MOLECULAR PATHOGENESIS OF MIXED LINEAGE LEUKAEMIA

Grant number: 1144649 | Funding period: 2019 - 2021

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Abstract

Chromosomal translocations in the MLL gene results in aggressive leukaemias. Several drugs developed to target proteins that interact with the MLL fusion proteins are now being tested in the clinic. Despite this progress, our understanding of how the MLL fusion proteins cause leukaemia remains incomplete. In particular, it is unclear how the MLL fusion protein drives the development of leukaemia. In this project I will address these important issues with cell and molecular biology methods.

University of Melbourne Researchers