RESCUING THE DYSTROPHIN-GLYCOPROTEIN COMPLEX TO PROTECT MUSCLES FROM WASTING CONDITIONS
Grant number: 1144772 | Funding period: 2018 - 2021
Existing medical strategies to counteract severe muscle wasting disorders are compromised because of dysfunctional signalling around a cluster of proteins called the dystrophin-glycoprotein complex (DGC) located at the muscle membrane. To address this significant unmet medical need, this proposal investigates novel approaches to retain or restore DGC integrity at the muscle membrane with the goals of preserving and protecting muscles during serious wasting conditions.
Related publications (5)
Phosphorylation of ERK and dystrophin S3059 protects against inflammation-associated C2C12 myotube atrophy
Kristy Swiderski, Christopher J Brock, Jennifer Trieu, Annabel Chee, Savant S Thakur, Dale M Baum, Paul Gregorevic, Kate T Murphy, Gordon S Lynch
The dystrophin-glycoprotein complex (DGC) is a multiprotein structure required to maintain muscle fiber membrane integrity, transm..