EXPLAINING THE CAUSAL EFFECT OF OBESITY ON COLORECTAL AND POSTMENOPAUSAL BREAST CANCER
Grant number: 1150591 | Funding period: 2018 - 2019
With rising rates in Australia and globally, obesity is fast surpassing smoking to become the biggest preventable cause of cancer. While losing weight might reduce the risk of cancer, most people find this hard to do. In this project, possible mechanisms linking obesity to bowel and postmenopausal breast cancer will be studied to work out how important they are for each cancer. Ultimately, the goal is to help design strategies for prevention and early detection of cancers caused by obesity.
Related publications (3)
Adiposity and Endometrial Cancer Risk in Postmenopausal Women: A Sequential Causal Mediation Analysis
S Ghazaleh Dashti, Dallas R English, Julie A Simpson, Amalia Karahalios, Margarita Moreno-Betancur, Carine Biessy, Sabina Rinaldi, Pietro Ferrari, Anne Tjonneland, Jytte Halkjaer, Christina C Dahm, Helene Tilma Vistisen, Florence Menegaux, Vittorio Perduca, Gianluca Severi, Krasimira Aleksandrova, Matthias B Schulze, Giovanna Masala, Sabina Sieri, Rosario Tumino
BACKGROUND: Adiposity increases endometrial cancer risk, possibly through inflammation, hyperinsulinemia, and increasing estrogens..
Explaining the link between adiposity and colorectal cancer risk in men and postmenopausal women in the UK Biobank: A sequential causal mediation analysis
S Ghazaleh Dashti, Vivian Viallon, Julie A Simpson, Amalia Karahalios, Margarita Moreno-Betancur, Dallas R English, Marc J Gunter, Neil Murphy
Mechanisms underlying adiposity-colorectal cancer (CRC) association are incompletely understood. Using UK Biobank data, we investi..
Adiposity and estrogen receptor-positive, postmenopausal breast cancer risk: Quantification of the mediating effects of fasting insulin and free estradiol
S Ghazaleh Dashti, Julie A Simpson, Amalia Karahalios, Vivian Viallon, Margarita Moreno-Betancur, Lyle C Gurrin, Robert J MacInnis, Brigid M Lynch, Laura Baglietto, Howard A Morris, Marc J Gunter, Pietro Ferrari, Roger L Milne, Graham G Giles, Dallas R English
Adiposity increases estrogen receptor (ER)-positive postmenopausal breast cancer risk. While mechanisms underlying this relationsh..