Novel Mechanisms Of Early Age Related Macular Degeneration

Grant number: 1138253 | Funding period: 2018 - 2021

Active

Abstract

Age Related Macular degeneration (AMD) is a leading cause of blindness in Australia. In this project we will examine a novel mechanism by which the cells at the back of the eye, called retinal pigment eptihelial cells contribute to vision loss early in the disease. In addition we will examine the potential for two currently used drugs as well as a novel laser treatment in slowing the progression of disease.

Related publications (7)

Scholarly works icon

Failure of Autophagy-Lysosomal Pathways in Rod Photoreceptors Causes the Early Retinal Degeneration Phenotype Observed in Cln6(nclf) Mice

Philipp von Eisenhart-Rothe, Alexandra Grubman, Ursula Greferath, Linda J Fothergill, Andrew Jobling, Joanna A Phipps, Anthony R White, Erica L Fletcher, Kirstan A Vessey

2018-10-01

Scholarly works icon

Treatment of age related macular degeneration using nanosecond laser therapy: Safety profile studies in humans and mice

Kirstan Anne Vessey, Tracy Ho, Andrew Ian Jobling, Samuel A Mills, Mai Tran, Alice Brandli, Jackson Lam, Robyn H Guymer, Erica L Fletcher

2018-07-01

Scholarly works icon

Prophylactic laser in age-related macular degeneration: the past, the present and the future

Quan Findlay, Andrew I Jobling, Kirstan A Vessey, Ursula Greferath, Joanna A Phipps, Robyn H Guymer, Erica L Fletcher

2018-05-01

Scholarly works icon

Nanosecond Laser Treatment for Age-Related Macular Degeneration Does Not Induce Focal Vision Loss or New Vessel Growth in the Retina

Kirstan A Vessey, Tracy Ho, Andrew I Jobling, Samuel A Mills, Mai X Tran, Alice Brandli, Jackson Lam, Robyn H Guymer, Erica L Fletcher

2018-02-01

Scholarly works icon

Reduced Phagocytosis as a novel pathogenic mechanism in AMD pathogenesis

Emily Caruso, Ben Gu, Erica L Fletcher, Xin Huang, Pavan Avula, Kirstan Anne Vessey, James Saville Wiley, Robyn H Guymer

2017-06-01

Scholarly works icon

Evaluation of lipofuscin accumulation and retinal degeneration in the mouse model of the Neuronal Ceroid Lipofuscinosis variant CLN6

Philipp Guennel, Kirstan Vessey, Alexandra Grubman, Anthony White, Erica Fletcher

2016-09-01

Scholarly works icon

Correlation of Histologic Features with In Vivo Imaging of Reticular Pseudodrusen

Ursula Greferath, Robyn H Guymer, Kirstan A Vessey, Kate Brassington, Erica L Fletcher

2016-06-01