IDENTIFICATION OF HOST RESTRICTION FACTORS THAT BLOCK RESPIRATORY VIRUS INFECTION
Grant number: 1143154 | Funding period: 2018 - 2021
Following inhalation, respiratory viruses can infect and grow in airway epithelial cells. Although immune cells such as macrophages are also susceptible to infection, this is generally abortive and new viruses are not released. This project will identify proteins induced in macrophages that block respiratory viruses and prevent their spread in the airways. We will also define mechanisms by which some virulent strains overcome this block to grow in macrophages.
Related publications (2)
Influenza A virus interactions with macrophages: Lessons from epithelial cells
Tina Meischel, Fernando Villalon-Letelier, Philippa M Saunders, Patrick C Reading, Sarah L Londrigan
Influenza viruses are an important cause of respiratory infection worldwide. In humans, infection with seasonal influenza A virus ..
IFITM3 and type I interferons are important for the control of influenza A virus replication in murine macrophages
Sarah L Londrigan, Linda M Wakim, Jeffrey Smith, Anne J Haverkate, Andrew G Brooks, Patrick C Reading
Abortive infection of macrophages serves as a "dead end" for most seasonal influenza A virus (IAV) strains, and it is likely to co..