Exploiting And Defining The Immune Regulatory Activities Of Bet Bromodomain Inhibitors

Grant number: 1151409 | Funding period: 2018 - 2021

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Abstract

Immune-based agents such as “checkpoint inhibitors” have the ability to re-awaken our own immune systems and activate previously dormant anti-tumour responses. We have discovered that small molecule inhibitors of gene regulatory proteins called bromodomain proteins act synergistically with checkpoint inhibitors in mouse cancer models. I will define the molecular and biological events underpinning this novel combination approach and assess the effects of the combination across different tumours.