RESCUING THE DYSTROPHIN-GLYCOPROTEIN COMPLEX TO PROTECT MUSCLES FROM WASTING CONDITIONS

Grant number: 1144772 | Funding period: 2018 - 2022

Completed

Abstract

Existing medical strategies to counteract severe muscle wasting disorders are compromised because of dysfunctional signalling around a cluster of proteins called the dystrophin-glycoprotein complex (DGC) located at the muscle membrane. To address this significant unmet medical need, this proposal investigates novel approaches to retain or restore DGC integrity at the muscle membrane with the goals of preserving and protecting muscles during serious wasting conditions.

Related publications (5)

Murine models of Duchenne muscular dystrophy: is there a best model?

Kristy Swiderski, Gordon S Lynch

2021-08-01

Phosphorylation of ERK and dystrophin S3059 protects against inflammation-associated C2C12 myotube atrophy

Kristy Swiderski, Christopher J Brock, Jennifer Trieu, Annabel Chee, Savant S Thakur, Dale M Baum, Paul Gregorevic, Kate T Murphy, Gordon S Lynch

2021-04-01

The dystrophin-glycoprotein complex (DGC) is a multiprotein structure required to maintain muscle fiber membrane integrity, transm..

Aging and Skeletal Muscle

Gordon S Lynch

2020-01-01

Some of the most serious consequences of aging are its effects on skeletal muscle particularly the progressive loss of mass and fu..

Overcoming nature's paradox in skeletal muscle to optimise animal production

Gordon S Lynch, Rene Koopman

2019-01-01

Nature's paradox in skeletal muscle describes the seemingly mutually exclusive relationship between muscle fibre size and oxidativ..

Dietary meat and protection against sarcopenia

Gordon S Lynch, Rene Koopman

2018-10-01

Sarcopenia describes the age-related loss of skeletal muscle mass and associated muscle weakness. Sarcopenia is a major global hea..

University of Melbourne Researchers

Gordon Lynch Anatomy and Physiology

Paul Gregorevic Anatomy and Physiology