MECHANISMS OF RESISTANCE TO IMMUNOLOGICAL TARGETING OF PRIMARY AND METASTATIC COLORECTAL CANCERS

Grant number: 1140147 | Funding period: 2018 - 2021

Active

Abstract

The immune system influences the outcome in patients with cancer. We have been early adopters of immunotherapy approaches to target cancer cells using the novel approaches to enhance immune attack on cells that aberrantly express cancer regulators. These represent drivers to which cancer cells are addicted. A central tenant of optimizing immunotherapies has been to employ immune stimuli in concert with removing immune blocking systems. Our research plan is to improve immunotherapy efficiency.

Related publications (3)

Scholarly works icon

CD8( ) tumor-infiltrating lymphocytes within the primary tumor of patients with synchronous de novo metastatic colorectal carcinoma do not track with survival

Rosemary Millen, Shona Hendry, Vignesh Narasimhan, Rebecca Abbott, Matthew Croxford, Peter Gibbs, Jeanne Tie, Hui-Li Wong, Ian Jones, Suzanne Kosmider, David Byrne, John Zalcberg, Stephen Fox, Jayesh Desai, Kumar Visvanathan, Robert G Ramsay, Ben Tran

2020-01-01

Objectives: Tumor-infiltrating lymphocytes (TIL), particularly CD8+ TILs in patients with colorectal cancer (CRC), are highly prog..

Scholarly works icon

First-in-human phase I clinical trial of a combined immune modulatory approach using TetMYB vaccine and Anti-PD-1 antibody in patients with advanced solid cancer including colorectal or adenoid cystic carcinoma: The MYPHISMO study protocol (NCT03287427)

Toan Pham, Lloyd Pereira, Sara Roth, Laura Galletta, Emma Link, Tim Akhurst, Ben Solomon, Michael Michael, Phillip Darcy, Shienny Sampurno, Alexander Heriot, Robert Ramsay, Jayesh Desai

2019-12-01

Background: MYB is a transcription factor that is overexpressed in colorectal cancer (CRC) and also a driver mutation in adenoid c..

Scholarly works icon

Modeling open surgery in mice to explore peritoneal damage, carbon dioxide humidification and desmoidogenesis

Timothy Chittleborough, Shienny Sampurno, Sandra Carpinteri, Andrew Craig Lynch, Alexander Graham Heriot, Robert George Ramsay

2019-12-01

Background: The exposure of the peritoneum to desiccation during surgery generates lasting damage to the mesothelial lining which ..