USING GENOMICS TO UNDERSTAND AND INTERRUPT TRANSMISSION OF SEXUALLY TRANSMITTED PATHOGENS IN AUSTRALIA

Grant number: 1147735 | Funding period: 2018 - 2020

Completed

Abstract

Prevention and control of STIs in the 21st century requires timely, effective and high-resolution investigations which may be provided by genomic technologies. Building on existing datasets and expertise, we will provide a blueprint for genomics-based tracking of bacterial STIs in Australia, including the translation of this information to effect novel targeted public health actions, including screening, monitoring for outbreaks, and focused interventions to enhance control.

Related publications (8)

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Characterisation of Treponema pallidum lineages within the contemporary syphilis outbreak in Australia: a genomic epidemiological analysis

Mona L Taouk, George Taiaroa, Shivani Pasricha, Sophie Herman, Eric PF Chow, Francesca Azzatto, Bowen Zhang, Cheryll M Sia, Sebastian Duchene, Alvin Lee, Nasra Higgins, Jacqueline Prestedge, Yi Wei Lee, Nicholas R Thomson, Bianca Graves, Ella Meumann, Manoji Gunathilake, Jane S Hocking, Catriona S Bradshaw, Mathew A Beale

2022-06-01

BACKGROUND: The incidence of syphilis has increased markedly in the past decade in high-income countries, including Australia. To ..

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Nonclassical Pathogens as Causative Agents of Proctitis in Men who Have Sex With Men

Eric PF Chow, Darren Lee, Stephanie Bond, Christopher K Fairley, Kate Maddaford, Rebecca Wigan, Glenda Fehler, Sigrid A Lange, Vesna De Petra, Melanie Bissessor, Catriona S Bradshaw, Benjamin P Howden, Jane S Hocking, Deborah A Williamson, Marcus Y Chen

2021-07-01

BACKGROUND: This study aimed to identify enteric and sexually acquired rectal pathogens, other than chlamydia and gonorrhea, assoc..

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Reflex Detection of Ciprofloxacin Resistance in Neisseria gonorrhoeae by Use of the SpeeDx ResistancePlus GC Assay

Darren YJ Lee, Melinda M Ashcroft, Eric PF Chow, Michelle Sait, Vesna De Petra, Marlene Tschaepe, Sigrid Lange, George Taiaroa, Catriona S Bradshaw, David M Whiley, Christopher K Fairley, Benjamin P Howden, Marcus Y Chen, Shivani Pasricha, Deborah A Williamson

2021-05-01

Resistance-guided therapy (RGT) for gonorrhea may reduce unnecessary use of broad-spectrum antibiotics. When reflexed from the Apt..

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Y Extensively Drug-Resistant Shigellosis in Australia among Men Who Have Sex with Men

Deborah Williamson, Danielle Ingle, Benjamin Howden

2019-12-19

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Co-circulation of Multidrug-resistant Shigella Among Men Who Have Sex With Men in Australia

Danielle J Ingle, Marion Easton, Mary Valcanis, Torsten Seemann, Jason C Kwong, Nicola Stephens, Glen P Carter, Anders Goncalves da Silva, James Adamopoulos, Sarah L Baines, Kathryn E Holt, Eric PF Chow, Christopher K Fairley, Marcus Y Chen, Martyn D Kirk, Benjamin P Howden, Deborah A Williamson

2019-11-01

BACKGROUND: In urban Australia, the burden of shigellosis is either in returning travelers from shigellosis-endemic regions or in ..

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Trends and Risk Factors for Antimicrobial-Resistant Neisseria gonorrhoeae, Melbourne, Australia, 2007 to 2018

Deborah A Williamson, Christopher K Fairley, Benjamin P Howden, Marcus Y Chen, Kerrie Stevens, Vesna De Petra, Ian Denham, Eric PF Chow

2019-10-01

Antimicrobial resistance (AMR) in Neisseria gonorrhoeae is a major public health problem. Traditionally, AMR surveillance programs..

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Bridging of Neisseria gonorrhoeae lineages across sexual networks in the HIV pre-exposure prophylaxis era

Deborah A Williamson, Eric PF Chow, Claire L Gorrie, Torsten Seemann, Danielle J Ingle, Nasra Higgins, Marion Easton, George Taiaroa, Yonatan H Grad, Jason C Kwong, Christopher K Fairley, Marcus Y Chen, Benjamin P Howden

2019-09-05

Whole genome sequencing (WGS) has been used to investigate transmission of Neisseria gonorrhoeae, but to date, most studies have n..

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Risk Factors for Asymptomatic Enteric Pathogen Detection Among Men Who Have Sex With Men

Deborah A Williamson, Eric PF Chow, Darren Lee, Kate Maddaford, Michelle Sait, Marion Easton, Danielle Ingle, Rebecca Wigan, Vesna De Petra, Benjamin P Howden, Christopher K Fairley, Marcus Y Chen

2019-09-01

Improved knowledge of factors that promote outbreaks of enteric pathogens among men who have sex with men (MSM) could enable targe..

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