YM Wang, Pei Ying Lee, Bang Bui, Andrew Jobling, Ursula Greferath, Alice Brandli, Michael A Dixon, Quan Findlay, Erica L Fletcher, Kirstan A Vessey

2020-09-01

Glaucoma is a neurodegenerative disease characterised by progressive damage to the retinal ganglion cells (RGCs), the output neuro..

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Contribution of microglia and monocytes to the development and progression of age related macular degeneration

Erica L Fletcher

2020-02-04

PURPOSE: Age related macular degeneration (AMD) is the leading cause of irreversible vision loss in industrialised nations. Based ..

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Failure of Autophagy-Lysosomal Pathways in Rod Photoreceptors Causes the Early Retinal Degeneration Phenotype Observed in Cln6(nclf) Mice

Philipp von Eisenhart-Rothe, Alexandra Grubman, Ursula Greferath, Linda J Fothergill, Andrew Jobling, Joanna A Phipps, Anthony R White, Erica L Fletcher, Kirstan A Vessey

2018-10-01

Purpose: Vision loss caused by photoreceptor death represents one of the first symptoms in neuronal ceroid lipofuscinosis, a condi..

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Treatment of age related macular degeneration using nanosecond laser therapy: Safety profile studies in humans and mice

Kirstan Anne Vessey, Tracy Ho, Andrew Ian Jobling, Samuel A Mills, Mai Tran, Alice Brandli, Jackson Lam, Robyn H Guymer, Erica L Fletcher

2018-07-01

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Prophylactic laser in age-related macular degeneration: the past, the present and the future

Quan Findlay, Andrew I Jobling, Kirstan A Vessey, Ursula Greferath, Joanna A Phipps, Robyn H Guymer, Erica L Fletcher

2018-05-01

The presence of drusen in the posterior eye is a hallmark feature of the early stages of age-related macular degeneration and thei..

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Nanosecond Laser Treatment for Age-Related Macular Degeneration Does Not Induce Focal Vision Loss or New Vessel Growth in the Retina

Kirstan A Vessey, Tracy Ho, Andrew I Jobling, Samuel A Mills, Mai X Tran, Alice Brandli, Jackson Lam, Robyn H Guymer, Erica L Fletcher

2018-02-01

Purpose: Subthreshold, nanosecond pulsed laser treatment shows promise as a treatment for age-related macular degeneration (AMD); ..

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Reduced Phagocytosis as a novel pathogenic mechanism in AMD pathogenesis

Emily Caruso, Ben Gu, Erica L Fletcher, Xin Huang, Pavan Avula, Kirstan Anne Vessey, James Saville Wiley, Robyn H Guymer

2017-06-01

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Evaluation of lipofuscin accumulation and retinal degeneration in the mouse model of the Neuronal Ceroid Lipofuscinosis variant CLN6

Philipp Guennel, Kirstan Vessey, Alexandra Grubman, Anthony White, Erica Fletcher

2016-09-01

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Correlation of Histologic Features with In Vivo Imaging of Reticular Pseudodrusen

Ursula Greferath, Robyn H Guymer, Kirstan A Vessey, Kate Brassington, Erica L Fletcher

2016-06-01

PURPOSE: To determine the histologic and cellular correlates in the retina and retinal pigment epithelium (RPE) with the presence ..

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