DEGRADABLE NANOCAPSULES FOR THROMBOPROPHYLAXIS AND TREATMENT OF ACUTE THROMBOSIS

Grant number: 1138361 | Funding period: 2018 - 2021

Completed

Abstract

The consequences of fat build up in vessels such as heart attacks and brain infarcts are the major cause of death in Australia. Clot busters have been proven to be beneficial for patients with heart attacks, clots in the legs or lungs and brain infarcts. However, the currently available drugs have major limitations in efficacy and in safety. The aim of this project is to develop novel drugs that have the potential to improve both significantly.

Related publications (2)

Polyphenol-Functionalized Cubosomes as Thrombolytic Drug Carriers

Haitao Yu, Jason S Palazzolo, Yi Ju, Be'eri Niego, Shuaijun Pan, Christoph E Hagemeyer, Frank Caruso

2022-09-13

The safe administration of thrombolytic agents is a challenge for the treatment of acute thrombosis. Lipid-based nanoparticle drug..

Bioresponsive Polyphenol-Based Nanoparticles as Thrombolytic Drug Carriers

Haitao Yu, Jason S Palazzolo, Jiajing Zhou, Yingjie Hu, Beeri Niego, Shuaijun Pan, Yi Ju, Ting-Yi Wang, Zhixing Lin, Christoph E Hagemeyer, Frank Caruso

2022-01-12

Thrombolytic (clot-busting) therapies with plasminogen activators (PAs) are first-line treatments against acute thrombosis and isc..

University of Melbourne Researchers

Frank Caruso Chemical Engineering