CONTRIBUTION OF MDSC-DERIVED CYSTEINE CATHEPSINS IN BREAST CANCER METASTASIS TO BONE

Grant number: 1091636 | Funding period: 2018 - 2018

Completed

Abstract

Cathepsins are enzymes called proteases that function to cleave specific proteins, a process that is important for many normal cellular functions. Aberrant cathepsin activity can result in a number of pathologies, including cancer and inflammation. We are developing tools called activity-based probes to study the function of cathepsins in disease. Specifically, we will investigate their activity within cells of the immune system with the goal of developing novel therapeutic approaches.