ESSENTIAL GENE REGULATION IN MULTI-DRUG RESISTANT GOLDEN STAPH: A NEW PATH TOWARDS CONTROL
Grant number: 1145075 | Funding period: 2018 - 2021
New antibiotics effective against Golden Staph are urgently needed. This project will investigate a new approach to weaken Golden Staph defences with the potential to make existing antibiotics more effective at killing these bacteria.
Related publications (2)
Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus
Ian R Monk, Nausad Shaikh, Stephanie L Begg, Mike Gajdiss, Liam KR Sharkey, Jean YH Lee, Sacha J Pidot, Torsten Seemann, Michael Kuiper, Brit Winnen, Rikki Hvorup, Brett M Collins, Gabriele Bierbaum, Saumya R Udagedara, Jacqueline R Morey, Neha Pulyani, Benjamin P Howden, Megan J Maher, Christopher A McDevitt, Glenn F King
WalKR (YycFG) is the only essential two-component regulator in the human pathogen Staphylococcus aureus. WalKR regulates peptidogl..