DEVELOPMENT OF AN INTERLEUKIN-11 SIGNALLING ANTAGONIST

Grant number: 1147621 | Funding period: 2018 - 2022

Active

Abstract

Interleukin (IL)-11 is a soluble signalling molecule that is associated with many types of cancer. We have recently discovered that IL-11 signalling is a novel and tractable therapeutic target for the treatment of colon cancer. The aims of this proposal are to understand the structural details of IL-11 signalling. We will use this information to develop new and improved therapeutics for colon cancer.

Related publications (4)

Scholarly works icon

Functional and structural analysis of cytokine-selective IL6ST defects that cause recessive hyper-IgE syndrome

Yin-Huai Chen, Diane B Zastrow, Riley D Metcalfe, Lisa Gartner, Freia Krause, Craig J Morton, Shruti Marwaha, Laure Fresard, Yong Huang, Chunli Zhao, Colleen McCormack, David Bick, Elizabeth A Worthey, Christine M Eng, Jessica Gold, Stephen B Montgomery, Paul G Fisher, Euan A Ashley, Matthew T Wheeler, Michael W Parker

2021-08-01

BACKGROUND: Biallelic variants in IL6ST, encoding GP130, cause a recessive form of hyper-IgE syndrome (HIES) characterized by high..

Scholarly works icon

Type 2 Innate Lymphoid Cells Protect against Colorectal Cancer Progression and Predict Improved Patient Survival

Qiutong Huang, Nicolas Jacquelot, Adele Preaudet, Soroor Hediyeh-zadeh, Fernando Souza-Fonseca-Guimaraes, Andrew NJ McKenzie, Philip M Hansbro, Melissa J Davis, Lisa A Mielke, Tracy L Putoczki, Gabrielle T Belz

2021-02-01

Chronic inflammation of the gastrointestinal (GI) tract contributes to colorectal cancer (CRC) progression. While the role of adap..

Scholarly works icon

The structure of the extracellular domains of human interleukin 11? receptor reveals mechanisms of cytokine engagement

Riley D Metcalfe, Kaheina Aizel, Courtney O Zlatic, Paul M Nguyen, Craig J Morton, Daisy Sio-Seng Lio, Heung-Chin Cheng, Renwick CJ Dobson, Michael W Parker, Paul R Gooley, Tracy L Putoczki, Michael DW Griffin

2020-06-12

Interleukin (IL) 11 activates multiple intracellular signaling pathways by forming a complex with its cell surface α-receptor, IL-..

Scholarly works icon

Emerging roles for Interleukin-11 in disease

Paul M Nguyen, Suad M Abdirahman, Tracy L Putoczki

2019-06-01

Interleukin (IL)-11 belongs to the IL-6 family of cytokines, discovered over 30 years ago. While early studies focused on the abil..

University of Melbourne Researchers