MECHANISMS OF RESISTANCE TO IMMUNOLOGICAL TARGETING OF PRIMARY AND METASTATIC COLORECTAL CANCERS

First-in-human phase I clinical trial of a combined immune modulatory approach using TetMYB vaccine and Anti-PD-1 antibody in patients with advanced solid cancer including colorectal or adenoid cystic carcinoma: The MYPHISMO study protocol (NCT03287427)

Toan Pham, Lloyd Pereira, Sara Roth, Laura Galletta, Emma Link, Tim Akhurst, Ben Solomon, Michael Michael, Phillip Darcy, Shienny Sampurno, Alexander Heriot, Robert Ramsay, Jayesh Desai

2019-12-01

Background: MYB is a transcription factor that is overexpressed in colorectal cancer (CRC) and also a driver mutation in adenoid c..

Modeling open surgery in mice to explore peritoneal damage, carbon dioxide humidification and desmoidogenesis

Timothy Chittleborough, Shienny Sampurno, Sandra Carpinteri, Andrew Craig Lynch, Alexander Graham Heriot, Robert George Ramsay

2019-12-01

<jats:title>Abstract</jats:title> <jats:sec id="j_pp-2019-0023_s_001a"> <jats:title id="d238055e10498">Background</jats:title> <ja..