ENDOCRINE CONTROL OF CELL FATE IN THE GONAD

Grant number: 1142481 | Funding period: 2018 - 2021

Completed

Abstract

Disorders of sexual development are amongst the most common birth defects in humans. These conditions have profound consequences for the physical and psychological health of affected individuals. The incidence of these disorders is on the rise, and this has been linked to our increased exposure to chemicals in the environment that affect how our hormones function. This project will investigate how these chemicals affect hormonal pathways that control early development.

Related publications (4)

Oestrogen Activates the MAP3K1 Cascade and beta-Catenin to Promote Granulosa-like Cell Fate in a Human Testis-Derived Cell Line

Melanie K Stewart, Pascal Bernard, Ching-Seng Ang, Deidre M Mattiske, Andrew J Pask

2021-09-01

Sex determination triggers the differentiation of the bi-potential gonad into either an ovary or testis. In non-mammalian vertebra..

Oestrogen regulates SOX9 bioavailability by rapidly activating ERK1/2 and stabilising microtubules in a human testis-derived cell line

Melanie K Stewart, Deidre M Mattiske, Andrew J Pask

2021-01-15

Nuclear SOX9 is essential for Sertoli cell differentiation and the development of a testis. Exposure of Sertoli cells to exogenous..

Exogenous Oestrogen Impacts Cell Fate Decision in the Developing Gonads: A Potential Cause of Declining Human Reproductive Health

Melanie K Stewart, Deidre M Mattiske, Andrew J Pask

2020-11-08

The increasing incidence of testicular dysgenesis syndrome-related conditions and overall decline in human fertility has been link..

Estrogen suppresses SOX9 and activates markers of female development in a human testis-derived cell line

Melanie K Stewart, Deidre M Mattiske, Andrew J Pask

2020-09-15

Background The increasing incidence of reproductive disorders in humans has been attributed to in utero exposure to estrogenic end..

University of Melbourne Researchers

Andrew Pask Biosciences

Dagmar Wilhelm Anatomy and Physiology

Marilyn Renfree Biosciences