NOVEL MECHANISMS OF EARLY AGE RELATED MACULAR DEGENERATION
Grant number: 1138253 | Funding period: 2018 - 2021
Age Related Macular degeneration (AMD) is a leading cause of blindness in Australia. In this project we will examine a novel mechanism by which the cells at the back of the eye, called retinal pigment eptihelial cells contribute to vision loss early in the disease. In addition we will examine the potential for two currently used drugs as well as a novel laser treatment in slowing the progression of disease.
Related publications (12)
Retinal ganglion cell dysfunction in mice following acute intraocular pressure is exacerbated by P2X7 receptor knockout
Anna YM Wang, Vickie HY Wong, Pei Ying Lee, Bang V Bui, Stefanie Dudczig, Kirstan A Vessey, Erica L Fletcher
There is increasing evidence for the vulnerability of specific retinal ganglion cell (RGC) types in those with glaucoma and in ani..
Transcriptomic Profiling of Human Pluripotent Stem Cell-derived Retinal Pigment Epithelium over Time.
Grace E Lidgerwood, Anne Senabouth, Casey JA Smith-Anttila, Vikkitharan Gnanasambandapillai, Dominik C Kaczorowski, Daniela Amann-Zalcenstein, Erica L Fletcher, Shalin H Naik, Alex W Hewitt, Joseph E Powell, Alice Pébay
Human pluripotent stem cell (hPSC)-derived progenies are immature versions of cells, presenting a potential limitation to the accu..
Photoreceptor Degeneration in Pro23His Transgenic Rats (Line 3) Involves Autophagic and Necroptotic Mechanisms
Kiana Kakavand, Andrew I Jobling, Ursula Greferath, Kirstan A Vessey, Robb U de Iongh, Erica L Fletcher
Photoreceptor death contributes to 50% of irreversible vision loss in the western world. Pro23His (P23H) transgenic albino rat str..
Potential mechanisms of retinal ganglion cell type-specific vulnerability in glaucoma
Anna YM Wang, Pei Ying Lee, Bang Bui, Andrew Jobling, Ursula Greferath, Alice Brandli, Michael A Dixon, Quan Findlay, Erica L Fletcher, Kirstan A Vessey
Glaucoma is a neurodegenerative disease characterised by progressive damage to the retinal ganglion cells (RGCs), the output neuro..
Failure of Autophagy-Lysosomal Pathways in Rod Photoreceptors Causes the Early Retinal Degeneration Phenotype Observed in Cln6(nclf) Mice
Philipp von Eisenhart-Rothe, Alexandra Grubman, Ursula Greferath, Linda J Fothergill, Andrew Jobling, Joanna A Phipps, Anthony R White, Erica L Fletcher, Kirstan A Vessey