HORMONAL RESPONSIVE CODING AND NON-CODING GENES IN PENILE DIFFERENTIATION AND HYPOSPADIAS
Grant number: 1138950 | Funding period: 2018 - 2021
Hypospadias, a failure of the correct formation of the penis, is the second-most common birth defect, occurring in around 1% of boys. It causes distress to both newborn and parents, requiring surgical intervention, and is a burden of cost and is a risk to the child. Furthermore, it is frequently associated with other abnormalities. We have a novel model in which we can induce penis abnormalities and define the link between hormonal exposures and defective penis differentiation.
Related publications (3)
Androgen and Oestrogen Affect the Expression of Long Non-Coding RNAs During Phallus Development in a Marsupial
Yu Chen, Yoko Kuroki, Geoff Shaw, Andrew J Pask, Hongshi Yu, Atsushi Toyoda, Asao Fujiyama, Marilyn B Renfree
There is increasing evidence that long non-coding RNAs (lncRNAs) are important for normal reproductive development, yet very few l..