MECHANISMS OF RESISTANCE TO IMMUNOLOGICAL TARGETING OF PRIMARY AND METASTATIC COLORECTAL CANCERS

Grant number: 1140147 | Funding period: 2018 - 2021

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Abstract

The immune system influences the outcome in patients with cancer. We have been early adopters of immunotherapy approaches to target cancer cells using the novel approaches to enhance immune attack on cells that aberrantly express cancer regulators. These represent drivers to which cancer cells are addicted. A central tenant of optimizing immunotherapies has been to employ immune stimuli in concert with removing immune blocking systems. Our research plan is to improve immunotherapy efficiency.

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